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Executive Functions Evaluation through Evoked Potentials among Children with Obsessive-Compulsive Disorder
Tatjana Zorcec , Nada Pop-Jordanova
Journal of Special Education and Rehabilitation , 2011, DOI: 10.2478/v10215-011-0004-8
Abstract: Introduction: Obsessive-compulsive disorder [OCD] is characterized by repetitive, disturbing obsessions and/or compulsions. Obsessions are thoughts, images or feelings which are unwanted, persistent and recurrent. Compulsions are repetitive and ritual motor acts which are performed to decrease the anxiety level caused by repetitive obsessions. The onset of the OCD is typically during adolescence or early adulthood. Its prevalence among children is from 1% to 3% and it appears to be more present among boys than girls. Nowadays, the most effective way to treat OCD is to combine psychopharmacological with cognitivebehavioral treatment strategies. In the past decades researchers were more involved in investigating the role of the executive functions [EF] in psychiatric disorders. Aim of the study: to investigate EF among children with OCD by using Event Related Potentials (ERPs) on the Go/NoGo tasks. Subjects and methods: The sample is comprised of 20 children from both genders, between seven and 14 years of age [M=10,33±1,83], all diagnosed with OCD. Psychological evaluation was performed with Child Behavior Check List, Kohs cubes for assessment of the intellectual capacities, Beck Depression Inventory, The Schedule for Affective Disorders and Schizophrenia for School-Age Children, Stroop Color Word Test and Wisconsin Card Sorting Test. Neuropsychological evaluation was performed with the Visual Continuous Performance Test [VCPT] from which the Event Related Potentials [ERP] components were extracted. Results: There is a clear presence of obsessions and/or compulsions, absence of symptoms of depression, presence of perseverative errors and mild difficulties in mental flexibility. The ERP results cannot be understood as a disturbance of the EF in a direct sense, rather than as a disturbed normal functioning caused by the high anxiety level. Conclusion: There is no significant clinical manifestation of cognitive dysfunction among children with OCD in the early stage of the disorder, but it could be expected the same one to be appearing in the later stages of the disorder.
Biofeedback Training for Peak Performance in Sport - Case Study
Nada Pop-Jordanova,Aneta Demerdzieva
Macedonian Journal of Medical Sciences , 2010,
Abstract: The use of peripheral biofeedback and neurofeedback is growing rapidly in sport psychology. The aim is to lower competition stress, anxiety, and muscle tension.We present a case report concerned to biofeedback training in an athlete in preparation to Olympic Game competition. It is the first case in our region to prepare athlete with biofeedback modalities. Obtained results are very encouraging.
Comparison of Biofeedback Modalities for Better Achievement in High School Students
Nada Pop-Jordanova,Irena Chakalaroska
Macedonian Journal of Medical Sciences , 2008,
Abstract: The aim of this pilot study was to compare three biofeedback methods for enhancement of cognitive abilities (concentration and attention) in high school students. The sample comprises 50 students in high school for nurses, aged 16-18 years, devised in three groups: I - 30 students trained with EEG-Peak Achievement Trainer (EEG-PAT); II - 10 students trained with Electrodermal Response Biofeedback (EDR); and III - 10 students trained with Heart Rate Variability (HRV). The EEG-PAT is supposed to activate the Executive Attention Network, while HRV and EDR were supposed to influence indirectly, through the stabilization of autonomous nervous system. As psychometric tests we used: Trail Making Test (form A and form B) and numbering forward and backward, each one applied prior and after the experiment. The obtained results suggested that EEG-PAT can be successfully used for improving the concentration and attention and to a less extend the Short Term Memory Span. The HRV showed modest improvement (only for numbers), and EDR group did not show significant improvement in the concentration, attention and the Short Term Memory Span. However, all the three methods are highly cost-benefit and very comfortable for application and can be used for stabilization of the homeostasis.
