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Search Results: 1 - 10 of 198024 matches for " Nadezhda N. Kakareka "
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Characterization of a Novel Far-Eastern Potato Virus Y Isolates
Yury G. Volkov,Nadezhda N. Kakareka,Larissa A. Balabanova,Zinaida N. Kozlovskaya
Plant Pathology Journal , 2009,
Abstract: Potato Virus Y (PVY) isolates differed in pathogenicity and molecular properties were found in potato and wild plants in the Far East of Russia. The results of linking research of nucleotide sequence similarity and polymorphism of P1 gene region and serological and biological assays suggested that the viruses originated from a recombination and/or host adaptation events involving the ordinary type virus (PVY0) that led to development of necrotic type virus (PVYN/NTN) properties in the Far-Eastern PVY isolates.
Neonatal Exposure to the Dipeptidyl Peptidase-IV Inhibitors Diprotin A and Sitagliptin Induces Depression-Like Behavior, Anxiety, and Latent Aggression in Adolescent and Adult Rats  [PDF]
Nataliya A. Krupina, Nadezhda N. Khlebnikova
Journal of Behavioral and Brain Science (JBBS) , 2016, DOI: 10.4236/jbbs.2016.64018
Abstract: Emotional and motivational disorders in adults are often considered to be the result of altered neurodevelopment. Clinical and experimental data provide evidence that serine protease dipeptidyl peptidase-IV (DPP-IV, EC is involved in the pathophysiology of psycho-emotional disorders. Recently, we have shown that adolescent and adult rats exhibit an increase in anxiety and depression-related behaviors after neonatal administration of a synthetic non-competitive inhibitor of DPP-IV, methionyl-2(S)-cyano-pyrrolidine. In the present study, we tested the effects of two competitive, selective DPP-IV inhibitors, sitagliptin (4 mg/kg) and diprotin A (2 mg/kg), administered at postnatal days 5 - 18 on the emotional and motivational behavior of adolescent and adult rats. We observed increased anxiety in one-month-old diprotin A- or sitagliptin-treated rats in the elevated plus maze; diprotin A also enhanced the animals’ anxiety score using a ranked scale for evaluating anxiety and phobias. In the sucrose consumption and preference test, depressive-like behavior was pronounced in both the diprotin A- and sitagliptin-treated one-month-old animals, while only the diprotin A-treated rats exhibited a decrease in sucrose consumption at the age of 2 months. The diprotin A-treated rats also demonstrated behavioral despair and decreased activity in the forced swimming test within 1 - 3 months of age. Increased aggression was observed in 1 - 3-month-old diprotin A-treated rats and in two-month-old sitagliptin-treated rats. These findings support the hypothesis that DPP-IV is involved in the genesis of emotional and motivational disorders. Additionally, the results show that diprotin А impairs the adolescent and adult rats’ behavior more significantly than sitagliptin when the animals were treated with the DPP-IV inhibitors in the early postnatal period.
Simulated Solar Microwave Radiation Blocks the Formation of Biofilms  [PDF]
Yulia S. Shishkova, Stanislav N. Darovskih, Nadezhda V. Vdovina, Nadezhda L. Pozdnyakova, I. A. Komarova, Elena V. Shishkova, Evgenij V. Vodyanitskiy
Natural Science (NS) , 2015, DOI: 10.4236/ns.2015.73014
Abstract: The article presents the results of the experimental study that was devoted to determining the blocking influence of the solar microwave radiation on the process of biofilm formation in Gram-positive and Gram-negative microorganisms. The microwave generator that allows simulating microwave “splashes” of the Sun in the frequency range (4.0 - 4.3 GHz) with the controlled intensity of radiation (from 50 μW/sm2 to 500 μW/sm2) was used for conducting this research. It is found out that the simulated solar radiation of the microwave range blocks the formation of the extracellular matrix by the opportunistic microorganisms. The results of this study confirm the hypothesis of the evolutionary nature of the leading role of the microwave radiation of the Sun in the life processes of organisms. The technology of the exposure on the microorganisms that was used in the experiment opens up the real prospects for reducing the persistent potential of microorganisms and improving the efficiency of the bacterial infections treatment.
Modern aspects of construction of information microwave therapy devices  [PDF]
Stanislav N. Darovskih, Evgenij P. Popechitelev, Nadezhda V. Vdovina, Ivan V. Novikov
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.512150

This article is devoted to presenting modern aspects of building information microwave therapy devices. And it presents an analysis of the existing problems of the organism homeostasis control by means of electromagnetic radiation. The new principles of synthesis of operating influences are formulated. On the basis of the thermodynamic approach is justified as a leading role modeling the space microwave background to restore disturbed homeostasis of the organism. The general patterns of development of the pathological process and possible mechanisms of corrective action of natural electromagnetic background are described. The implementation of the approach offered by the authors to constructing device information physiotherapy allowed creating high-performance hardware and software means for the prevention and treatment of a wide range of human diseases.

