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Search Results: 1 - 10 of 6362 matches for " Nan Sui "
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Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction
Shu bo Jin,Nan Sui
Frontiers in Behavioral Neuroscience , 2014, DOI: 10.3389/fnbeh.2014.00333
Abstract: Tree shrews represent a suitable animal model to study the pathogenesis of human diseases as they are phylogenetically close to primates and have a well-developed central nervous system that possesses many homologies with primates. Therefore, in our study, we investigated whether tree shrews can be used to explore the addictive behaviors induced by morphine. Firstly, to investigate the psychoactive effect of morphine on tree shrews’ behavior, the number of jumping and shuttling, which represent the vertical and horizontal locomotor activity respectively, was examined following the injection of different dosage of morphine. Our results showed intramuscular (IM) injection of morphine (5 or 10 mg/kg) significantly increased the locomotor activity of tree shrews 30-60 min post-injection. Then, using the conditioned place preference/aversion (CPP/CPA) paradigm, we found morphine-conditioned tree shrews exhibited place preference in the morphine-paired chamber on the test day. In addition, naloxone-precipitated withdrawal induced place aversion in the chronic morphine-dependent tree shrews. We evaluated the craving for morphine drinking by assessing the break point that reflects the maximum effort animals will expend to get the drug. Our data showed the break point was significantly increased when compared to the baseline on the 1st, 7th and 14th day after the abstinence. Moreover, in the intravenous morphine self-administration experiment, tree shrews conditioned with morphine responded on the active lever significantly more frequently than on the inactive lever after training. These results suggest that tree shrew may be a potential candidate for study the addictive behaviors and the underling neurological mechanisms.
DRUG ADDICTION BEHAVIOR AND ITS POTENTIAL BIOLOGICAL MECHANISM
药物成瘾行为的脑机制及其研究进展

SUI Nan,Chen Jing,
隋南
,陈晶

心理学报 , 2000,
Abstract: Drug addiction is a time-dependent course during which specific nucleus or cells in the brain adapt to repeated exposure to the drugs. The possible mechanism of addiction is explained basically and biologically by adaptation of cAMP pathway signaling, opioid and DA receptor-G protein coupling, etc. Biological changes from the acute effects of drugs to tolerance, sensitization, dependence and withdrawal syndromes have been revealed by much evidence. But at present it is still one of the greatest challenges to explicate the mechanism of long-term adaptation in specific brain regions.
Epigenetics: A Mechanism of Addictive Memory
成瘾相关记忆的表观遗传学机制 ——药物成瘾研究的新视角

LI Yong-Hui,HAN Jin,SUI Nan,
李勇辉
,韩锦,隋南

心理科学进展 , 2008,
Abstract: 成瘾相关记忆长期性的脑机制一直是药物成瘾研究领域的难点与热点,该文简要介绍了成瘾记忆长期性分子机制的研究脉络,提示表观遗传学修饰可能是研究药物成瘾的新视角.成瘾药物可以调节染色体不同亚型组蛋白乙酰化水平,不同基因DNA的甲基化程度从而改变染色体的空间结构,进而调节基因的表达导致成瘾,特别是DNA甲基化改变的相对的稳定性可能是成瘾记忆长期存在的分子基础.记忆再巩固过程中学习记忆相关脑区的记忆促进基因与记忆抑制基因的表观遗传学改变可能是未来研究的新趋势.
The Brain Mechanisms of Psychological Dependence and Relapse of Abusive Drugs
成瘾药物心理依赖及复发的脑机制研究

Zheng Xigeng,Li Yonghui,Sui Nan,
郑希耕
,李勇辉,隋南

心理科学进展 , 2006,
Abstract: This project focuses on investigations of the brain mechanisms of the psychological dependence of abusive drugs. By using various animal models, such as conditioned place preference (CPP), conditioned place aversion (CPA), drug-seeking intensity gradation model of Morris water maze, behavioral and conditioned behavioral sensitization, the roles of environmental stress, positive and negative emotional states on psychological dependence and its relapse, neural mechanism comparisons between drug reward and natural reward were explored from behavioral to neuronal and genetic level.
Glucocorticoids and Memory
糖皮质激素与记忆

Hu Jiafen,Sui Nan,Kuang Peizi,
胡家芬
,隋南,匡培梓

心理科学进展 , 1999,
Abstract: 对近年来有关糖皮质激素对记忆的作用的研究进行了小结。由于糖皮质激素的受体广泛分布在与记忆行为相关的脑区,而且对相应的神经元可塑性进行调节,因此糖皮质激素对个体的记忆的形成有着重要的影响。
Research Paradigms and Neural Mechanisms for Decision-making Deficits in Addicts
成瘾人群的决策障碍:研究范式与神经机制

YAN Wan-Sen,LI Shu,SUI Nan,
严万森
,李纾,隋南

心理科学进展 , 2011,
Abstract: Drug addicts and pathological gamblers usually prefer immediate reward and ignore the future consequences. They are inclined to choose the bad options those bring immediate gains but long-term losses, which implies a kind of decision-making deficits. The Delay Discounting Task (DDT), the Iowa Gambling Task (IGT) and the Cambridge Gamble Task (CGT) are mainly three typical research paradigms and methods on decision -making deficits including impulsivity, myopia and risk-taking in addicts. Studies in recent y...
PERCEPTUAL UNCONSCIOUS PROCESSING OF THE BRAIN
脑的感知觉无意识加工及其研究进展

