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Search Results: 1 - 10 of 11254 matches for " Nadia Vieira Sambiase "
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Narrowed lumen of the right coronary artery in chronic chagasic patients is associated with ischemic lesions of segmental thinnings of ventricles
Vieira Sambiase,Nadia; Lourdes Higuchi,Maria; Benvenuti,Luiz Alberto;
Investigación Clínica , 2010,
Abstract: thinning of myocardial segments, mainly at the apex and basal posterior region of left ventricle, are frequent lesions in chronic chagasic cardiopathy (ccc), but still without a well determined etiology. previously we found severe myocardial microvascular dilatation that could cause ischemia in watershed regions. in this study we analyzed whether narrowness in epicardial coronary arteries in ccc might explain these thinned ventricular lesions. two groups of dilated hearts with similar weights were compared: eleven hearts from patients with ccc versus four hearts from patients with dilated cardiomyopathy (idcm). as normal controls we studied three non dilated normal weight hearts. there were no atherosclerotic plaques in the main branches of epicardial coronary arteries and cross-sectional luminal areas of proximal and distal segments were histologically measured. it was found that ccc hearts presented a lower mean luminal area in the right coronary artery (rca) branch than idcm, in proximal (4.3 ± 1.4 vs 6.6 ± 2.0 mm2; p= 0.02) and in distal (1.6 ± 1.0 vs 3.4 ± 0.9 mm2; p= 0.01) segments, with no statistical differences with normal hearts (2.7 ± 1.3 and 1.5 ± 0.3 mm2) in proximal (p= 0.2) and distal (p=0.11) sections. in conclusion thinning of ventricular wall in ccc patients seems to be ischemic lesions in the peripheral territory irrigated by the right coronary artery, possibly due to a steal phenomenon by the left coronary, induced by micro vessels dilatation
Narrowed lumen of the right coronary artery in chronic chagasic patients is associated with ischemic lesions of segmental thinnings of ventricles El lumen estrecho de la arteria coronaria derecha en pacientes chagásicos crónicos está asociado con lesiones de adelgazamientos segmentales de los ventrículos
Nadia Vieira Sambiase,Maria Lourdes Higuchi,Luiz Alberto Benvenuti
Investigación Clínica , 2010,
Abstract: Thinning of myocardial segments, mainly at the apex and basal posterior region of left ventricle, are frequent lesions in chronic chagasic cardiopathy (CCC), but still without a well determined etiology. Previously we found severe myocardial microvascular dilatation that could cause ischemia in watershed regions. In this study we analyzed whether narrowness in epicardial coronary arteries in CCC might explain these thinned ventricular lesions. Two groups of dilated hearts with similar weights were compared: eleven hearts from patients with CCC versus four hearts from patients with dilated cardiomyopathy (IDCM). As normal controls we studied three non dilated normal weight hearts. There were no atherosclerotic plaques in the main branches of epicardial coronary arteries and cross-sectional luminal areas of proximal and distal segments were histologically measured. It was found that CCC hearts presented a lower mean luminal area in the right coronary artery (RCA) branch than IDCM, in proximal (4.3 ± 1.4 vs 6.6 ± 2.0 mm2; p= 0.02) and in distal (1.6 ± 1.0 vs 3.4 ± 0.9 mm2; p= 0.01) segments, with no statistical differences with normal hearts (2.7 ± 1.3 and 1.5 ± 0.3 mm2) in proximal (p= 0.2) and distal (p=0.11) sections. In conclusion thinning of ventricular wall in CCC patients seems to be ischemic lesions in the peripheral territory irrigated by the right coronary artery, possibly due to a steal phenomenon by the left coronary, induced by micro vessels dilatation Adelgazamientos segmentares del miocardio son frecuentes lesiones en la cardiomiopatía crónica chagásica (CCC), principalmente en el ápice de la región posterior del ventrículo izquierdo, cuya etiopatogenia todavía no está bien conocida. En trabajos anteriores se observó intensa dilatación de la micro circulación que podría llevar a isquemia en regiones de irrigaciones limítrofes. Este estudio analizó si estrechez de las arterias epicárdicas in CCC podrían explicar las lesiones de adelgazamientos ventriculares. Se compararon 2 grupos de corazones con pesos semejantes: 11 corazones de pacientes con CCC versus 4 corazones de pacientes con cardiomiopatia dilatada idiopática (IDCM). Como controles normales fueran estudiados 3 corazones no dilatados y con pesos normales. No estuvieron presentes placas ateroscleróticas en los principales ramos de las arterias coronarias epicárdicas. Las áreas de lumen en cortes transversales de los segmentos proximales e distales arteriales fueran medidas por histología. Los corazones con CCC mostraron una media de lumen menor en el ramo de la coronaria derecha que en