The Relationship of SmokingOpioidAntidepressant Use and History of Spine Surgery  [PDF]
Walid Mohammad, Zaytseva Nadezhda
International Journal of Clinical Medicine (IJCM) , 2010, DOI: 10.4236/ijcm.2010.11003
Abstract: Introduction: In a recent paper, smoking was shown to be an independent predictor of longterm continued opioid use in spine patients (Krebs et al. 2010). In this paper, we study the interaction of smoking with opioid and antidepressant use and the relationship with prior spine surgery and future spine surgery. Methods: Data on smoking, opioid and antidepressant use were retrospectively collected from 758 spine surgery inpatients [lumbar microdiskectomy (LMD), anterior cervical decompression and fusion (ACDF) and lumbar decompression and fusion (LDF)]. Interaction with history of previous spine surgery and return for additional spine surgery was studied. Followup ranged from one to four years. Results: Significant correlation was detected between smoking and opioid use and between opioid and antidepressant use. History of previous spine surgery correlated with antidepressant use and return for additional spine surgery. Additional spine surgery correlated with opioid use and history of previous spine surgery. Smoking LMD patients on both opioids and antidepressants and smoking ACDF patients on antidepressants who have a history of prior spine surgery were more likely to return for additional spine surgery. However, in the LDF group, smoking patients on antidepressants without previous spine surgery were more likely to come for another spine surgery. Conclusion: Smokingantidepressantopioid use could be predictive of return for additional spine surgery during the followup years especially if a history of prior spine surgery was reported. Further research is needed on the implications of such an association.
Extra Investigation Might Be Necessary in High-Risk CT-Negative Cerebrovascular Cases  [PDF]
Mohammad Sami Walid, Nadezhda Zaytseva
Neuroscience & Medicine (NM) , 2013, DOI: 10.4236/nm.2013.42017

Cerebrovascular accidents occur in elderly patients in whom neurodegenerative changes increase the risk of vascular permeation and concomitant intracranial bleeding. In rare cases, intracerebral massive hemorrhage happens in hospitalized patients with apparently stable clinical picture. We report two cases illustrating this phenomenon, discuss the possible pathomechanism involved in those tragic incidents and suggest possible prevention measures for these patients. A negative CT image in a patient with neurological symptoms, especially who are on warfarin with or without considerably elongated coagulation time, may be subject to a sudden intracranial hemorrhage. Microvascular abnormalities might be detected on perfusion CT imaging and should therefore be performed in all CT negative patients with close observation for 24 hours before contemplating discharge.

Crop Water Supply and its Relation to Yield of Spring Wheat in the South of Russian Plain
Nadezhda Shumova
Journal of Hydrology and Hydromechanics , 2009, DOI: 10.2478/v10098-009-0003-3
Abstract: The proposed method to estimate water supply of spring wheat crop is based on the ratio of the water amount extracted by plants under actual conditions of growth (transpiration) to cover needs for maximum (potential) yield (potential transpiration). Estimates of spatial, inter- and intra-annual water supply variability of the spring wheat crop in basic agricultural zones are given. Dependence of the spring wheat yield on water supply is presented.
Nadezhda Egorova
Sovremennye Issledovania Social?nyh Problem , 2012,
Abstract: Methods of relay race technical preparation of athletics freshmen in the course of Physical Training classes in higher education institutions on activ game base are represented in this paper.
The myth-making in the media
Shulga Nadezhda
Koncept : Scientific and Methodological e-magazine , 2013,
Abstract: The article considers the system of functioning of the myths in the mass political consciousness. Identified methods of influence of mass media by means of mythological elements in the mass consciousness. The main emphasis is on the methods of implementation of political myths in the media.
Irkutsk Development Regulation before the Revolution: Basic Provisions Регулирование застройки дореволюционного Иркутска: основные положения
Nadezhda Bubis
Project Baikal , 2010,
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