EXECUTIVE FUNCTIONS EVALUATION PERFORMED BY EVENT RELATED POTENTIALS INCHILDREN WITH OBSESSIVE-COMPULSIVE DISORDER
Tatjana ZORCEC,Nada POP-JORDANOVA
Journal of Special Education and Rehabilitation , 2011,
Abstract: Introduction: Obsessive-compulsive disorder [OCD] is characterized by repetitive, disturbing obsessions and/or compulsions. Obsessions are thoughts, images or feelings which are unwanted, persistent and recurrent. Compulsions are repetitive and ritual motor acts which are performed to decrease the anxiety level caused by repetitive obsessions. The onset of the OCD is typically during adolescence or early adulthood. Its prevalence among children is from 1% to 3% and it appears to be more present among boys than girls. Nowadays, the most effective way to treat OCD is to combine psychopharmacological with cognitive-behavioral treatment strategies. In the past decades researchers were more involved in investigating the role of the executive functions [EF] in psychiatric disorders.Aim of the study: to investigate EF among children with OCD by using Event Related Potentials (ERPs) on the Go/NoGo tasks. Subjects and methods: The sample is comprised of 20 children from both genders, between seven and 14 years of age [М=10,33±1,83], all diagnosed with OCD. Psychological evaluation was performed with Child Behavior Check List, Kohs cubes for assessment of the intellectual capacities, Beck Depression Inventory, The Schedule for Affective Disorders and Schizophrenia for School-Age Children, Stroop Color Word Test and Wisconsin Card Sorting Test. Neuropsychological evaluation was performed with the Visual Continuous Performance Test [VCPT] from which the Event Related Potentials [ERP] components were extracted.Results: There is a clear presence of obsessions and/or compulsions, absence of symptoms of depression, presence of perseverative errors and mild difficulties in mental flexibility. The ERP results cannot be understood as a disturbance of the EF in a direct sense, rather than as a disturbed normal functioning caused by the high anxiety level.Conclusion: There is no significant clinical manifestation of cognitive dysfunction among children with OCD in the early stage of the disorder, but it could be expected the same one to be appearing in the later stages of the disorder.
Osteoskeletal Manifestation of Scurvy in a Male Infant (Case Report)
Nada Pop-Jordanova,Nevenka Slavevska,Stojka Fustic
Macedonian Journal of Medical Sciences , 2008,
Abstract: Scurvy, a disease of dietary deficiency of vitamin C, was uncommon in the last century due to improved nutrition and health care. However, in the last decade it was increasingly reported in adult population. In a period of infancy, scurvy appears after the age of five months and is related mainly to malnutrition. The main symptoms are vascular purpura, bleeding and gum abnormalities, but musculoskeletal manifestations could also be prominent. Children experience severe lower limb pain related to subperiosteal bleeding. The misdiagnosis with rickets and arthritis is common. We present a case of scurvy in 8 month boy with osteoskeletal manifestation, very rare seen in contemporary European pediatrics. The diagnosis of our patient is made by clinical presentation (such as haematuria, edema of lower extremities as well as swollen right leg), some biochemical parameters and radiological finding. The therapeutically outcome and follow-up of the boy confirmed the diagnosis and etiology.
Quantitative EEG Characteristics of Attention Deficit Hyperactivity Disorder in Adults
Silvana Markovska-Simoska,Nada Pop-Jordanova
Macedonian Journal of Medical Sciences , 2010,
Abstract: Background. Attention Deficit Hyperactivity Disorder (ADHD) in adults is fairly common, though it often goes unrecognized. The few published studies concerning the EEG assessment in the ADHD adults have demonstrated divergent EEG activity. Aim. Our aim was to identify whether the dividing the ADHD adults into the four QEEG subtypes (according to the Kropotov’s classification by comparing the each individual spectra to the Human Brain Institute (HBI) reference database) corresponds to our findings of electrophysiological measures - spectra absolute power (mV2) for each frequency band (delta, theta, alpha, beta).Material and Methods. In this study we examined the absolute spectra power of the brain waves through quantitative EEG (QEEG) in two resting conditions (eyes closed and eyes opened) and two neuropsychological tasks (visual and emotional continuous performance tests) from 67 adults diagnosed with ADHD.Results. Four distinct QEEG subtypes of adults with ADHD were selected according to the Kropotov’s classification and then were attested using statistical analysis. These were characterized by (a) increased delta-theta wave activity, (b) increased frontal midline theta, (c) beta excess and (d) alpha excess groups.Conclusion. We can conclude that the QEEG spectrum power relatively clearly differentiates the ADHD adults into four subtypes. Namely, the obtained results confirmed that the absolute power of all frequency bands depends on the group qualification. These results indicate that adults with ADHD diagnosis constitute a heterogeneous group either with different underlying electrophysiological abnormalities or in clinical expression. These valid subtypes may also have significantly different causes underlying their behaviour, and may respond differentially to medication and neurotherapy, possibilities which merit further investigation.
