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Search Results: 1 - 10 of 33507 matches for " Myeong-Sun Gil "
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Efficient 2-Step Protocol and Its Discriminative Feature Selections in Secure Similar Document Detection
Sang-Pil Kim,Myeong-Sun Gil,Yang-Sae Moon,Hee-Sun Won
Computer Science , 2015,
Abstract: Secure similar document detection (SSDD) identifies similar documents of two parties while each party does not disclose its own sensitive documents to another party. In this paper, we propose an efficient 2-step protocol that exploits a feature selection as the lower-dimensional transformation and presents discriminative feature selections to maximize the performance of the protocol. For this, we first analyze that the existing 1-step protocol causes serious computation and communication overhead for high dimensional document vectors. To alleviate the overhead, we next present the feature selection-based 2-step protocol and formally prove its correctness. The proposed 2-step protocol works as follows: (1) in the filtering step, it uses low dimensional vectors obtained by the feature selection to filter out non-similar documents; (2) in the post-processing step, it identifies similar documents only from the non-filtered documents by using the 1-step protocol. As the feature selection, we first consider the simplest one, random projection (RP), and propose its 2-step solution SSDD-RP. We then present two discriminative feature selections and their solutions: SSDD-LF (local frequency) which selects a few dimensions locally frequent in the current querying vector and SSDD-GF (global frequency) which selects ones globally frequent in the set of all document vectors. We finally propose a hybrid one, SSDD-HF (hybrid frequency), that takes advantage of both SSDD-LF and SSDD-GF. We empirically show that the proposed 2-step protocol outperforms the 1-step protocol by three or four orders of magnitude.
Anti-Microbial, Anti-Biofilm Activities and Cell Selectivity of the NRC-16 Peptide Derived from Witch Flounder, Glyptocephalus cynoglossus
Ramamourthy Gopal,Jun Ho Lee,Young Gwon Kim,Myeong-Sun Kim,Chang Ho Seo,Yoonkyung Park
Marine Drugs , 2013, DOI: 10.3390/md11061836
Abstract: Previous studies had identified novel antimicrobial peptides derived from witch flounder. In this work, we extended the search for the activity of peptide that showed antibacterial activity on clinically isolated bacterial cells and bacterial biofilm. Pseudomonas aeruginosa was obtained from otitis media and cholelithiasis patients, while Staphylococcus aureus was isolated from otitis media patients. We found that synthetic peptide NRC-16 displays antimicrobial activity and is not sensitive to salt during its bactericidal activity. Interestingly, this peptide also led to significant inhibition of biofilm formation at a concentration of 4–16 μM. NRC-16 peptide is able to block biofilm formation at concentrations just above its minimum inhibitory concentration while conventional antibiotics did not inhibit the biofilm formation except ciprofloxacin and piperacillin. It did not cause significant lysis of human RBC, and is not cytotoxic to HaCaT cells and RAW264.7 cells, thereby indicating its selective antimicrobial activity. In addition, the peptide’s binding and permeation activities were assessed by tryptophan fluorescence, calcein leakage and circular dichroism using model mammalian membranes composed of phosphatidylcholine (PC), PC/cholesterol (CH) and PC/sphingomyelin (SM). These experiments confirmed that NRC-16 does not interact with any of the liposomes but the control peptide melittin did. Taken together, we found that NRC-16 has potent antimicrobial and antibiofilm activities with less cytotoxicity, and thus can be considered for treatment of microbial infection in the future.
Linear Detrending Subsequence Matching in Time-Series Databases
Myeong-Seon Gil,Yang-Sae Moon,Bum-Soo Kim
Computer Science , 2010, DOI: 10.1587/transinf.E94.D.917
Abstract: Each time-series has its own linear trend, the directionality of a timeseries, and removing the linear trend is crucial to get the more intuitive matching results. Supporting the linear detrending in subsequence matching is a challenging problem due to a huge number of possible subsequences. In this paper we define this problem the linear detrending subsequence matching and propose its efficient index-based solution. To this end, we first present a notion of LD-windows (LD means linear detrending), which is obtained as follows: we eliminate the linear trend from a subsequence rather than each window itself and obtain LD-windows by dividing the subsequence into windows. Using the LD-windows we then present a lower bounding theorem for the index-based matching solution and formally prove its correctness. Based on the lower bounding theorem, we next propose the index building and subsequence matching algorithms for linear detrending subsequence matching.We finally show the superiority of our index-based solution through extensive experiments.
