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Search Results: 1 - 10 of 18585 matches for " Nahla Ali Mobark "
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Pediatric Non-Hodgkin Lymphoma: A Retrospective 7-Year Experience in Children & Adolescents with Non-Hodgkin Lymphoma Treated in King Fahad Medical City (KFMC)  [PDF]
Nahla Ali Mobark, Suha A. Tashkandi, Wafa Al Shakweer, Khalid Al Saidi, Suha A. Fataftah, Mohammed M. Al Nemer, Awatif Alanazi, Mohammed Rayis, Walid Ballourah, Othman Mosleh, Zaheer Ullah, Fahad El Manjomi, Musa Al Harbi
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.64033

Background: Non-Hodgkin’s lymphoma is an aggressive malignant disease in children and adolescents. Although it is the fourth most common malignancy in Saudi children as reported in Saudi cancer registry, less information is available about pediatric Non-Hodgkin lymphoma and its outcome in Saudi Arabia. Study Objectives: To provide demographic data, disease characteristics, treatment protocol, toxicity and outcome of treatment in children & adolescents with Non-Hodgkin’s lymphoma treated at KFMC. This study will form base line for future studies about pediatric Non-Hodgkin’s lymphoma in KFMC, which may help to improve outcome for children with cancer in Saudi Arabia. Study Patients and Method: We retrospectively analyzed 28 children and adolescents diagnosed to have Non-Hodgkin’s lymphoma at KFMC between December 2006 and December 2013, followed-up through June 2014. Results: Of the 28 patients, 10 (35.7%) girls and 18 (64.3%) boys, the male-to-female ratio was 1.8; 1. The median age at time of diagnosis was 6.4 years old (range 2.0 to 13.0 years old). The majority of patients (64.3%) were aged between 5 and 12 years old. Burkitt’s lymphoma BL/BLL was the most common pathological subtype (60.7%), and DLBCL was the second most common subtype (21.4%). Abdominal and Retroperitoneal involvement was the most common primary site (78.6%) including the ileocaecal region. Most of the children presented with advanced Stage III and IV (75%), Cytogenetic study which screens specifically for the t (8; 14) (q24; q32) a characteristic genetic feature of Burkitt’s Lymphoma was obtained from 21 patients, variant rearrangement was observed in 3/21 samples and complex chromosomes karyotype in addition to IGH/MYC rearrangement was observed in 2/21 samples. Those patients presented with very aggressive lymphoma and combined BM and CNS involvement. We use the French-American-British Mature B-Cell Lymphoma 96 Protocol (FAB LMB 96) for treatment fornewly diagnosed Mature B-Cell type NHL and high risk ALL CCG 1961 Protocol for lymphoblastic lymphoma and international Anaplastic Large Cell Lymphoma 99 Study Protocol for ALCL. The median follow-up in patients not experiencing an adverse event was 53.1 months. The estimated 3-year EFE and OS rates in the entire cohort of patients with newly diagnosed NHL treated in the KFMC were 85.2% and 89.2% respectively; Overall survival (OS) rate of patients with mature

Locally internal stability of weakly elastic Bresse system
Nahla Noun,Ali Wehbe
Mathematics , 2012,
Abstract: In their paper "Stability to weak dissipative bresse system", Alabau et al. studied the exponential and polynomial stability of the Bresse system with one globally distributed dissipation law. Our goal is to extend their results, by taking into consideration the important case when the dissipation law is locally distributed and to improve the polynomial energy decay rate. We then study the energy decay rate of the Bresse system with one locally internal distributed dissipation law acting on the equation about the shear angle displacement. Under the equal speed wave propagation condition, we show that the system is exponentially stable. On the contrary, we establish a new polynomial energy decay rate.
