oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

9 ( 1 )

2019 ( 16 )

2018 ( 16 )

2017 ( 18 )

Custom range...

Search Results: 1 - 10 of 2304 matches for " Najaf Amin "
All listed articles are free for downloading (OA Articles)
Page 1 /2304
Display every page Item
A Genomic Background Based Method for Association Analysis in Related Individuals
Najaf Amin, Cornelia M. van Duijn, Yurii S. Aulchenko
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0001274
Abstract: Background Feasibility of genotyping of hundreds and thousands of single nucleotide polymorphisms (SNPs) in thousands of study subjects have triggered the need for fast, powerful, and reliable methods for genome-wide association analysis. Here we consider a situation when study participants are genetically related (e.g. due to systematic sampling of families or because a study was performed in a genetically isolated population). Of the available methods that account for relatedness, the Measured Genotype (MG) approach is considered the ‘gold standard’. However, MG is not efficient with respect to time taken for the analysis of genome-wide data. In this context we proposed a fast two-step method called Genome-wide Association using Mixed Model and Regression (GRAMMAR) for the analysis of pedigree-based quantitative traits. This method certainly overcomes the drawback of time limitation of the measured genotype (MG) approach, but pays in power. One of the major drawbacks of both MG and GRAMMAR, is that they crucially depend on the availability of complete and correct pedigree data, which is rarely available. Methodology In this study we first explore type 1 error and relative power of MG, GRAMMAR, and Genomic Control (GC) approaches for genetic association analysis. Secondly, we propose an extension to GRAMMAR i.e. GRAMMAR-GC. Finally, we propose application of GRAMMAR-GC using the kinship matrix estimated through genomic marker data, instead of (possibly missing and/or incorrect) genealogy. Conclusion Through simulations we show that MG approach maintains high power across a range of heritabilities and possible pedigree structures, and always outperforms other contemporary methods. We also show that the power of our proposed GRAMMAR-GC approaches to that of the ‘gold standard’ MG for all models and pedigrees studied. We show that this method is both feasible and powerful and has correct type 1 error in the context of genome-wide association analysis in related individuals.
An R package "VariABEL" for genome-wide searching of potentially interacting loci by testing genotypic variance heterogeneity
Maksim V Struchalin, Najaf Amin, Paul HC Eilers, Cornelia M van Duijn, Yurii S Aulchenko
BMC Genetics , 2012, DOI: 10.1186/1471-2156-13-4
Abstract: We and Pare with colleagues (2010) developed a method allowing to overcome such difficulties. The method is based on the fact that loci which are involved in interactions can show genotypic variance heterogeneity of a trait. Genome-wide testing of such heterogeneity can be a fast scanning approach which can point to the interacting genetic variants.In this work we present a new method, SVLM, allowing for variance heterogeneity analysis of imputed genetic variation. Type I error and power of this test are investigated and contracted with these of the Levene's test. We also present an R package, VariABEL, implementing existing and newly developed tests.Variance heterogeneity analysis is a promising method for detection of potentially interacting loci. New method and software package developed in this work will facilitate such analysis in genome-wide context.Genome-wide association studies (GWAS) have been instrumental in identifying genetic variants involved in complex diseases. In GWAS, the relation between a trait of interest and genetic variation (usually a single nuclear polymorphism -- a SNP) is studied by assessing hundreds of thousands of polymorphisms in thousands of individuals. Several hundreds of loci for dozens of complex human diseases and quantitative traits have been discovered using GWAS [1].Though GWASs were successful in finding single loci associated with a trait, complex genetic models which include many interacting loci and environmental factors are of interest as they may help finding new loci and improve our understanding of the genetics of complex traits. A search for genetic interactions by direct analysis, in which all possible genetic models are examined, meets substantial computational and methodological difficulties. When millions of SNPs are considered, which nowadays has become routine in GWAS, testing for interaction for all possible pairwise combinations of SNPs becomes cumbersome requiring parallel computations using hundreds or thous
