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Search Results: 1 - 10 of 143473 matches for " Nagamalleswara Rao K. "
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Comparative modeling of CDP-diacylglycerol-serine O-phosphatidyl transferase in Clostridium botulinum: A potent target of Botulism
Koteswara Reddy G.,Mohan Kalyan Reddy K.,Nagamalleswara Rao K.,Gyana R.Satpathy
International Journal of Drug Discovery , 2010,
Abstract: The bacteria Clostridium botulinum causing botulism. Botulism also known as botulinusintoxication is a rare but serious paralytic illness caused by botulinum toxin, which is produced by thebacterium Clostridium botulinum.CDP-diacylglycerol-serine O-phosphatidyltransferase is an enzymethat catalyzes the CDP-diacylglycerol, L-serine and produce Cytidine monophosphate (CMP), (3-snphosphatidyl)-L-serine in Clostridium botulinum. CMP is a nucleotide that is helpful in RNA synthesis inClostridium botulinum.The objective of enzyme inhibition needs structural characterization from its 3-Dstructure in rational structure based drug design. Homology modeling can produce high-quality structuralmodels when the target and templates are closely related. MODELLER is the program used forhomology modeling which provides accurate and efficient models to build loops and side chains foundnon-identical in sequence. It implements comparative protein structure modeling by satisfaction ofspatial restraints. The stereo chemical quality of a best model is validated by PROCHECK server with86.2% residues under favored region from Ramachandran plot. The CASTp is used for locating,delineating and measuring concave surface regions on three-dimensional structures of proteins. Theresidues are identified in burial cavity of the best model as Leu (131,141,156), Ala (132), Ile (138,142),Asn (145), Thr (149,153), and Gly (151) with hydrophobic nature. These include pocket located onprotein surfaces and voids buried in the interior of proteins that are frequently associated with bindingevents. Thus present studies of modeling of CDP-diacylglycerol-serine O-phosphatidyltransferasenzyme has brought future prospective to fight against botulism disease and provide better healthstandaaards for community.
In silico identification of potential therapeutic targets in Clostridium botulinum by the approach subtractive genomics
Koteswara Reddy G.,Nagamalleswara Rao K.,Phani Rama Krishna B.,Aravind S.
International Journal of Bioinformatics Research , 2010,
Abstract: The completion of genome sequences of pathogenic bacteria and the completion of humangenome project has provided lot amount of data that can be utilized to design vaccines and drug targets.One of the recently adopting strategies for drug designing is based on comparative genomics approach,in which the subtraction dataset between the host and the pathogen genome provides information for aset of genes that are likely to be essential to the pathogen but absent in the host. This approach hasbeen used to identify vaccine and drug targets of Pseudomonas aeruginosa and Helicobacter pylori. Wehave used the same approach to identify the vaccine and drug targets of Clostridium botulinum F strain.Our analysis has revealed that out of 3631 coding sequences of the pathogen, 446 represent essentialgenes that have no human homolog. We have further analyzed these 446 genes by the proteinsequence database to list some 96 genes whose products are possibly exposed on the pathogensurface. This preliminary work reported here identifies a small subset of the Clostridium botulinum Fstrain proteome that might be investigated further for identifying potential drug and vaccine targets inthis pathogen.
International Journal on Computer Science and Engineering , 2010,
Abstract: Using smart cards, remote user authentication and key agreement can be simplified, flexible, and efficient for creating a secure distributed computers environment. Addition to user authenticationand key distribution, it is very useful for providing identity privacy for users. In this paper, we propose novel multi server authentication and key agreement schemes with user protection in network security. We first propose a single-server scheme and then apply this scheme to a multi-server environment. The main meritsinclude: (1) The privacy of users can be ensured; (2) a user canfreely choose his own password; (3) the computation and communication cost is very low; (4) servers and users can authenticate each other; (5) it generates a session key agreed by the server and the user; (6) our proposed schemes are Nonce-based schemes which does not have aserious time synchronization problem.
Particle Horizons in Cosmology  [PDF]
K. Purnachandra Rao
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.49162

The importance of investigating particle horizons in order to interpret a cosmological solution of Einstein’s field equations has been described. We have presented the formula and studied the particle horizons in some of the cosmological models presented in our earlier papers. It is well known that the Friedman-Robertson-Walker (F-R-W) models, the energy density of the free gravitational field denoted by ε, equivalently denoted by MacCallum parameter ξ, vanishes but the particle horizons exist and thus the former has no bearing on the latter. However, we have shown in our models presented herein that ε is related with particle horizons. Further, it is shown that as ε grows, the segment of the corresponding particle horizon decreases and thus the radius of the corresponding visible universe decreases.

