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Search Results: 1 - 10 of 197996 matches for " N. Leporé "
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Single Dilepton Production at $e^+e^-$, $eγ$ and $γγ$ Colliders
N. Leporé,B. Thorndyke,H. Nadeau,D. London
Physics , 1994, DOI: 10.1103/PhysRevD.50.2031
Abstract: We calculate the cross sections for the single production of doubly-charged dileptons, both scalar and vector, at $e^+e^-$, $e\gamma$ and $\gamma\gamma$ colliders at $\sqrt{s}=500$ GeV and 1 TeV. The $e\gamma$ mode is by far the most promising -- dileptons whose coupling is as weak as $O(10^{-4})\alpha_{em}$ can be observed, for masses virtually up to the kinematic limit. Dileptons of mass up to $\sqrt{s}$ can also be seen in $e^+e^-$ and $\gamma\gamma$ colliders, for couplings of order $\alpha_{em}$. In all three colliders, most of the cross section comes from events in which the only particles detected are $e^-e^-$, the decay products of the dilepton, yielding an unmistakeable experimental signature.
A Functional Interface at the rDNA Connects rRNA Synthesis, Pre-rRNA Processing and Nucleolar Surveillance in Budding Yeast
Nathalie Leporé, Denis L. J. Lafontaine
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024962
Abstract: Ribogenesis is a multistep error-prone process that is actively monitored by quality control mechanisms. How ribosomal RNA synthesis, pre-rRNA processing and nucleolar surveillance are integrated is unclear. Nor is it understood how defective ribosomes are recognized. We report in budding yeast that, in vivo, the interaction between the transcription elongation factor Spt5 and Rpa190, the largest subunit of RNA polymerase (Pol) I, requires the Spt5 C-terminal region (CTR), a conserved and highly repetitive domain that is reminiscent of the RNA Pol II C-terminal domain (CTD). We show that this sequence is also required for the interaction between Spt5 and Nrd1, an RNA specific binding protein, and an exosome cofactor. Both the Spt4-Spt5, and the Nrd1-Nab3 complexes interact functionally with Rrp6, and colocalize at the rDNA. Mutations in the RNA binding domain of Nrd1, but not in its RNA Pol II CTD-interacting domain, and mutations in the RRM of Nab3 led to the accumulation of normal and aberrant polyadenylated pre-rRNAs. Altogether these results indicate that Nrd1-Nab3 contributes to recruiting the nucleolar surveillance to elongating polymerases to survey nascent rRNA transcripts.
Bmp7 Functions via a Polarity Mechanism to Promote Cloacal Septation
Kun Xu, Xinyu Wu, Ellen Shapiro, Honging Huang, Lixia Zhang, Duane Hickling, Yan Deng, Peng Lee, Juan Li, Herbert Lepor, Irina Grishina
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029372
Abstract: Background During normal development in human and other placental mammals, the embryonic cloacal cavity separates along the axial longitudinal plane to give rise to the urethral system, ventrally, and the rectum, dorsally. Defects in cloacal development are very common and present clinically as a rectourethral fistula in about 1 in 5,000 live human births. Yet, the cellular mechanisms of cloacal septation remain poorly understood. Methodology/Principal Findings We previously detected Bone morphogenetic protein 7 (Bmp7) expression in the urorectal mesenchyme (URM), and have shown that loss of Bmp7 function results in the arrest of cloacal septation. Here, we present evidence that cloacal partitioning is driven by Bmp7 signaling in the cloacal endoderm. We performed TUNEL and immunofluorescent analysis on cloacal sections from Bmp7 null and control littermate embryos. We found that loss of Bmp7 results in a dramatic decrease in the endoderm survival and a delay in differentiation. We used immunological methods to show that Bmp7 functions by activating the c-Jun N-terminal kinase (JNK) pathway. We carried out confocal and 3D imaging analysis of mitotic chromosome bundles to show that during normal septation cells in the cloacal endoderm divide predominantly in the apical-basal direction. Loss of Bmp7/JNK signaling results in randomization of mitotic angles in the cloacal endoderm. We also conducted immunohistochemical analysis of human fetal sections to show that BMP/phospho-SMAD and JNK pathways function in the human cloacal region similar as in the mouse. Conclusion/Significance Our results strongly indicate that Bmp7/JNK signaling regulates remodeling of the cloacal endoderm resulting in a topological separation of the urinary and digestive systems. Our study points to the importance of Bmp and JNK signaling in cloacal development and rectourethral malformations.
