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Search Results: 1 - 10 of 32350 matches for " Nadine Correia Santos "
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Risk and clinical-outcome indicators of delirium in an emergency department intermediate care unit (EDIMCU): an observational prospective study
Mariz José,Santos Nadine Correia,Afonso Hugo,Rodrigues Pedro
BMC Emergency Medicine , 2013, DOI: 10.1186/1471-227x-13-2
Abstract: Background Identification of delirium in emergency departments (ED) is often underestimated; within EDs, studies on delirium assessment and relation with patient outcome in Intermediate Care Units (IMCU) appear missing in European hospital settings. Here we aimed to determine delirium prevalence in an EDIMCU (Hospital de Braga, Braga, Portugal) and assessed routine biochemical parameters that might be delirium indicators. Methods The study was prospective and observational. Sedation level was assessed via the Richmond Agitation-Sedation Scale and delirium status by the Confusion Assessment Method for the ICU. Information collected included age and gender, admission type, Charlson Comorbidity Index combined condition score (Charlson score), systemic inflammatory response syndrome criteria (SIRS), biochemical parameters (blood concentration of urea nitrogen, creatinine, hemoglobin, sodium and potassium, arterial blood gases, and other parameters as needed depending on clinical diagnosis) and EDIMCU length of stay (LOS). Statistical analyses were performed as appropriate to determine if baseline features differed between the ‘Delirium’ and ‘No Delirium’ groups. Multivariate logistic regression was performed to assess the effect of delirium on the 1-month outcome. Results Inclusion and exclusion criteria were met in 283 patients; 238 were evaluated at 1-month for outcome follow-up after EDIMCU discharge (“good” recovery without complications requiring hospitalization or institutionalization; “poor” institutionalization in permanent care-units/assisted-living or death). Delirium was diagnosed in 20.1% patients and was significantly associated with longer EDIMCU LOS. At admission, Delirium patients were significantly older and had significantly higher blood urea, creatinine and osmolarity levels and significantly lower hemoglobin levels, when compared with No Delirium patients. Delirium was an independent predictor of increased EDIMCU LOS (odds ratio 3.65, 95% CI 1.97-6.75) and poor outcome at 1-month after discharge (odds ratio 3.51, CI 1.84-6.70), adjusted for age, gender, admission type, presence of SIRS criteria, Charlson score and osmolarity at admission. Conclusions In an EDIMCU setting, delirium was associated with longer LOS and poor outcome at1-month post-discharge. Altogether, findings support the need for delirium screening and management in emergency settings.
The Use of Bayesian Latent Class Cluster Models to Classify Patterns of Cognitive Performance in Healthy Ageing
Patrício Soares Costa, Nadine Correia Santos, Pedro Cunha, Joana Almeida Palha, Nuno Sousa
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071940
Abstract: The main focus of this study is to illustrate the applicability of latent class analysis in the assessment of cognitive performance profiles during ageing. Principal component analysis (PCA) was used to detect main cognitive dimensions (based on the neurocognitive test variables) and Bayesian latent class analysis (LCA) models (without constraints) were used to explore patterns of cognitive performance among community-dwelling older individuals. Gender, age and number of school years were explored as variables. Three cognitive dimensions were identified: general cognition (MMSE), memory (MEM) and executive (EXEC) function. Based on these, three latent classes of cognitive performance profiles (LC1 to LC3) were identified among the older adults. These classes corresponded to stronger to weaker performance patterns (LC1>LC2>LC3) across all dimensions; each latent class denoted the same hierarchy in the proportion of males, age and number of school years. Bayesian LCA provided a powerful tool to explore cognitive typologies among healthy cognitive agers.
