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Search Results: 1 - 10 of 198122 matches for " N. Pelliccia "
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Electrogenesis via primordial black holes
Pelliccia, Diego N.
High Energy Physics - Phenomenology , 2007,
Abstract: It was recently shown that the vanishing of the Coulomb field related to the electric charge of a black hole by virtue of a tiny but non-vanishing photon mass can produce an electric asymmetry in the universe. This process can have place both at a cosmological early stage, through primordial black holes, and in contemporary universe, by means of supermassive black holes at galactic centers. Possible consequences of the latter case about the role of electrogenesis in the generation of magnetic fields coherent on galactic scale have been investigated. In this paper we will discuss the electrogenesis mediated by primordial black holes and analyze different realizations of the mechanism in this case.
Scalar field instability in de Sitter space-time
Alexander Dolgov,Diego N. Pelliccia
Physics , 2005, DOI: 10.1016/j.nuclphysb.2005.12.002
Abstract: Starting from the equation of motion of the quantum operator of a real scalar field phi in de Sitter space-time, a simple differential equation is derived which describes the evolution of quantum fluctuations of this field. Full de Sitter invariance is assumed and no ad hoc infrared cutoff is introduced. This equation is solved explicitly and in massive case our result agrees with the standard one. In massless case the large time behavior of our solution differs by sign from the expression found in earlier papers. A possible cause of discrepancy may be a spontaneous breaking of de Sitter invariance.
A two-step method for retrieving the longitudinal profile of an electron bunch from its coherent radiation
Daniele Pelliccia,Tanaji Sen
Physics , 2014, DOI: 10.1016/j.nima.2014.07.024
Abstract: The coherent radiation emitted by an electron bunch provides a diagnostic signal that can be used to estimate its longitudinal distribution. Commonly only the amplitude of the intensity spectrum can be measured and the associated phase must be calculated to obtain the bunch profile. Very recently an iterative method was proposed to retrieve this phase. However ambiguities associated with non-uniqueness of the solution are always present in the phase retrieval procedure. Here we present a method to overcome the ambiguity problem by first performing multiple independent runs of the phase retrieval procedure and then second, sorting the good solutions by mean of cross-correlation analysis. Results obtained with simulated bunches of various shapes and experimental measured spectra are presented, discussed and compared with the established Kramers-Kronig method. It is shown that even when the effect of the ambiguities is strong, as is the case for a double peak in the profile, the cross-correlation post-processing is able to filter out unwanted solutions. We show that, unlike the Kramers-Kronig method, the combined approach presented is able to faithfully reconstruct complicated bunch profiles.
Comparison of Different Neural Network Approaches for the Tropospheric Profiling over the Inter-tropical lands Using GPS Radio Occultation Data
Stefania Bonafoni,Fabrizio Pelliccia,Roberta Anniballe
Algorithms , 2009, DOI: 10.3390/a2010031
Abstract: In this study different approaches based on multilayer perceptron neural networks are proposed and evaluated with the aim to retrieve tropospheric profiles by using GPS radio occultation data. We employed a data set of 445 occultations covering the land surface within the Tropics, split into desert and vegetation zone. The neural networks were trained with refractivity profiles as input computed from geometrical occultation parameters provided by the FORMOSAT-3/COSMIC satellites, while the targets were the dry and wet refractivity profiles and the dry pressure profiles obtained from the contemporary European Centre for Medium-Range Weather Forecast data. Such a new retrieval algorithm was chosen to solve the atmospheric profiling problem without the constraint of an independent knowledge of one atmospheric parameter at each GPS occultation.
Contextual, Optimal and Universal Realization of the Quantum Cloning Machine and of the NOT gate
Francesco De Martini,Daniele Pelliccia,Fabio Sciarrino
Physics , 2003, DOI: 10.1103/PhysRevLett.92.067901
Abstract: A simultaneous realization of the Universal Optimal Quantum Cloning Machine (UOQCM) and of the Universal-NOT gate by a quantum injected optical parametric amplification (QIOPA), is reported. The two processes, forbidden in their exact form for fundamental quantum limitations, are found universal and optimal, and the measured fidelity F<1 is found close to the limit values evaluated by quantum theory. This work may enlighten the yet little explored interconnections of fundamental axiomatic properties within the deep structure of quantum mechanics.
