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Search Results: 1 - 10 of 200755 matches for " Nélida Alicia; "
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?Dilemas?: metodológicos y éticos en la investigación antropológica en Servicios de salud
Barber,Nélida Alicia;
Av?? , 2009,
Abstract: in this paper we examine some particularities of anthropological research in hospitality institutions, on the basis of fieldwork carries out in hospitals of the metropolitan and suburban areas of buenos aires. on one side, we focus on the institutional requirements for allowing access to the hospital and, on the other side, on the emotional and ethical commitments of researchers. in what concern to the former, we discuss the problematic arising from procuring authorization from the ethical research committee of the hospital to conduct a research in these premises. on the other hand, we discuss some ethic problems and dilemmas and we analyze the methodological and theoretical implications of such issues.
Dilemas?: metodológicos y éticos en la investigación antropológica en Servicios de salud
Nélida Alicia Barber
Avá : Revista de Antropología , 2009,
Abstract: En esta ponencia se examinan algunas especificidades de la investigación antropológica en instituciones hospitalarias, a partir de la experiencia de trabajo de campo en hospitales de Ciudad de Buenos Aires y conurbano bonaerense. Focalizamos por un lado, en los requisitos institucionales que posibilitan el acceso al hospital como lugar de estudio y, por otro, en el compromiso emocional y ético del investigador. En cuanto a lo primero, analizamos los problemas que derivan del enfrentamiento de dos lenguajes y marcos epistémicos de índole diversa - el antropológico y el biomédico- en el proceso de autorización a cargo de los Comité de ética y de Docencia e Investigación. Respecto a lo segundo, reflexionamos sobre algunas situaciones en las cuales el trabajador de campo se enfrenta a problemas éticos, aparentemente, dilemáticos. Indagamos acerca de las implicancias y consecuencias metodológicas y por ende teóricas de ambos problemas. In this paper we examine some particularities of anthropological research in hospitality institutions, on the basis of fieldwork carries out in hospitals of the Metropolitan and suburban areas of Buenos Aires. On one side, we focus on the institutional requirements for allowing access to the hospital and, on the other side, on the emotional and ethical commitments of researchers. In what concern to the former, we discuss the problematic arising from procuring authorization from the ethical research Committee of the hospital to conduct a research in these premises. On the other hand, we discuss some ethic problems and dilemmas and we analyze the methodological and theoretical implications of such issues.
Molecular confirmation of CHARGE syndrome from umbilical cord blood stem cells from a death newborn and identification of a new mutation in the exon 29 of the CHD7 gene  [PDF]
Nélida Montano, Andrea Quadrelli, Aubrey Milunsky, Alicia Vaglio, Roberto Quadrelli
Stem Cell Discovery (SCD) , 2012, DOI: 10.4236/scd.2012.21001
Abstract: CHARGE syndrome (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth and/or development, Genital and/or urinary abnormalities, and Ear abnormalities) is an autosomal dominant disorder characterized by a specific and a recognizable pattern of anomalies. De novo mutations in the CHD7 gene are the major cause of CHARGE syndrome. Here, we present a family who sought genetic counseling because of a newborn with dysmorphic features suggesting CHARGE syndrome. The baby died three months later. Afterwards, a molecular genetic testing for sequence analysis of the CHD7 coding region was performed with DNA extracted from umbilical cord blood stem cells confirming the diagnosis of CHARGE syndrome. Although the diagnosis is first suspected clinically, in the newborn case presented here, we illustrate the importance of the molecular testing to confirm the diagnosis, and to enable precise genetic counseling. Also, even though cord blood has been stored in private banks for more than ten years, there is as yet no routine clinical application of autologous (self-donation) hematopoietic stem cells from cord blood. Now, we illustrate for the first time the usefulness of umbilical cord blood stem cells for diagnosis and genetic counseling in a case that involve a dead propositus.
