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Search Results: 1 - 10 of 199122 matches for " N.; Conde Redondo "
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Comparación entre la posición de Valdivia y la posición prona en la nefrolitectomía percutánea (NLP)
Amón Sesmero,J.H.; Del Valle González,N.; Conde Redondo,C.; Rodriguez Toves,A.; Cepeda Delgado,M.; Martínez-Sagarra Oceja,J.M.;
Actas Urológicas Espa?olas , 2008, DOI: 10.4321/S0210-48062008000400007
Abstract: introduction: although the supine position created by dr. valdivia two decades ago to perform the procedure known as percutaneous nephrolitectomy (pnl) presents advantages against the prone position in some aspects concerning anesthesia and surgical ergonomy, its use has failed to spread widely among the urology community due to certain technical difficulties, a lower rate of calculi clearing and a higher rate of complications, in spite of the fact that the scarce comparative studies do not show enough data to support this opinion. the present study compares both positions considering the technical difficulties encountered, their effectiveness and their results and complications. material and methods: a series of 50 patients that underwent pcnl by prone position is compared retrospectively with another series of 54 patients that underwent consecutively pcnl by prone position. all procedures were performed under general anesthesia, the inferior calyx approach was the one used the most over the supracostal approach, and the sole tract over the multi-tract approach was predominant. dilatation of the nephrostomy tract was done, in most of the cases, with a high-pressure balloon catheter. the stone surface treated was 399.93±58.2 mm2 for the supine group, and 416.36±46.54 mm2 for the prone one (p=0.456). the management of the stones was carried out by ultrasonic or ballistic fragmentation, and a small group of patients underwent direct stone removal. results: as far as demographic parameters and operative variables such as number of tracts performed, calyx election, type of tract dilatation and kind of energy used for fragmentation, both groups were homogeneous. in 3 cases of each group there was a failure to access the kidney. the rate of failure was 6%, and 5.56%, for the supine and prone groups, respectively (p=0.716). average operating time was 74.55±25.54 and 91.82±24.82 minutes, respectively, p=0.123. a postoperative x-ray showed a stone-free rate of 76% for the su
Sellado intravesical del uréter terminal en la nefroureterectomía
Amón Sesmero,José H.; Conde Redondo,Consuelo; Cepeda Delgado,Marcos; Castroviejo Royo,Fátima; Rodríguez Tesedo,Verónica; Martínez-Sagarra Oceja,José Ma;
Archivos Espa?oles de Urología (Ed. impresa) , 2010, DOI: 10.4321/S0004-06142010000300008
Abstract: objectives: to study the effectiveness and reliability of a new minimally invasive technique for the treatment of the terminal ureter in nephroureterectomy due to transitional cell carcinoma, both in open and laparoscopic procedures. methods: observational retrospective study of 14 patients that underwent intravesical sealing and endoscopic excision of terminal ureter, before ureterectomy (11 laparoscopic, 3 open), due to an upper urinary tract tumor, between july 2003 and november 2007. this procedure was performed on 11 males and 3 females, average age 59.5 years, (range: 35-70). the tumor settled on the renal pelvis in 12 cases and on the proximal ureter in 2. stage was ta - t1 in 10 patients, t2 in 3, and t3 in 1. tumor grade was g3 in 9 cases and g2 in 5. excision was carried out with a collins knife. in order to avoid contact between the urine and retroperitoneal space, the meatus was quickly sealed with a clip introduced by means of a transvesical trocar. results: total surgical time of nephroureterectomy was 231.15 minutes (range 200-340). global complication rate for the procedure was 28.4%, but the rate for the cases associated with this technique (meatus sealing and disinsertion) was 14.2%. all patients were discharged after removing bladder catheter. mean hospital stay was 10.14 days (range: 6-22). after an average follow-up of 25.3 months (range: 12-64), no retroperitoneal recurrence has been reported. one of the patients had bladder recurrence and another one developed metastasis to the suprarenal gland that was treated satisfactorily. conclusions: quick sealing of distal ureter by transvesical application of a clip before its endoscopic excision in nephrourecterectomy is a sound technique from an oncological point of view, with an acceptable complication rate that avoids a second open time to manage distal ureter.
