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Search Results: 1 - 10 of 138919 matches for " Muralidhar K "
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The spin bivector and zeropoint energy in geometric algebra
K. Muralidhar
Advanced Studies in Theoretical Physics , 2012,
Mechanical Characterization of Micro/Nano Structures
Daniel Kujawski and Muralidhar K. Ghantasala
The Open Nanoscience Journal , 2007, DOI: 10.2174/1874140100701010060]
Abstract: This paper reviews some of the important characterization techniques used to evaluate the mechanical properties of the micro or nanostructures and components. Three techniques based on AFM, nanoindentation and electric field induced resonance excitation methods were discussed in detail. In the following section mechanical characteristics of typical semiconducting or metallic materials with an emphasis on their micro/nano components are discussed. The influence of cross-section dimensions on the quasi-static strength of single and poly crystalline silicon micro specimens in bending and tension is examined. The differences in mechanical properties, testing methods and specimen dimensions were analyzed based on the recently reported data. A simple empirical correlation is presented with interpretation of the experimental data.
Assessment of Pseudoaffinity Chromatography Using Textile Dyes for Isolation of Buffalo Pituitary Luteinizing Hormone
Taruna Arora,Pankaj Patel,K. Muralidhar
ISRN Chromatography , 2012, DOI: 10.5402/2012/639514
Commissioning and quality assurance of the X-ray volume Imaging system of an image-guided radiotherapy capable linear accelerator
Muralidhar K,Murthy P,Kumar Rajneesh
Journal of Medical Physics , 2008,
Abstract: An Image-Guided Radiotherapy-capable linear accelerator (Elekta Synergy) was installed at our hospital, which is equipped with a kV x-ray volume imaging (XVI) system and electronic portal imaging device (iViewGT). The objective of this presentation is to describe the results of commissioning measurements carried out on the XVI facility to verify the manufacturer′s specifications and also to evolve a QA schedule which can be used to test its performance routinely. The QA program consists of a series of tests (safety features, geometric accuracy, and image quality). These tests were found to be useful to assess the performance of the XVI system and also proved that XVI system is very suitable for image-guided high-precision radiation therapy.
Assessment of Pseudoaffinity Chromatography Using Textile Dyes for Isolation of Buffalo Pituitary Luteinizing Hormone
Taruna Arora,Pankaj Patel,K. Muralidhar
ISRN Chromatography , 2012, DOI: 10.5402/2012/639514
Abstract: Extensive investigation has been carried out to elucidate the mechanisms involved in pseudoligand affinity chromatography using textile dyes, and, empirically, it has been attributed to the chemical and steric structures of dye and protein. Possibly, a variety of interactions especially ionic and/or hydrophobic influence with a varying share in the binding and differ from protein to protein and from dye to dye. In this study, we have attempted to understand the effect of various biophysical parameters like the nature of the eluant, pH, and ionic strength on the binding of crude luteinizing hormone (LH) with various triazine-based dyes and thus predict their nature. Based on the elution patterns, cibacron and reactive brown suggested a dual electrostatic and hydrophobic nature. Reactive blue and reactive yellow reflected a major electrostatic/ionic nature with yellow offering 50-fold purification in a single step, while reactive red and reactive green had a predominant hydrophobic nature. Appreciably, reactive red was binding LH very tightly unlike other dyes, and addition of the arginine in the elution buffer substantially weakened the protein-dye interactions. pH was observed to be a principal factor assisting the protein-dye binding as well as hydrophobicity of the dye and the proteins. 1. Introduction Dye ligand chromatography is rapidly arising as a suitable substitute to specific affinity chromatographies owing to their easy accessibility and economical and effortless immobilization. Despite being synthetic in nature, the triazine-based dyes have a high affinity for many proteins and enzymes [1–7]. In the immobilized form, the dye has rapidly been identified and used as an affinity ligand in chromatographic isolation of a variety of proteins including dehydrogenases, kinases, serum albumin, interferon, several plasma proteins, and a host of other proteins owing to their ability to mimic the configuration of substrates, cofactors, or binding agents, thereby leading to high recovery and many a time purity in tandem, both achieved in a single chromatographic step [8–11]. Most of the dye and protein interaction studies have been performed on the blue sepharose (cibacron blue linked to beaded agarose) involving different dehydrogenase [12, 13]. The affinity ligands both synthetic as well as biological are being designed using a variety of procedures; however, an interesting alternative is presently being offered in the form of biomimetic dyes or chimaeric dye-ligands involving a chloro-triazinlyl scaffold which is often replaced with various amino
S Muralidhar*,K Kirankumar,M Krishnamurthy,K Kranthiteja
Pharmacie Globale : International Journal of Comprehensive Pharmacy , 2011,
Abstract: Roxithromycin, is one of the macrolid antibiotics for respiratory infections.It is slightly soluble in water, hence present study was carried out to enhance dissolution properties of Roxithromycin. Through the preparation of Solid Dispersions using Mannitol as carrier at various proportions (1:1,1:2,&1:4) by using different techniques like Physical mixtures, Melt Solvent and Melting method. The drug release profile was studied in 900ml of distilled water. UV Spectrophotometer method was selected for assay as well as in-vitro dissolution studies at 203 nm. The dispersions were evaluated for drug content uniformity, dissolution rate study; DE20, T50.The FTIR and DSC were used to characterize the solid state of solid dispersions. A marked increase in dissolution rate was observed with all solid dispersions among that the optimized solid dispersion was selected for tablet formulation.
