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Search Results: 1 - 10 of 552667 matches for " Naidu M.U.R "
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Promise of translational medicine: An evidence-based therapeutics
Naidu M.U.R
Indian Journal of Pharmacology , 2011,
Abstract:
Phase 0 - Microdosing strategy in clinical trials
Naidu M.U.R,Rani P
Indian Journal of Pharmacology , 2008,
Abstract: Drug development is an activity that is long, complex and expensive. In 2004, attrition in the drug development paradigm prompted the US Food and Drug Administration (FDA) to introduce its ′Critical Path′ document, which highlighted the serious discordance between major scientific advances and limited drug development process. One issue addressed was that of microdosing. The concept of microdosing involves the use of extremely low, nonpharmacologically active doses of a drug to define the pharmacokinetic profile of the medication in human subjects. Microdosing, thus, appears as a new viable concept in the ′toolbox′ of the drug development activity. It appears that microdosing strategy could complement standard animal-to-human scaling, redefining the existing concept of phase I clinical research. In future, when research methods and technology involved in Phase 0 studies become more sophisticated, human microdosing may be applied to a number of drugs developed subsequently.
An Electrooculographic Method for the Evaluation of Psychotropic Drugs on Saccadic Eye Movements in Healthy Subjects
Raveendranadh Pilli,Naidu M.U.R,Usha Rani Pingali,Ramesh Kumar Rao Takallapally
International Journal of Psychological Studies , 2012, DOI: 10.5539/ijps.v4n2p75
Abstract: Recording of saccadic eye movements has proved to be a valuable tool for investigation of brain function and dysfunction and is very sensitive to centrally acting drugs. Since there is a lack of agreement concerning velocity–amplitude characteristics of saccadic eye movements, the present study obtained saccadic eye movements from 24 healthy subjects using indigenously developed electro-oculographic recording and analysis system in forward and countdown sequence. The validity of the system was further tested by evaluating the psychotropic effects of 5mg zolpidem and 500mg caffeine in randomized, double blind, placebo controlled three way cross over design on 24 healthy subjects. Saccadic eye movements were measured at baseline and 1, 2 and 3 hrs after administration of study medication. Mean (±SD) values for peak saccadic velocity (PSV) over saccades of ±10, ±20, ±30, ±40, ±50 & ±60 degrees were in agreement with those previously reported. Zolpidem produced statistically significant decrease in PSV compared to placebo at all the angular displacements at 1 & 2 hrs. In contrast, caffeine produced non-significant increase in PSV at all angular displacements at 1hr. Similarly latency period (LP) increased with zolpidem and decreased with caffeine compared to placebo. The electro-oculographic recording and analysis system is simple, sensitive to centrally acting drug effects and therefore has potential for future experimental psychomotor assessment studies.
Bioequivalence Study of two Long Acting Isosorbide Mononitrate Formulations Assessed by Digital Pulse Plethysmography
Mohsin Mohd, M.U.R. Naidu, Jaydip Bhadun,Aravinda Babu P,T. Ramesh Kumar Rao
JK Science : Journal of Medical Education & Research , 2000,
Abstract: Not available
Replacement of Sesame Oil Cake by Duckweed (Lemna minor) in Broiler Diet
M.U. Ahammad,M.S.R. Swapon,T. Yeasmin,M.S. Rahman
Pakistan Journal of Biological Sciences , 2003,
Abstract: An experiment was conducted with 120, seven-day old Vencobb commercial broiler chick feeding ad libitum upto 42 days of age on 4 different iso-nitrogenous and iso-energetic diet formulated by replacing dietary sesame oil cake (SOC) by duckweed (DW) to have its effect on performance of broilers. Live weight, feed conversion and profitability increased when sesame oil cake was partially replaced by duck weed. Complete SOC replaced diet significantly reduced live weight gain, feed intake, feed conversion and profitability, as compared with partial replacement of SOC by duckweed and SOC based control diet. Partial replacement of SOC by DW did not affect survivability of broiler. So it might be concluded that replacement of costly SOC partially by cheaper unconventional DW in broiler diet resulted in increased profitability. Therefore, cheaper duckweed could be practiced in formulating economic balanced diet for broiler.
Seasonal Nutrient Variations in Two Acacia Species Growing under Saline Environment
Shirazi M.U.,B. Khanzada,S.M. Alam,R. Ansari
Pakistan Journal of Biological Sciences , 2001,
Abstract: Nutrients variation studies were conducted to understand the nutrient cycle (particularly nitrogen, phosphorus and cations) in four year old Acacia plantation ( Acacia nilotica and Acacia ampliceps) and the impact of salinity on nutrient cycling. Leaf samples were collected around the umbrella of 10 trees of each Acacia for nutrient content at the interval of two months. Soil salinity in the immediate proximity of the tree trunk was also monitored. Analytical results showed that both the species had adequate amount of nitrogen and phosphorus. Potassium was also near the critical levels. However, the Ca content was comparatively higher, which might be due to presence of organic acids during decomposition of organic residues present at the soil surface. Studies on monthly variation in mineral elements suggested that only single time period for sampling to study the nutrient status or scheduling time of fertilizer application is not appropriate. Therefore, the best time for studying nutrient status and fertilizer application would be during March-April or September-October, when the weather is mild and salinity is moderate.