Morfometría fluvial aplicada a una cuenca urbana en Ingeniero White, República Argentina
Campo, Alicia María;Aldalur, Nélida Beatriz;Fernández, Sandra Noemí;
Investigaciones geográficas , 2012,
Abstract: the fluvial morphometry studies several variables that characterize the form of a drainage basin. the aim of this paper is to apply the natural watershed morphometric method to an urban watershed. the study area (6 km2) drains its waters into the waterfront and includes the town of ingeniero white, república argentina. hierarchical organization of the drainage network was done. three sub-basins that have low-gradient flood events, most dangerous extreme rainfall, were identified. the length relationship values showed greater concentration of power in event of major avenues. the elongation relationship values showed that one of the sub-basins is circular and has more speed in the avenues of runoff. the two elongated basins have greater delay in the avenues. the increased flow of the study area flows through the basin that has the largest number of order and the largest area. the other two basins are subject to increasing surface snapshot and immediate response. the slope and area values applied to hydrologic and hydraulic models determined the section of the ducts and channels. the calculated flow for the area drained was 22.41 m3/s.
Maternal Chronic Stress Induces Premature Telencephalic Vesicles Development El Estrés Crónico Materno Induce el Desarrollo Prematuro de la Vesícula Telencefálica
María Teresa Mugnaini,Carlos Alberto So?ez,Alicia Nélida Rolando,María Cristina Romanini
International Journal of Morphology , 2006,
Abstract: Exposure to physical or psychological stress causes brain damage ranging from minimal behavioural alterations to different neurodegeneration degrees implying the overproduction of oxidative-nitrosative compounds, apoptosis and cell proliferation. In the present investigation, we have analysed the effect of the chronic stress by immobilisation applied to pregnant rats over the forebrain development of the embryos. The morphometric analyses showed an accelerated evagination of the telencephalic vesicles in 12 days old fetus from stressed mothers. The forebrain perimeter and the thickness showed significative differences in relation to age-matched controls. This stress effect seemed reversible during subsequent gestational stages. This is the first work showing a transient acceleration in the development induced by the gestational stress. Our model provides a new tool for studying the effect of the stress on the development La exposición a diferentes estresantes físicos y/o psicológicos causa da o cerebral, que se manifiesta en alteraciones comportamentales mínimas hasta diferentes grados de neurodegeneración, y que implican la sobreproducción de compuestos nitrosativos-oxidativos, apoptosis y proliferación celular. En el presente trabajo hemos analizado el efecto del estrés crónico por inmovilización, sobre el desarrollo embriológico del cerebro anterior en fetos de ratas pre adas. El análisis morfométrico estereológico demostró que en los fetos de 12 días de gestación de madres estresadas muestran un aumento del tama o de la vesícula telencefálica. El perímetro y el espesor del cerebro anterior demostraron diferencias significativas en relación a los controles de la misma edad gestacional, pero, no fue así con su forma. Este efecto provocado por el estrés crónico se podría considerar reversible en los estadíos gestacionales subsecuentes. Es el primer trabajo que demuestra una considerable aceleración del desarrollo del sistema nervioso central inducido por el estrés gestacional. Nuestro modelo provee una nueva herramienta para los estudios de los efectos del estrés durante el desarrollo embriológico
Chronic Stress Effects on NPY Neuronal Population During Rat Development Efectos del Stress Crónico sobre la Población Neuronal NPY Durante el Desarrollo de Ratas
Karina Alejandra Buljubacich,María Teresa Mugnaini,Carlos Alberto So?ez,Alicia Nélida Rolando
