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FORMULATION DEVELOPMENT AND EVALUATION OF TERBUTALINE SULPHATE MUCOADHESIVE BUCCAL TABLETS
Gururaj S.Kulkarni,N.G RaghavendraRao,D.Narasimhareddy
International Research Journal of Pharmacy , 2013, DOI: 10.7897/2230-8407.04340
Abstract: The main objective of developing any new dosage form is reduce the side effects and increase the therapeutic effect of drug in existing dose of dosage form. Mucoadhesive drug delivery system is oral dosage form, where the tablet, gel or patch is attached to the buccal region for direct absorption of drug into blood circulation. This route can prevent the metabolism of drug in G.I tract or liver and side effects of metabolites avoided. In this study, the attempt was made to prepare mucoadhesive buccal tablets of Terbutaline sulphate with natural polymer sodium alginate with one side absorption by backing layer with ethyl cellulose. The buccal tablets of Terbutaline sulphate studied in detail. I R Spectroscopy did the compatible study between polymers and Terbutaline sulphate and No interaction was found between drug and polymers. Different formulations of oral Mucoadhesive buccal tablets of Terbutaline Sulphate (TS) were prepared using polymer sodium alginate, in different concentrations by direct compression. Post compressed evaluation studies, hardness, thickness, friability; weight variation and drug content, mucoadhesive strength of tablets were studied. The in-vitro release of TS was studied in buffer pH 6.8 at 370C. All parameters of TS buccal tablets are passed the standard of mucoadhesive buccal tablets. It was found that mucoadhesive natural polymers exhibited better adhesiveness and mucoadhesiveness. The in vitro study of TS exhibited greater drug release profile with release of in the range of 79.25 to 99.85%.
Would Chrysomya albiceps (Diptera: Calliphoridae) be a beneficial species?
Madeira, N.G.;
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2001, DOI: 10.1590/S0102-09352001000200004
Abstract: chrysomya albiceps (widemann) develops on animal carcasses and may cause secondary myiases. an adult female merino sheep presented a lesion of roughly circular shape with a 7.5cm radius in the anterior part of the thorax. a large number of second-instar larvae was removed from the lesion in addition to first-instar larvae from the wool. a third-instar larva was also obtained from the same lesion site and in the laboratory gave origin to a cochliomyia hominivorax (coquerel) adult insect. the larvae retrieved from the lesion were nurtured in laboratory. pairs consisting of 100 individuals were formed with the adult specimens obtained from the larvae and kept in two cages. in all of the 800 adults reared in the laboratory and examined (100 per generation) the propisternal seta was absent in the spiracle on both sides, this trait was highly stable. the 200 larvae examined, 15 per generation, did not present spines in the column of the ventral process of the penultimate abdominal segment and the column of the ventral process was triangular and the apex of the column process presented numerous spines. these characteristics allowed identifying these specimens as c. albiceps. however, since c. albiceps has the ability to damage intact tissues, it may be causing relevant aggravation when associated with c. hominivorax and can not be considered innocuous.
Would Chrysomya albiceps (Diptera: Calliphoridae) be a beneficial species?
Madeira N.G.
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2001,
Abstract: Chrysomya albiceps (Widemann) develops on animal carcasses and may cause secondary myiases. An adult female Merino sheep presented a lesion of roughly circular shape with a 7.5cm radius in the anterior part of the thorax. A large number of second-instar larvae was removed from the lesion in addition to first-instar larvae from the wool. A third-instar larva was also obtained from the same lesion site and in the laboratory gave origin to a Cochliomyia hominivorax (Coquerel) adult insect. The larvae retrieved from the lesion were nurtured in laboratory. Pairs consisting of 100 individuals were formed with the adult specimens obtained from the larvae and kept in two cages. In all of the 800 adults reared in the laboratory and examined (100 per generation) the propisternal seta was absent in the spiracle on both sides, this trait was highly stable. The 200 larvae examined, 15 per generation, did not present spines in the column of the ventral process of the penultimate abdominal segment and the column of the ventral process was triangular and the apex of the column process presented numerous spines. These characteristics allowed identifying these specimens as C. albiceps. However, since C. albiceps has the ability to damage intact tissues, it may be causing relevant aggravation when associated with C. hominivorax and can not be considered innocuous.