A Validated Stability-Indicating UHPLC Method for Determination of Naproxen and Its Related Compounds in Bulk Drug Samples  [PDF]
K. Tirumala Rao, L. Vaikunta Rao
American Journal of Analytical Chemistry (AJAC) , 2013, DOI: 10.4236/ajac.2013.46036

A simple, rapid, precise, accurate, rugged and robust stability-indicating ultra-fast high performance liquid chromatographic (UHPLC) method has been developed for the estimation of related compounds (imp-A, imp-B, imp-C, imp-D and imp-E) in Naproxen and also the assay of Naproxen from bulk drug samples. The stability indicating capability of the method was proven by subjecting the samples to stress conditions such as acid, base, oxidation, photolysis and thermal degradation. The efficient chromatographic separation was achieved using mobile phase solution A prepared as buffer solution 10 mM monobasic potassium phosphate pH 4.0 ± 0.05 adjusted with diluted ortho phosphoric acid solution and solution B acetonitrile with linear gradient elution on poroshell 120 EC-C18 shot column (50 mm × 4.6 mm, 2.7 μm) and UV detection at 235 nm at a flow rate 1.0 mL/min, column oven temperature was set to 25?C. The above are all known impurities and degradation impurities are well resolved with Naproxen peak and these are eluted within a 10 min runtime of HPLC. The photo diode array detector was used for peak homogeneity testing during stress study experiments and the overall mass balance was found to be 99.2% to 100.2% in all stress conditions. The linear calibration range was found to be 0.05 μg/mL to 0.75 μg/mL for related compounds and 50 μg/mL to 150 μg/mL for Naproxen and the accuracy of the method was found to be 91.5% to 98.5% recovery for the related substance method and 95.4% to 97.4% recovery for the assay method. The Naproxen and related compounds were found to be stable up to 48 hours and the method validation data show excellent results for precision, linearity, specificity, limit of detection, limit of quantitation and robustness. The present method can be successfully used for routine QC and stability studies and it will help to

Optic neuritis and ophthalmoplegia caused by snake bite
Rao K
Indian Journal of Ophthalmology , 1981,
Speech Enhancement Using Cross-Correlation Compensated Multi-Band Wiener Filter Combined with Harmonic Regeneration  [PDF]
Venkata Rama Rao, Rama Murthy, K. Srinivasa Rao
Journal of Signal and Information Processing (JSIP) , 2011, DOI: 10.4236/jsip.2011.22016
Abstract: The speech signal in general is corrupted by noise and the noise signal does not affect the speech signal uniformly over the entire spectrum. An improved Wiener filtering method is proposed in this paper for reducing background noise from speech signal in colored noise environments. In view of nonlinear variation of human ear sensibility in frequency spectrum, nonlinear multi-band Bark scale frequency spacing approach is used. The cross-correlation between the speech and noise signal is considered in the proposed method to reduce colored noise. To overcome harmonic distortion introduced in enhanced speech, in the proposed method regenerate the suppressed harmonics are regenerated. Objective and subjective tests were carried out to demonstrate improvement in the perceptual quality of speeches by the proposed technique.
Clinical study of proptosis
Rao K,Rao K,Rao M,Rao B
Indian Journal of Ophthalmology , 1982,
Role of aspirin in cataract surgery
Chinnayya Rao K,Rao M
Indian Journal of Ophthalmology , 1985,
Improved Routing Protocol for Health Care Communications  [PDF]
Jayanthi K. Murthy, V. Sambasiva Rao
Open Journal of Applied Biosensor (OJAB) , 2013, DOI: 10.4236/ojab.2013.22006
Abstract: Wireless Body Area Network (WBAN) technology has significantly increased the potential of remote healthcare monitoring systems. The devices used for WBAN have limited energy resources. For most devices it is impossible to recharge or change the batteries. Since the data mostly consists of medical information, high reliability and low delay is required. The main objective of this simulation study is to evaluate the performance of routing protocol on static IEEE 802.15.4 to determine the most suitable routing protocol for Wireless Body Area Networks. Here, investigations on the various routing protocol suggest cluster topology and AODV as the probable candidate. About 16% improvement in the energy consumption was observed when modifications were made considering the energy and mobility, thus achieving high residual battery capacity and eliminating the need for recharging the batteries.
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