A Multivariate Surface-Based Analysis of the Putamen in Premature Newborns: Regional Differences within the Ventral Striatum
Jie Shi, Yalin Wang, Rafael Ceschin, Xing An, Yi Lao, Douglas Vanderbilt, Marvin D. Nelson, Paul M. Thompson, Ashok Panigrahy, Natasha Leporé
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066736
Abstract: Many children born preterm exhibit frontal executive dysfunction, behavioral problems including attentional deficit/hyperactivity disorder and attention related learning disabilities. Anomalies in regional specificity of cortico-striato-thalamo-cortical circuits may underlie deficits in these disorders. Nonspecific volumetric deficits of striatal structures have been documented in these subjects, but little is known about surface deformation in these structures. For the first time, here we found regional surface morphological differences in the preterm neonatal ventral striatum. We performed regional group comparisons of the surface anatomy of the striatum (putamen and globus pallidus) between 17 preterm and 19 term-born neonates at term-equivalent age. We reconstructed striatal surfaces from manually segmented brain magnetic resonance images and analyzed them using our in-house conformal mapping program. All surfaces were registered to a template with a new surface fluid registration method. Vertex-based statistical comparisons between the two groups were performed via four methods: univariate and multivariate tensor-based morphometry, the commonly used medial axis distance, and a combination of the last two statistics. We found statistically significant differences in regional morphology between the two groups that are consistent across statistics, but more extensive for multivariate measures. Differences were localized to the ventral aspect of the striatum. In particular, we found abnormalities in the preterm anterior/inferior putamen, which is interconnected with the medial orbital/prefrontal cortex and the midline thalamic nuclei including the medial dorsal nucleus and pulvinar. These findings support the hypothesis that the ventral striatum is vulnerable, within the cortico-stiato-thalamo-cortical neural circuitry, which may underlie the risk for long-term development of frontal executive dysfunction, attention deficit hyperactivity disorder and attention-related learning disabilities in preterm neonates.
Functional Domains of Androgen Receptor Coactivator p44/Mep50/WDR77and Its Interaction with Smad1
Yirong Li, Liantian Tian, Martin Ligr, Garrett Daniels, Yi Peng, Xinyu Wu, Mandeep Singh, Jianjun Wei, Yongzhao Shao, Herbert Lepor, Ruliang Xu, Zhijie Chang, Zhengxin Wang, Peng Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064663
Abstract: p44/MEP50/WDR77 has been identified as a coactivator of androgen receptor (AR), with distinct growth suppression and promotion function in gender specific endocrine organs and their malignancies. We dissected the functional domains of p44 for protein interaction with transcription factors, transcriptional activation, as well as the functional domains in p44 related to its growth inhibition in prostate cancer. Using a yeast two-hybrid screen, we identified a novel transcription complex AR-p44-Smad1, confirmed for physical interaction by co-immunoprecipitaion and functional interaction with luciferase assays in human prostate cancer cells. Yeast two-hybrid assay revealed that the N-terminal region of p44, instead of the traditional WD40 domain at the C-terminus, mediates the interaction among p44, N-terminus of AR and full length Smad1. Although both N and C terminal domains of p44 are necessary for maximum AR transcriptional activation, the N terminal fragment of p44 alone maintains the basic effect on AR transcriptional activation. Cell proliferation assays with N- and C- terminal deletion mutations indicated that the central portion of p44 is required for nuclear p44 mediated prostate cancer growth inhibition.
Implementation of a Higher Quality dc Power Converter  [PDF]
N. N. Barsoum
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2010, DOI: 10.4236/jemaa.2010.22012
Abstract: Many single and three-phase converters are well developed, and covered up in most of electric markets. It is used in many applications in power systems and machine drives. However, an exact definite output signal from the dc side still not recognized. The waveforms of output voltage and current demonstrate an imperfect dc signal and constitute losses, harmonic distortion, low power factor, and observed some ripples. An approximately perfect rectifier bridge is the aim of this research. Perhaps it gives the ability to identify the parameters of the converter to obtain, as much as possible, a perfect dc signal with less ripple, high power factor and high efficiency. Design is implemented by simulation on Power Simulator PSIM, and practically, a series regulator LM723 is applied to provide regulating output voltage. Comparisons of both simulation and hardware results are made to observe differences and similarities.