Management staff differentiation matrix as a reference point for the determination of strategic workers in the enterprise control
N.G . Kalyuzhna
Marketing ì Mened?ment Innovacìj , 2012,
Abstract: It is proved that the strategic differentiation of the management staff plays a key role in the realization of the development strategy of the enterprise control system potential. The possibilities to adapt the staff differentiation tool for deciding the task of strategic differentiation of the management staff are investigated. A management staff differentiation matrix is proposed which can be considered as a reference-point for the determination of strategic workers of the enterprise control system.
The most important tool in MLM-business
N.G. Gromyko
Marketing ì Mened?ment Innovacìj , 2011,
Abstract: In article it is considered one of the most important tools in work of the distributor. The purposes which are pursued by consideration and application of the author's approach to this point in question are opened. Stages of the offered approach, their results, a role and value in MLM are in details stated the industry.
Aplica o do herbicida diclofop na cultura da soja para controle de papu , Brachiaria plantaginea (Linck) Hitch Application of the herbicide diclofop in soybean for control of Brachiaria plantaginea (Linck) Hitch
N.G. Fleck
Planta Daninha , 1979,
Abstract: Durante o ano agrícola de 1977/78 foi conduzida uma pesquisa a campo na regi o da Depress o Central do Rio Grande do Sul, com o objetivo de estabelecer a dose e a época de aplica o do herbicida diclofop que proporcionassem controle mais eficiente do Papua e que oferecessem maior seletividade à cultura. Os tratamentos constaram de combina es das doses de 720, 1080 e 1440 g/ha de diclofop, e aplica es em pré-plantio incorporadas a o solo (PPI), pré-emergência (PRE), pós-emergência quando as plantulas de papu se apresentavam com duas folhas (POS-2) e outra na ocasi o em que se encontravam no estádio de quatro folhas (POS-4), as quais foram comparadas às testemunhas com papu durante o ciclo da soja (TCP) e sem papu (TSP). Os efeitos dos tra tamentos foram estimados através de avalia es visuais de controle e pelo rendimento de gr os de soja. Todos os tratamentos com diclofop proporcionaram rendimentos estatisticamente equivalente s, os quais n o se diferenciaram do controle sem papu , embora tivessem apresentado rendimentos significativamente superiores ao daquele com papu . Resultados das avalia es visuais, interpretados conjuntamente, evidenciaram que todas as combina es de doses e épocas de aplica o do diclofop controlaram eficientemente o papu . As percentagens do controle alcan ado, em rela o às testemunhas , variaram de 68 a 99%, dependendo do tratamento e da época da avalia o. Contudo, as aplica es em POS-2 nas dosesde 1080 e 1440 g/ha e em POS-4 na dose de 1080 g/ha demonstraram maior eficiência em controlar papu do que aquelas em PPI e em PRE à 720 g/ha. Several herbicide mixtures were tested on cotton, (Gossypium hirsutum L.) in the main production areas of the State of Minas Gerais, Brasil. The cultivar "Minas Dona Beta", was used in the Metalúrgica region, whilst in Triangulo and Norte the cultivar employed was ."IAC-13-1", . In Triangulo litle regrowth occurred up to 30 days after application when the following mixtures were used: dinitramine + diuron, dinitroanilin + prometryne and pendimethalin + diuron. These treatments controlled 96.2%, 92.5% and 96.5% of the total weeds, respectively. When yields were compared, 1,962 Kg/ha were obtained in the best treatment (pendimethalin + diuron), against the control plots average of 1,130 Kg/ha. Tank mixtures of 2,00 Kg/ha of alachlor and 0.35 Kg/ha of metribuzin, or 3,00 Kg/ha of alachlor and 0,50 Kg/ha of metribuzin, and 1,00 Kg/ha of trifluralin and 0,50 Kg/ha of metribuzin were the most efficient in controlling grasses and dicotyledons. Effective weed control was recorded in Nor th of
Competi o de azevém (Lolium multiflorum L. ) com duas cultivares de trigo Ryegrass (Lolium multiflorum L. ) competition with two wheat cultivars
N.G. Fleck
Planta Daninha , 1980, DOI: 10.1590/s0100-83581980000200001