Solution Estimates for Semilinear Difference-Delay Equations with Continuous Time
Michael Gil',Sui Sun Cheng
Discrete Dynamics in Nature and Society , 2007, DOI: 10.1155/2007/82027
Abstract: We consider semilinear difference-delay equations with continuous time in a Euclidean space. Estimates are found for the solutions. Such estimates are then applied to obtain the stability and boundedness criteria for solutions.
Randomized Clinical Trials of Constitutional Acupuncture: A Systematic Review
Myeong Soo Lee,Byung-Cheul Shin,Sun-Mi Choi,Jong Yeol Kim
Evidence-Based Complementary and Alternative Medicine , 2009, DOI: 10.1093/ecam/nep085
Abstract: The aim of this systematic review is to compile and critically evaluate the evidence from randomized clinical trials (RCTs) for the effectiveness of acupuncture using constitutional medicine compared to standard acupuncture. Ten databases were searched through to December 2008 without language restrictions. We also hand-searched nine Korean journals of oriental medicine. We included prospective RCTs of any form of acupuncture with or without electrical stimulation. The included trials had to investigate constitutional medicine. There were no restrictions on population characteristics. Forty-one relevant studies were identified, and three RCTs were included. The methodological quality of the trials was variable. One RCT found Sasang constitutional acupuncture to be superior to standard acupuncture in terms of the Unified PD Rating Scale and freezing gate in Parkinson's disease (PD). Another two RCTs reported favorable effects of eight constitutional acupuncture on pain reduction in patients with herniated nucleus pulposi and knee osteoarthritis. Meta-analysis demonstrated positive results for eight constitutional acupuncture compared to standard acupuncture on pain reduction (weighted mean difference: 10 cm VAS, 1.69, 95% CI 0.85–2.54, P < 0.0001; heterogeneity: τ2 = 0.00, Χ2 = 0.00, P = 0.96, I2 = 0%). Our results provide suggestive evidence for the effectiveness of constitutional acupuncture in treating pain conditions compared to standard acupuncture. However, the total number of RCTs and the total sample size included in our analysis were too small to draw definite conclusions. Future RCTs should assess larger patient samples with longer treatment periods and appropriate controls.
Body Acupuncture for Nicotine Withdrawal Symptoms: A Randomized Placebo-Controlled Trial
Min-Kyung Hyun,Myeong Soo Lee,Kyungwon Kang,Sun-Mi Choi
Evidence-Based Complementary and Alternative Medicine , 2010, DOI: 10.1093/ecam/nem179
Abstract: This study evaluated whether improvements in nicotine withdrawal symptoms (NWS), depression and anxiety are greater for body acupuncture than for sham acupuncture. Smoking volunteers from the public were randomized to receive six sessions of either real or sham acupuncture for 2 weeks. The primary outcome measure was NWS measured by the Minnesota Nicotine Withdrawal Score, and the secondary measures were scores on the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Eighty volunteers were randomized into real acupuncture (n = 38) and sham acupuncture (n = 42) groups, of which 46 subjects (22 and 24 in the real and sham acupuncture groups, respectively) completed the treatment and the 2-week follow-up. An intention-to-treat analysis revealed that the NWS did not differ significantly between the real and sham acupuncture groups immediately after the treatment (12.2 ± 9.7 and 12.8 ± 7.7, respectively; mean ± SD) and at the 2-week follow-up (11.7 ± 10.2 and 12.6 ± 7.8). Both groups also showed similar improvements in BDI and BAI scores. These results indicate that the real acupuncture treatment tested in this trial was no more effective than sham acupuncture at reducing NWS, depression and anxiety for smoking cessation.
