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Search Results: 1 - 10 of 306144 matches for " N. V. Mahipal Reddy "
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF METAXALONE IN BULK AND ITS PHARMACEUTICAL FORMULATION BY UV SPECTROSCOPIC METHOD
N. V. Mahipal Reddy,B. Mohammed Ishaq,V. S. Thiruvengada Rajan,C. Gopinath
International Research Journal of Pharmacy , 2013, DOI: 10.7897/2230-8407.04329
Abstract: Metaxalone, a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains and othermusculoskeletal conditions. A simple, accurate, precise, reproducible, highly sensitive, economic UV spectrophotometric method has been developed for the estimation of metaxalon in bulk and tablet dosage form. In this method metaxalon showed maximum absorbance at 280 nm in methanol. The developed spectrophotometric method was validated in accordance with ICH guidelines. Linearity of the method was found to be 5 - 160μg/ml. The method obeyed Beer’s law in the concentration range of 5 -160 μg/ml. The LOD and LOQ were found to be 3.489μg/ml and 10.575μg/ml respectively. A mean recovery of metaxalon in tablet dosage form was found to be 99.69%.the method was found to be simple, accurate, precise, specific, sensitive, reproducible and can be directly and easily applied to tablet dosage form.
DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLETS OF FOSINOPRIL BY DIRECT COMPRESSION METHOD
N. G. Raghavendra Rao,Mahesh Kumar,Mettu Srikanth reddy,B. Mahipal Reddy
International Research Journal of Pharmacy , 2012,
Abstract: Fosinopril is an anti-hypertensive, angiotensin converting enzyme inhibitor. This is used in the treatment of various cardiovascular disorders such as heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients and hypertension. In present research work an attempt has been made to prepare fast dissolving tablets of Fosinopril with increased rate of dissolution may leads to increase bioavailability. The fast dissolving tablets of Fosinopril were prepared by using direct compression method. Sodium starch glycolate, Croscarmellose sodium, kyronT-314 and crospovidone are used as a superdisintegrants. The prepared tablets were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug content, water absorption ratio, wetting time, in-vitro drug release, FTIR, DSC studies and short term stability studies. IR spectral analysis and DSC study showed that there was no drug interaction with formulation additives of the tablet. The blend was examined for the pre-compressional parameters. The prepared tablets formulations were evaluated for post-compressional parameters. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. All the post-compressional parameter are evaluated were prescribed limits and results were within IP acceptable limits. The in-vitro disintegration time of fast dissolving tablets were found to be 28 to 69 sec. Based on the in-vitro disintegration time, formulation F12 (12.5% Crosspovidone) were found to be promising and showed a disintegration time of 28 sec. The formulations F4, F8, F12 and F16 50 % of drug released in 0.66 min, 0.67 min, 0.65 min, and 0.72 min respectively, and 90 % of drug released in 5.82min, 5.66 min, 5.41 min, and 5.90 min respectively when compared to other tablet formulation. Among all the formulation F12 (12.5% Crosspovidone) were found to be promising and showed a disintegration time of 28 sec, 50 % of drug released in 0.65 min, and 90 % of drug released in 5.41 min. The stability study conducted as per the ICH guidelines and the formulations were found to be stable. The results concluded that fast dissolving tablets Fosinopril showing enhanced dissolution, will lead to improved bioavailability, improved effectiveness and hence better patient compliance.