Contextual Realization of the Universal Quantum Cloning Machine and of the Universal-NOT gate by Quantum Injected Optical Parametric Amplification
D. Pelliccia,V. Schettini,F. Sciarrino,C. Sias,F. De Martini
Physics , 2003, DOI: 10.1103/PhysRevA.68.042306
Abstract: A simultaneous, contextual experimental demonstration of the two processes of cloning an input qubit and of flipping it into the orthogonal qubit is reported. The adopted experimental apparatus, a Quantum-Injected Optical Parametric Amplifier (QIOPA) is transformed simultaneously into a Universal Optimal Quantum Cloning Machine (UOQCM) and into a Universal NOT quantum-information gate. The two processes, indeed forbidden in their exact form for fundamental quantum limitations, will be found to be universal and optimal, i.e. the measured fidelity of both processes F<1 will be found close to the limit values evaluated by quantum theory. A contextual theoretical and experimental investigation of these processes, which may represent the basic difference between the classical and the quantum worlds, can reveal in a unifying manner the detailed structure of quantum information. It may also enlighten the yet little explored interconnections of fundamental axiomatic properties within the deep structure of quantum mechanics. PACS numbers: 03.67.-a, 03.65.Ta, 03.65.Ud
Tumor-infiltrating B lymphocytes as an efficient source of highly specific immunoglobulins recognizing tumor cells
Emiliano Pavoni, Giorgia Monteriù, Daniela Santapaola, Fiorella Petronzelli, Anna Anastasi, Angela Pelliccia, Valeria D'Alessio, Rita De Santis, Olga Minenkova
BMC Biotechnology , 2007, DOI: 10.1186/1472-6750-7-70
Abstract: The ability of a patient's immune system to produce specific antibodies inside tumor tissue, capable of recognizing tumor cells, was explored through analysis of the oligoclonality of antibodies derived from tumor-infiltrating lymphocytes and construction of a series of recombinant antibody libraries in scFv format, derived from breast tumor-infiltrating B lymphocytes. These libraries and one from peripheral blood lymphocytes of a single breast cancer patient were panned against three purified surface tumor antigens, such as CEA, MUC1 and ED-B domain, and against intact MCF7 breast carcinoma cells.Application of novel display vector, pKM19, allowed isolation of a large panel of breast cancer-specific antibodies against known tumor antigens, as well as against breast carcinoma cells. Reactivity of novel scFvs was confirmed by ELISA, immunohistochemistry, fluorescence staining and flow cytometry. We demonstrated that seven of ten primary breast tumor specimens, obtained using discarded surgical material, could be exploited as an appropriate source for generation of phage display libraries, giving highly specific antitumor antibodies which recognize heterologous tumor cells.Local humoral immune response within tumor tissue in breast cancer patients frequently has an oligoclonal character. Efficient selection of specific antitumor antibodies from recombinant antibody libraries, derived from such oligoclonal tumor-infiltrated B lymphocytes, indicates the presence of natural immune response against tumor antigens in these patients. The described method is very promising for development of antitumor antibodies, potentially useful for diagnostic and therapeutic approaches.The discovery of monoclonal antibody technology [1] stimulated rapid development of targeted therapies against cancer. The use of monoclonal antibodies as a drug delivery vehicles, or trigger for human immune response is already an accepted method for therapeutic treatment of patients in modern clinical on
Distal left circumflex coronary artery flow reserve recorded by transthoracic Doppler echocardiography: a comparison with Doppler-wire
Antonio Auriti, Christian Pristipino, Cinzia Cianfrocca, Antonino Granatelli, Vincenzo Guido, Francesco Pelliccia, Salvatore Greco, Giuseppe Richichi, Massimo Santini
Cardiovascular Ultrasound , 2007, DOI: 10.1186/1476-7120-5-22
Abstract: To evaluate the reliability of TTDE in assessing CFR in LCx when compared to the intracoronary Doppler flow-wire gold standard.we evaluated 5 patients (age = 60 ± 9 years, 5 males) on LCx by TTDE and invasive CFR assessment. TTDE recording was performed using a low-frequency probe, with a four-chamber as a guiding 2D view. The 2 tests were performed on different days and in random order within 48 hours in a blind fashion. Vasodilator stimulus was adenosine, intravenously (140 γ/kg/min × 3–6 min) for TTDE and intracoronary (40 γ bolus) for DW recordings.CFR values on LCx ranged from 1.9 to 2.8 for DW, and from 2.0 to 3.0 for TTDE, with an overall correlation of R = 0,85 (p = 0,06); normal (CFR > 2.5) or abnormal (CFR < 2.5) value was concordantly identified by the 2 techniques in 4 out 5 cases (80%).CFR of LCx artery can be obtained noninvasively with TTDE.Coronary flow reserve (CFR) recording by means of transthoracic echocardiography (TTDE) in all the main distal coronary arteries is a challenge for advanced echocardiography. Clinical implications of such a possibility are involving an improved indication for invasive exams and for revascularisation, the evaluation of coronary flow after revascularisation, the new generation of stress-echo testing (CFR plus wall motion) and the non-invasive follow-up of patients [1-8].Several studies concerning coronary flow and CFR recorded in the Left Anterior Descending coronary artery (LAD) and few in the Posterior Descending coronary artery (PD) have been published so far [9-12], and the measurement of CFR by TTDE was validated, by comparing it with intracoronary Doppler recordings (DW) in the same patient and in the same vessel, in some studies [13-16].However, only few papers concerning the distal Left Circumflex coronary artery (LCx) have been published [17-19]. Technical difficulties may pose feasibility challenges to LCx recording like the supposed lack of a reference structure to identify the position of the distal branc
