OALib Journal期刊

ISSN: 2333-9721



匹配条件: “Myriam;” ,找到相关结果约1142条。
Effects of genetic and environmental factors and gene-environment interaction on expression variations of genes related to stroke in rat brain  [PDF]
Yuan De Tan, Myriam Fornage
American Journal of Molecular Biology (AJMB) , 2011, DOI: 10.4236/ajmb.2011.12011
Abstract: To determine if genetic and environmental (dietary) factors and gene-environment interaction impact on the expression variation of genes related to stroke, we conducted microarray experiments using two homozygous rat strains SHRSR and SHRSP fed with high and low dietary salt levels. We obtained expression data of 8,779 genes and performed the ranking analysis of microarray data. The results show that the genetic difference for stroke in rat brain has a strong effect on expression variations of genes. At false discovery rate (FDR) ≤ 5%, 534 genes were found to be differentially expressed between the genotypes resistant and prone to stroke, among which 304 genes were up-regulated in the resistant genotype and down-regulated in the prone genotype and 230 were down-regulated in the former and up-regulated in the latter. In addition, 365 were functional genes for transcription and translation, receptors (in particular, neurotransmitter receptor), channels of ions, transportation, metabolism and enzymes, and functional and structural proteins. Some of these genes are pivotal genes that cause stroke. However, dietary salt levels and GE interaction do not strongly impact on the expression variations of these genes detected on arrays.
Delta-opioid receptor endocytosis in spinal cord after dermenkephalin activation
Myriam Gastard
BMC Neuroscience , 2000, DOI: 10.1186/1471-2202-1-1
Abstract: Using immunocytochemistry and electron microscopy, we observed in control rats that membrane labelling was strictly localized at the interface between two neurites. Fifteen minutes after dermenkephalin stimulation, the plasma membrane labelling was associated with invaginated areas. Thirty minutes after stimulation, labelled vesicles were found in the cytoplasm confirming the internalization process.The present findings support the view that δ-opioid receptors are internalized in response to prolonged exposure to dermenkephalin in vivo and confirm the presynaptic localization of δ-opioid receptors in the dorsal horn of the rat spinal cord.The G protein-coupled receptors constitute a large family of receptors widely distributed in the mammalian central nervous system (CNS). Classical neurotransmitter receptors such as muscarinic acetylcholine receptors (mAChR), adrenergic, dopaminergic, serotoninergic as well as neuropeptide receptors belong to this family (1). In vitro studies in transfected cells show that following receptor activation by an agonist that induces signal transduction, G protein-coupled receptor undergoes phosphorylation, endocytosis, and dissociation from their ligand in the endosome, and finally the receptors are recycled to the plasma membrane (2, 3,4). The delta(δ)-opioid receptor is a member of the seven transmembrane superfamily of G-protein coupled receptors (5, 6). In vitro studies, carried out on NG108-15 neurohybrid cells which express large numbers of δ-opioid receptors, show that these receptors undergo a rapid agonist-induced desensitization that occurs within minutes and down-regulation that occurs more slowly over several hours (4, 7). The internalization of receptor-agonist ligand complex has been detected with similar kinetics to those of down-regulation (8, 9). These findings raise two related questions: 1) can δ-opioid receptors be internalized in vivo by the same agonist-induced endocytosis observed in vitro? and if this is the cas
Hablemos de Soberanía Alimentaria
Diaeta , 2010,
Abstract: in april 2009, the argentina association of dietitians and nutritionists-dietitians formed the study group on food sovereignty, made up of graduates in nutrition who have an interest in the subject. this article presents an introduction to said group's findings.
La notion de handicap et ses transformations à travers les classifications internationales du handicap de l'OMS, 1980 et 2001
Dynamis , 2008, DOI: 10.4321/S0211-95362008000100016
Abstract: dans cet article, l'auteur analyse l'évolution de la notion de handicap en s'intéressant aux deux classifications du handicap publiées par l'oms, en 1980 puis en 2001. la "classification internationale du handicap: déficiences, incapacités et désavantages. un manuel de classification des conséquences des maladies", de 1980, prolonge la "classification internationales des maladies"; le handicap y désigne les conséquences sociales des maladies. dans la "classification internationale du fonctionnement, du handicap et de la santé", publiée en 2001, le handicap désigne un "défaut de fonctionnement" et est associé à la notion de santé. l'auteur s'intéresse à la question de la norme de référence utilisée dans les classifications pour définir le handicap.
La redefinición del espacio público: el caso de las escuelas autogestionadas en Argentina
Feldfeber, Myriam;
Educa??o & Sociedade , 2003, DOI: 10.1590/S0101-73302003000300009
Abstract: the educational reform that took place in argentina during the '90s was an answer to the crisis of the state-centered model that fostered the expansion of the school system in the xxth. century. this reform assumed that the solution to improve the quality of education should focus on such issues as: reducing the role of the state in the system assessment; profoundly reforming the school organization; considering new forms of demand-side financing; introducing incentives; giving autonomy to individual schools; involving non-state institutions in policy management; producing information in order to guarantee the freedom of choice; offering new career for teachers based on merit and derogation of the labor statute. nevertheless, the educational reform should be analyzed in the context of a broader reform process implemented in the whole latin america in the '90s, aimed at legitimating a new economic, social, political and cultural model. inspired in the "charter schools" model, the experimental schools project in the province of san luis is a leading case in the region of what is characterized as the "necessary and imperative reform of the educational systems". in this context, the aim of this article is both to analyze the logic behind this model and to discuss the main issues of its implementation process.