Prostatectomía radical laparoscópica: experiencia preliminar
Estébanez Zarranz,J.; Amón Sesmero,J.; Conde Redondo,C.; Santos Largo,J.; Alonso Fernández,D.; Robles Samaniego,A.; Valle González,N. Del; Martínez-Sagarra Oceja,J.Ma;
Actas Urológicas Espa?olas , 2003, DOI: 10.4321/S0210-48062003000500007
Abstract: objetive: laparoscopic technique has been developped with the aim to decrese the morbidity of the open radical prostatectomy. material and methods: from january 2002 to may 2002, 8 patients were treated for prostate cancer with laparoscopic radical prostatectomy. unilateral linfadenectomy has been carried out in oly one patient. we usually employ the transperitoneal technique published by the montsouris institute, with some modifications. results: the main surgical time was 356 minuts (540-240). transfusion wasn't needed in any case. intraoperative complications were: 2 bladder injuries, 1 bleeding of the epigastric artery. postoperative complications were: 1 ileus, 2 compressive neurapraxia, 4 anastomotic fistutas. all complications were treated conservatively. no patient were converted to open surgery. surgical limits were negatifs in all cases, and the psa rate was less than 0.1 ng/ml in the first month follow up. conclusion: laparoscopic radical prostatectomy is a dificult technique, but we think that, the learning curve is getting lower and lower than in the first series. oncologic results with this technique is similar to the open one. however, laparoscopic approach shows us some benefits such as less bleeding, less time catheterisation, less hospital stay, better continence, better sexual fonction, better stetic result, less postoperative pain, and finally an earlier back to work.
A Comparison of EGFR Mutation Testing Methods in Lung Carcinoma: Direct Sequencing, Real-time PCR and Immunohistochemistry
Bárbara Angulo, Esther Conde, Ana Suárez-Gauthier, Carlos Plaza, Rebeca Martínez, Pilar Redondo, Elisa Izquierdo, Belén Rubio-Viqueira, Luis Paz-Ares, Manuel Hidalgo, Fernando López-Ríos
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0043842
Abstract: The objective of this study is to compare two EGFR testing methodologies (a commercial real-time PCR kit and a specific EGFR mutant immunohistochemistry), with direct sequencing and to investigate the limit of detection (LOD) of both PCR-based methods. We identified EGFR mutations in 21 (16%) of the 136 tumours analyzed by direct sequencing. Interestingly, the Therascreen EGFR Mutation Test kit was able to characterize as wild-type one tumour that could not be analyzed by direct sequencing of the PCR product. We then compared the LOD of the kit and that of direct sequencing using the available mutant tumours. The kit was able to detect the presence of a mutation in a 1% dilution of the total DNA in nine of the 18 tumours (50%), which tested positive with the real-time quantitative PCR method. In all cases, EGFR mutation was identified at a dilution of 5%. Where the mutant DNA represented 30% of the total DNA, sequencing was able to detect mutations in 12 out of 19 cases (63%). Additional experiments with genetically defined standards (EGFR ΔE746-A750/+ and EGFR L858R/+) yielded similar results. Immunohistochemistry (IHC) staining with exon 19-specific antibody was seen in eight out of nine cases with E746-A750del detected by direct sequencing. Neither of the two tumours with complex deletions were positive. Of the five L858R-mutated tumours detected by the PCR methods, only two were positive for the exon 21-specific antibody. The specificity was 100% for both antibodies. The LOD of the real-time PCR method was lower than that of direct sequencing. The mutation specific IHC produced excellent specificity.
Seguimiento a largo plazo de la endopielotomía anterógrada: Factores que influyen en el resultado
Amón Sesmero,Jose H.; Valle González,Noelia del; Rodríguez Toves,Luis A.; Conde Redondo,Consuelo; Rodríguez Tesedo,Verónica; Martínez-Sagarra Oceja,José M.;
Actas Urológicas Espa?olas , 2009, DOI: 10.4321/S0210-48062009000100012
Abstract: objective: to find out the outcomes of endopyelotomy alter a long-term follow-up and determine the variables that may influence the results. material and methods: we review the results obtained in 77 patients that underwent antegrade endopyelotomy with ureteropelvic junction obstruction, after 10- year follow-up. we used the kaplan-meier curve in order to determine the probable failure rate at a certain point. we took measurements of the pyelocalix area and studied its shape to find out the influence of hydronephrosis in the outcomes. other variables, such as renal function, previous surgery, lithiasis and renal malformation associated, were analysed. results: mean follow-up was 149.26 months. faliure rate probability was 26.9, 34.5 and 36.8% a year, 5 years and 10 years later, respectively. major failure concentration occurred in the first 20 months. mean pyelocalix area success was 19.70±8.32 cm2 vs 30.19±11.07 cm2 of failure, (p=0,018). there were no differences between the values of the shape factor in either success and failure. (0, 87 vs 0.88, p= 0.135, respectively). renal function (45.1% success vs 40,9% failure, p=0,625), previous surgery (62% success after previous surgery vs 64.7% first procedure, p=0.843), and lithiasis associated (69.3% success through lithiasis vs 61.1% without lithiasis, p=0.541) did not affect the outcomes. concomitance of hydronephrosis and renal malformation affected the outcomes negatively. conclusion: endopyelotomy success rate reduces long-term follow-up, however, after the fifth year it becomes stable. selecting cases to apply this technique according to the value of hydronephrosis area could improve the results.