A Clinical-EEG Study of Sleepiness and Psychological Symptoms in Pharmacoresistant Epilepsy Patients Treated with Lacosamide
Filippo S. Giorgi,Chiara Pizzanelli,Veronica Pelliccia,Elisa Di Coscio,Michelangelo Maestri,Melania Guida,Elena Iacopini,Alfonso Iudice,Enrica Bonanni
Epilepsy Research and Treatment , 2013, DOI: 10.1155/2013/593149
Abstract: Our aim was to evaluate the EEG and clinical modifications induced by the new antiepileptic drug lacosamide (LCM) in patients with epilepsy. We evaluated 10 patients affected by focal pharmacoresistant epilepsy in which LCM (mean 250?mg/day) was added to the preexisting antiepileptic therapy, which was left unmodified. Morning waking EEG recording was performed before (t0) and at 6 months (t1) after starting LCM. At t0 and t1, patients were also administered questionnaires evaluating mood, anxiety, sleep, sleepiness, and fatigue (Beck Depression Inventory; State-Trait Anxiety Inventory Y1 and Y2; Pittsburgh Sleep Quality Index; Epworth Sleepiness Scale; Fatigue Severity Scale). We performed a quantitative analysis of EEG interictal abnormalities and background EEG power spectrum analysis. LCM as an add-on did not significantly affect anxiety, depression, sleepiness, sleep quality, and fatigue scales. Similarly, adding LCM to preexisting therapy did not modify significantly patient EEGs in terms of absolute power, relative power, mean frequency, and interictal abnormalities occurrence. In conclusion, in this small cohort of patients, we confirmed that LCM as an add-on does not affect subjective parameters which play a role, among others, in therapy tolerability, and our clinical impression was further supported by evaluation of EEG spectral analysis. 1. Introduction Epilepsy is one of the most common neurological disorders, affecting up to two percent of the population worldwide. Many patients show recurrent seizures despite treatment with appropriate antiepileptic drugs (AEDs’) [1, 2], and many experience AEDs side effects. In the last decades, new AEDs have been developed with the aim of balancing, as far as possible, significant efficacy with good tolerability. Among them, Lacosamide (LCM) has been recently authorized in Italy and worldwide as a new add-on AED for the treatment of pharmacoresistant focal epilepsy. Side effects of classical AEDs often involve cognitive functions, mood, and behavior to varying degrees, and this is the case also for newer AEDs (see, for instance, [3–5]). Unfortunately, a clear evaluation of these types of side effects in the single patient is often difficult because of the subjectivity of such complaints. This assessment is even harder in patients undergoing AED polytherapy. It has been proposed by several authors the usefulness of a quantitative analysis on EEG in patients undergoing treatment with drugs acting on the CNS (for a review, see for instance, [6]), in this setting, abnormalities of EEG power spectrum have
Chemical Linkage to Injected Tissues Is a Distinctive Property of Oxidized Avidin
Rita De Santis, Anna Maria Anastasi, Angela Pelliccia, Antonio Rosi, Claudio Albertoni, Antonio Verdoliva, Fiorella Petronzelli, Valeria D'Alessio, Serenella Serani, Carlo Antonio Nuzzolo
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021075
Abstract: We recently reported that the oxidized avidin, named AvidinOX?, resides for weeks within injected tissues as a consequence of the formation of Schiff's bases between its aldehyde groups and tissue protein amino groups. We also showed, in a mouse pre-clinical model, the usefulness of AvidinOX for the delivery of radiolabeled biotin to inoperable tumors. Taking into account that AvidinOX is the first oxidized glycoprotein known to chemically link to injected tissues, we tested in the mouse a panel of additional oxidized glycoproteins, with the aim of investigating the phenomenon. We produced oxidized ovalbumin and mannosylated streptavidin which share with avidin glycosylation pattern and tetrameric structure, respectively and found that neither of them linked significantly to cells in vitro nor to injected tissues in vivo, despite the presence of functional aldehyde groups. The study, extended to additional oxidized glycoproteins, showed that the in vivo chemical conjugation is a distinctive property of the oxidized avidin. Relevance of the high cationic charge of avidin into the stable linkage of AvidinOX to tissues is demonstrated as the oxidized acetylated avidin lost the property. Plasmon resonance on matrix proteins and cellular impedance analyses showed in vitro that avidin exhibits a peculiar interaction with proteins and cells that allows the formation of highly stable Schiff's bases, after oxidation.
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