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Search Results: 1 - 10 of 155050 matches for " Nancy H.; Ray "
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Impact of an educational intervention on steroid prescribing and dosing effect on patient outcomes in COPD exacerbations
Hope,Nancy H.; Ray,Shaunta′M.; Franks,Andrea S.; Heidel,Eric;
Pharmacy Practice (Internet) , 2010, DOI: 10.4321/S1886-36552010000300002
Abstract: the increasing number of patients affected by chronic obstructive pulmonary disease (copd) and associated exacerbations has led to both rising hospital admissions and significant economic impact. evidence-based guidelines have been formulated for copd management recommending the use of low dose, oral corticosteroid therapy in the treatment of exacerbations. however, fewer than 50% of physicians′ prescribing practices appropriately reflect the published clinical guidelines on the use of systemic corticosteroids in these patients. objective: the purpose of this study was to evaluate the impact of a pharmacist-led educational intervention on prescribing practices and patient outcomes when using systemic corticosteroids in patients with copd exacerbations. methods: this retrospective case-control study included patients admitted to an inpatient family medicine service with a copd exacerbation who received systemic corticosteroids. two pharmacist-led educational interventions were delivered to prescribers to review current guidelines for managing copd exacerbations with systemic corticosteroids. patients were retrospectively identified over a three month span prior to and following the educational intervention. data was collected via chart review to evaluate prescribing practices prior to and following the educational sessions. in addition, data was collected to evaluate the effects of an educational intervention on length of stay, adverse events, and cost of treatment. results: a total of 23 pre-intervention patients and 18 post-intervention patients met inclusion criteria. after pharmacist-led interventions, guidelines were not more likely to be adhered to by prescribers when compared to guideline adherence in the pre-intervention patients. because no statistically significant change in guideline adherence was observed, there was no impact on secondary outcomes. conclusion: pharmacist-led didactic educational interventions and guideline dissemination do not improve gui
The MiniBooNE Experiment : An Overview
H. Ray
Physics , 2007,
Abstract: Neutrino oscillations have been observed in three sectors : solar ($\nu_e$ disappearance), atmospheric ($\nu_{\mu}$ disappearance), and accelerator ($\bar{\nu_{\mu}} \to \bar{\nu_e}$). The probability for two-neutrino oscillation is a function of four variables : two are determined by the conditions of the experiment, and two are the quantities fit for when performing an oscillation search ($\sin^2(2\theta)$ and $\Delta m^2$). $\Delta \mathrm{m}^2$ is the difference in squares of the mass states of the neutrinos ($\Delta \mathrm{m}^2_{12}$ = $\mathrm{m}^2_2$ - $\mathrm{m}^2_1$). If the observed oscillations only occur between neutrinos in the Standard Model a summation law of the $\Delta \mathrm{m}^2$ is valid ($\Delta \mathrm{m}^2_{13}$ = $\Delta \mathrm{m}^2_{12}$ + $\Delta \mathrm{m}^2_{23}$). The observed oscillations do not follow this summation law. This implies one of the results is incorrect or there exists physics beyond the Standard Model. While the solar and atmospheric results have been confirmed by several different experiments, the accelerator based result, from the Los Alamos LSND experiment, has yet to be fully vetted. The MiniBooNE experiment, located at Fermi National Laboratory, is designed to fully explore the LSND result. MiniBooNE is in the final stages of performing a blind oscillation search ($\nu_{\mu} \to \nu_e$) using neutrino data collected through November, 2005. A blind analysis is one in which you may analyze some of the information in all of the data, all of the information in some of the data, but not all of the information in all of the data. As MiniBooNE hasn't yet opened the box, this discussion will focus on the different components of MiniBooNE relevant for the oscillation analysis.
Implications of Confirmation of the LSND anti-nu_mu -> anti-nu_e Oscillation Signal
H. Ray
Physics , 2004, DOI: 10.1016/j.nuclphysbps.2005.05.091
Abstract: Neutrino oscillations have been observed in solar and atmospheric neutrinos, and in the LSND accelerator experiment. The Standard Model cannot accommodate all three positive results. The solar and atmospheric results have been confirmed. An oscillation signal seen by MiniBooNE will validate the oscillation signal seen by LSND. The question then becomes one of refining the Standard Model to allow for these three results. Four theories which can accommodate all three oscillation observations are the existence of sterile neutrinos, CP violation, the existence of variable mass neutrinos, and small Lorentz violations. The Spallation Neutron Source (SNS), located at Oak Ridge Laboratories, Oak Ridge, Tennessee, will provide an ideal site to test these hypotheses. The SNS, due to turn on in 2008, will supply a high intensity neutrino source of known flux and energy spectrum. This source permits experiments to probe the high delta-m^2 region for measurements, where a positive signal from MiniBooNE would lie.
