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Search Results: 1 - 10 of 3301 matches for " Mustafa Cakar "
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Guillain-Barré Syndrome after Thrombolysis with Streptokinase
Ertugrul Okuyan,Mehmet Akif Cakar,Mustafa H. Dinckal
Cardiology Research and Practice , 2010, DOI: 10.4061/2010/315856
Abstract: Guillain-Barre syndrome (GBS) is an eponym for a heterogeneous group of immune-mediated peripheral neuropathies. We describe a case of GBS in a patient who recieved intravenous streptokinase therapy for acute anterior myocardial infarction. Clinical symptoms are thought to result from streptokinase-antibody complex mediated damage to the local blood-nerve barrier. Patient was treated with 5-days course of intravenous gammaglobulin and his outcome was good. 1. Introduction Guillain-Barré syndrome (GBS) is an eponym for a heterogeneous group of immune-mediated peripheral neuropathies. A feature common in all GBS variants is a rapidly evolving polyradiculoneuropathy preceded by a triggering event, most often an infection [1]. Some cases of GBS after intravenous streptokinase administration have been reported previously [2–5]. We describe a new case of GBS in a patient who received intravenous streptokinase therapy for acute anterior myocardial infarction. 2. Case Report A man 52-year-old taxi driver has been admitted to our clinic with a 1-hour onset chest pain. On electrocardiography, signs of hyperacute anterior wall myocardial infarction were evident. Streptokinase 1500000 unit was administrated over 1 hour intravenously. Reperfusion was positive clinically. Detailed medical history of the patient revealed no exposure to any drugs or toxins. Additionally, there was no evidence of any upper respiratory or gastrointestinal infection within the last 2 months. Medical history was also negative for arterial or venous embolism, connective tissue disease, and vasculitis. He was discharged on the 7th day with oral aspirin, metoprolol, spironolactone, simvastatin, and ramipril. Eleven days after discharge, he complained of progressive weakness on his legs and distal parasthesias. He was unable to walk without aid. On neurological examination, speech was dysarthric, left peripheral type facial paralysis, glove- and stocking-type sensorial impairment and absence of deep-tendon reflexes were prominent findings. Fundoscopic examination was normal. Cranial MRI revealed nothing. Blood chemistry was normal except hyperglycemia. Cerebrospinal fluid (CSF) analysis showed elevation of protein levels (216?mg/dl). CSF cultures were negative. Electromyographic investigation revealed extensive sensorymotor demyelinized type peripheral neuropathy, supporting the diagnosis of GBS. Patient was treated with 5-days course of intravenous gammaglobulin. Patient’s outcome was good and 1 month later he was able to walk without aid, and 2 months later he was able to work. 3. Discussion
Early Age at Onset of Diabetes Mellitus May Be Worse in Terms of Metabolic Side Effects
Mustafa Cakar,Hakan Sarlak,Murat Karaman,Seyit Ahmet Ay
Oman Medical Journal , 2013,
Any Variation Existing in Pathways Inducing Hyperlipidemia in Experimental Animal Models And in Real Humans May Cause Difference in Treatment Success
Sevket Balta,Mustafa Cakar,Sait Demirkol,Murat Unlu
Oman Medical Journal , 2013,
Pivotal roles of risk factors for incident atrial fibrillation in patients with newly diagnosed hyperthyroidism
Sevket Balta,Sait Demirkol,Turgay Celik,Mustafa Cakar
老年心脏病学杂志(英文版) , 2013,
Abstract: None.
Pivotal roles of risk factors for incident atrial fibrillation in patients with newly diagnosed hyperthyroidism
The Pivotal Roles of Risk Factors for Incident Atrial Fibrillation in Patients with Newly Diagnosed Hyperthyroidism

Sevket Balt,Sait Demirkol,Turgay Celik,Mustafa Cakar,Murat Unlu,Atila Iyisoy,
Sevket Balt
,Sait Demirkol,Turgay Celik,Mustafa Cakar,Murat Unlu,Atila Iyisoy

老年心脏病学杂志(英文版) , 2013,
Comments on the study by Taniguchi and coworkers – proving Hippocrates is alive
Nahit Cakar
Critical Care , 2009, DOI: 10.1186/cc7957
Abstract: The study did not compare automated weaning with manual weaning. Rather, it compared automated weaning using a RR target versus manual weaning using tidal a volume/RR ratio target. To justify the conclusions reached by Taniguchi and coworkers and the title of the report, these treatment groups would have needed to differ only in terms of the automated versus manual management component.Second, they weaned the patients when the PS level decreased to 5 to 7 cmH2O without conducting a spontaneous breathing trial at the start of the study. This may complicate weaning and prolong the weaning time in this group of patients.Third, are postoperative patients suitable for such a weaning study? It is likely that whatever protocol you use for weaning, most of them will be weaned without any difficulty in a very short period of time.To prove that Hippocrates is alive we need fine-tuned studies. If not we may believe that he is alive but it will be unproven.Corinne Taniguchi and Carmen SV BarbasWe read with interest the comments by Cakar about our article [1] and the commentary by Adigüzel and colleagues in Critical Care [2]. Regarding Cakar's doubts about the methodology of our study that randomized postoperative patients to mandatory rate ventilation or to manual reduction of pressure support, we invite Cakar to observe Figures 5 and 7 of Taniguchi and colleagues study [1] in which the intention to treat analysis showed a mean respiratory rate around 15 bpm and a mean RR/TV (L) around 30 in both groups with no statistical differences between them during the weaning period. According to these results Taniguchi and colleagues actually compared automatic versus manual pressure support reduction in the weaning of postoperative patients as stated in the title of the study.Regarding the second question about the fact that Taniguchi and colleagues did not perform a spontaneous breathing trial at the initiation of the study the authors would like to clarify that their postoperative pa
Effect of recruitment maneuver on hypoxemia during apnea test: after or before?