Using Guasha to treat musculoskeletal pain: A systematic review of controlled clinical trials
Myeong Soo Lee, Tae-Young Choi, Jong-In Kim, Sun-Mi Choi
Chinese Medicine , 2010, DOI: 10.1186/1749-8546-5-5
Abstract: We searched 11 databases (without language restrictions): MEDLINE, Allied and Complementary Medicine (AMED), EMBASE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Korean Studies Information (KSI), DBPIA, Korea Institute of Science and Technology Information (KISTI), KoreaMed, Research Information Service System (RISS), China National Knowledge Infrastructure (CNKI) and the Cochrane Library. The search strategy was Guasha (OR scraping) AND pain. Risk of bias was assessed with the Cochrane criteria (i.e. sequence generation, blinding, incomplete outcome measures and allocation concealment).Five randomized controlled trials (RCTs) and two controlled clinical trials (CCTs) were included in the present study. Two RCTs compared Guasha with acupuncture in terms of effectiveness, while the other trials compared Guasha with no treatment (1 trial), acupuncture (4 trials), herbal injection (1 trial) and massage or electric current therapy (1 trial). While two RCTs suggested favorable effects of Guasha on pain reduction and response rate, the quality of these RCTs was poor. One CCT reported beneficial effects of Guasha on musculoskeletal pain but had low methodological quality.Current evidence is insufficient to show that Guasha is effective in pain management. Further RCTs are warranted and methodological quality should be improved.Guasha was defined as a therapeutic modality that uses several tools to scrape or rub the surface of the body to relieve blood (Xue) stagnation. Guasha is used for pain relief in Chinese medicine. Tools for Guasha including a Chinese soup spoon, an edge-worn coin, a slice of water-buffalo horn, a cow rib, honed jade and a simple metal cap with a smooth round lip with oil or water are used in Guasha to scrape or rub the skin to relieve blood stagnation at the body surface [1]. Guasha is also used to treat common cold, flu, respiratory problems and musculoskeletal (MS) pain [2].There are three possible mechanisms of using Guasha t
Durability of viral response after off-treatment in HBeAg positive chronic hepatitis B
Myeong Jun Song,Do Seon Song,Hee Yeon Kim,Sun Hong Yoo
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i43.6277
Abstract: AIM: To evaluate the durability in hepatitis B e antigen (HBeAg) positive chronic hepatitis B patients who discontinued antiviral treatment. METHODS: A total of 48 HBeAg positive chronic hepatitis B patients who were administered nucleoside analogues and maintained virological response for ≥ 6 mo [hepatitis B virus (HBV) DNA < 300 copies/mL and HBeAg seroconversion] before cessation of treatment were enrolled between February 2007 and January 2010. The criteria for the cessation of the antiviral treatment were defined as follows: (1) achievement of virological response; and (2) duration of consolidation therapy (≥ 6 mo). After treatment cessation, the patients were followed up at 3-6 mo intervals. The primary endpoint was serologic and virologic recurrence rates after withdrawal of antiviral treatment. Serologic recurrence was defined as reappearance of HBeAg positivity after HBeAg seroconversion. Virologic recurrence was defined as an increase in HBV-DNA level > 104 copies/mL after HBeAg seroconversion with previously undetectable HBV-DNA level. RESULTS: During the median follow-up period of 18.2 mo (range: 5.1-47.5 mo) after cessation of antiviral treatment, the cumulative serological recurrence rate was 15 % at 12 mo. The median duration between the cessation of antiviral treatment and serologic recurrence was 7.2 mo (range: 1.2-10.9 mo). Of the 48 patients with HBeAg positive chronic hepatitis, 20 (41.6%) showed virological recurrence. The cumulative virologic recurrence rates at 12 mo after discontinuing the antiviral agent were 41%. The median duration between off-treatment and virologic