International Journal of Morphology , 2009,
Abstract: The aim of this work was to determine the chronical stress effects on the encephalic NPY neurons population during the fetal Central nervous system development. Immunocytochemical techniques were used for this purpose: NPY neurons presented a similar morphology during the gestation days studied but their distribution varied in the anterior, medium and posterior brain. Statistical Highly significant differences in number of NPY positive neurons (p<0.01) among anterior, medium and posterior brain of stressed fetus (SF) were determined depending on the gestation period and the brain area. The NPY neurons were increased in ARC (Arcuate Hypothalamic Nucleus), PH (Posterior Hypothalamic Area) and DM (Dorsomedial Hypothalamic Nucleus) in stressed fetuses (SF) of 17 days, and in ARC of 19 days SF (p< 0.01) were detected in the different brain nucleus. The NPY population increased in PnO (Pontine Reticular Nu, Oral Part) and RITg (Reticulotegmental Nu of the Pons) of 17 days SF, while they were detected in posterior brain at Pyx (Pyramidal Decussation), Rob (Raphe Obscurus Nucleus) and RPA (Raphe Pallidus Nucleus) in SF of 19 days. They also increased in number (p<0.05) in DPGI (Dorsal Paragigantocellular Nu), CGPn (Central Gray of Pons) and PrH (Prepositus Hypoglossal Nucleus) of 17 days SF. Finally, any statistical differences were found among CF and SF in the following nuclei: anterior brain, AH (Anterior Hypothalamic Nucleus), DM (Dorsomedia L Hypothalamic Nucleus) of 17 days; ME (Median Eminence)., VMH (Ventromedial Hypothalamic Nucleus) of 19 days; medium brain in CG (Central Periaqueductal Gray), DR (Dorsal Raphe Nucleus) of 17 days and posterior brain in PnC (Pontine Reticular Nu, Caudal Part), PrH (Prepositus Hypoglossal Nucleus), RMgG (Raphe Magnus Nucleus), IO (Inferior Olive) of 17 days. The increase number of NPY neurons found in the stressed rat fetuses in all periods studied would indicate the participation of the NPY System in the regulation of H.H.A axis. El propósito del presente estudio fue determinar los efectos del estrés crónico en la población de neuronas NPY encefálicas durante el desarrollo del S.N.C. fetal mediante técnicas inmunocitoquímicas. Se demostró que las neuronas NPY presentan un morfología similar en los días de gestación estudiados, pero su distribución varía en el cerebro anterior, medio y posterior. Se comprobaron diferencias altamente significativas entre el cerebro anterior, medio y posterior (p<0,01) de fetos estresados (FE), variando dicha significación dependiendo del día de la gestación y del área estudiada. En los dif
Chronic stress effects on the apoptotic index of the adrenal cortex of pregnant rats
Bozzo,Andrea; So?ez,Carlos Alberto; Mugnaini,María Teresa; Pastorino,Isabel Cecilia; Rolando,Alicia Nélida; Romanini,María Cristina; Gauna,Héctor Fernando;
Biocell , 2006,
Abstract: chronic stress by immobilization during gestation can alter several mechanisms that maintain homeostasis in adrenal gland. the aim of this work was to quantify the apoptotic index of adrenal cortex during mid-pregnancy and to prove cytological characteristics by electron microscopy. the apoptotic index did not present significant differences between the adrenal cortex areas of control and experimental rats in any of the three ages studied. the day of gestation influenced significantly on the apoptotic index in both groups. this index increased as gestation progressed. it may be concluded that chronic stress by immobilization might induce the increase of apoptotic index in adrenal cortex as gestation progresses which might be related variations of plasmatic corticosterone and prolactin, and to the decrease of specific growth factors. on the other hand, it might be concluded that each zone of adrenal cortex behaves independently in regards to apoptosis and cellular proliferation via paracrine and/or autocrine regulatory mechanisms without being affected by other zones.