QEEG characteristics and spectrum weighted frequency for children diagnosed as autistic spectrum disorder
Pop-Jordanova Nada,Zorcec Tatjana,Demerdzieva Aneta,Gucev Zoran
Nonlinear Biomedical Physics , 2010, DOI: 10.1186/1753-4631-4-4
Abstract: Background Autistic spectrum disorders are a group of neurological and developmental disorders associated with social, communication, sensory, behavioral and cognitive impairments, as well as restricted, repetitive patterns of behavior, activities, or interests. The aim of this study was a) to analyze QEEG findings of autistic patients and to compare the results with data base; and b) to introduce the calculation of spectrum weighted frequency (brain rate) as an indicator of general mental arousal in these patients. Results Results for Q-EEG shows generally increased delta-theta activity in frontal region of the brain. Changes in QEEG pattern appeared to be in a non-linear correlation with maturational processes. Brain rate measured in CZ shows slow brain activity (5. 86) which is significantly lower than normal and corresponds to low general mental arousal. Recent research has shown that autistic disorders have as their basis disturbances of neural connectivity. Neurofeedback seems capable of remediating such disturbances when these data are considered as part of treatment planning. Conclusions Prognosis of this pervasive disorder depends on the intellectual abilities: the better intellectual functioning, the possibilities for life adaptation are higher QEEG shows generally increased delta-theta activity in frontal region of the brain which is related to poor cognitive abilities. Brain rate measured in CZ shows slow brain activity related to under arousal. Pharmacotherapy combined with behavior therapy, social support and especially neurofeedback technique promise slight improvements
Signatures of Depression in Non-Stationary Biometric Time Series
Milka Culic,Biljana Gjoneska,Hiie Hinrikus,Magnus J ndel,Wlodzimierz Klonowski,Hans Liljenstr m,Nada Pop-Jordanova,Dan Psatta,Dietrich von Rosen,Bj rn Wahlund
Computational Intelligence and Neuroscience , 2009, DOI: 10.1155/2009/989824
Abstract: This paper is based on a discussion that was held during a special session on models of mental disorders, at the NeuroMath meeting in Stockholm, Sweden, in September 2008. At this occasion, scientists from different countries and different fields of research presented their research and discussed open questions with regard to analyses and models of mental disorders, in particular depression. The content of this paper emerged from these discussions and in the presentation we briefly link biomarkers (hormones), bio-signals (EEG) and biomaps (brain-maps via EEG) to depression and its treatments, via linear statistical models as well as nonlinear dynamic models. Some examples involving EEG-data are presented.
COST-ESSEA PROJECT
Nada POP JORDANOVA
Journal of Special Education and Rehabilitation , 2013,
Abstract:
Morphofunctional characteristics of the adrenal cortex in tesetctomised rats acclimated on different ambient temperature
Popovska-Percinic Florina,Miteva Nada,Jordanova Maja,Ilieski Vlatko
Macedonian Veterinary Review , 2010,
Abstract: The activity of the adrenal gland is connected with the activity of other endocrine glands, such as the gonads. The experiments were conducted on testectomized adult, male rats, Wistar strain, acclimated on two ambient temperatures: room and moderately high temperature. Bilateral testectomy was performed on the rats of both temperatures and analyses were made 15-20 days after surgery. It was shown that the adrenal weight of testectomized heat acclimated rats was significantly increased. The widening of zona reticularis, shortening of zona fasciculata, as well as presence of supracortical nodules in the adrenal cortex of testectomized rats, regardless of the ambient temperature, was evidenced. Lipid content in the adrenocortical cells was lowered in both groups, but that was more prominent in testectomized rats from room temperature. The morphometric measurements of the nuclear area and volume were significantly elevated only in zona reticularis cells of testectomised animals from room temperature. Those parameters were significantly decreased in testectomized heat acclimated rats in comparison with the same values in the testectomized animals from room temperature. These results suggest that testectomy provokes changes towards increased activity of the adrenal cortex in both ambient temperatures, but those changes are less intense in heat acclimated animals.
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