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Efficacy of Sonicated and Acid-Extractable Antigens in the Serodiagnosis of H. pylori infection in Peptic Ulcer Patients
Parimala N,Ishaq M
Indian Journal of Medical Microbiology , 2005,
Abstract: Helicobacter pylori is implicated in causation of peptic ulcers and gastric cancer and plays a pivotal role in gastric pathophysiology. In the present study we evaluated the relative efficacy of sonicated and acid-extractable antigens in the serodiagnosis of H. pylori infection in peptic ulcer patients by ELISA. In the present study we evaluated the relative efficacy of sonicated and acid-extractable antigens in the serodiagnosis of H. pylori infection in peptic ulcer patients by ELISA. The two types of antigens mentioned above were prepared from H. pylori subcultures following appropriate procedures. Sera were collected from 13 subjects of whom eight were diagnosed to be suffering from duodenal ulcer (DU) and five from non-ulcer dyspepsia (NUD) and screened for the presence of anti H. pylori antibodies by ELISA. A case was considered seropositive, if the OD value was more than or equivalent to twice the mean OD value of blank. Analysis of our results showed that, with acid extractable antigen at a concentration of 2 mg/mL, 12 cases were seropositive. Contrastingly, with sonicated antigen, at a concentration of 2 mg/mL only eight cases were positive. It is concluded from this study, that the use of relatively purified antigens like acid extractable antigens enhances the sensitivity and specificity of this serodiagnostic test, indicative of its relatively higher efficacy over sonicated lysate containing multiple antigens.
Histological and Histochemical Investigations of Myristica fragrans Houtt. (Myristicaceae)
N.Parimala,S.Amerjothy
Journal of Pharmacognosy and Phytochemistry , 2013,
Abstract: Myristica fragrans Houtt. of Myristicaceae yields the nut-mug and mace which are credited with high flavours and fragrance. They are used in all parts of the world for both as food flavours and for medicinal uses. The present study provides comprehensive microscopic details of the fruit and histochemical localization of the aroma compounds. The study fills the lacuma found in the account of previous investigations
EFFECT OF MIRROR NEURONS IN ENHANCING THE TEACHING COMPETENCY
N.SASIKUMAR,M. PANIMALAR ROJA,M. PARIMALA FATHIMA
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Cognitive neuroscience is an academic field concerned with the scientific study of biological mechanisms underlying cognition, with a specific focus on the neural substrates of mental processes and their behavioral manifestations. At the cognitive level, cognitive neuroscience addresses the questions of how psychological/cognitive functions are produced by the neural circuit. A neuron is a nerve cell that is the basic building block of the nervous system. Neurons are similar to other cells in the human body is a number of ways, but there is one key difference between neurons and other cells. Neurons are specialized to transmit information throughout the body. Competency means the right way of doing things. In teaching the competency means the right way of convening the units of knowledge application and skills to the students and the knowledge of contents, methods and communication. Teacher education is the research based understanding of teacher competencies like contextual, conceptual, content, transactional and evaluative management competencies. Mirror neuron system is involved in empathy. Firing of mirror neurons will be more when we observe an action which is familiar to us. Memory can be enhanced due to the stimulation of mirror neurons. The impact of mirror neurons on class room activities and other educational activities is more to enhancing the teaching competency
ACE I/D gene polymorphism in diabetic nephropathy: Clinical implications
M. Kaleemullah Khan,N. Parimala,Mohammed Ishaq,Mohammed Siraj
Journal of Medical and Allied Sciences , 2011,
Abstract: Diabetic nephropathy (DN) is a major microvascular complication accounting for about 30% of End-Stage Renal Disease (ESRD) cases. An insertion/deletion (I/D) polymorphism of the gene encoding angiotensin-I converting enzyme (ACE) is reported to be a candidate gene predisposing to diabetic nephropathy. Accordingly, we investigated the ACE I/D gene polymorphism in 52 Type 2 diabetes mellitus (T2DM) cases suffering from nephropathy as assessed by 24 hrs urinary protein levels. 50 age and sex matched healthy subjects served as controls. ACE I/D genotyping was carried out by polymerase chain reaction (PCR) amplification using allele specific primers. The frequencies of ACE DD, ID and II genotypes in the diabetic nephropathy patients were 38.5% , 50% and 11.5% and in the control subjects, 22%, 38% and 40% respectively. There was an increase of 16.5% in the frequency of DD genotype in the patients compared to controls. The frequency of D allele in the patients was 63% which was found to be statistically significant (p< 0.05, Odds ratio=2.6) compared to 41% in the controls. These results indicate that Type 2 diabetic patients with D allele (those with DD & ID genotypes) have more than two fold risk of developing nephropathy. Clinical implications of ACE genotyping in planning for patient’s management have been discussed.
