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Search Results: 1 - 10 of 375999 matches for " NAIARA C NOGUEIRA DE SOUZA "
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Increased Risk of Acute Myeloid Leukemia in Patients with CYP1A1 Polymorphisms  [PDF]
Luís Arthur Flores Pelloso, Ismael Dale Cotrim Guerreiro da Silva, Naiara C?rrea Nogueira de Souza, Mihoko Yamamoto, Maria de Lourdes L. Ferrari Chauffaille
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.45111
Abstract:

Acute Myeloid Leukemia (AML) is a group of genetically diverse hematopoietic malignancies arising from cell progenitors developing in the myeloid pathway or from primitive stem cells. Genetic susceptibility of AML may account for an increased risk of AML due to partial metabolism of or biocativation of carcinogens. Chemical compounds are metabolized by a two-tiered phase detoxifying system. Polymorphisms in these pathways may lead to DNA damage and development of AML. We determined the frequencies of carcinogen metabolism gene polymorphisms (CYP1A1, del{GSTM1} and del{GSTT1}) in a case control-study based on polymorphism analysis. Fifty-eight consecutively AML patients (median age 62 years) and 174 sex and age-matched control group were assessed by a PCR-RFLP assay. There were 51 de novo and 7 secondary AML. CYP1A1*2A and CYP1A1*2C polymorphisms were more frequent in CG than AML p < 0.001 and in contrast, CYP1A1*3 and CYP1A1*4 were more frequent in AML than CG p <

Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
JOSé JUVENAL LINHARES,ISMAEL DALE COTRIM GUERREIRO DA SILVA,NAIARA C NOGUEIRA DE SOUZA,EMMANUELLE COELHO NORONHA
Biological Research , 2005,
Abstract: Due to the conflicting results regarding the association between breast cancerand the GSTM1 null mutation, our aim was to research this associationin a Brazilian population and correlations withsmoking, reproductive history and several clinical pathologies. A case-control study was performed on 105 women with breast cancer and 278 controls. Extraction of DNA was accomplished according to the protocol of the GFX kit and polymorphism analysis by the PCR technique. The control and experimental groups were compared and statistical analysis assessed by X2 or Fisher's exact test. The deletion in the GSTM1 gene in the breast cancer group had a prevalence of 32 (30.4%) individuals with the presence of null mutation. In the control group, the null mutation was present in 104 (37.4%) women. Upon comparison of the two groups, no statistically significant difference of the GSTM1 gene was observed, with an odds ratio (OR) of 0.74, 95%, confidence interval (CI) 0.45 - 1.20, p = 0.277. The results conclusively show that singlegene GSTM1 polymorphisms do not confer a substantial risk of breastcancer to its carriers. Furthermore, in this study no correlation was found between GSTs andsmoking, reproductive history and several clinical pathologies with respect to cancer risk.
Mechanisms and role of microRNA deregulation in cancer onset and progression
Palmero, Edenir Inês;Campos, Silvana Gisele P de;Campos, Marcelo;Souza, Naiara C Nogueira de;Guerreiro, Ismael Dale C.;Carvalho, Andre L.;Marques, Marcia Maria C.;
Genetics and Molecular Biology , 2011, DOI: 10.1590/S1415-47572011000300001
Abstract: micrornas are key regulators of various fundamental biological processes and, although representing only a small portion of the genome, they regulate a much larger population of target genes. mature micrornas (mirnas) are single-stranded rna molecules of 20-23 nucleotide (nt) length that control gene expression in many cellular processes. these molecules typically reduce the stability of mrnas, including those of genes that mediate processes in tumorigenesis, such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis and invasion. microrna targeting is mostly achieved through specific base-pairing interactions between the 5' end ('seed' region) of the mirna and sites within coding and untranslated regions (utrs) of mrnas; target sites in the 3' utr diminish mrna stability. since mirnas frequently target hundreds of mrnas, mirna regulatory pathways are complex. calin and croce were the first to demonstrate a connection between micrornas and increased risk of developing cancer, and meanwhile the role of micrornas in carcinogenesis has definitively been evidenced. it needs to be considered that the complex mechanism of gene regulation by micrornas is profoundly influenced by variation in gene sequence (polymorphisms) of the target sites. thus, individual variability could cause patients to present differential risks regarding several diseases. aiming to provide a critical overview of mirna dysregulation in cancer, this article reviews the growing number of studies that have shown the importance of these small molecules and how these micrornas can affect or be affected by genetic and epigenetic mechanisms.
Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
LINHARES,JOSé JUVENAL; GUERREIRO DA SILVA,ISMAEL DALE COTRIM; NOGUEIRA DE SOUZA,NAIARA C; COELHO NORONHA,EMMANUELLE; FERRARO,ODAIR; DE CARVALHO,CRISTINA VALLETA; CHADA BARACAT,EDMUND; FARAH BARACAT,FAUSTO;
Biological Research , 2005, DOI: 10.4067/S0716-97602005000200017
Abstract: due to the conflicting results regarding the association between breast cancer and the gstm1 null mutation, our aim was to research this association in a brazilian population and correlations with smoking, reproductive history and several clinical pathologies. a case-control study was performed on 105 women with breast cancer and 278 controls. extraction of dna was accomplished according to the protocol of the gfx? kit and polymorphism analysis by the pcr technique. the control and experimental groups were compared and statistical analysis assessed by x2 or fisher's exact test. the deletion in the gstm1 gene in the breast cancer group had a prevalence of 32 (30.4%) individuals with the presence of null mutation. in the control group, the null mutation was present in 104 (37.4%) women. upon comparison of the two groups, no statistically significant difference of the gstm1 gene was observed, with an odds ratio (or) of 0.74, 95%, confidence interval (ci) 0.45 - 1.20, p = 0.277. the results conclusively show that single gene gstm1 polymorphisms do not confer a substantial risk of breast cancer to its carriers. furthermore, in this study no correlation was found between gsts and smoking, reproductive history and several clinical pathologies with respect to cancer risk.
Polimorfismo do gene do receptor de progesterona (PROGINS) em mulheres com cancer de mama: estudo caso-controle
Linhares, José Juvenal;Silva, Ismael Dale Cotrim Guerreiro da;Souza, Naiara Correa Nogueira de;Noronha, Emmanuelle Coelho;Ferraro, Odair;Baracat, Fausto Farah;
Revista Brasileira de Ginecologia e Obstetrícia , 2005, DOI: 10.1590/S0100-72032005000800007
Abstract: purpose: to analyze the correlation between progins polymorphism and breast cancer. methods: a case-control study was carried out from april to october 2004. the genotypes of 50 women with breast cancer and 49 healthy women were analyzed. the 306-base pair alu insertion polymorphism in the g intron of progesterone receptor gene was detected by polymerase chain reaction and analyzed on 2% agarose gel stained with ethidium bromide. the control and experimental groups were compared regarding genotypes using the statistical epi-info 6.0 program and for frequencies the exact fisher test or c2 test were used. p value smaller p than 5% was considered to be significant. results: in relation to progins we found in the studied population a prevalence of 62 (62.6%) wild homozygous, 35 (35.3%) heterozygous individuals and two (2.1%) cases with the presence of the mutation. regarding progins polymorphism, significance was not evidenced when cases and controls were compared, as related to homozygosis (62 vs 65.3%), heterozygosis (36 vs 34,6%) or the mutation (2.0 vs 2.1%), with p=0.920 (or=1.01), 0.891 (or=1.06), and 0.988 (or=1.10), respectively. conclusions: the results show that single-gene progins polymorphism does not confer a substantial risk of breast cancer to its carriers.