Candidate Gene-Based Association Study of Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients: A Prospective Study
P. Roberto Bakker, Egbert Bakker, Najaf Amin, Cornelia M. van Duijn, Jim van Os, Peter N. van Harten
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0036561
Abstract: Objective Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and tardive dystonia, subtypes of TD (orofacial and limb truncal dyskinesia), subtypes of parkinsonism (rest tremor, rigidity, and bradykinesia), as well as a principal-factor of the movement disorders and their subtypes, were examined for association with variation in 10 candidate genes (PPP1R1B, BDNF, DRD3, DRD2, HTR2A, HTR2C, COMT, MnSOD, CYP1A2, and RGS2). Methods Naturalistic study of 168 white long-stay patients with chronic mental illness requiring long-term antipsychotic treatment, examined by the same rater at least two times over a 4-year period, with a mean follow-up time of 1.1 years, with validated scales for TD, parkinsonism, akathisia, and tardive dystonia. The authors genotyped 31 SNPs, associated with movement disorders or schizophrenia in previous studies. Genotype and allele frequency comparisons were performed with multiple regression methods for continuous movement disorders. Results Various SNPs reached nominal significance: TD and orofacial dyskinesia with rs6265 and rs988748, limb truncal dyskinesia with rs6314, rest tremor with rs6275, rigidity with rs6265 and rs4680, bradykinesia with rs4795390, akathisia with rs4680, tardive dystonia with rs1799732, rs4880 and rs1152746. After controlling for multiple testing, no significant results remained. Conclusions The findings suggest that selected SNPs are not associated with a susceptibility to movement disorders. However, as the sample size was small and previous studies show inconsistent results, definite conclusions cannot be made. Replication is needed in larger study samples, preferably in longitudinal studies which take the fluctuating course of movement disorders and gene-environment interactions into account.
Antipsychotic-Induced Movement Disorders in Long-Stay Psychiatric Patients and 45 Tag SNPs in 7 Candidate Genes: A Prospective Study
P. Roberto Bakker, Asmar F. Y. Al Hadithy, Najaf Amin, Cornelia M. van Duijn, Jim van Os, Peter N. van Harten
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050970
Abstract: Objective Four types of antipsychotic-induced movement disorders: tardive dyskinesia (TD), parkinsonism, akathisia and tardive dystonia, subtypes of TD (orofacial and limb truncal dyskinesia), subtypes of parkinsonism (rest tremor, rigidity, and bradykinesia), as well as a principal-factor of the movement disorders and their subtypes, were examined for association with variation in 7 candidate genes (GRIN2B, GRIN2A, HSPG2, DRD3, DRD4, HTR2C, and NQO1). Methods Naturalistic study of 168 white long-stay patients with chronic mental illness requiring long-term antipsychotic treatment, examined by the same rater at least two times over a 4-year period, with a mean follow-up time of 1.1 years, with validated scales for TD, parkinsonism, akathisia, and tardive dystonia. The authors genotyped 45 tag SNPs in 7 candidate genes, associated with movement disorders or schizophrenia in previous studies. Genotype and allele frequency comparisons were performed with multiple regression methods for continuous movement disorders. Results Various tag SNPs reached nominal significance; TD with rs1345423, rs7192557, rs1650420, as well as rs11644461; orofacial dyskinesia with rs7192557, rs1650420, as well as rs4911871; limb truncal dyskinesia with rs1345423, rs7192557, rs1650420, as well as rs11866328; bradykinesia with rs2192970; akathisia with rs324035; and the principal-factor with rs10772715. After controlling for multiple testing, no significant results remained. Conclusions The findings suggest that selected tag SNPs are not associated with a susceptibility to movement disorders. However, as the sample size was small and previous studies show inconsistent results, definite conclusions cannot be made. Replication is needed in larger study samples, preferably in longitudinal studies which take the fluctuating course of movement disorders and gene-environment interactions into account.