The Use of Multiple Correspondence Analysis to Explore Associations between Categories of Qualitative Variables in Healthy Ageing
Patrício Soares Costa,Nadine Correia Santos,Pedro Cunha,Jorge Cotter,Nuno Sousa
Journal of Aging Research , 2013, DOI: 10.1155/2013/302163
Abstract: The main focus of this study was to illustrate the applicability of multiple correspondence analysis (MCA) in detecting and representing underlying structures in large datasets used to investigate cognitive ageing. Principal component analysis (PCA) was used to obtain main cognitive dimensions, and MCA was used to detect and explore relationships between cognitive, clinical, physical, and lifestyle variables. Two PCA dimensions were identified (general cognition/executive function and memory), and two MCA dimensions were retained. Poorer cognitive performance was associated with older age, less school years, unhealthier lifestyle indicators, and presence of pathology. The first MCA dimension indicated the clustering of general/executive function and lifestyle indicators and education, while the second association was between memory and clinical parameters and age. The clustering analysis with object scores method was used to identify groups sharing similar characteristics. The weaker cognitive clusters in terms of memory and executive function comprised individuals with characteristics contributing to a higher MCA dimensional mean score (age, less education, and presence of indicators of unhealthier lifestyle habits and/or clinical pathologies). MCA provided a powerful tool to explore complex ageing data, covering multiple and diverse variables, showing if a relationship exists and how variables are related, and offering statistical results that can be seen both analytically and visually. 1. Introduction Analysis of research data requires unique considerations depending on the type of data collected and/or on the main purpose of the research. For instance, while in some cases data is collected in ordinal mode, often it is also obtained in categorized groups. Or, as opposed to the traditional hypothesis testing designed to verify a priori hypotheses about relations between variables, exploratory data analysis is used to identify systematic relations between variables, when there are incomplete a priori expectations as to the nature of those relations. Falling in the latter category, the method correspondence analysis (CA), a (multivariate) descriptive data analytic technique, allows simplifying complex data and provides a detailed description of the data, yielding a simple, yet exhaustive analysis (a review of the development of the correspondence analysis methodology can be found in [1]). Specifically, multiple CA (MCA) allows for the analysis of categorical or categorized variables encompassing more than two categorical variables (whereas “simple”
Revisiting Thyroid Hormones in Schizophrenia
Nadine Correia Santos,Patrício Costa,Dina Ruano,António Macedo,Maria Jo?o Soares,José Valente,Ana Telma Pereira,Maria Helena Azevedo,Joana Almeida Palha
Journal of Thyroid Research , 2012, DOI: 10.1155/2012/569147
Abstract: Thyroid hormones are crucial during development and in the adult brain. Of interest, fluctuations in the levels of thyroid hormones at various times during development and throughout life can impact on psychiatric disease manifestation and response to treatment. Here we review research on thyroid function assessment in schizophrenia, relating interrelations between the pituitary-thyroid axis and major neurosignaling systems involved in schizophrenia’s pathophysiology. These include the serotonergic, dopaminergic, glutamatergic, and GABAergic networks, as well as myelination and inflammatory processes. The available evidence supports that thyroid hormones deregulation is a common feature in schizophrenia and that the implications of thyroid hormones homeostasis in the fine-tuning of crucial brain networks warrants further research. 1. Introduction In 1888 a report by the Committee of the Clinical Society of London explored the association of hypothyroidism with psychosis [1]. Not surprisingly, given the essential role of thyroid hormones for mammalian brain development, the effect of thyroid hormones (THs) in the modulation of affective illness and behavior continues to be an avenue of research in the pathophysiology of mood disorders [2–12]. Complementarily, research has revealed the TH modulation of crucial brain neurotransmitter systems [12–15] including the dopaminergic, serotonergic, glutamatergic, and GABAergic networks [14, 16–20]. As elaborated on throughout this paper, the misregulation of these pathways, as well as the participation of myelination and of cytokines, is of particular relevance in the schizophrenic brain [18, 21–23]. Schizophrenia is one of the most severe psychiatric disorders with an estimated prevalence of 0.7–1.0% in the population worldwide. It often runs a chronic and debilitating course, with many patients responding poorly to medication and suffering frequent and disrupting relapses. Furthermore, it is accompanied by a great social cost in terms of productivity loss and treatment-related expenses [21]. Its core features include cognitive impairment, delusions, hallucinations, altered volition and emotional reactivity and disorganized behavior. It is now clear that the heterogeneity and complexity of schizophrenia is both at the clinical and aetiological levels and that this complex disorder arises from the interaction of a range of deviant genetic traits and environmental “insults,” which may begin to act in the prenatal period [21]. The clear understanding of schizophrenia’s molecular mechanism(s) is elusive, and no