Estudo comparativo da aplica o de modelos clássicos de previs o de demanda no agronegócio
Odair Oliva de Farias,Mário de Souza Nogueira Neto,Carlos César Sales Nogueira
Revista Organiza??es em Contexto , 2006,
Abstract: Para delinear a dinamica dos arranjos produtivos locais e alicer ar a eficiência coletiva no agronegócio, o cluster de indústrias de fertilizantes precisa dispor de um sistema de previs o de demanda adaptado às incertezas relacionadas ao processo e ao mercado global. Por meio das proje es futuras, a empresa estima metas objetivando orientar todo o sistema logístico e o fluxo de produtos e matéria-prima por meio do sistema portuário. O foco é agregar um grande volume de informa es e por meio de sua análise realizar previs es com a precis o desejada. As incertezas s o caracterizadas pela varia o dos componentes sistemáticos da série de dados, o que influencia o comportamento das vendas. Será apresentado um comparativo de análises quantitativas das séries sazonais relacionadas à demanda nacional de fertilizantes e à demanda de três produtos de um complexo industrial de fosfatados da regi o sudeste. Modelos clássicos de avalia o da série sazonal foram aplicados, comparando-se seus coeficientes de sazonalidade, tendência e periodicidade, buscando atenuar os efeitos da incerteza nos períodos seguintes.
Avalia o econ mico-financeira da microgera o de energia elétrica proveniente de biogás da suinocultura Economic evaluation of microgeneration of electricity from biogas of swine manure
Angelica B. Avaci,Samuel N. M. de Souza,Luiz I. Chaves,Carlos E. C. Nogueira
Revista Brasileira de Engenharia Agrícola e Ambiental , 2013,
Abstract: Uma das maiores fontes de energia disponíveis nas áreas rurais e agroindustriais é a biomassa, que aparece na forma de resíduos vegetais e animais, tais como resto de colheita, esterco animal, planta es energéticas e efluentes agroindustriais. Esses resíduos podem ser utilizados pelo produtor rural ou na agroindústria para a queima direta, visando à produ o de calor ou à produ o de biogás em biodigestores. A produ o de suínos gera grande quantidade de dejetos causando problemas ao meio ambiente, que quando n o tratados possuem quantidade relevante de metano. Objetivou-se com este trabalho avaliar, economicamente, a produ o de energia elétrica via biogás da suinocultura. Constatou-se que a melhor op o para o produtor é a venda de crédito carbono quando o custo de produ o de energia elétrica é viável quando vendido à concessionária de energia. A melhor condi o encontrada foi a de gera o de 20 h d-1, caso o tempo de retorno do investimento seja de 8 anos e o valor de produ o de energia elétrica, de R$ 120,11 kWh. One of the biggest sources of energy available in rural areas is biomass and agribusiness. The same appears in the form of plant and animal residues such as crop residues, animal manure, energy crops and agro-industrial effluents. These residues can be used by the farmer or agribusiness for direct burning in order to produce heat or production of biogas. Swine production generates large amounts of wastes causing environmental problems if left untreated. The same has lot of methane. The objective of this study was to evaluate the production cost of electricity through biogas from swine manure. It was found that the best option for the producer is selling carbon credit when the production cost of electricity is viable when sold to utility power. The best condition was found to generate 20 h d-1, when the time for return on investment is 8 years and the production of electricity is R$ 120.11 kWh.
Atrativo para as abelhas Apis mellifera e poliniza??o em café (Coffea arabica L.)