Association Analysis of Bitter Receptor Genes in Five Isolated Populations Identifies a Significant Correlation between TAS2R43 Variants and Coffee Liking
Nicola Pirastu, Maarten Kooyman, Michela Traglia, Antonietta Robino, Sara M. Willems, Giorgio Pistis, Pio d’Adamo, Najaf Amin, Angela d’Eustacchio, Luciano Navarini, Cinzia Sala, Lennart C. Karssen, Cornelia van Duijn, Daniela Toniolo, Paolo Gasparini
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092065
Abstract: Coffee, one of the most popular beverages in the world, contains many different physiologically active compounds with a potential impact on people’s health. Despite the recent attention given to the genetic basis of its consumption, very little has been done in understanding genes influencing coffee preference among different individuals. Given its markedly bitter taste, we decided to verify if bitter receptor genes (TAS2Rs) variants affect coffee liking. In this light, 4066 people from different parts of Europe and Central Asia filled in a field questionnaire on coffee liking. They have been consequently recruited and included in the study. Eighty-eight SNPs covering the 25 TAS2R genes were selected from the available imputed ones and used to run association analysis for coffee liking. A significant association was detected with three SNP: one synonymous and two functional variants (W35S and H212R) on the TAS2R43 gene. Both variants have been shown to greatly reduce in vitro protein activity. Surprisingly the wild type allele, which corresponds to the functional form of the protein, is associated to higher liking of coffee. Since the hTAS2R43 receptor is sensible to caffeine, we verified if the detected variants produced differences in caffeine bitter perception on a subsample of people coming from the FVG cohort. We found a significant association between differences in caffeine perception and the H212R variant but not with the W35S, which suggests that the effect of the TAS2R43 gene on coffee liking is mediated by caffeine and in particular by the H212R variant. No other significant association was found with other TAS2R genes. In conclusion, the present study opens new perspectives in the understanding of coffee liking. Further studies are needed to clarify the role of the TAS2R43 gene in coffee hedonics and to identify which other genes and pathways are involved in its genetics.
Strategic Planning Model Formulation Based on Balanced Score Card: A Case Study
Elaheh Enteshari Najaf Abadi,Ali Karbasi Najaf Abadi,Iraj Soltani
International Journal of Academic Research in Business and Social Sciences , 2012,
Abstract: At the present age, strategic planning is considered as an important and vital matter for organizations and formulating and implementing strategic plans and accurate parameters may result in organizations long-term superiority in competitive field. But, regarding that competitive factors of all organizations are not the same, formulating the strategy with a similar trend is unlikely to be effective and the prerequisite for success of any organization is to focus and pay attention to its own capacities and unique competitive advantages and to formulate strategies based on those capacities along with focusing on the weakness and threats points. This article presents a model integrated of the strategic planning process and balanced score card and considering four dimensions of the Balanced Score Card (BSC), it accomplishes the process of strategic planning in the fields of financial, customer, internal processes and growth and learning separately and then determines the position of an organization in each dimension. Therefore, the strength and weakness points of the organization are identified and the type of strategies needed for any dimension determined separately. With the aid of this model, top managers are able to determine the organization expects and goals of different sectors clearly and in line with the vision and strategy of organization and deliver to the managers and authorities of different sectors. The results of this model are the analysis of factors influencing on the strategy formulation, extraction of key dimensions, provision of the SWOT matrix for four-folds dimensions of BSC and the identification of organization situation in each dimension such that through basing it on, integrated strategies and operational plans will be formulated for the organization. In this survey, Isfahan Company of tile industry has been studied as a sample and the results of the model implementation for this company described in the text.