Schottky Barrier Parameters of Pd/Ti Contacts on N-Type InP Revealed from I-V-T And C-V-T Measurements  [PDF]
D. Subba Reddy, M. Bhaskar Reddy, N. Nanda Kumar Reddy, V. Rajagopal Reddy
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.23018
Abstract: We report on the current-voltage (I-V) and capacitance-voltage (C-V) characteristics of the Pd/Ti/n-InP Schottky barrier diodes (SBDs) in the temperature range 160-400 K in steps of 40 K. The barrier heights and ideality factors of Schottky contact are found in the range 0.35 eV (I-V), 0.73 eV (C-V) at 160 K and 0.63 eV (I-V), 0.61 eV (C-V) at 400 K, respectively. It is observed that the zero-bias barrier height decreases and ideality factor n increase with a decrease in temperature, this behaviour is attributed to barrier inhomogeneities by assuming Gaussian distribution at the interface. The calculated value of series resistance (Rs) from the forward I-V characteristics is decreased with an increase in temperature. The homogeneous barrier height value of approximately 0.71 eV for the Pd/Ti Schottky diode has been obtained from the linear relationship between the temperature-dependent experimentally effective barrier heights and ideality factors. The zero-bias barrier height ( ) versus 1/2kT plot has been drawn to obtain evidence of a Gaussian distribution of the barrier heights and values of = 0.80 eV and = 114 mV for the mean barrier height and standard deviation have been obtained from the plot, respectively. The modified Richardson ln(I0/T2)- ( ) versus 1000/T plot has a good linearity over the investigated temperature range and gives the mean barrier height ( ) and Richardson constant (A*) values as 0.796 eV and 6.16 Acm-2K-2 respectively. The discrepancy between Schottky barrier heights obtained from I-V and C-V measurements is also interpreted.
Evaluation of reproductive traits in three strains of japanese quail
A. Ashok,P. Mahipal Reddy
Veterinary World , 2010,
Abstract: A study was undertaken to evaluate the reproductive performance in two plumage colour variant strains of quail, viz; Brown, White Breasted and a dark Cinnamon Brown (commercial) strain. A total of 694 straight run active chicks were obtained in three hatches at weekly intervals from the three strains. Sex was determined at six weeks of age and female progenies were separated and data on reproductive traits were recorded. The Brown strain exhibited superior egg weights (P<0.05) than the other two strains. The commercial strain came into egg production earlier and produced significantly (P<0.05) more number of eggs than the other two strains. [Vet World 2010; 3(4.000): 169-170]
A Stability Indicating UPLC Method for Finasteride and Its Related Impurities  [PDF]
Y. Koti Reddy, G. V. Subba Reddy, K. N. Jaya Veera, Kishore Kumar Hotha
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.311098
Abstract: The objective of the present research work is to develop a gradient, reversed-phase liquid chromatographic (RP-UPLC) method for the determination of Finasteride in pharmaceutical bulk drugs for assay and its related impurities. The chromatographic separation was achieved on a Waters ACQUITY UPLC BEH Phenyl Column (150 mm × 2.1 mm, 1.7 μm), The gradient LC method employs solutions A and B as mobile phase. The solution A Contains 2.5 mM ortho phosphoric acid (Buffer) and solution B contains a mixture of acetonitrile and water in the ratio of (90:10 v/v). The flow rate was 0.22 ml/min and the detection wavelength was 210 nm. In the developed UPLC method, the resolution between Finasteride and its potential impurities, namely Imp-1, Imp-2, Imp-3 and Imp-4 was found to be greater than 2.0. The drug was subjected to stress conditions of hydrolysis, oxidation, photolysis and thermal degradation. Considerable degradation was found to occur in alkaline medium and oxidative stress conditions. Degradation product formed during oxidative hydrolysis was found to be Imp-1. The stress samples were assayed against a qualified reference standard and the mass balance was found close to 99.5%. The developed RP-UPLC method was validated with respect to linearity, accuracy, precision and robustness. The limit of quantification of Imp-1, Imp-2, Imp-3 and Imp-4 were 0.06, 0.06, 0.05 and 0.036% (of analyte concentration, i.e. 0.5 mg/ml) with 1μl injection volume. The developed method was found to be linear in the range of 2.5 - 15 μg/mL with correlation coefficient of 0.999 for assay procedures and found to be linear in the range of 0.05 - 3 μg/mL with correlation coefficient of 0.999 for related impurities.