An Assessment of Regulatory Framework for Monitoring of Pesticides in Sindh Province of Pakistan
A.A. Khooharo,R.A. Memon,M.Y. Memon,M.U. Mallah
Journal of Applied Sciences , 2006,
Abstract: Numerous companies have entered the pesticide market in Pakistan due to windfall profits and liberal policies of the government since 1980s, when new agriculture policy was announced and the import and sale of pesticides were shifted to private sector. Easy imports, low prices and availability of a variety of pesticides are the distinct advantages of liberal policies. On the other hand, sale of substandard pesticides is a common problem of farming community due to regulatory and institutional deficiencies. This study was conducted to evaluate and to redesign regulatory framework for monitoring of pesticides by Agriculture Extension in view of stakeholders` perceptions during 2003-04. Finding of the study revealed that during three years (2000-2002) 2190 samples were tested in provincial laboratories of Sindh and 268 (12%) were declared substandard. Out of 268, 150 FIRs (56%) were lodged and 86 (32%) cases were challenged in courts while only 47 (18%) cases were decided by the courts. Majority of the stakeholders including District Officers Agriculture (100%) and Sales Executives(63%) were not satisfied with the present monitoring system for pesticides. All the Pesticide Dealers interviewed were of the opinion that pesticide companies be named in FIR when samples are declared unfit by the laboratories, because they purchase sealed pesticides from pesticide companies.
A Linear Regression Model to Study the Relationship of Pesticide Imports with Agricultural Productivity Growth in Pakistan
A.A. Khooharo,R.A. Memon,M.U. Mallah
Journal of Applied Sciences , 2006,
Abstract: The purpose of this study was to examine the import of pesticides in Pakistan since February 1980, when import and sale of pesticide was shifted to private sector and subsidy on ground spraying was withdrawn. Various pesticide registration schemes of import have been discussed and number of pesticides registered in each scheme has been reported. The pros and cons of registration schemes have been discussed. An appropriate regression model satisfying basic assumptions has been developed for the import and consumption of pesticides. Using the model estimates, it was concluded that the growth rate of pesticide import was computed to be 35% in 1981 taking 1980 as base year, 30% in 1982 taking 1981 as base year; and for subsequent years, the growth rate of pesticide import has lowered and has reached at 8% in 1999 taking corresponding preceding year as base year. The same growth rate has been calculated till 2002. The agricultural growth rate has been recorded lower than that of pesticide import excepting 1995-96, when highest agricultural growth rate of the decade was recorded to be 11.7% and with pesticide import growth rate of 10%. This indicates that the trend of using pesticide for pest control is higher when compared to agricultural growth trend.
SALINITY INDUCED CHANGES IN THE LEAF ANATOMY OF THE MANGROVE Avicennia marina ALONG THE ANTHROPOGENICALLY STRESSED TROPICAL CREEK
M.U.Borkar, Athalye R.P. and Quadros Goldin
Journal of Coastal Development , 2011,
Abstract: The mangrove Avicennia marina is a dominant mangrove along the anthropogenically stressed tropical Thane creek, west coast of India. Leaf anatomy of the mangrove along the Thane creek, was assessed in relation to stationwise and seasonwise variations in salinity. It was noticed that under the conditions of higher salinity, Avicennia marina showed increased thickness of hypodermal water storage tissue in the leaf (for conservation of water) and produced taller salt extruding glands at the lower epidermis to eliminate more salt; whereas, the thickness of the photosynthetic mesophyllic tissue significantly reduced. At lower salinity or with reduction in salinity in monsoon, contrary to above occurred. These changes probably explain the stunted growth of Avicennia marina in high salinity environment and its vigorous growth at lower salinity.
Fertility Studies on two Methods of Libido Maintenance in West African Dwarf Rams
D.O. Umesiobi,U. Kalu,U. Ogundu,M.U. Iloeje,D.C. Anyanwu,L.R. Mcdowell
Journal of Animal and Veterinary Advances , 2012,
Abstract: An experiment was conducted to determine the effects of false mountings and sexual restraint on libido and semen fertility of West African Dwarf rams. Eighteen rams were assigned to nine treatment combinations involving 0, 5 and 10 minutes of restraint and 0, 2 and 3 false mounts. Semen quantity and quality were evaluated. Results from this study indicate that it requires the shortest time of 28.0 ? 0.65 sec at ten minutes of restraint and three false mounts (10R - 3FM) to achieve the highest libido. Mounting and prompt ejaculation provided a definite, clearly recognizable end point, for establishing that a ram was sexually stimulated sufficiently. Changes of stimulus animals and semen collection location were not commonly required to stimulate most of the rams and to maintain their sexual interest during teasing. Collection of semen with the highest total volumes (2.39?0.05ml), sperm motility (90.02?0.82%), live spermatozoa (87.88?0.65%) and total sperm per ejaculate (5.0 x109) were obtained when rams were sexually teased for 10 minutes that included three false mounts (10R - 3FM). The results of this present study suggest that 10 minutes of sexual restraint in conjunction with three false mounts are not too time consuming to be practical as methods for increasing semen output. In an attempt to maximize sperm quality and quantity sexual teasing might precede each ejaculate.
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