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Search Results: 1 - 10 of 287 matches for " Nagpal Pran "
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Medical ethics - Some thoughts
Nagpal Pran
Indian Journal of Ophthalmology , 2000,
Abstract:
Role of Early Radial Optic Neurotomy in Central Retinal Vein Occlusion
Nagpal Manish,Nagpal Kamal,Bhatt Chirag,Nagpal Pran
Indian Journal of Ophthalmology , 2005,
Abstract: Purpose : To determine safety, clinical and visual results, and potential complications of early radial optic neurotomy (RON) surgery in eyes with central retinal vein occlusion (CRVO), with relative afferent pupillary defect and visual acuity < 6/60. Materials and Methods : This prospective, interventional case-series included 24 patients of CRVO who underwent RON within 2 months of disease onset. The preoperative examination included slitlamp biomicroscopy, fundus photography and fluorescein angiography. Foveal thickness was measured using optical coherence tomography (OCT) in the last 6 eyes only. In each case, RON was performed after informed consent. Two radial incisions were placed in the nasal quadrant of the optic disc, using a micro-vitreoretinal blade. The postoperative change in vision, clinical picture, fundus photographs, angiograms and foveal thickness by OCT were the main outcome variables studied. The Wilcoxan signed test was used to assess the results. Results : Average symptom duration was 37.8 ± 15.2 days (range 15-60 days, median: 34.5 days) and follow-up 7.7 ± 2.1 months (range 1-12 months, median: 8 months). Visual outcome: 2 (8.33%) eyes each had fall and preservation of pre-RON visual acuity respectively. Twenty eyes (83.33%) showed increase in vision (of average 3 lines). Pre and postoperative vision ranged from 0.017-0.1 (average:0.061) and 0.017-0.667 (average: 0.17) respectively ( P < 0.05). Clinical and angiographic outcome: Decline in macular oedema, decreased or resolved intraretinal haemorrhages, resolution of venous dilatation and disc oedema could be appreciated in all cases. Foveal thickness: Average pre and postoperative foveal thickness was 834.17 μm and 556.17 μm respectively ( P < 0.05) in the 6 eyes where it was measured before and after RON. One eye developed retinal-detachment. Conclusion : Radial optic neurotomy is better than the natural course in eyes with CRVO, with vision <6/60.
Authors′ reply
Dubey Arvind,Nagpal Pran,Chawla Shobhit,Dubey Benu
Indian Journal of Ophthalmology , 2008,
Abstract:
A proposed new classification for diabetic retinopathy: The concept of primary and secondary vitreopathy
Dubey Arvind,Nagpal Pran Nath,Chawla Shobhit,Dubey Benu
Indian Journal of Ophthalmology , 2008,
Abstract: Background: Many eyes with proliferative diabetic retinopathy (PDR) require vitreous surgery despite complete regression of new vessels with pan retinal laser photocoagulation (PRP). Changes in the vitreous caused by diabetes mellitus and diabetic retinopathy may continue to progress independent of laser regressed status of retinopathy. Diabetic vitreopathy can be an independent manifestation of the disease process. Aim: To examine this concept by studying the long-term behavior of the vitreous in cases of PDR regressed with PRP. Materials and Methods: Seventy-four eyes with pure PDR (without clinically evident vitreous traction) showing fundus fluorescein angiography (FFA) proven regression of new vessels following PRP were retrospectively studied out of a total of 1380 eyes photocoagulated between March 2001 and September 2006 for PDR of varying severity. Follow-up was available from one to four years. Results: Twenty-three percent of eyes showing FFA-proven regression of new vessels with laser required to undergo surgery for indications produced by vitreous traction such as recurrent vitreous hemorrhage, tractional retinal detachment, secondary rhegmatogenous retinal detachment and tractional macular edema within one to four years. Conclusion: Vitreous changes continued to progress despite regression of PDR in many diabetics. We identifies this as "clinical diabetic vitreopathy" and propose an expanded classification for diabetic retinopathy to signify these changes and to redefine the indications for surgery.
Author′s reply
Nagpal Kamal,Nagpal Manish
Indian Journal of Ophthalmology , 2005,
Abstract:
Author′s reply
Nagpal Kamal,Nagpal Manish
Indian Journal of Ophthalmology , 2005,
Abstract:
A comparative debate on the various anti-vascular endothelial growth factor drugs: Pegaptanib sodium (Macugen), ranibizumab (Lucentis) and bevacizumab (Avastin)
Nagpal Manish,Nagpal Kamal,Nagpal P
Indian Journal of Ophthalmology , 2007,
Abstract: Wet age-related macular degeneration and diabetic retinopathy are pathological consequences of vascular endothelial growth factor (VEGF) release as a reaction to deficiency of oxygen and nutrients in the macular cells. Conventional treatment modalities have been constrained by limited success. Convincing evidence exists that targeting VEGF signaling is a significant approach for the therapy of these ocular angiogenesis-dependent disorders. We have come a long way since the approval of the first angiogenesis inhibitors in medicine. The clinical use of these drugs has provided enormous tempo to clinical and pharmacological research. It has also significantly altered patient outcome and expectations. In the following brief, we will discuss the development and emergence of these drugs as well as the anticipated future course based on evidence.
Author′s reply
Nagpal Manish,Nagpal Kamal,Nagpal P
Indian Journal of Ophthalmology , 2008,
Abstract:
Predicted Signatures at the LHC from U(1) Extensions of the Standard Model
Nath, Pran
High Energy Physics - Phenomenology , 2008, DOI: 10.1142/S0217732310034444
Abstract: We discuss the $U(1)_X$ extensions of the standard model with focus on the Stueckelberg mechanism for mass growth for the extra $U(1)_X$ gauge boson. The assumption of an axionic connector field which carries dual U(1) quantum numbers, i.e., quantum numbers for the hypercharge $U(1)_Y$ and for the hidden sector gauge group $U(1)_X$, allows a non-trivial mixing between the mass growth for the neutral gauge vector bosons in the $SU(2)_L\times U(1)_Y$ sector and the mass growth for the vector boson by the \st mechanism in the $U(1)_X$ sector. This results in an extra $Z'$ which can be very narrow, but still detectable at the Large Hadron Collider (LHC). The $U(1)_X$ extension of the minimal supersymmetric standard model is also considered and the role of the Fayet-Illiopoulos term in such an extension discussed. The $U(1)_X$ extensions of the SM and of the MSSM lead to new candidates for dark matter.
High Scale Physics Connection to LHC Data
Nath, Pran
High Energy Physics - Phenomenology , 2008, DOI: 10.1142/S0217751X10051190
Abstract: The existing data appears to provide hints of an underlying high scale theory. These arise from the gauge coupling unification, from the smallness of the neutrino masses, and via a non-vanishing muon anomaly. An overview of high scale models is given with a view to possible tests at the Large Hadron Collider. Specifically we discuss here some generic approaches to deciphering their signatures. We also consider an out of the box possibility of a four generation model where the fourth generation is a mirror generation rather than a sequential generation. Such a scenario can lead to some remarkably distinct signatures at the LHC.
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