ANTICANCER STUDIES ON ETHANOL EXTRACT OF IMPATIENS BALSAMINA
N.Baskar,B.Parimala Devi,B.Jayakar
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: Ethanol Extract of Impatiens balsamina was investigated for anticancer and in-vitro cytotoxic activities against transplantable tumors and human cell line. In vitro cycotoxicity was evaluated in Hela and NIH3T3 cells by MTT assay and in-vivo antitumor activity with Dalton’s ascites lymphoma (DLA) tumor bearing mice. Activity was measured by monitoring the Cancer Cell number, packed cell volume and increase in life span. Hematological parameters were evaluated and compared with the respective controls. The extract exhibited strong in vitro cytotoxicity against Hela cell line, it was found to be safe with normal cell. EEIB at the doses 200 and 400 mg/kg significantly increase the life span and decrease in the cancer cell number and body weight (P<0.01) and exert a protective effect on the hemopoietic system. The results showed significant antitumor and cytotoxic effects against DLA and human Cancer Cell line and support the ethno-medical use of Impatiens balsamina in cancer therapy.
Supracutaneous Locking Compression Plate for Grade I & II Compound Fracture Distal Tibia—A Case Series  [PDF]
S. K. Venkatesh Gupta, Shyam Prasad Parimala
Open Journal of Orthopedics (OJO) , 2013, DOI: 10.4236/ojo.2013.32021
Abstract:

Background: Supracutaneous plating using a locking compression plate (LCP) as an external fixator in compound periarticular areas is facilitated by the development of anatomical plates. The soft tissue around the distal tibia is easily compromised by trauma and subsequent operative fracture treatment posing a definitive challenge in the distal tibia compound fractures. The purpose of this report is to describe our successful results using the metaphyseal locking compression plate (LCP) as an external fixator in the treatment of Grade I & II compound fractures of distal tibia. Methodology: A total of five (05) patients underwent “supracutaneous plating” of the tibia using a metaphyseal locking compression plate. Average age was 36 years. Regular screw tract dressings were done. Average period of follow-up was 15 months. Results: The plate was in situ for an average of 24 weeks. There were no clinically significant screw site infections. In all five patients the plate was kept in place until there was complete consolidation both clinically and radiologically. At the latest follow-up (average 15 months), all patients were fully weight bearing with a fully healed tibia. All patients were infection-free with well-healed wounds. Conclusion: Routinely, after initial debridement and temporary bony stabilization is provided by external fixation in compound fractures of the distal tibia with significant soft tissue injury. Most external frames for the lower leg are bulky and cumbersome, causing significant problems for the patient. To circumvent these issues, we have successfully used an anatomically-contoured supracutaneous metaphyseal locking compression plate as external fixator in a series of five patients for grade I & II compound fracture of the distal tibia.

ASSESSMENT OF PHARMACOLOGY TEACHING - A CRITICAL APPRAISAL BY MEDICAL SCHOOL LEARNERS
Parimala K, Subash KR, Jagan N, Vijay Kumar S, Viswanathan S, Chandrasekhar M
International Journal of Medical Research and Health Sciences , 2013, DOI: 10.5958/j.2319-5886.2.2.001
Abstract: Background: Students feedback is an indicator of the success of any teaching methodology followed in a department. Aim: To identify strengths and weaknesses in the current teaching-learning and evaluation methodology in pharmacology using feedback from second MBBS students in Meenakshi Medical College and Research Institute. Materials and Methods: Questionnaire was designed and finalised after a departmental discussion in concurrence with the Medical Education Unit. The study subjects were 115 (2011batch) second-year medical students. They were requested to fill the questionnaire. A 10-item multiple choice questionnaires were used to explore the student’s opinion on teaching. The questionnaires were analyzed. Results: 115 II M.B.B.S students participated and descriptive statistics was used for analysis of data. The analysis revealed 82.82%, 72.17% and 93.64% student’s interest towards writing classification of drugs, weekly test and viva-voice respectively. Conclusion: The present study has helped us to elicit the student preference regarding pharmacology teaching and its outcome would be helpful in modifying undergraduate pharmacology teaching patterns.