Differential Relationships among Facets of Alexithymia and BDNF- and Dopamine-Related Polymorphisms  [PDF]
Nancy S. Koven, Leah H. Carr
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.31002
Abstract: Alexithymia refers to a cluster of emotion-related deficits such as difficulty attending to and identifying one’s feelings. Although not a diagnosable psychiatric condition, alexithymia is considered a personality risk factor for multiple pathologies, including somatoform, substance use, eating, and mood disorders. Evidence suggests heritability, but few studies have examined the influence of specific genes on alexithymic traits. Candidate genes explored thus far include those involved in modulation of brain-derived neurotrophic factor (BDNF) and dopamine, two neurotransmitters whose functions have been implicated in human emotion processing. This study investigated the relationship between the C270T polymorphism of the BDNF gene, facets of alexithymia, and possible interactions with the COMT, DAT1, and ANKK1 genes in a sample of 130 healthy adults. Given the multidimensionality of the alexithymia construct and its overlap with the related constructs of emotional intelligence and mood awareness, we used principal components analysis to derive Clarity of Emotion and Attention to Emotion as specific facets of alexithymia. Results showed that the C270T C/C genotype group had lower Clarity of Emotion scores relative to the C/T genotype group, even after covarying for COMT, DAT1, and ANKK1 genotypes. Dopamine-related genes had no association with alexithymia dimensions, nor did they interact with the C270T polymorphism to predict Clarity of Emotion. Although the molecular mechanisms by which this polymorphism influences BDNF are unknown, this study suggests a role for BDNF in modulating aspects of alexithymia. We discuss these results in the context of BDNF’s trophic effects in the nervous system.
Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma
Nancy H. Ruddle
Frontiers in Immunology , 2012, DOI: 10.3389/fimmu.2012.00350
Abstract: In this communication, the contribution of stromal, or non-hematopoietic, cells to the structure and function of lymph nodes (LNs), as canonical secondary lymphoid organs (SLOs), is compared to that of tertiary lymphoid tissue or organs (TLOs), also known as ectopic lymphoid tissues. TLOs can arise in non-lymphoid organs during chronic inflammation, as a result of autoimmune responses, graft rejection, atherosclerosis, microbial infection, and cancer. The stromal components found in SLOs including follicular dendritic cells, fibroblast reticular cells, lymphatic vessels, and high endothelial venules and possibly conduits are present in TLOs; their molecular regulation mimics that of LNs. Advances in visualization techniques and the development of transgenic mice that permit in vivo real time imaging of these structures will facilitate elucidation of their precise functions in the context of chronic inflammation. A clearer understanding of the inflammatory signals that drive non-lymphoid stromal cells to reorganize into TLO should allow the design of therapeutic interventions to impede the progression of autoimmune activity, or alternatively, to enhance anti-tumor responses.
Numb chin syndrome as a manifestation of metastatic squamous cell carcinoma of esophagus
Narendra H,Ray Satadru
Journal of Cancer Research and Therapeutics , 2009,
Abstract: Numb chin syndrome (NCS) is a sensory neuropathy presenting with numbness of the chin in the distribution of the mental nerve and the branches of the mandibular division of the trigeminal nerve. Though it can be caused by a benign process, NCS should be regarded as being due to malignancy until proven otherwise. Among the malignancies that cause NCS the most common are breast cancer, prostate cancer, and lymphoreticular malignancy. In squamous cell carcinoma (SCC) of the esophagus, spread to the mandible is a rare and often late event. An often overlooked clinical sign in mandibular metastases is hypoesthesia or paresthesia over the peripheral distribution of the inferior alveolar nerve/mental nerve; this sign has been referred to in the literature as NCS or numb lip syndrome or mental nerve neuropathy. Rarely, this may be the first presentation of a disseminated malignancy. Prognosis is usually poor. The discovery of this symptom should alert the clinician to the possibility of disseminated disease. In this article we report a rare case of metastatic SCC of the esophagus in a 40-year-old male patient who presented with NCS. We also review the mechanism, causes, and evaluation of NCS.