Patterns of Cognitive Performance in Healthy Ageing in Northern Portugal: A Cross-Sectional Analysis
Ana Cristina Paulo, Adriana Sampaio, Nadine Correia Santos, Patrício Soares Costa, Pedro Cunha, Joseph Zihl, Jo?o Cerqueira, Joana Almeida Palha, Nuno Sousa
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024553
Abstract: Background The Minho Integrative Neuroscience Database (MIND)-Ageing project aims to identify predictors of healthy cognitive ageing, including socio-demographic factors. In this exploratory analysis we sought to establish baseline cohorts for longitudinal assessment of age-related changes in cognition. Methods The population sample (472 individuals) was strictly a convenient one, but similar to the Portuguese population in the age profile. Participants older than 55 years of age were included if they did not present defined disabling pathologies or dementia. A standardized clinical interview was conducted to assess medical history and a battery of neuropsychological tests was administered to characterize global cognition (Mini Mental State Examination), memory and executive functions (Selective Reminding Test; Stroop Color and Word Test; and Block Design subtest of the Wechsler Adult Intelligence Scale). Cross-sectional analysis of the neuropsychological performance with individual characteristics such as age, gender, educational level and setting (retirement home, senior university, day care center or community), allowed the establishment of baseline clusters for subsequent longitudinal studies. Results Based on different socio-demographic characteristics, four main clusters that group distinctive patterns of cognitive performance were identified. The type of institution where the elders were sampled from, together with the level of formal education, were the major hierarchal factors for individual distribution in the four clusters. Of notice, education seems to delay the cognitive decline that is associated with age in all clusters. Conclusions Social-inclusion/engagement and education seem to have a protective effect on mental ageing, although this effect may not be effective in the eldest elders.
Stress Impact on Resting State Brain Networks
José Miguel Soares, Adriana Sampaio, Luís Miguel Ferreira, Nadine Correia Santos, Paulo Marques, Fernanda Marques, Joana Almeida Palha, Jo?o José Cerqueira, Nuno Sousa
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066500
Abstract: Resting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal functional patterns in many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little is known about the effect of stress in the architecture of RSNs, both in resting state conditions or during shift to task performance. Herein we assessed the architecture of the RSNs using functional magnetic resonance imaging (fMRI) in a cohort of participants exposed to prolonged stress (participants that had just finished their long period of preparation for the medical residence selection exam), and respective gender- and age-matched controls (medical students under normal academic activities). Analysis focused on the pattern of activity in resting state conditions and after deactivation. A volumetric estimation of the RSNs was also performed. Data shows that stressed participants displayed greater activation of the default mode (DMN), dorsal attention (DAN), ventral attention (VAN), sensorimotor (SMN), and primary visual (VN) networks than controls. Importantly, stressed participants also evidenced impairments in the deactivation of resting state-networks when compared to controls. These functional changes are paralleled by a constriction of the DMN that is in line with the pattern of brain atrophy observed after stress exposure. These results reveal that stress impacts on activation-deactivation pattern of RSNs, a finding that may underlie stress-induced changes in several dimensions of brain activity.
Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus
Sandro D. Mesquita,Jo?o C. Sousa,Nadine C. Santos,Margarida Correia-Neves,Nuno Sousa,Joana A. Palha,Fernanda Marques
Frontiers in Cellular Neuroscience , 2012, DOI: 10.3389/fncel.2012.00025
Abstract: Iron is essential for mammalian cellular homeostasis. However, in excess, it promotes free radical formation and is associated with aging-related progressive deterioration and with neurodegenerative disorders such as Alzheimer's disease (AD). There are no mechanisms to excrete iron, which makes iron homeostasis a very tightly regulated process at the level of the intestinal absorption. Iron is believed to reach the brain through receptor-mediated endocytosis of iron-bound transferrin by the brain barriers, the blood-cerebrospinal fluid (CSF) barrier, formed by the choroid plexus (CP) epithelial cells and the blood-brain barrier (BBB) formed by the endothelial cells of the brain capillaries. Importantly, the CP epithelial cells are responsible for producing most of the CSF, the fluid that fills the brain ventricles and the subarachnoid space. Recently, the finding that the CP epithelial cells display all the machinery to locally control iron delivery into the CSF may suggest that the general and progressive senescence of the CP may be at the basis of the impairment of regional iron metabolism, iron-mediated toxicity, and the increase in inflammation and oxidative stress that occurs with aging and, particularly, in AD.