Mapping Iterative Medical Imaging Algorithm on Cell Accelerator
Meilian Xu,Parimala Thulasiraman
International Journal of Biomedical Imaging , 2011, DOI: 10.1155/2011/843924
Abstract: Algebraic reconstruction techniques require about half the number of projections as that of Fourier backprojection methods, which makes these methods safer in terms of required radiation dose. Algebraic reconstruction technique (ART) and its variant OS-SART (ordered subset simultaneous ART) are techniques that provide faster convergence with comparatively good image quality. However, the prohibitively long processing time of these techniques prevents their adoption in commercial CT machines. Parallel computing is one solution to this problem. With the advent of heterogeneous multicore architectures that exploit data parallel applications, medical imaging algorithms such as OS-SART can be studied to produce increased performance. In this paper, we map OS-SART on cell broadband engine (Cell BE). We effectively use the architectural features of Cell BE to provide an efficient mapping. The Cell BE consists of one powerPC processor element (PPE) and eight SIMD coprocessors known as synergetic processor elements (SPEs). The limited memory storage on each of the SPEs makes the mapping challenging. Therefore, we present optimization techniques to efficiently map the algorithm on the Cell BE for improved performance over CPU version. We compare the performance of our proposed algorithm on Cell BE to that of Sun Fire , a shared memory machine. The Cell BE is five times faster than AMD Opteron dual-core processor. The speedup of the algorithm on Cell BE increases with the increase in the number of SPEs. We also experiment with various parameters, such as number of subsets, number of processing elements, and number of DMA transfers between main memory and local memory, that impact the performance of the algorithm. 1. Introduction Medical imaging such as X-ray computed tomography has revolutionized medicine in the past few decades. The use of X-ray computed tomography has increased rapidly since 1970 when Radon's technique for reconstructing images from a set of projections was first introduced in the medical field. In 2007, it was estimated that more than 62 million scans per year were obtained in United States and about 4 million for children [1]. The number of scanners has also increased in many countries due to the ease of using these machines. The commonly used analytic technique in CT scanners to produce diagnostic evaluation of an organ or the region of interest is Fourier back projection (FBP). This technique requires a large number of projections measured uniformly over 180° to 360° [2], inducing a large amount of radiation into the body to produce quality
Asynchronous Pattern Mining for Mixed Sequences Using Ant Colony Optimization
M. Parimala,S. Sathiyabama
Research Journal of Applied Sciences , 2012, DOI: 10.3923/rjasci.2012.354.358
Abstract: In data mining, sequential pattern mining is a fundamental and essential field since of its broad possibility of applications spanning from forecasting the user shopping patterns and scientific discoveries. In many applications, the most vital part of mining problem is mining periodic patterns in time series databases. It can be visualized as a tool for forecasting and identifying the potential activities of time-series data. Previous studies have measured hash based asynchronous periodic patterns where uneven occurrences of datasets are sequenced. Still, asynchronous periodic pattern mining has expected less attention and in effective. Most researches are explained about an occurrence of long and closed sequence in an asynchronous pattern by a form of numerical derivatives. To improve the asynchronous pattern mining more effective in this study, researchers are going to present an Ant Colony Optimization technique to identify the pattern matching in a mixed sequences (long and closed sequences) raised in the asynchronous pattern mining. The Ant Colony Optimization algorithm (ACO) is an optimized technique for resolving computational problems which can be condensed to discovering good paths and identified the best pattern from the given database. Using ACO, the optimal pattern matching is made efficiently for mixed sequences (closed or long set of sequences) in the given database. Experimental evaluation will conduct with time series dense data sets in arff format in Weka tool and show the performance improvement of asynchronous pattern mining for mining mixed sequences in the given database in terms of running time, pattern matching factor, optimality rate and scalability.
Feature Selection using a Novel Particle Swarm Optimization and It’s Variants
R. Parimala,R. Nallaswamy
International Journal of Information Technology and Computer Science , 2012,
Abstract: Feature selection has been keen area of research in classification problem. Most of the researchers mainly concentrate on statistical measures to select the feature subset. These methods do not provide a suitable solution because the search space increases with the feature size. The FS is a very popular area for applications of population-based random techniques. This paper suggests swarm optimization technique, binary particle swarm optimization technique and its variants, to select the optimal feature subset. The main task of the BPSO is the selection of the features used by the SVM in the classification of spambase data set. The results of our experiments show a very strong relation between number of features and accuracy. Comparison of the optimized results and the un-optimized results showed that the BPSO-MS method could significantly reduce the computation cost while improving the classification accuracy.
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