Ke Xue,Sui Nan,
柯学
,隋南,沈德立

心理学报 , 2001,
Abstract: Consciousness has become a challenging question in life sciences. The viewpo int that consciousness is the processing of information at various levels of awareness is being widely accepted. It is inevitable to deal with unconscious or automatic p rocessing for explicating consciousness. The main concern is how consciousness i s converted into unconsciousness, how unconsciousness is done into consciousness , and the potential brain mechanisms of the conversion, including involvements o f anatomical and functional structure, synaptic connections in the neural networ ks and so on. The study of unconsciousness is of great benefit to untie the myst ery of consciousness that has been coming into focus by contemporary neuroscienc e. Recent progress of the study on the mechanisms of unconscious processing was reviewed from the points of cognitive neuroscience at different levels: the cogn itive profile of unconsciousness, the correlation between unconsciousness and br ain structures, and the interplay of synaptic connections. Contemporary research in cognitive psychology revealed that unconscious processing could even reach s emantic level, including unconscious processing of image, character and figure. In addition, unconscious processing was different from conscious processing in n ature and was distributed widely across the processing system of the brain, rath er than localized in any particular unit. Recently, cognitive neuroscience has g ot lots of findings on perceptual unconscious processing with functional magneti c resonance imaging (fMRI), positron emission tomography (PET), electroencephalo gram (EEG) etc. Various regions of the brain were involved in perceptual unconsc ious processing. Both the higher-and lower-order cortical areas had computation al power to make inferences about specific features of complex objects. The mech anism of synchronous neural activation of cortex was likely to bind together var ious features that belonged to each object and separate them from features of ot her objects. Evidence from neural networks and synapse also indicated that synch ronous neural activation of the cortex was an important mechanism of information processing. Finally, some potential perspectives of how to study unconsciousnes s and consciousness in cognitive neuroscience were presented.
EFFECT OF AMYGADALAE LESSION ON SPATIAL COGNITIVE ABILITY IN RATS
杏仁复合体损毁对大鼠空间认知能力的影响

Sui Nan,Xie Dong,Kuang Peizi,
隋南
,谢东,匡培梓

心理学报 , 1995,
Abstract: The effects of amygdalae(AE)lession in rats were tested for the aquisition and retention of spatial cognitive tasks in the Morris maze.The results indicated that subjects with AE Lesion produced spatial cognitive deficits and they usually used taxic strategies which were different from the mapping strategies used by the control subjects.The different strategies suggest that AE is related to the spatial cognitive system and belong to the auxiliary structure of the systme.
UNCONSCIOUS PRIMING OF NUMERAL
数字概念的视知觉无意识语义启动效应

Ke Xue,Bai Xuejun,Sui Nan,
柯学
,白学军,隋南

心理学报 , 2002,
Abstract: This study aims at investigating whether masked numerical primes can activate cognitive processes in semantic level without gaining access to consciousness. Ss were 56 university students (Exp 1, 2 and 3) in Tianjin Normal University, China. The experimental software E prime was used to control the presentation of stimuli to participants. In Exp 1, it was confirmed that the masked numerical primes presented for 30ms could not reach awareness level via signal detection techniques. In Exp 2, the primes and the targets were the same numerals and the subjects were simply told to classify the target as larger or smaller than 5. With multivariate analysis of variance (MANOVA), the priming effects were investigated at different priming conditions with either the prime number or the target number presented as an Arabic digit or a Chinese character. The results showed that the unseen numerical prime could facilitate or inhibit the subsequent processing of the target. In Exp3, priming remained significant under all conditions even when the primes and the targets belonged to two different stimulus serials. It is suggested that unconscious utilization of semantic information without awareness does exist.
SPATIAL COGNITIVE ABILITY: THE DIFFERENTIAL ROLE OF SEPTUM AND PARIETAL CORTEX
隔区或皮质顶叶损毁对大鼠空间认知能力的影响及大鼠搜索策略差异的研究

Sui Nan,Kuang Pei-zi Institute of Psychology,Academia Sinica,
隋南
,匡培梓

心理学报 , 1992,
Abstract: Separate groups of rats with lesions in the septum or parietal cortex were tested for acquisition and retention of the Morris water maze spatial cognitive task. Some of them in each lesion group received preoperative training in the task. Others in each group received no preoparative training. The results in- dicated that although both lesions lead to a spatial cognitive impairment in both the acquisition and retention of the task, the animals with septum lesions were more severely impaired than were the animals with parietal cortex lesions, as indicated by quantitative measures. Searching strategies were used as an index to eximine the qualitative difference of the animal's swimming beha- vior. The septum damaged animals tended to use "nonmapping" strategies to solve the task, and the strategies emerged a dynamic change. All of these su- ggested that the qualitative nature of the impairment differed from that of the parietal cortex damaged animals. The results of this study support the hypo- thesis that septum plays an important role in the processing of spatial mapping cognition.
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