Abstract:
p53 tumor suppressor gene is the most commonly mutated gene in human and mouse cancers. Disruption of the p53 and Rb pathways is a fundamental trend of most human cancer cells. Inactivation of CDKN2A can lead to deregulation of these two pathways. Genetic abnormalities in CDKN2A gene have been well documented in human melanoma but their involvement in human nonmelanoma skin cancer (NMSC) and in particular in squamous cell carcinoma (SCC) is less clear. Several studies have shown that human SCCs harbour unique mutations in the p53 gene as well as inactivation of the CDKN2A gene. While mutations in the p53 gene are induced by UV radiation and represent tumor initiating events, the majority of alterations detected in the CDKN2A gene do not appear to be UV-dependent. In conclusion, in addition to p53 mutations, silencing of the CDKN2A gene might play a significant role in SCC development.

Abstract:
Betavulgaris genus comprises wild and cultivated subspecies. The “maritima” subspecies is formed by wild or weedy accessions, well adapted to low-water potential environments; it was previously shown that B. vulgaris ssp. maritima has mechanisms of osmotic adjustment more effective than the cultivated B. vulgaris ssp. vulgaris. The response to a progressive lowering of soil potential was compared in two Beta accessions, a cultivated and a wild one. Throughout the 4-months experiment under rain shelters, osmotic potential and relative water content were measured and total RNA was extracted to test the expression of six target genes known in sugar beet or in other plants to be modulated by water shortage.The mild occurrence of drought was paralleled by slow increase in transcription for sucrose synthase 1 and choline monoxygenase, in a way that was in some cases accession-dependent, e.g. the gene for choline monoxygenase was found to be up-regulated at the later stages of growth in stressed plants compared to control ones, and showed a higher constitutive transcription in sea beet compared to sugar beet. Transcription factor DREB2Aalso was slowly induced during the growth season and upon onset of water shortage, and this induction was stronger in sea beet than in sugar beet. In control plants, the transcription of all genes tested except DREB2Awere significantly higher in maritima

A renewed interest in
interspecific varieties has recently emerged, due mainly to producers and consumers
more aware of organic farming and impact of phytochemicals in the environment.
The assessment of 19 European Vitis hybrids
was investigated in an area mostly dedicated to viticulture, the North-EasternItaly. Major
agronomic traits, yield, quality characteristics and disease resistance were
evaluated during a three-year period (2004 to 2006). Wine sensory analyses were
performed and compared with international Vitis
vinifera varieties. Even though no genotypes resulted adequate for market release, the results obtained confirm the potential importance of hybrids in an
“eco-friendly” viticulture and identify the genotypes interesting for further
investigation and breeding: GF 138-3 and GA 48-12 showed good agronomic performance, resistance to more grape diseases and high quality wine.

Abstract:
We study the dynamics of generic unfoldings of saddle-node circle local diffeomorphisms from the measure theoretical point of view, obtaining statistical stability results for deterministic and random perturbations in these kind of one-parameter families.

Abstract:
We describe some recent results on the dynamics of singular-hyperbolic (or Lorenz-like) attractors: attractors in this class are expansive and so sensitive with respect to initial data; they admit a unique physical measure whose support is the whole attractor, which is hyperbolic and the equilibrium state with respect to the center-unstable Jacobian; the hitting time associated to a geometric Lorenz attractor satisfies a logarithm law; the rate of large deviations for the physical measure on the ergodic basin of a geometric Lorenz attractor is exponential.

Abstract:
In this paper we prove that the Poincar\'e map associated to a Lorenz like flow has exponential decay of correlations with respect to Lipschitz observables. This implies that the hitting time associated to the flow satisfies a logarithm law. The hitting time $\tau_r(x,x_0)$ is the time needed for the orbit of a point $x$ to enter for the first time in a ball $B_r(x_0)$ centered at $x_0$, with small radius $r$. As the radius of the ball decreases to 0 its asymptotic behavior is a power law whose exponent is related to the local dimension of the SRB measure at $x_0$: for each $x_0$ such that the local dimension $d_{\mu}(x_0)$ exists, \lim_{r\to 0} \frac{\log \tau_r(x,x_0)}{-\log r} = d_{\mu}(x_0)-1 holds for $\mu$ almost each $x$. In a similar way it is possible to consider a quantitative recurrence indicator quantifying the speed of coming back of an orbit to its starting point. Similar results holds for this recurrence indicator.

Abstract:
We analyze certain parametrized families of one-dimensional maps with infinitely many critical points from the measure-theoretical point of view. We prove that such families have absolutely continuous invariant probability measures for a positive Lebesgue measure subset of parameters. Moreover we show that both the densities of these measures and their entropy vary continuously with the parameter. In addition we obtain exponential rate of mixing for these measures and also that they satisfy the Central Limit Theorem.

Abstract:
We obtain large deviation results for non-uniformly expanding maps with non-flat singularities or criticalities and for partially hyperbolic non-uniformly expanding attracting sets. That is, given a continuous function we consider its space average with respect to a physical measure and compare this with the time averages along orbits of the map, showing that the Lebesgue measure of the set of points whose time averages stay away from the space average decays to zero exponentially fast with the number of iterates involved. As easy by-products we deduce escape rates from subsets of the basins of physical measures for these types of maps. The rates of decay are naturally related to the metric entropy and pressure function of the system with respect to a family of equilibrium states.

Abstract:
We study the expansion properties of the contracting Lorenz flow introduced by Rovella via thermodynamic formalism. Specifically, we prove the existence of an equilibrium state for the natural potential $\hat\phi_t(x,y, z):=-t\log J_{(x, y, z)}^{cu}$ for the contracting Lorenz flow and for $t$ in an interval containing $[0,1]$. We also analyse the Lyapunov spectrum of the flow in terms of the pressure.

Abstract:
this article deals with the existing scientific divergence with regard to the surplus of frozen embryos, especially between biology, religion, the law and bioethics, with a specific focus on the ways in which each of these areas determines the onset of life. the aim of the authors is to suggest alternatives that protect the human embryo, such as adoption by couples or by single women, who, for medical reasons, are infertile, but are capable of bearing a child. in the case of brazil, the authors conclude that it is legal and legitimate to donate and adopt human embryos for fertilization, so long as the principle of human dignity is upheld and confidentiality maintained regarding the identity of the donors of the gametes, whose data should remain on file permanently at the center where fertilization occurred.