Estimation of Sensitivity of the DS/AHP Method While Solving Foresight Problems with Incomplete Data  [PDF]
N. Pankratova, N. Nedashkovskaya
Intelligent Control and Automation (ICA) , 2013, DOI: 10.4236/ica.2013.41011

The paper provides mathematical analysis of sensitivity of different combination rules in the DS/AHP method when an alternative is added to the set of decision alternatives while solving foresight problems. Different cases of rank reversals are defined and two sets of conditions for these cases using the method DS/AHP are considered. Rank reversals are illustrated when the DS/AHP method is used to solve practical problem of critical technologies of energy conservation and power efficiency evaluation in Ukraine. It is shown that the DS/AHP method is not sensitive to exclusion (or addition) of an irrelevant decision alternative from (or to) the set of decision alternatives.

Computation of the Genetic Code: Full Version  [PDF]
N. N. Kozlov
Journal of Computer and Communications (JCC) , 2017, DOI: 10.4236/jcc.2017.510008
Abstract: One of the problems in the development of mathematical theory of the genetic code (summary is presented in [1], the detailed—to [2]) is the problem of the calculation of the genetic code. Similar problem in the world is unknown and could be delivered only in the 21st century. One approach to solving this problem is devoted to this work. For the first time a detailed description of the method of calculation of the genetic code was provided, the idea of which was first published earlier [3]), and the choice of one of the most important sets for the calculation was based on an article [4]. Such a set of amino acid corresponds to a complete set of representation of the plurality of overlapping triple gene belonging to the same DNA strand. A separate issue was the initial point, triggering an iterative search process all codes submitted by the initial data. Mathematical analysis has shown that the said set contains some ambiguities, which have been founded because of our proposed compressed representation of the set. As a result, the developed method of calculation was reduced to two main stages of research, where at the first stage only single-valued domains were used in the calculations. The proposed approach made it possible to significantly reduce the amount of computation at each step in this complex discrete structure.
The Study of the Secrets of the Genetic Code  [PDF]
N. N Kozlov
Journal of Computer and Communications (JCC) , 2018, DOI: 10.4236/jcc.2018.67007
Abstract: The disclosure of many secrets of the genetic code was facilitated by the fact that it was carried out on the basis of mathematical analysis of experimental data: the diversity of genes, their structures and genetic codes. New properties of the genetic code are presented and its most important integral characteristics are established. Two groups of such characteristics were distinguished. The first group refers to the integral characteristics for the areas of DNA, where genes are broken down in pairs and all 5 cases of overlap, allowed by the structure of DNA, were investigated. The second group of characteristics refers to the most extended areas of DNA in which there is no genetic overlap. The interrelation of the established integral characteristics in these groups is shown. As a result, a number of previously unknown effects were discovered. It was possible to establish two functions in which all the over-understood codons in mitochondrial genetic codes (human and other organizations) participate, as well as a significant difference in the integral characteristics of such codes compared to the standard code. Other properties of the structure of the genetic code following from the obtained results are also established. The obtained results allowed us to set and solve one of the new breakthrough problems—the calculation of the genetic code. The full version of the solution to this problem was published in this journal in August 2017.
Guidelines for Optimization of the Absorber Layer Energy Gap for High Efficiency Cu(In,Ga)Se2 Solar Cells  [PDF]
N. Severino, N. Bednar, N. Adamovic
Journal of Materials Science and Chemical Engineering (MSCE) , 2018, DOI: 10.4236/msce.2018.64015
Abstract: This work investigates in-depth the effects of variation of the compositional ratio of the absorber layer in Cu(In,Ga)Se2 (CIGS) thin-film solar cells. Electrical simulations were carried out in order to propose the most suitable gallium double-grading profile for the high efficiency devices. To keep the model as close as possible to the real behavior of the thin film solar cell a trap model was implemented to describe the bulk defects in the absorber layer. The performance of a solar cell with a standard CIGS layer thickness (2 μm) exhibits a strong dependence on the front grading height (decreasing band gap toward the middle of the CIGS layer). An absolute gain in the efficiency (higher than 1%) is observed by a front grading height of 0.22. Moreover, simulation results show that the position of the plateau (the region characterized by the minimum band gap) should be accurately positioned at a compositional ratio of 20% Ga and 80% In, which corresponds to the region where a lower bulk defect density is expected. The developed model demonstrates that the length of the plateau is not playing a relevant role, causing just a slight change in the solar cell performances. Devices with different absorber layer thicknesses were simulated. The highest efficiency is obtained for a CIGS thin film with thicknesses between 0.8 and 1.1 μm.
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