Chlamydia pneumoniae e Mycoplasma pneumoniae nos nódulos de calcifica??o da estenose da valva aórtica
Higuchi-dos-Santos, Marilia Harumi;Pierri, Humberto;Higuchi, Maria de Lourdes;Nussbacher, Amit;Palomino, Sueli;Sambiase, Nadia Vieira;Ramires, José Antonio Franchini;Wajngarten, Maurício;
Arquivos Brasileiros de Cardiologia , 2005, DOI: 10.1590/S0066-782X2005000600002
Abstract: objective: we investigated whether chlamydia pneumoniae (cp) and mycoplasma pneumoniae (mp) are present in aortic valve stenosis (as). methods: immunohistochemistry was utilized to identify cp antigens, in situ hybridization to identify mp dna, and electron microscopy was used to evaluate the following three groups: normal - 11 normal autopsy valves; atherosclerosis - 10 autopsy valves from patients with systemic atherosclerosis and no as; and as - 14 surgical specimens of as analyzed in 3 sub-regions: as-preserved - peripheral, preserved regions; as-fibrosis - peri-calcified fibrotic tissue; and as-calcification - calcified nodules. results: the positive area fraction of cp antigen median values were 0.09, 0.30, 0.18, 1.33, and 3.3 in groups normal, atherosclerosis, as-preserved, as-fibrosis, and as-calcification, respectively. cp density was significantly greater in atherosclerosis and as-calcification than in normal (p<0.05). within the as group, the amount of cp was greater in the calcification and fibrosis regions (p<0.05). mp-dna positive area fraction (median values) were 0.12, 0.44, 0.07, 0.36, and 1.52 in groups normal, atherosclerosis, as-preserved, as-fibrosis, and as-calcification, respectively. the amount of mp-dna was greater in as-calcification than in normal (p<0.05). within the as group, mp-dna was in larger quantity in the calcification and fibrosis regions (p<0.05). conclusion: as calcified nodes present higher concentration of cp and mp suggesting that these bacteria may be associated with the development of calcification and inflammation. this adds novel similarities between as and the atherosclerosis process, which may have infection mechanisms involved.
Mycoplasma pneumoniae and Chlamydia pneumoniae in calcified nodules of aortic stenotic valves
HIGUCHI, Maria de Lourdes;HIGUCHI-DOS-SANTOS, Marilia Harumi;PIERRI, Humberto;PALOMINO, Sueli;SAMBIASE, Nadia Vieira;RAMIRES, José Antonio Franchini;WAJNGARTEN, Maurício;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2002, DOI: 10.1590/S0036-46652002000400005
Abstract: aortic valve stenosis (avs) has been explained as an atherosclerotic process of the valve as they often exhibit inflammatory changes with infiltration of macrophages, t lymphocytes and lipid infiltration. the present study investigated whether the bacteria chlamydia pneumoniae (cp) and mycoplasma pneumoniae (mp), detected previously in atherosclerotic plaques, are also present in avs. ten valves surgically removed from patients with avs were analyzed by immunohistochemistry, in situ hybridization, and electron microscopy. the mean and standard deviation of the percentage areas occupied by cp antigens and mp - dna were respectively 6.21 +/- 5.41 and 2.27 +/- 2.06 in calcified foci; 2.8 +/- 3.33 and 1.78+/- 3.63 in surrounding fibrotic areas, and 0.21 +/- 0.17 and 0.12 +/- 0.13 in less injured parts of the valve. there was higher amount of cp and mp in the calcified foci and in the surrounded fibrosis than in more preserved valvular regions. in conclusion, the fact that there were greater amounts of cp and mp in calcification foci of avs favors the hypothesis that as is not an inevitable degenerative process due to aging, but rather that it may be a response to the presence of these bacteria, similarly to the morphology detected in atherosclerosis damage.
Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction
Higuchi Maria de Lourdes,Reis Marcia Martins,Sambiase Nádia Vieira,Palomino Suely Aparecida Pinheiro
Arquivos Brasileiros de Cardiologia , 2003,
Abstract: OBJECTIVE: To study atheromas, Mycoplasma pneumoniae (M. pneumoniae), and Chlamydia pneumoniae (C. pneumoniae). METHODS: C. pneumoniae was studied with immunohistochemistry and M. pneumoniae with in situ hybridization (ISH), in segments of coronary arteries (SCA) as follows: group A - thrombosed ruptured plaques (TRP) of 23 patients who died due to acute myocardial infarction (AMI); group B - 23 nonruptured plaques (NRP) of group A patients; group C - NRP of 11 coronary patients who did not die due to AMI; and group D - 11 SCA from patients with dilated cardiomyopathy or Chagas' disease without atherosclerosis. RESULTS: The mean number of C. pneumoniae+ cells/400x in groups A, B, C, and D was, respectively, 3.3±3.6; 1.0±1.3; 1.2±2.4; and 0.4±0.3; and the percentage of M. pneumoniae area was, respectively, 3.9±3.5; 1.5± 1.6; 0.9±0.9; and 0.4±0.2. More M. pneumoniae and C. pneumoniae were found in of group A than in group B (P<0.01). Good correlation was seen between the area of the vessel and the M. pneumoniae area in the plaque (r = 0.46; P=0.001) and between C. pneumoniae+ cells and CD4+ T lymphocytes (r = 0.42; P<0.01). The number of C. pneumoniae+ cells correlated with CD20+ B cells (r=0.48; P<0.01). CONCLUSION: M. pneumoniae and C. pneumoniae are more frequently found in TRP correlate with the intensity of the inflammation and diameter of the vessel (positive remodeling).
Great amount of C.pneumoniae in ruptured plaque vessel segments at autopsy. A comparative study with stable plaques
Higuchi, Maria de Lourdes;Castelli, Jussara Bianchi;Aiello, Vera D.;Palomino, Sueli;Reis, Marcia M.;Sambiase, Nadia V.;Fukasawa, Shizie;Bezerra, Hiram G.;Ramires, José A. F.;
Arquivos Brasileiros de Cardiologia , 2000, DOI: 10.1590/S0066-782X2000000200005
Abstract: a possible relationship between c.pneumoniae (cp) infection, atherosclerosis and acute myocardial infarction is a debated matter. now we performed the search of cp in histological segments of fatal ruptured plaques and of stable plaques by histochemistry (macchiavello stain), immunohistochemistry and in situ hybridization techniques. electron microscopy and confocal laser microscopy techniques were used in two additional cases. the semi-quantitification of cp + cells (0-4+) and quantification of lymphocytes demonstrated greater amount of cp + cells and more inflammation in the adventitia of vulnerable plaque vessel segments than of stable ones, larger amount of cp + cells in adventitia than in the plaque and high frequency of cp + cells in all groups studied. this preliminary study strongly suggests a direct pathogenetic involvement of adventitial cp in the rupture of the atheromatous plaque, development of acute myocardial infarction and also in the development of atherosclerosis.
