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Search Results: 1 - 10 of 32 matches for " Nagori "
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Resolving issues of content uniformity and low permeability using eutectic blend of camphor and menthol
Gohel M,Nagori S
Indian Journal of Pharmaceutical Sciences , 2009,
Abstract: The aim of present study were to arrest the problem of content uniformity without the use of harmful organic solvent and to improve ex vivo permeability of captopril, a low dose class III drug as per biological classification system. Eutectic mixture of camphor and menthol was innovatively used in the work. Captopril solution in eutectic mixture was blended with Avicel PH 102 and then the mixture was blended with mannitol in different ratios. Formulated batches were characterized for angle of repose and Carr′s index. A selected batch was filled in hard gelatin capsule. Tablet dosage form was also developed. Capsules and tablets were characterized for in vitro drug release in 0.1N HCl. Additionally, the captopril tablets were analyzed for content uniformity and ex vivo drug permeation study using rat ileum in modified apparatus. The measurement of angle of repose and Carr′s index revealed that the powder blend exhibited good flow property and compressibility. The captopril capsules and tablets exhibited immediate drug release in 0.1 N HCl. The captopril tablets passed content uniformity test as per IP 1996. Ex vivo permeation of captopril, formulated with eutectic mixture, was faster than control. The permeation was increased by 15% at the end of 3 h. Tablets and capsule exhibited reasonable short term stability with no considerable change in performance characteristics.
RP-HPLC method for simultaneous estimation of frusemide and amiloride hydrochloride in tablet formulation
Nagori B,Solanki Renu
Indian Journal of Pharmaceutical Sciences , 2010,
Abstract: A new reverse phase high performance liquid chromatography method for the simultaneous estimation of frusemide and amiloride hydrochloride in tablet formulation is developed. The determination was carried out on a HIQ SIL, C18 (250Χ4.6 mm, 5 μm) column using a mobile phase of 50 mM phosphate buffer solution:acetonitrile (50:50 v/v, pH 3.0). The flow rate was 1.0 ml/min with detection at 283 nm. The retention time for frusemide was 3.038 min and for amiloride hydrochloride 10.002 min. Frusemide and amiloride hydrochloride showed a linear response in the concentration range of 20-200 μg/ml and 10-100 μg/ml, respectively. The results of analysis have been validated statistically and by recovery studies. The mean recoveries found for frusemide was 99.98% and for amiloride hydrochloride was 100.09%. Developed method was found to be simple, accurate, precise and selective for simultaneous estimation of frusemide and amiloride hydrochloride in tablets.
A novel colonic drug delivery system of ibuprofen
Gohel M,Nagori S
Asian Journal of Pharmaceutics , 2009,
Abstract: The present endeavor was directed towards fabrication of the novel colonic drug delivery system of ibuprofen. To begin with, the hydroxypropyl methylcellulose capsules containing adsorbate of eutectic mixture of ibuprofen and menthol and pregelatinized starch were coated with ethyl cellulose. These ethyl cellulose coated capsules were filled in another capsule and the capsules were coated with a Eudragit S100. The in vitro drug release study was conducted using sequential dissolution technique at pH 1.2 (two hour), 6.0 (1hr), 7.2 (two hour) and 6.4 (three hour) mimicking different regions of gastrointestinal tract. The optimized batch with two per cent and 6.5% weight gain of ethyl cellulose and Eudragit S100 showed less than eight per cent drug release in stomach and intestinal pH. The remaining 92% drug release was obtained thereafter from the optimized batch within two hours in colonic pH. Scanning electron microscopy study of the optimized batch confirmed presence of ibuprofen crystals (rod shape) in the formulation. The infrared spectroscopy study of the optimized batch indicated stability of ibuprofen during processing of the formulation.
Pre-hCG 3D and 3D power Doppler assessment of the follicle for improving pregnancy rates in intrauterine insemination cycles
Panchal Sonal,Nagori C
Journal of Human Reproductive Sciences , 2009,
Abstract: Background: The assessment of follicular maturity at the time of human chorionic gonadotropin (hCG) is one of the key factors for the success of all assisted reproductive techniques. Aim: To assess follicles by three dimensional (3D) and 3D power Doppler (PD) before giving hCG to improve pregnancy rates in intrauterine insemination (IUI) cycles. Design: Prospective randomized study. Materials and Methods: Ultrasound for pre-hCG follicular assessment was performed over a period of 10 months for all 1000 cycles of IUI. Follicular assessment was performed using a transvaginal multifrequency volume probe. Follicles considered mature by 2D US and color Doppler were assessed by 3D and 3D PD. These values were independently evaluated for the conception and the non-conception groups. Results: Conception rates were 32.3 and 27% respectively and individually when the perifollicular resistance index was < 0.50 and the peak systolic velocity was > 11 cm/s 10-12 h before hCG. Conception rates of 32% were achieved with a follicular volume between 3 and 7 cc. The conception rate was 32.3% in the cumulus group. A perifollicular vascularity index of between six and 20 gave conception rates of 35% and perifollicular flow index of 27-43 gave conception rates of 33%. Conclusions: 3D ultrasound is much more accurate for volume assessment of the follicle. Presence of cumulus increases the surety of the presence of a mature ovum in the follicle. 3D and 3D PD when used with 2D US and color Doppler for pre-hCG follicular assessment would definitely improve pregnancy rates in IUI cycles.