As múltiplas tarefas e atividades interferentes em Centrais de Atendimento Telef?nico
Santos, Venétia Correia;
Revista Brasileira de Saúde Ocupacional , 2004, DOI: 10.1590/S0303-76572004000100004
Abstract: the aim of this article is to understand the forms of temporal management of multiplicity and intervention between tasks. the results obtained in the study of the intensification in call centers show that the operators, in order to be able to do their activities, overlap the phases of the service, doing multiple tasks to compress the time spent on service. on the other hand, it was found that there is an overlapping of calls which leads to intervenient tasks to the main call that must be managed by the operators.
As muitas faces da Economia Política da Comunica o no Brasil
Luciano Correia dos Santos
Comunica??o, Mídia e Consumo , 2008,
Abstract: A Economia Política da Comunica o (EPC) é ainda uma jovem debutante entre as disciplinas que integram as ciências da comunica o, assim tratadas nos vários eventos científicos que procuram enquadrar os fen menos dessa área para tratá-los com os métodos da pesquisa acadêmica. Jovem que ganhou status de GT (Grupo de Trabalho) próprio na Compós, a Associa o Nacional dos Programas de Pós-gradua o em Comunica o, essa linha conquista cada vez mais terreno, seja pela amplitude das pesquisas desenvolvidas seja pela prolífica produ o dos autores associados. é o caso de Valério Cruz Brittos e Adilson Cabral , que acabam de lan ar Economia política da comunica o: interfaces brasileiras. O livro é uma coletanea de artigos de vários pesquisadores relacionados com a área de estudo, mas que atuam em segmentos distintos, incluindo os dois organizadores, percorrendo trechos que v o desde a própria conceitua o da Economia Política da Comunica o e as tens es exercidas dentro do campo científico, passando por abordagens sobre a indústria cultural, novas tecnologias e as plataformas digitais, além do conflituoso terreno das políticas de comunica o e as legisla es específicas. S o textos baseados nas principais mesas do Encontro da Ulepicc-Brasil, realizado na Universidade Federal Fluminense, em Niterói (RJ), de 18 a 20 de outubro de 2006. No primeiro texto do livro, Suzy dos Santos mostra a que veio a EPC nos estudos da comunica o, lembrando que o servi o prestado pela linha é fruto de consenso: é imprescindível adotar um olhar crítico para retratar empiricamente os objetos das comunica es, sob a luz de um propósito também crítico, o da necessidade emergencial de participa o ativa da pesquisa científica no processo de constru o de um ambiente de comunica es efetivamente democrático (p. 15). Ao analisarem a indústria cultural e sua inser o no capitalismo contemporaneo, Valério Brittos e Jo o Miguel apontam a tendência (lamentável) dos estados de deixar a cultura e o comunicativo entregues às lógicas dessa indústria, ficando, conseqüentemente, sujeitos às invers es do capital. Assim, o capitalismo deixa de ser apenas do domínio econ mico para determinar a política e a cultura, ou seja, penetra em todas as dimens es das pessoas. Por esta via, é cada vez mais do que um modo de produ o, para estabelecer-se como um processo civilizatório, onde a subsun o do simbólico é sucessiva, contínua e inconclusa (p. 41). Os autores discutem os resultados desse processo dentro do ambiente tecnológico, as estratégias adotadas pelas firmas do setor e o predomínio da publicidad
Sobre o choro: análise de perspectivas teóricas
Santos,Ana Sofia Correia Dos;
Análise Psicológica , 2000,
Abstract: infant crying has been vastly studied as a diagnostic indicator of neurologic disorders. however, contributes from mother-infant interaction theory suggest, even though indirectly, the value of this manifestation - crying - in the context of the mother-infant relationship. lebovici underlines the importance of crying in this context when he says: ?it is enough to imagine what would be the parents task without infant crying: they would have to be constantly guessing when the baby is hungry, when he is dirty, and what are his various needs and discomforts. undoubtedly, a more calm and less anxious situation, at first view, would be a more preoccupying reality, because it would constrain parents to be permanently interrogating themselves about the baby condition.? (lebovici, 1987). the present theorical reflection attempts to frame infant crying in different theorical models and, from those approaches, to discuss its value and function, in mother-infant interaction domain.
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