Successful Conservative Management of Scrotal Edema Resulting from Uncomplicated Peritoneal Fluid Leak
A Mobark, J Eltahir, O Mahir, H Ali, M Hummieda, S Khalid, M Mudawi, E Elhassan, H Abu-Aisha
Arab Journal of Nephrology and Transplantation , 2009,
Abstract: Introduction: Peritoneal fluid leaks are frequent in continuous ambulatory peritoneal dialysis (CAPD) patients and may manifest as subcutaneous or genital edema or as apparent ultrafiltration (UF) failure. Genital swelling in CAPD patients is often due to dialysate leak through a small clinically-undetectable inguinal hernia, and may require herniorrhaphy. If imaging studies exclude an associated hernia or patent processus vaginalis, a conservative approach may be adopted. Case report: An 80 year-old bed-ridden male developed gross bilateral scrotal swelling (without cough impulse) and apparent UF failure shortly after initiation of CAPD. Computed tomography peritoneography (CTP) showed bilateral scrotal fluid collections without a hernia or patent processus vaginalis. An attempt to maintain the patient on CAPD by reducing the dialysate volume, scrotal elevation and adopting a supine position was not successful; CAPD was substituted with temporary hemodialysis (HD) for four weeks. Scrotal swelling reversed after one week of CAPD cessation and did not recur when supine PD with intermittent dry periods was reinstituted a few weeks later. Satisfactory UF could also be easily attained. This was compatible with caudal fluid migration through peritoneal defects being the underlying cause. The patient had been successfully maintained on CAPD for the last 18 months. Conclusion: Fluid dissection through soft tissues can result in gross genital edema and apparent ultrafiltration failure in CAPD patients. Supine PD, scrotal elevation with intermittent dry periods may be a practical alternative management in the absence of automated dialysis facilities. The severity of dialysate leak does not preclude a satisfactory response to this conservative management.
Phytochemical Investigation of Antimicrobial and Antioxidant Activity Leaves Extracts of Corchorus olitorius  [PDF]
Rehab Mobark Osman Mohammed
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102225
Abstract: The leaves extracts of Corchorus olitorius, the family Malvaceae, are commonly called khudra, the plant extensively used in Sudanese traditional medicine. The Sudanese varieties are one of the best in the market, which prompted investigation of leaves extracts. Some chemical analyses of the leaves have been done such as determination of ash content and trace elements (Ca, Fe, Mg, and Na) by atomic absorption spectrometry. The 96% ethanolic, Ethyl acetate and chloroform extracts exhibited significant antimicrobial activity and highlighted the biological monitoring of activity in order to isolate the active metabolites from the ethanolic extract of the leaves. The presence of sterols and triterpenes, carotenoids, coumarins, alkaloids, saponins, tannins, flavonoid and carbohydrates was confirmed by phytochemical screening of the diethyl ether, methanolic and aqueous extracts of the leaves. The extracts were screened in different solvent systems by thin layer chromatography. The methanolic, Ethyl acetate extract exhibited significant antioxidant activity. From the above-mentioned extract we prepare cream and ointment as antibacterial and antifungal dosage forms.
Study of Phytochemical Screening and Antimicrobial Activity of Citrus aurantifolia Seed Extracts  [PDF]
Rehab Mobark Osman Mohammed, Saad Mohmmed Hussein Ayoub
American Journal of Analytical Chemistry (AJAC) , 2016, DOI: 10.4236/ajac.2016.73022
Abstract: Citrus aurantifolia, the family Rutaceae, which consists of 150 genera and 900 species, is gaining grounds as important source for treatment in complementary medicine, and commonly called limone. Chloroform, methanol and ethanol extract exhibited significant antimicrobial activity and highlighted the biological monitoring of activity from the methanol extract of seeds. Phytochemical screening of the diethyl ether, methanol and aqueous extracts of seeds confirmed the presence of alkaloids, saponins, sterols and triterpenes, carotenoids, coumarins, tannins and carbohydrates. Chloroform extract was fractionated by sing liquid solid column chromatographic technique and column fractions eluted with chloroform and methanol. The antibacterial secondary metabolites were achieved by fractionation of the active. The seed extracts were monitored analytically by TLC preparative and some chemical analyses of seeds have been done such as determination of ash, nitrogen, protein content.