Maternal Chronic Stress Induces Premature Telencephalic Vesicles Development
Mugnaini,María Teresa; So?ez,Carlos Alberto; Rolando,Alicia Nélida; Romanini,María Cristina; Bozzo,Aída Andrea; Pastorino,Isabel Cecilia; Gauna,Héctor Fernando; Paz,Dante Agustín;
International Journal of Morphology , 2006, DOI: 10.4067/S0717-95022006000500001
Abstract: exposure to physical or psychological stress causes brain damage ranging from minimal behavioural alterations to different neurodegeneration degrees implying the overproduction of oxidative-nitrosative compounds, apoptosis and cell proliferation. in the present investigation, we have analysed the effect of the chronic stress by immobilisation applied to pregnant rats over the forebrain development of the embryos. the morphometric analyses showed an accelerated evagination of the telencephalic vesicles in 12 days old fetus from stressed mothers. the forebrain perimeter and the thickness showed significative differences in relation to age-matched controls. this stress effect seemed reversible during subsequent gestational stages. this is the first work showing a transient acceleration in the development induced by the gestational stress. our model provides a new tool for studying the effect of the stress on the development
Chronic Stress Effects on Adrenal Cortex Cellular Proliferation in Pregnant Rats
Bozzo,Aída Andrea; So?ez,Carlos Alberto; Monedero Cobeta,Ignacio; Avila,Rodolfo; Rolando,Alicia Nélida; Romanini,María Cristina; Lazarte,Mario; Gauna,Héctor Fernando; Mugnaini,María Teresa;
International Journal of Morphology , 2011, DOI: 10.4067/S0717-95022011000400013
Abstract: chronic stress by immobilization during pregnancy may cause alterations in mechanisms maintaining homeostasis in the adrenal gland. the objective of this study was to quantify cellular proliferation index in the adrenal cortex during pregnancy second half and assess the effects of chronic stress on it. adrenal cortex proliferation index in stressed rats showed a significant decrease at 12 and 17 days of gestation, while at day 21 it did not show differences with the control treatments. moreover, proliferation index of reticular zones in control and experimental rats, exhibited a significant reduction in comparison to glomerular and fascicular zones of adrenal cortex during the three gestation days studied. in conclusion, chronic stress by immobilization produces a decrease in cellular proliferation index at 12 and 17 gestation days, which may be related to changes in plasmatic concentrations of corticosterone and prolactin and, to the reduction of specific growth factors. furthermore, the observed proliferation diminishment in reticular zone regarding the other cortical zones would be consistent with the migration theory of adrenal cells.
Chronic Stress Effects on NPY Neuronal Population During Rat Development
Buljubacich,Karina Alejandra; Mugnaini,María Teresa; So?ez,Carlos Alberto; Rolando,Alicia Nélida; Romanini,María Cristina; Bozzo,Aída Andrea; So?ez,María Cristina; Gauna,Héctor Fernando;
International Journal of Morphology , 2009, DOI: 10.4067/S0717-95022009000300039
Abstract: the aim of this work was to determine the chronical stress effects on the encephalic npy neurons population during the fetal central nervous system development. immunocytochemical techniques were used for this purpose: npy neurons presented a similar morphology during the gestation days studied but their distribution varied in the anterior, medium and posterior brain. statistical highly significant differences in number of npy positive neurons (p<0.01) among anterior, medium and posterior brain of stressed fetus (sf) were determined depending on the gestation period and the brain area. the npy neurons were increased in arc (arcuate hypothalamic nucleus), ph (posterior hypothalamic area) and dm (dorsomedial hypothalamic nucleus) in stressed fetuses (sf) of 17 days, and in arc of 19 days sf (p< 0.01) were detected in the different brain nucleus. the npy population increased in pno (pontine reticular nu, oral part) and ritg (reticulotegmental nu of the pons) of 17 days sf, while they were detected in posterior brain at pyx (pyramidal decussation), rob (raphe obscurus nucleus) and rpa (raphe pallidus nucleus) in sf of 19 days. they also increased in number (p<0.05) in dpgi (dorsal paragigantocellular nu), cgpn (central gray of pons) and prh (prepositus hypoglossal nucleus) of 17 days sf. finally, any statistical differences were found among cf and sf in the following nuclei: anterior brain, ah (anterior hypothalamic nucleus), dm (dorsomedia l hypothalamic nucleus) of 17 days; me (median eminence)., vmh (ventromedial hypothalamic nucleus) of 19 days; medium brain in cg (central periaqueductal gray), dr (dorsal raphe nucleus) of 17 days and posterior brain in pnc (pontine reticular nu, caudal part), prh (prepositus hypoglossal nucleus), rmgg (raphe magnus nucleus), io (inferior olive) of 17 days. the increase number of npy neurons found in the stressed rat fetuses in all periods studied would indicate the participation of the npy system in the regulation of h.h.a axis.
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