recurrence was 7.6 mo (range: 4.3-27.1 mo). The mean age of the virological recurrence group was older than that of the non-recurrence group (46.7 ± 12.1 years vs 38.8 ± 12.7 years, respectively; P = 0.022). Age (> 40 years) and the duration of consolidation treatment (≥ 15 mo) were significant predictive factors for offtreatment durability in the multivariate analysis [P = 0.049, relative risk (RR) 0.31, 95% CI (0.096-0.998) and P = 0.005, RR 11.29, 95% CI (2.054-65.12), respectively]. Patients with age (≤ 40 years) who received consolidation treatment (≥ 15 mo) significantly showed durability in HBeAg positive chronic hepatitis B patients (P = 0.014). These results suggest that additional treatment for more than 15 mo after HBeAg seroconversion in patients who are ≤ 40 years old may be beneficial in providing a sustained virological response. CONCLUSION: Our data suggest that HBeAg seroconversion is an imperfect end point in antiviral treatment. Long-term consol
Stability of a time discrete perturbed dynamical system with delay
Michael I. Gil',Sui Sun Cheng
Discrete Dynamics in Nature and Society , 1998, DOI: 10.1155/s1026022699000084
Abstract: Let Cn be the set of n complex vectors endowed with a norm ¢ € – ¢ … ¢ € –Cn. Let A,B be two complex n —n matrices and a positive integer. In the present paper we consider the nonlinear difference equation with delay of the type uk+1=Auk+Buk ¢ ’ +Fk(uk,uk ¢ ’ ), ¢ € ‰ ¢ € ‰ ¢ € ‰ ¢ € ‰ ¢ € ‰ ¢ € ‰k=0,1,2, ¢ € |, where Fk:Cn —Cn ¢ ’Cn satisfies the condition ¢ € –Fk(x,y) ¢ € –Cn ¢ ‰ ¤p ¢ € –x ¢ € –Cn+q ¢ € –y ¢ € –Cn, ¢ € ‰ ¢ € ‰ ¢ € ‰ ¢ € ‰ ¢ € ‰ ¢ € ‰ ¢ € ‰k=0,1,2, ¢ € |, where p and q are positive constants. In this paper, absolute stability conditions for this equation are established.
Moxibustion for ulcerative colitis: a systematic review and meta-analysis
Dong-Hyo Lee, Jong-In Kim, Myeong Soo Lee, Tae-Young Choi, Sun-Mi Choi, Edzard Ernst
BMC Gastroenterology , 2010, DOI: 10.1186/1471-230x-10-36
Abstract: We searched the literature using 18 databases from their inception to February 10, 2010, without language restrictions. We included randomized clinical trials (RCTs), in which human patients with UC were treated with moxibustion. Studies were included if they were placebo-controlled or controlled against a drug therapy or no treatment group. The methodological quality of all RCTs was assessed using the Cochrane risk of bias.In total, five RCTs were included. All were of low methodological quality. They compared the effects of moxibustion with conventional drug therapy. Three tested moxibustion against sulfasalazine and two against sulfasalazine plus other drugs. A meta-analysis of five RCTs showed favorable effects of moxibustion on the response rate compared to conventional drug therapy (n = 407; risk ratio = 1.24, 95% CI = 1.11 to 1.38; P < 0.0001; heterogeneity: I2 = 16%).Current evidence is insufficient to show that moxibustion is an effective treatment of UC. Most of included trials had high risk of bias. More rigorous studies seem warranted.Ulcerative colitis (UC) is a common, chronic idiopathic inflammatory bowel disease (IBD) [1]. Patients typically present with bloody diarrhea, passage of pus, mucus, or both, and abdominal cramping during bowel movements [2]. UC often requires lifelong medication, but poor adherence to medication has been an important barrier to successful management. Relapse rates are high, and the risk of colorectal cancer has increased [3,4].Complementary and alternative medicine (CAM) is increasingly used for treatment of IBD [5], and acupuncture and moxibustion are particularly popular options. Moxibustion is a traditional Oriental medicine that uses the heat generated by burning herbal preparations containing Artemisia vulgaris to stimulate acupuncture points. Direct moxibustion is applied directly to the skin surface at an area around an acupuncture point, whereas indirect moxibustion is performed with some insulating materials (e.g.
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