La regulación de la formación y el trabajo docente: un análisis crítico de la "agenda educativa" en América Latina
Feldfeber, Myriam;
Educa??o & Sociedade , 2007, DOI: 10.1590/S0101-73302007000200008
Abstract: this paper analyses the discussions about teacher training and work that have been gaining momentum in the educational agendas of the region in recent years. it argues that the proposed forms of regulation are heteronomous modes of imposition that are contradictory with their declared goals in terms of professionalization and teacher autonomy.
Lenguas minoritarias: Un desafio para la mayoría
Educere , 2008,
Abstract: the constitution of the bolivarian republic of venezuela states since 1999 in its article 81 that: "deaf or mute people are recognized as having the right to express and communicate through sign language", and in article 119: "the state shall recognize the existence of indigenous towns and communities, their social, political and economical organization, their cultures, uses and costumes, languages and religion, as well as their habitat and originary rights over the lands they inhabit ancestrally and traditionally that are necessary to develop and guarantee their ways of living." the following paper aims to recognize the rights expressed on these articles about venezuelans with identical rights to ours, which could not have been exercised in a permanent and natural way because, without intending it, we kept them in an authentic social silence. it is intended to illustrate, in a very general analysis, the challenge it represents for most of venezuelan spanish speakers to understand that we live next to fellow venezuelans who have a particular way of seeing, understanding and naming life; venezuelans who have a particular biological and cultural mark which above those differences, share the same country and the same moral patrimony with the rest of the population.
Emo??es e política: a vítima e a constru??o de comunidades emocionais
Jimeno, Myriam;
Mana , 2010, DOI: 10.1590/S0104-93132010000100005
Abstract: this text focuses on the cultural construction of the category of victim as an affirmation of civility. over the last few years colombia has seen the emergence of a genre of language dedicated to narrating experiences of suffering in the form of personal testimony. this highly emotive language creates bonds between different members of ‘civil society' who find common ground in sharing ‘the truth' concerning the acts of violence perpetrated in recent years. i argue that the idiom of personal testimony produces political effects since it creates a shared version of the violent events occurring over the last decade. moreover it opens the way for an ethics based on the recognition of demands for reparation by providing a symbolic mediation between subjective experience and the society at large. i examine the social construction of the category of victim in three different settings: the mobilization of the indigenous community in response to violent acts; the massive protests held in 2008 against these acts; and the campaign for approval of the victims law. i also highlight the crucial role played by women and indigenous peoples in testifying publicly about this violence as a way of arriving at the truth, a process leading to the construction of a shared narrative and to the generalization of moral principles vis-à-vis acts of violence perpetrated in the name of ‘politics.'
O oficial e o oficioso: objeto e regula??o de conflitos nas Antilhas Francesas (1848-1850)
Cottias, Myriam;
Mana , 2004, DOI: 10.1590/S0104-93132004000200002
Abstract: the abolition of slavery by the provisional government of the second french republic in april 1848 redefined public space in the colonies by establishing a statutory civil, political and 'racial' equality among the citizens of the republic. this article examines the implications of this decision in the context of the french antilles, particularly in relation to the attribution and registration of property by past slaves and the interplay between the new juridical relations of work and the old relations of social dependency. the article goes on to discuss the formation and history of the cantonal juries, an institution created to administrate the new civil and labour regime in the colonies, as well as the civil and criminal legal actions taken by agents in this new juridical context - actions in which the conflicting aspirations of the past slaves and their old masters become clearly evident.
Antipoda. Revista de Antropología y Arqueología , 2007,
Abstract: i guess that the communication of suffering experiences -violence experiences-makes possible an emotional community, which encourages the personal recovering and becomes a cultural and political recomposition vehicle. i propose that the process of overcoming of victim condition puts up with the recomposition of person like a emotional being, through the clear and shared expression of his experience. i use the veena das' discussion about of reduccionist shapes of "the act of witnessing" about of violence, and the interview realized by johanna wahanik to starring of the film la noche de los lápices.

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