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Search Results: 1 - 10 of 3463 matches for " Nancy Reilly "
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Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects
Vishwanath Venketaraman, Tatanisha Rodgers, Rafael Linares, Nancy Reilly, Shobha Swaminathan, David Hom, Ariel C Millman, Robert Wallis, Nancy D Connell
AIDS Research and Therapy , 2006, DOI: 10.1186/1742-6405-3-5
Abstract: Tuberculosis (TB) is a major global health problem [7]. Approximately one-third of the world's population is latently infected with Mycobacterium tuberculosis (LTBI). Individuals with LTBI have a 5–10% lifetime risk of developing active disease [7]. Human immunodeficiency virus (HIV) infected subjects with LTBI are at very high risk of developing active tuberculosis. Development of active TB in HIV patients is due not only to reactivation of latent M. tuberculosis infection but also due to increased susceptibility to primary progressive M. tuberculosis infection [7].Innate and adaptive immune responses are required for successful control of M. tuberculosis infection. Macrophages provide first line defense against M. tuberculosis infection. Murine macrophages can be activated to kill intracellular M. tuberculosis by treatment with LPS (a stimulus for TNF-α expression, via triggering of toll-like receptors) and IFN-γ (a product of activated lymphocytes). Nitric oxide (NO) produced by infected macrophages is the main mediator (effector molecule) in this process. Like those of mice, human macrophages also acquire antimycobacterial activity through IFN-dependent interactions with lymphocytes [12]. However, exogenous IFN-γ does not enhance the mycobactericidal activity of isolated human macrophages as it does those of mice. Several studies indicate instead that direct cellular contact is required for the induction of antimycobacterial activity in human macrophages [6,33], and that this activity reflects caspase-mediated induction of apoptosis, triggering of toll-like receptors, the release of antibiotic peptides (e.g., granulysin), or unknown mechanisms [4,36].Glutathione (GSH) is an antioxidant and plays a vital role in cellular detoxification and enhancement of immune functions [10]. Interestingly, HIV-infected people have subnormal GSH levels in their plasma, lung epithelial lining fluid, peripheral blood mononuclear cells (PBMC), and other blood cells [5,11,14,23]. It
Investors Perception Regarding Depository Services
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Depository is an organization which holds securities of investors in electronic form. The objectives ofdepository system are to reduce the time for transfer of securities, to avoid the risk of settlement of securities, toenhance liquidity and efficiency, to reduce cost of transaction for the investor, to create a system for the centralhandling of all securities, to promote the county's competitiveness by complying with global standards, to provideservice infrastructure in a capital market.In this article, Investigator gave brief overview about depository participants, eligibility criteria for DPsand the legal framework of Depository system in India. In research, investigator has used a structured questionnairefor eliciting the required responses relating to Depository Services from the general public. For the purpose ofsecondary data books, articles, reports, annual reports of the stock exchanges, news papers and internet has beenused.
Predictors of Retention and Passing the National Council Licensure Examination for Registered Nurses  [PDF]
Nancy Elkins
Open Journal of Nursing (OJN) , 2015, DOI: 10.4236/ojn.2015.53026
Abstract: Using Seidman’s retention formula as a theoretical foundation, this study investigated historical data from a Bachelor of Science (BSN) nursing program to determine whether the admission variables of the preprogram grade point averages (GPA), American College Testing (ACT) scores, anatomy and physiology course grades, and/or the Health Education System Inc. (HESI) Exit Exam scores could predict completing the nursing program, as well as passing the NCLEX-RN. A significant relationship (p < 0.01) was identified between the preprogram GPA, ACT scores, anatomy grades, and the HESI Exit Exam scores with the completion of the BSN program and passing the NCLEX-RN.