Emotionally Strangulated Relationships in Dattani's Thirty Days in September
Nagori, Smita R
Journal of Literature, Culture and Media Studies , 2011,
Abstract: In the present paper Dattani brings home the horrors of a very identifiable mother-daughter relationship. It is the first Indian English Drama on ‘incest’ or ‘child sexual abuse’. Mala, the daughter, is molested by her maternal uncle, Vinay. Whenever she endeavored to tell her mother, Shanta,she would stuff her with her favorite alu-parathas or rushed to her Lord Krishna to take support from Him. This estranged their relationship more and more. She always preferred escapism to fulfilling her daughter’s emotional expectation of giving her strength. Mala blames her mother for the painful life she is living. She feels that only her mother could help her to prevent her agony. At last, the horrid truth comes out by the mother in front of Mala’s molester. She reveals that she too had been molested by the same person, Vinay, her real brother, for ten long years. Her tongue was cut off and had fallen down. When she could not save herself how could she save Mala? The sky falls on Mala. She apprehends the meaning of silence now. The mother-daughter relation is entirely metamorphosed now sharing their emotional, psychological, physical and social effect of child sex abuse. Thus, Dattani applies the healing mechanism.
New Method for Extracting Phytoconstituents from Plants
Renu Solanki,Badri Prakash Nagori
International Journal of Biomedical and Advance Research , 2012, DOI: 10.7439/ijbar.v3i10.779
Abstract: The present work is in the technical field of plant extraction. More particularly, the work relates to the extraction of medicinal plants using liquid nitrogen in a closed environment. The principal objective of this work is to provide a new method of plant extraction using liquid nitrogen which is simple, safe and less time consuming as compared to the existing open method of plant extraction using liquid nitrogen. The plant used for the study was Cynodon dactylon (Linn.) Pers. The new method includes the steps of size reduction of the plant material, taking the plant material and solvent in culture tubes, closing the tubes properly and dipping these tubes into liquid nitrogen at below -196 °C, melting the frozen material inside the tubes and collecting the liquid extract. The new method of plant extraction avoids exposing liquid nitrogen in open environment and thus avoids the drawbacks of the available methods of plant extraction using liquid nitrogen in open environment.
SCREENING OF ANTIBACTERIAL ACTIVITY OF HYDROALCOHOLIC EXTRACT OF CYNODON DACTYLON
Solanki Renu,Nagori Badri Prakash
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: Cynodon dactylon is a well-known plant used as a folk remedy in treatment of many symptoms and diseases like cramps, measles, tumors, wounds and warts. In this study the hydroalcoholic extract of Cynodon dactylon was investigated for their antibacterial activity against two gram positive bacteria (Staphylococcus aureus, Staphylococcus albus) and two gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) using agar-well diffusion method (zone of inhibition) and micro-dilution method (minimum inhibitory concentration). Ciprofloxacin was taken as positive control. Hydroalcoholic extract of Cynodon dactylon was taken as test sample and hydroalcoholic solvent was taken as negative control in a ratio of 60:40 of water and ethanol. From the results of zone of inhibition, it was concluded that hydroalcoholic extract of Cynodon dactylon possess an effective antibacterial activity while from results of minimum inhibitory concentration, it was revealed that all tested bacterial strains were sensitive towards Cynodon dactylon extract.
Managing Asthma in Children And Analyzing Best Possible Treatment With Data Mining Approach of Classification
Meghana Nagori,Pawar Suvarna,Vivek Kshirsagar
Lecture Notes in Engineering and Computer Science , 2009,
Abstract:
MEDICINAL PLANTS OF RAJASTHAN (INDIA) WITH ANTIDIABETIC POTENTIAL
Batra Shikha,Nagori Badri Prakash,Batra Nikhil
International Research Journal of Pharmacy , 2011,
Abstract: Rajasthan has a rich heritage of traditional system of medicine and many medicinally useful plants are found growing wildly because of vast area and variety of agro-climatic conditions. These plants are being used for the treatment of many human ailments including diabetes. Plants that are specifically employed for the treatment of diabetes are Acacia nilotica, Acacia senegal, Aegle marmelos, Calotropis procera, Capparis deciduas, Cassia auriculata, Cassia sophera, Cayratia trifolia, Cyamopsis tetragonoloba, Dalbergia sisso, Gymnema sylvestre, Momordica charantia, Syzygium cumini, Withania somnifera. This article aims to provide a comprehensive review on the some plants of Rajasthan having antidiabetic potential.
An unusual case of bear bite with severe loss of tissue
Jethani Jitendra,Nagori Ruchika,Ghodadara Bharat
Indian Journal of Ophthalmology , 2006,
Abstract:
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