The educational needs at time of hospital discharge of patients who haveundergone coronary artery bypass graft (CABG)
V. Shafiepour,A. Najaf Yarandi
Journal of Mazandaran University of Medical Sciences , 2006,
Abstract: Background and purpose: Patients education should be done according to assessment and determination of their educational needs and their gender. The purpose of this study was to determine and compare educational needs from the view point of men and women with coronary artery bypass at discharge time.Materials and Methods: This was a descriptive-comparative study. Questionnaire was used to determine the educational needs of 100 men and 100 women who had undergone CABG for the first time in six domains (activity, medication, diet, treatment & complication, enhancing quality of life and skin care) and then compared the results.Results: The findings showed that the immediate educational needs of patients were information about their activity while the least important mens need was information about improving quality of life and for women it was information about diet. Findings showed that there was a significant difference between mens and womens educational needs except medication (P<0.0001).Conclusion: Accordings to the results of this research there was a significant difference between mens and womens educational needs, therefore attention should be paid to the specific educational requirements of different genders. So it is highly recommended that the educational needs of men and women are determined and adequate and proper education should be given to them at the time of discharge.
Comparison of the frequency of nausea and vomitting, patients, and surgeons, satisfaction based on different anesthesia techniques in cataract surgery
Jabal Amoli,Noryan Najaf Abadi
Journal of Mazandaran University of Medical Sciences , 2006,
Abstract: Background and purpose: Cataract surgery is the most frequent surgery in old patients. Forty six percent of people older than 75 years of age have cataract. These elderly patients frequently have associated diseases. It is important to select the best anesthetic method with least complications. This study compared 3 anesthetic methods. Regarding to patients, and surgens, comfort, frequency of nausea and vomiting in the patients undergoing cataract surgery.Materials and Methods: This cross sectional observational study with simple sample recruitment was performed on 120 patients divided in three groups of 40 cases, with general anesthesia, topical anesthesia +light IV sedation and local anesthesia + light IV sedation in summer 2004 in Feiz Medical Center. Data collected using check list. One way Anova and Chi-square tests were used to compare mean qualitative and frequency of qualitative variables. The level of statistical significance was set at P< 0.05.Results: There were significant differences in mean score of surgeons, and patients, comfort, mean severity of nausea after surgery and mean score of pain between 3 groups (P<0.001). There was no significance difference in frequency of vomiting after surgery between 3 groups (P=0.33)Conclusion: It has been suggested that topical anesthesia +light IV sedation is a safe and effective method for cataract surgery.
Geothermal Water in Lebanon: An Alternative Energy Source  [PDF]
Amin Shaban
Low Carbon Economy (LCE) , 2010, DOI: 10.4236/lce.2010.11003
Abstract: Recently, demand for energy has been increased worldwide, notably in the view of high economic value and competi-tion of fossil fuel, as well as the negative impact of fuel consumption through carbon release, and thus the consequences on human health and environment. Various aspects of energy sources into Earth’s crust have been discovered and utilized. Geothermal energy is one aspect of these sources where they have been well pronounced in many countries and proved to be a potential energy source for the future needs. Lebanon, the country with rare natural energy, the renewable energy sources are almost ignored and there is only limited utilization of hydro-power, wind and solar energy, whilst oil imports occupy a substantial portion for energy use. Yet, geothermal energy has not raised and no concern has been given to this renewable source. Meanwhile, there are several indicators showing the existence of geothermal water in different regions in Lebanon. They almost occur where basalt rocks are exposed. This was evidenced whether from water in drilled wells or from various discharging springs, as well as indications of thermal water was observed also in many localities along the Lebanese coastal water. This study shows the available information in this respect, considering the occurrence of geothermal water in Lebanon as an alternative energy source. Thus four major geothermal domains were recognized. The study introduces detailed characterization on the existing aspects of geothermal water and inducing its hydrologic regime and mechanism of groundwater heating. It would be a reconnaissance stage that may help applying further detailed assessment.
Preferential Trade Agreements and the Law and Politics of GATT Article XXIV  [PDF]
Amin Alavi
Beijing Law Review (BLR) , 2010, DOI: 10.4236/blr.2010.11002
Abstract: The tasks Preferential Trade Agreements (PTAs) perform are expressed in their scope and covered issues, thus in order to be WTO compatible these aspects of PTAs should comply with the relevant WTO rules. This paper examines which aspects of PTAs can violate these rules and therefore can be challenged before the WTO Dispute Settlement Body, who may initiate such cases and why there hasn´t been more cases dealing with this important issue.
Page 1 /2304
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.