Current Status of the MiniBooNE Experiment
H. Ray,for the MiniBooNE collaboration
Physics , 2004, DOI: 10.1142/S0217751X05025759
Abstract: MiniBooNE is an experiment designed to refute or confirm the LSND anti-nu_mu -> anti-nu_e oscillation result. MiniBooNE will look for oscillations of nu_mu -> nu_e in a closed-box appearance analysis. MiniBooNE began collecting data in 2002, and is expected to continue data taking through 2005. Current MiniBooNE results are presented.
Preceptor preferences for participating in electronic preceptor development
Davison,Machelle; Medina,Melissa S.; Ray,Nancy E.;
Pharmacy Practice (Internet) , 2009, DOI: 10.4321/S1886-36552009000100007
Abstract: objectives: new guidelines require preceptors to deliver approximately 30% of the doctor of pharmacy curricula. with preceptor?s increasing responsibilities, colleges are faced with the task of training preceptors as educators. identifying preceptor?s training format preferences (i.e. electronic vs. live) should contribute to the more effective and efficient creation of training materials and programs. methods: a preceptor training video was created and made available electronically and was distributed to 400 preceptors with a brief 2-part questionnaire about preceptor training preferences, electronic training preferences after viewing the video, and available technology resources for participating in electronic training. results: 38.25% of the questionnaires were returned. the majority of respondents (57%) preferred electronic to live preceptor developing training and the majority (53%) had not previously attended the live annual preceptor development conference offered by the college. 51.6% participants reviewed the electronic training video created by the ou college of pharmacy. of the respondents who did not watch the video, 73% cited having too little time, problems accessing the video, or technical reasons for not watching the training video. the majority of responders in all age groups preferred electronic training to face-to-face training except those ages 61-65 and the majority (55.7%) would participate in on-line training again in the future. the majority of respondents have the technical resources to participate in electronic training. conclusion: preceptors have limited time to participate in preceptor development training, although they view training as an important activity. this study reveals three main findings: (1) the majority of preceptors prefer electronic preceptor development training programs regardless of age; (2) would participate in future electronic training after having participated in electronic training; and (3) have the available resou
Neuroprotective Effects of Vitamin D in Multiple Sclerosis  [PDF]
Margaret H. Cadden, Nancy S. Koven, Mitchell K. Ross
Neuroscience & Medicine (NM) , 2011, DOI: 10.4236/nm.2011.23027
Abstract: Multiple sclerosis (MS), an autoimmune and neurodegenerative disease with no available cure, is marked by both physical and cognitive disability. In MS, central nervous system white matter lesions, believed to be consequences of inappropriate immune system reactivity, compromise inter-neuronal communication and, depending on the location of damage, beget a variety of symptoms including fatigue, loss of sensation, weakness of limbs, slowed psychomotor processing, and impaired memory. Recently, low vitamin D levels have been identified as a potential risk factor for MS, precipitating research into the immunomodulating properties of this vitamin that allow it to work in both a protective and therapeutic manner. Despite its promise as a disease-modifying agent, however, there is scant research that looks explicitly at vitamin D levels and cognitive symptoms of MS. Given the cognitive enhancing effects of vitamin D in other chronic inflammatory conditions such as chemotherapy-induced cognitive dysfunction and Alzheimer’s disease, there is urgent need to research whether vitamin D may prove equally beneficial in reducing cognitive sequelae in MS. Guidelines for future research are suggested.
Evaluation of grain corn grown in New Brunswick for dairy cows  [PDF]
Essi H. Evans, Nancy Clark, Josh Lamont, David Walker
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.31010

Corn harvested as grain is a relatively new crop for the province of New Brunswick. The recent availability of local corn has the potential to improve the sustainability of the dairy industry in New Brunswick, but there is debate within the industry concerning the value and best use of the grain. This experiment was conducted to assess the feeding value of locally-produced corn grain stored as dry grain, ensiled high moisture corn, or ensiled as high moisture corncob meal (HMCCM, unhusked ears sometimes referred to as snaplage) relative to dry grain obtained from Ontario. Three samples of each were evaluated In Sacco. Rates and extent of digestion were similar for local and Ontario corn regardless of presentation for crude protein and starch, but acid detergent fiber, neutral detergent fiber and dry matter digestibility values were lower for HMCCM than other treatments. A 4 × 4 Latin square study was conducted with 16 Holstein cows and 28 day feeding periods. Milk production and milk protein production were higher (P < 0.05) with the locally produced dry corn than with other treatments. Energy corrected milk was lowest with the HMCCM diet. These results indicated that the value of corn produced in New Brunswick is similar to that produced in Ontario.

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