Abstract: Com os objetivos de avaliar a habilidade de duas cultivares de trigo em competir com azevém (Lolium multiflorum, L.) e de estimar os efeitos da concorrência de várias densidades desta espécie sobre a cultura, foi conduzido experimento a campo durante a esta o de crescimento de 1978, na Esta o Experimental Agron mica da UFRGS, em Guaíba, RS. Foram comparadas as cultivares de trigo 'E-7414' e 'PAT-7219', na popula o de 300 plantas por m', com azevém semeado nas densidades de 0, 2,5, 5,0, 10,0 e 20,0 kg/ha, as quais originaram popula es médias de 0, 130, 210, 470 e 750 plantas por m2 , respectivamente. A competi o entre as espécies foi mantida durante o ciclo da cultura. Para o rendimento de gr os da cultivar 'E-7414', a competi o exercida pelo azevém ocasionou decréscimos variáveis entre 18% e 56%, dependendo da infesta o; enquanto para a cultivar 'PAT-7219', as redu es no rendimento de gr os se situaram entre 4c é 22%, conforme a densidade do azevém. Enquanto para 'PAT-7219' n o foram significativas as redu es no rendimento de gr os, para `E-7414' os decréscimos verificados alcan aram significancia estatística. A análise do peso da matéria seca do azevém demonstrou que este aumentou proporcionalmente ao aumento de sua popula o, mas que aquela variável foi significativamente menor quando o azevém esteve competindo com 'PAT-7219' do que com `E-7414'. Em média, diminuiu em 31% a matéria seca do azevém produzida sob 'PAT-7219' em rela o à `E-7414'. A field experiment was conducted to evaluate the ability of two wheat cultivars to compete with ryegrass (Lolium multiflorum L.), and to estimate the competition effects of various densities of this species on the crop, at the Agronomy Experimental Station, in Guaiba, RS, during the 1978 wheat growing season. Two wheat cultivars ('E-7414' and 'PAT-7219') were grown in competition with ryegrass at the densities of 0, 130, 210, 470, and 750 plants per m'. The competition effects were maintained during the whole wheat cycle. Depending on the weed population, ryegrass competition caused significant decreases, varying from 18 to 56%, in seed yield of the wheat cultivar `E-7414'; whereas, for `PAT-7219' cultivar, although seed yield reductions varied from 4 to 22% , were not statistically significant. Ryegrass dry matter production increased proportionally to its population. However, ryegrass dry matter yield was significantly lower whe n this specie s competed with 'PAT-7219' wheat cultivar than with 'E-7414'. As an average for the established densities, ryegrass dry matter produced in competi tion with 'PAT
Comparative study of influence of system and local treatment by Ronkoleykin on indicators of immune status of children with atopic bronchial asthma
Sultanova N.G.
Saratov Journal of Medical Scientific Research , 2010,
Abstract: In the article the results of study of comparative influence of system and local treatment by Ronkoleykin on indicators of immune status at 33 children with medium severe bronchial asthma are listed. As a result of fulfilled research it was established that therapy by Ronkoleykin both in the form of injections, and in the form of an aerosol, introduced on a background of basic inflammatory treatment of atopic bronchial asthma, provided positive dynamics of immune and cytokine status. The received results specify the necessity of Ronkoleykin use for complex therapy of children with atopic bronchial asthma
State regulation models are formed the region territory develops on the basis of state-private partnership / Формирование модели градостроительного регулирования развития территории региона на основе государственно-частного партнерства
Juschkova N.G. / Юшкова Наталия Геннадиевна
Internet-Vestnik VolgGASU , 2006,
Abstract: Basic positions of town planning regulation is formulated. The necessity perfection his structural organization is proved by role increase state-private partnership. / Сформулированы принципиальные положения системы градостроительного регулирования, обоснована необходимость совершенствования его структурной организации посредством повышения роли государственно-частного партнерства.
Numerical technique and program for solving non-linear integrodifferential algebraic equations of a general type / Численный метод и программа для решения нелинейных интегро-дифференциально-алгебраических уравнений общего вида
Bandurin N.G. / Бандурин Николай Григорьевич
Internet-Vestnik VolgGASU , 2006,
Abstract: The numerical method and created for the first time in a history of mathematics and program-ming the program for the automatic solution of systems of the nonlinear integro-differential-algebraic equations of enough any structure is briefly described. The results of the solution of 4 test examples are resulted. / Кратко описан численный метод и созданная впервые в истории математики и программирования программа для автоматического решения систем нелинейных интегро-дифференциально-алгебраических уравнений (ИДАУ) достаточно произвольной структуры. Теоретическое обоснование метода не приводится. Решены четыре тестовых примера.
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