Coinfection with Mycoplasma Pneumoniae and Chlamydia Pneumoniae in ruptured plaques associated with acute myocardial infarction
Higuchi, Maria de Lourdes;Reis, Marcia Martins;Sambiase, Nádia Vieira;Palomino, Suely Aparecida Pinheiro;Castelli, Jussara Bianchi;Gutierrez, Paulo Sampaio;Aiello, Vera Demarchi;Ramires, José Antonio Franchini;
Arquivos Brasileiros de Cardiologia , 2003, DOI: 10.1590/S0066-782X2003000900001
Abstract: objective: to study atheromas, mycoplasma pneumoniae (m. pneumoniae), and chlamydia pneumoniae (c. pneumoniae). methods: c. pneumoniae was studied with immunohistochemistry and m. pneumoniae with in situ hybridization (ish), in segments of coronary arteries (sca) as follows: group a - thrombosed ruptured plaques (trp) of 23 patients who died due to acute myocardial infarction (ami); group b - 23 nonruptured plaques (nrp) of group a patients; group c - nrp of 11 coronary patients who did not die due to ami; and group d - 11 sca from patients with dilated cardiomyopathy or chagas' disease without atherosclerosis. results: the mean number of c. pneumoniae+ cells/400x in groups a, b, c, and d was, respectively, 3.3±3.6; 1.0±1.3; 1.2±2.4; and 0.4±0.3; and the percentage of m. pneumoniae area was, respectively, 3.9±3.5; 1.5± 1.6; 0.9±0.9; and 0.4±0.2. more m. pneumoniae and c. pneumoniae were found in of group a than in group b (p<0.01). good correlation was seen between the area of the vessel and the m. pneumoniae area in the plaque (r = 0.46; p=0.001) and between c. pneumoniae+ cells and cd4+ t lymphocytes (r = 0.42; p<0.01). the number of c. pneumoniae+ cells correlated with cd20+ b cells (r=0.48; p<0.01). conclusion: m. pneumoniae and c. pneumoniae are more frequently found in trp correlate with the intensity of the inflammation and diameter of the vessel (positive remodeling).
Valida??o brasileira da escala de autopercep??o de harter para crian?as
Valentini, Nadia Cristina;Villwock, Gabriela;Vieira, Lenamar Fiorese;Vieira, José Luiz Lopes;Barbosa, Marcus Levi Lopes;
Psicologia: Reflex?o e Crítica , 2010, DOI: 10.1590/S0102-79722010000300001
Abstract: harter's self-perception profile for children (sppc) is used to evaluate children's self-worth. the objective of this study was to translate and verify the validity of the items, the confirmatory factorial analysis and the test-retest internal consistence of the brazilian version of sppc. the participants of this study were 7 professionals and 746 children (8 to 12 years old) who answered the instrument at two different moments. the results indicated that the brazilian version contains clear and pertinent questions (cvct > 0.70), shows satisfactory indices of the confirmatory factorial validity (χ2/gl = 4.33; non-normed fit index = 0.958; comparative fit index = 0.967 and tucker and lewis's index of fit = 0.962) as well as of internal consistence. thus, the brazilian version showed to be valid.
Brazilian validity of the harter' self-perception profile for children / Valida o brasileira da escala de autopercep o de harter para crian as
Nadia Cristina Valentini,Gabriela Villwock,Lenamar Fiorese Vieira,José Luiz Lopes Vieira
Psicologia: Reflex?o e Crítica , 2010,
Abstract: Harter's Self-perception Profile for Children (SPPC) is used to evaluate children's self-worth. The objective of this study was to translate and verify the validity of the items, the confirmatory factorial analysis and the test-retest internal consistence of the Brazilian version of SPPC. The participants of this study were 7 professionals and 746 children (8 to 12 years old) who answered the instrument at two different moments. The results indicated that the Brazilian version contains clear and pertinent questions (CVCt > 0.70), shows satisfactory indices of the confirmatory factorial validity (χ2/gl = 4.33; Non-normed Fit Index = 0.958; Comparative Fit Index = 0.967 and Tucker and Lewis's Index of Fit = 0.962) as well as of internal consistence. Thus, the Brazilian version showed to be valid.
Advocacy and Policy Change in the Multilevel System of the European Union: A Case Study within Health Policy  [PDF]
Nadia Carboni
Open Journal of Political Science (OJPS) , 2012, DOI: 10.4236/ojps.2012.23005
Abstract: Health policy is basically Member States’ competence. However, the European Union has recently raised a number of key questions facing both (pharmaceutical) industries and public health interests. By applying the Advocacy Coalition Framework, the paper sheds light on policy change within the European multilevel system. The analysis is based on a case-study strategy. Two processes in the pharmaceutical policy are taken into account: the “Pharma Forum” and the “Pharma Package”. They both concern “information to patient”—a controversial policy issue at the crossroad of competing pressures.
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