Thermal Annealing Behaviour on Electrical Properties of Pd/Ru Schottky Contacts on n-Type GaN
N. Nanda Kumar Reddy,V. Rajagopal Reddy
Journal of Nano- and Electronic Physics , 2011,
Abstract: We have investigated the electrical properties of Pd/Ru Schottky contacts on n-GaN as a function of annealing temperature by current-voltage (I-V) and capacitance-voltage (C-V) measurements. The Schottky barrier height of the as-deposited Pd/Ru contact is found to be 0.67 eV (I-V) and 0.79 eV (C-V), respectively. Measurements showed that the Schottky barrier height increased from 0.68 eV (I-V) and 0.80 eV (C-V) to 0.80 eV (I-V) and 0.96 eV (C-V) as the annealing temperature is varied from 200 °C to 300 °C. Upon annealing at 400 °C and 500 °C, the Schottky barrier height decreased to 0.73 eV (I-V) and 0.85 eV (C-V) and 0.72 eV (I-V) and 0.84 eV (C-V), respectively. It is noted that the barrier height further decreased to 0.59 eV (I-V) and 0.72 eV (C-V) when the contact is annealed at 600 °C. The change of Schottky barrier heights and ideality factors with annealing temperature may be due to the formation of interfacial compounds at the Ru/Pd/n-GaN interface.
New Method of Palladium Metal Trapping through Resins in Antiviral Drug: Valacyclovir HCl  [PDF]
Keshava Navin Kumar Reddy, Murugulla Adharvana Chari, Mayur D. Khunt, V. V. N. K. V. Prasada Raju, Bojja Ramachandra Reddy, Vurimidi Himabindu, Ghanta Mahesh Reddy
International Journal of Organic Chemistry (IJOC) , 2013, DOI: 10.4236/ijoc.2013.34036
Abstract:

This process describes a novel technique for effective trapping of “Pd” metal through resins during the process development of L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl) methoxy] ethyl ester, and mono hydrochloride known as a Valacyclovir hydrochloride (1). This technique is suitable for large-scale production of 1 and it is described here Pd metal trapping by using different resins.

 


Performance Analysis of Three Routing Protocols for Varying MANET Size
N Vetrivelan,A V Reddy
Lecture Notes in Engineering and Computer Science , 2008,
Abstract:
Dentin comparison in primary and permanent molars under transmitted and polarised light microscopy: An in vitro study
Chowdhary N,Subba Reddy V
Journal of the Indian Society of Pedodontics and Preventive Dentistry , 2010,
Abstract: Dentin is the fundamental substrate of restorative dentistry and its properties and characteristics are key determinants of nearly all restorative, preventive and disease processes of the teeth. The intrinsic permeability of dentin is responsible for permitting bacterial or chemical substances to diffuse across the dentin and irritate the pulpal and periradicular tissues. Improved understanding of the dentin structure and nature will have important consequences for today′s dental procedures. The aims of the study were to observe the direction of dentinal tubules, interglobular dentin, incremental lines of dentin and the dead tracts. Materials and Methods: A total of 30 teeth (15 primary and 15 permanent molars), unrestored, noncarious, hypoplastic extracted molars were used. Longitudinal ground sections of teeth were obtained using hard tissue microtome. Results: Examination of ground sections of the primary teeth dentin showed "s"-shaped curvature in four (26.7%) specimens and a straight course of dentinal tubules in 11 (73.3%) specimens out of 15 teeth examined whereas in permanent teeth, all 15 (100%) specimens showed an "s"-shaped curvature. These results are statistically highly significant (P < 0.001). Conclusion: Dentinal tubules followed an "s"-shaped course in all the 15 (100%) permanent molars and in four (26.7%) primary molars. There was no significant difference in the occurrence of interglobular dentin of primary and permanent molars. But, they were at angles in the primary teeth.
Synthesis and Antibacterial Activity of Urea and hiourea Derivatives at C-8 Alkyl Chain of Anacardic Acid Mixture Isolated from a Natural Product Cashew Nut Shell Liquid (CNSL)  [PDF]
N. Subhakara Reddy, A. Srinivas Rao, M. Adharvana Chari, V. Ravi Kumar, V. Jyothi, V. Himabindu
International Journal of Organic Chemistry (IJOC) , 2011, DOI: 10.4236/ijoc.2011.14025
Abstract: Synthesis and antibacterial activity of some novel urea and thiourea derivatives (7a-7k, 8a-8f) of anacardic acid prepared from commercially available anacardic acid which is obtained from natural product Cashew Nut Shell Liquid (CNSL). Compounds (7a-7k, 8a-8f) were tested for Gram positive and Gram negative bac- terial cultures. Most of the compounds were showed active compared with standard drug ampicilline.
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