Biopsia prostática ecodirigida: comparación de dos métodos anestésicos
Conde Redondo,C.; Alonso Fernández,D.; Robles Samaniego,A.; Valle González,N. Del; Castroviejo Royo,F.; Delgado Marcos,C.; Rodríguez Toves,A.; Martínez-Sagarra Oceja,J.M.;
Actas Urológicas Espa?olas , 2006, DOI: 10.4321/S0210-48062006000200004
Abstract: purpose: the aim of the present study is to compare two analgesic techniques for ultrasound transrectal biopsy. oral analgesia vs periprosthetic nerve blockade with 2 % mevicaine. patients and methods: a total of 200 patients were randomized prospectively into 2 groups, namely group i: 100 patients treated with metamizol, oral morphine 30 minutes before the procedure, and group ii: 100 patients anesthesied with periprosthetic nerve blockade with 2% mepivacaine. both groups were treated with bromacepán 3 mg 30 minutes before the biopsy. the first intention was to obtain 10 core trus-guided biopsy in all patients underwent. after the procedure, a ten visual analogue pain score (vas) from 0 = no discomfort to 10 = severe pain was administered to the biopsied patients and a global estimation of pain associated with the procedure was obtained. test t de student was used for statistical analysis. results: there were no significant differences in age, psa and prostate volume. 3 core trus-guided biopsy were obtain in group i (3±1,3), and 10 in group ii (5±1,2) in the periprosthetic block group (ii) 95% of patients referred no pain after the procedure (vas = 0), 2% middle pain (vas=5-6) and 3% strong pain (vas=7-8); while patients in group i referred 12,5% no pain , 42,4% middle pain, 20% strong pain. the level of pain reported by this group of patients was significantly different from those reported by patients who performed prostate biopsy with periprosthetic nerve blockade. (p<0.05). there were no significant differences in major complications. conclusions: the use of bilateral periprosthetic block with mepivacaine is a very effective and useful technique, well tolerated by the patient, which almost completely abolishes the pain and discomfort associated with the prostate biopsy procedure. and also allows increase the number of cores.
The Use of P63 Immunohistochemistry for the Identification of Squamous Cell Carcinoma of the Lung
Esther Conde,Bárbara Angulo,Pilar Redondo,Oscar Toldos,Elena García-García,Ana Suárez-Gauthier,Belén Rubio-Viqueira,Carmen Marrón,Ricardo García-Luján,Montse Sánchez-Céspedes,Angel López-Encuentra,Luis Paz-Ares,Fernando López-Ríos
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012209
Abstract: While some targeted agents should not be used in squamous cell carcinomas (SCCs), other agents might preferably target SCCs. In a previous microarray study, one of the top differentially expressed genes between adenocarcinomas (ACs) and SCCs is P63. It is a well-known marker of squamous differentiation, but surprisingly, its expression is not widely used for this purpose. Our goals in this study were (1) to further confirm our microarray data, (2) to analize the value of P63 immunohistochemistry (IHC) in reducing the number of large cell carcinoma (LCC) diagnoses in surgical specimens, and (3) to investigate the potential of P63 IHC to minimize the proportion of “carcinoma NOS (not otherwise specified)” in a prospective series of small tumor samples.
La administración de justicia en las sociedades rurales del Nuevo Reino de Granada, 1739-1803
Jorge Conde Calderón
Historia Crítica , 2013, DOI: http://dx.doi.org/10.7440/histcrit49.2013.03
Abstract: This ar ticle analyzes the administration and operation of the justice system through three cases occurred in the rural regions of the provinces of Santa Marta, Cartagena and Antioquia. These cases involved various institutions and authorities that also administered justice. We conclude that the administration of justice in rural neo-Grenadian societies recreated a world politicized by the same characteristics of the justice being dispensed: jurisdiction-based, diverse, and with various elements taken from custom. The article also shows other nuances such as the existence of institutions and authorities in constant communication with the centers of viceroyal power.
Ciudadanía, representación política y elecciones en el Caribe colombiano, 1820-1836
Jorge Conde Calderón
Memorias: Revista Digital de Historia y Arqueología desde el Caribe , 2009,
Abstract: El presente artículo muestra el papel que jugaron las elecciones entre los diferentes sectores sociales de la sociedad cartagenera entre 1820 y 1836. El interés principal se centra en las articulaciones de la sociedad alrededor del voto, los valores que aparecieron durante la competencia electoral, las modificaciones operadas en las nuevas y viejas jerarquías políticas y como era concebida la representación política entre los diversos actores políticos.
Hermenéutica analógica, filosofía y derechos humanos. Entrevista con Mauricio Beuchot
Napoleón Conde Gaxiola
Andamios , 2007,
Abstract:
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