RNA Genome Profiles of Some Sudanese and South African Serotypes of Bluetongue Virus Using Agarose Gel Electrophoresis and SDS-PAGE
Nahla Ali,Abdel Rahim Karrar,Ali A. Magid,Mohammed E. H. Mohammed,Imadeldin Aradaib
Journal of Animal and Veterinary Advances , 2012,
Abstract: The double stranded RNA (dsRNA) genome segments of the Sudanese serotypes of Bluetongue virus (BTV) serogroup were analysed by agarose gel and sodium dodecyl sulphate (SDS)- polyacrylamide gel electrophoresis (SDS-PAGE). The dsRNA genome segments profiles of Sudanese BTV serotypes 1, 2, 4 and 16 were compared with those of South African BTV serotypes 1, 19 and 24. Both systems (agarose gel and SDS-PAGE) showed 10 segments, which is characteristic pattern of BTV serogroup. The agarose gel showed identical genome profiles for all Sudanese and South African serotypes of BTV serogroup. However, SDS-PAGE system was able to detect genetic variation between Sudanese and South African BTV serotypes and among the Sudanese serotypes of BTV. The result of this study suggested that, the agarose gel electrophoresis could be used as supportive or complementary method to facilitate tentative diagnosis of BTV infection in susceptible animal populations. In addition, the SDS-PAGE could also be used to detect genetic variations between serotypes of BTV serogroup from different continents.
Molecular Cloning, Characterization and Overexpression of a Novel Cyclin from Leishmania mexicana
Nahla O.M. Ali,Muntaser E. Ibrahim,Karen M. Grant,Jeremy C. Mottram
Pakistan Journal of Biological Sciences , 2010,
Abstract: We are reporting here, the cloning and characterization of the first cyclin from Leishmania mexicana. We have identified a cyclin-like motif from the L. major genome sequencing project. A cyclin homologue was cloned and sequenced from L. mexicana genome and it showed 96.1% amino acid identity with the putative L. major cyclin. It has also sequence identity to mitotic cyclins from other organisms. Southern analysis showed that it is present as a single copy gene. CYCa has been over-expressed in E. coli as a histidine fusion and western blot has confirmed the immunoreactive property of the recombinant cyclin, which then used to reconstitute active recombinant L. mexicana CRK3. No phosphorylation of histone HI was detected by both wild type and mutated CRK3 on the activation assays suggesting that phosphorylation status and cyclin binding are important for reconstituting protein kinase activity. The results confirm that we have isolated a cyclin molecule from L. mexicana (LmCYCa) which may play an important role in the regulation of the parasite cell cycle.
Design and construction optical fiber sensor system for detection the stress and fine motion
Bushra R. Mhdi,Nahla A.Aljabar,Suad M.Ali,Abeer H.Khalid
International Journal of Advances in Applied Sciences , 2013, DOI: 10.11591/ijaas.v2i2.459
Abstract: Two main concepts in design and construction of stress and fine motion detection system using fiber optic sensor was included in this project .The first is design and construction concept using Intensity Modulation techniques using plastic multimode optical fiber(125μm dim)and has NA(0.27) with losses rate (2.1 db)and directionality about(25 db),and we used (He-Ne)laser source(632.8 nm)with (LLM-2 light power meter) to detect the variation in output laser power due to micro-displacement for movement body under test. The second concept include Modeling for laser beam tracking through fiber and that which reflected for mirror to detector. Variation in output power due to target movement was theoretical analyzed from study of variation of Gaussian front wave profile of using (MATLAB) program within displacement range from(0-5 mm).Non-linear relation between separated distance and beam intensity was investigated. Finally our design are evaluated in comporizim with published research which found compatible in Theoretical and experimental results.
Respectable people in Mamluk sultans era: Religious and scientific life :
Nahla Moustafa
Historical Kan Periodical , 2010,
Abstract: . . . .
Respectable people in Mamluk sultans era: The economic conditions :
Nahla Moustafa
Historical Kan Periodical , 2009,
Abstract: .
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