Malerbo-Souza, Darclet Teresinha;Nogueira-Couto, Regina Helena;Couto, Leoman Almeida;Souza, Julio César de;
Brazilian Journal of Veterinary Research and Animal Science , 2003, DOI: 10.1590/S1413-95962003000400006
Abstract: the present experiment was carried out in jaboticabal, sp, brazil, to study the frequency and behaviour of insects with respect coffee (coffea arabica l., var. mundo novo) flowers, the effect insects on fruit production, forage types of more frequent bees and the effectiveness of bee-herer (hoescht shering agrevo do brasil ltda) attractant on honeybee visits. for that the time of development and the amount of soluble sugar of the nectar of the flowers were verified, frequency of the visitations of the insects in elapsing of the day by means of insects number visiting the flowers, to every 60 minutes, of 8:00 at the 17 hours, 10 minutes in every schedule; time (in seconds) and collection type (nectar and/or pollen) ; loss of floral buttons; percentage of flowers that they became fruits; time of formation and number of coffee grains, being observed the fruition percentage in visited flowers or not for the insects. tests were also accomplished by spraying being used the product bee-here, diluted in syrup and in water in different schedules. the flower lasted on the average about 3 days from its opening to the withering. the amount of soluble sugar of the nectar presented significant difference among the schedules, being larger at the 8 hours (on the average, 102.18 ± 8,75 mg of glucose for flower). the most frequent insect to visit the coffee flowers was the africanized honey bees, collecting mainly nectar during the day. the number of fruits in the uncovered treatment was 38,79% and 168,38% higher in 1993 and 1994, respectively, than the covered ones. in spite of the efficiency of the product bee-herer to be affected by climatic conditions, it can be used to attract honeybees in coffee orchards.
Validation of pinto and pais-ribeiro’s spirituality scale in patients with chronic renal insufficiency in hemodyalisis
Erika de Cássia Lopes Chaves, Emília Campos de Carvalho, Rosana Aparecida Spadoti Dantas, Fábio de Souza Terra, Denis de Paula Nogueira, Luiz de Souza
Revista de Enfermagem UFPE On Line , 2010,
Abstract: Objective: performing the validation of the Pinto and Pais-Ribeiro Spirituality Scale, an instrument of evaluation of spirituality for application in the health context. It is a self-applied five-item instrument, whose answers are obtained in a Likert-type scale with four alternatives. Method: the methodological procedure has comprised two phases: the analysis of the scale semantics capacity and the statistical analyses of the psychometric proprieties. The application of the instrument was performed in the hemodialysis unit of a general hospital with 52 patients under hemodyalitic treatment. This study was approved by the Committee of Ethics in Research of the Nursing College of the University of S o Paulo State (protocol number 036/2008). Results: the analysis of the comprehensive capacity has shown that there was both equivalence and reconciliation of items. The internal consistency presented α Cronbach global of 0.64, and for the constructs Belief and Hope/Optimism, 0.78 and 0.69, respectively. These are considered acceptable values, since the scale contains only five items. Conclusion: that instrument proved to be valid and useful to clinical practices.
Crescimento e qualidade de mudas de Senna macranthera (collad.)irwin et barn. em resposta à calagem
Souza, Paulo Henrique de;Paiva, Haroldo Nogueira de;Neves, Júlio César Lima;Gomes, José Mauro;Marques, Lissandra Silva;
Revista árvore , 2010, DOI: 10.1590/S0100-67622010000200005
Abstract: the present work was developed with the objective of verifying the influence on the base saturation of the substratum in the initial growth and seedling quality of the senna macranthera (fedegoso) seeds. a complete randomized design in blocs with four repetitions per treatment was utilized. three different soils were used as a substratum, and for each, the original saturation was raised to the following values: redyellow claysoil 50, 60, and 70%; red-yellow dystrophic latosoil 30, 50, and 70%; red-yellow alic latosoil 25, 45, e 65%. the seedlings morphological parameters, their relationships and the dickson's quality index were evaluated. the fedegoso seedlings did not present any significant difference to any of the characteristics evaluated in the argisoil, with the largest average values in the 70% base saturation. in the red-yellow dystrophic latosoil and the alic latosol there was a significant difference in all of the evaluated characteristics, except for the height of the aerial parts in the former soil and for the weight of the dry material of the aerial part of the latter one, with the 65% base saturation providing the best seedling of the species.
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