Evren Senturk, Nahit Cakar
Critical Care , 2012, DOI: 10.1186/cc11873
Abstract: The 'ideal' apnea test (AT) should permit an increase in PaCO2 (partial pressure of carbon dioxide in arterial blood) but prevent a detrimental decrease in PaO2 (partial pressure of oxygen in arterial blood). We agree that a recruitment maneuver (RM) after the AT can improve oxygenation and result in protection of donor organs. However, we have two comments.First, changes in PaCO2 are not reported in the article. It has been shown that RM can affect CO2 elimination in different ways [2]. We think that the course of - already elevated - PaCO2 after RM would be of interest, and may also have clinical consequences. The structure of the study is appropriate to report the changes in PaCO2.Second, we have shown in an animal model that a RM prior to AT followed by apneic oxygenation was associated with an increase in PaO2 without affecting the increase in PaCO2[3]. RM plus apneic oxygenation also improved the survival time during AT, and there was no change in PaCO2 (which is a warranted result).We think that the 'optimal' method for the AT should also consider changes in PaCO2. A RM before (likewise after) the AT could prevent hypoxemia. Whether a 'combination' of RM's before and after the AT would have additive effects should also be examined in further clinical studies.AT: apnea test; PaCO2: partial pressure of carbon dioxide in arterial blood; PaO2: partial pressure of oxygen in arterial blood; RM: recruitment maneuver.The authors declare that they have no competing interests.
Journal of Special Education and Rehabilitation , 1999,
Abstract: The author of this paper presents the results of examination of the hearing level on 64 subject. We used the method of BAEP-TRESCHOLD comparing with the signal-noise test. The validity of this test and importance of its application in audiologial assessment at infants is for discussion.
Determination of saccharin in pharmaceuticals by high performance thin layer chromatography
Journal of the Serbian Chemical Society , 2006,
Abstract: A simple, accurate and selective high performance thin layer chromatographic method for the determination of saccharin in pharmaceuticals has been developed. The chromatography was performed on silica-gel 60F254 plates with ethyl acetate–carbon tetrachloride–acetic acid (3 + 4 + 0.5 v/v/v) as the mobile phase. The chromatographic zones corresponding to the saccharin spots were scanned in the reflectance/absorbance mode at l= 230 mm. For the standard curves, two series of saccharin sodium salt solutions were prepared: in methanol (solvent 1) and in ethyl acetate–acetic acid (9:1, v/v) mixture (solvent 2). A linear calibration relationship was observed within the concentration range from 300 – 1200 ng saccharin sodium salt per spot, correlation coefficients being 0.998 (solvent 1) and 0.995 (solvent 2). The relationship between the peak area and the amount of saccharin sodium salt was evaluated by linear regression analysis. The limits of detection and quantification of saccharin sodium salt were 35 ng and 110 ng per spot (solvent 1), respectively, and 45 ng and 150 ng per spot (solvent 2), respectively. Mean recovery values of 103.5 % (solvent 1) and 102.3 % (solvent 2), and RSD values of 4.42 % (solvent 1) and 2.53 % (solvent 2) were obtained. The proposed method was applied for saccharin determination in two pharmaceutical preparations, effervescent tablets and a carbomer-based gel.
The effects of b-cyclodextrin and pH on bifonazole hydrosolubility
Journal of the Serbian Chemical Society , 2004,
Abstract: The equlibria of bifonazole in saturated water solution within the pH range 4 to 10 [I = 0.1 mol/dm3 (NaCl); 25 oC] were studied spectrophotometrically. Based on the equlibrium constants determined in a heterogeneous system, the acidity constant (pKa = 5.72) and solubility in water (S = 10-5.79 + 10-(pH + 0.07) were calculated. The influence of b-cyclodextrin on bifonazole solubility was examined in the presence of 10-3 and 10-4 mol/dm3 b-cyclodextrin. At pH values over 8, bifonazole solubility was two- and 13-fold increased in the presence of 10-4 and 10-3 mol/dm3 b-cyclodextrin, respectively, compared to its solubility in water. The ratio of bifonazole solubility in the presence of b-cyclodextrin and that in water decreased in parallel to the increase of acidity.
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