Gender, Culture, and Sex-Typed Cognitive Abilities
David Reilly
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039904
Abstract: Although gender differences in cognitive abilities are frequently reported, the magnitude of these differences and whether they hold practical significance in the educational outcomes of boys and girls is highly debated. Furthermore, when gender gaps in reading, mathematics and science literacy are reported they are often attributed to innate, biological differences rather than social and cultural factors. Cross-cultural evidence may contribute to this debate, and this study reports national gender differences in reading, mathematics and science literacy from 65 nations participating in the 2009 round of the Programme for International Student Assessment (PISA). Consistently across all nations, girls outperform boys in reading literacy, d = ?.44. Boys outperform girls in mathematics in the USA, d = .22 and across OECD nations, d = .13. For science literacy, while the USA showed the largest gender difference across all OECD nations, d = .14, gender differences across OECD nations were non-significant, and a small female advantage was found for non-OECD nations, d = ?.09. Across all three domains, these differences were more pronounced at both tails of the distribution for low- and high-achievers. Considerable cross-cultural variability was also observed, and national gender differences were correlated with gender equity measures, economic prosperity, and Hofstede’s cultural dimension of power distance. Educational and societal implications of such gender gaps are addressed, as well as the mechanisms by which gender differences in cognitive abilities are culturally mediated.
Adrian Reilly
Romanian Journal of European Affairs (RJEA) , 2004,
Abstract: The EU has long had a goal of ‘reducing economic and social disparities.’ Since the reforms to the European Structural Funds in 1988 the Commission has encouraged enhanced subnational actor participation in policy-making, although subsequent reforms in 1993 and 1999 have been seen as attempts to ‘renationalize’ the policy. This paper argues that the minimal effect the Funds have had on the ground results not from renationalization but from inherent differences between multilevel actors on one of the key principles of Structural Funding i.e. partnership. The research findings show that whilst intergovernmental mechanisms have not changed since 1988, neither has the acceptance of the need for partnership between national and regional actors, especially in federal or quasi-federal states. The inability of the Funds to reduce disparities and the lack of understanding of partnership both provide lessons for new entrants to the EU: transforming domestic governance arrangements to accommodate the requirements of EU regional funding may only be successful if there are wider understandings of changes in ‘governance’; Europe’s poorer regions have not been able to close the gap with their richer neighbours with the implication that the regions of the Accession States will be in no better position in ten years time than they are now when compared to other regions throughout the EU.
Disabilities among refugees and conflict-affected populations
Rachael Reilly
Forced Migration Review , 2010,
Abstract: In 2007 the Women’s Refugee Commission launched a major research project to assess the situation for those living with disabilities among displaced and conflict-affected populations.
Unforgettable, I Wish You Were
Stephen Reilly
Humanising Language Teaching , 2013, DOI: 17559715
Classification and diagnosis of the inherited neuropathies
Reilly Mary
Annals of Indian Academy of Neurology , 2009,
Pharmacogenomics: The Significance of Genetics in the Metabolism of Natural Medicines  [PDF]
Nancy W. Hanna
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2012, DOI: 10.4236/jbnb.2012.34046
Abstract: Natural products have been implemented in medicine through use as herbal medications, chemical compound extraction for prescription medication, or a natural source of food to fight various infections and diseases. Genetics has played a role in identifying various interactions between existing drugs and side effects. In addition, various food allergies have been identified with children in recent years, suggesting genetic associations between certain populations carrying specific genetic alleles. The recent availability of genomic data and our increased understanding of the effects of genetic variations permit a quantitative examination of the contribution of genetic variation to efficacy or toxicity of compounds derived from natural sources. The identification of target molecules relevant for diseases allows screening for natural products capable of inhibiting targets which can lead to the development of rational treatment of various diseases including neurobiological disorders, cancer, osteoporosis, and cardiovascular diseases. This allows for more opportunities to predict the response of individual patients. Identification of genetic variations that arose as a consequence of naturally occurring compounds will help identify gene alleles, or protein ligands that can affect the pharmacodynamic and pharmacokinetics of the natural products in question. In addition, diet modification and precautions to food products can be identified to help consumers limit or increase certain food intake. Understanding the molecular mechanisms underlying these interactions and their modification by genetic variation is expected to result in the development of new drugs that optimize individual health. We expect that strategies for individualized therapies will lead to improved results for patients.
Building Trust: Children Experiences with Food Allergies at Summer Camp  [PDF]
Sydney Leibel, Nancy Fenton
Health (Health) , 2016, DOI: 10.4236/health.2016.814143
Abstract: Introduction: The objective of this study was to explore the experiences and perceptions of children with food allergies at summer camp. Methods: Qualitative draw-and-tell interviews were conducted with 14 food allergic individuals aged 5 - 12 years to capture their lived experience with food allergies at summer camp. Results: Four key interdependent themes: trust, accommodation, proactive parents and coping strategies were identified in how children perceive their food allergies in unregulated summer camp environments.
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