Magnitude of shift of tumor position as a function of moderated deep inspiration breath-hold: An analysis of pooled data of lung patients with active breath control in image-guided radiotherapy
Muralidhar K,Murthy P,Mahadev D,Subramanyam K
Journal of Medical Physics , 2008,
Abstract: The purpose of this study was to evaluate the reproducibility and magnitude of shift of tumor position by using active breathing control and iView-GT for patients with lung cancer with moderate deep-inspiration breath-hold (mDIBH) technique. Eight patients with 10 lung tumors were studied. CT scans were performed in the breath-holding phase. Moderate deep-inspiration breath-hold under spirometer-based monitoring system was used. Few important bony anatomic details were delineated by the radiation oncologist. To evaluate the interbreath-hold reproducibility of the tumor position, we compared the digital reconstruction radiographs (DRRs) from planning system with the DRRs from the iView-GT in the machine room. We measured the shift in x, y, and z directions. The reproducibility was defined as the difference between the bony landmarks from the DRR of the planning system and those from the DRR of the iView-GT. The maximum shift of the tumor position was 3.2 mm, 3.0 mm, and 2.9 mm in the longitudinal, lateral, and vertical directions. In conclusion, the moderated deep-inspiration breath-hold method using a spirometer is feasible, with relatively good reproducibility of the tumor position for image-guided radiotherapy in lung cancers.
Control of a Circular Jet
Trushar B. Gohil,Arun K Saha,K. Muralidhar
Physics , 2010,
Abstract: The present study report direct numerical simulation (DNS) of a circular jet and the effect of a large scale perturbation at the jet inlet. The perturbation is used to control the jet for increased spreading. Dual-mode perturbation is obtained by combining an axisymmetric excitation with the helical. In the fluid dynamics videos, an active control of the circular jet at a Reynolds number of 2000 for various frequency ratios (both integer and non-integer) has been demonstrated. When the frequency ratio is fixed to 2, bifurcation of the jet on a plane is evident. However, for a non-integer frequency ratio, the axisymmetric jet is seen to bloom in all directions.
Aortic Root Abscess with Disruption of Aorto-Mitral Curtain and Anterior Mitral Leaflet Perforation Causing Severe Mitral Regurgitation
Garg Rajnish,Mohanty SK,Murthy Keshava,Muralidhar K
Annals of Cardiac Anaesthesia , 2005,
Influence of changes in the pulmonary artery pressure on ventilation requirements in patients undergoing mitral valve replacement.
Muralidhar K,Rupert E,Singh R,Gowda N
Annals of Cardiac Anaesthesia , 2004,
Abstract: The study was designed to evaluate the influence of changes in pulmonary artery pressure on the ventilation requirements in patients undergoing mitral valve surgery. Thirty patients with mitral valve disease with significant pulmonary arterial hypertension undergoing mitral valve replacement under cardiopulmonary bypass were included in this prospective study. All patients had a pulmonary artery catheter placed after the anaesthetic induction. The minute ventilation was adjusted to achieve an arterial carbon dioxide tension (PaCO2) of 35-40 mm Hg. After a stabilisation period of 15 minutes, the pulmonary artery pressure and the minute volume needed for maintaining a PaCO2 of 35-40 mm Hg in the precardiopulmonary bypass, post-cardiopulmonary bypass and six hours postoperatively were measured after ensuring stable haemodynamics and normothermia. There was a significant decrease in the mean pulmonary artery pressure from pre-cardiopulmonary bypass value of 41.3+/-15 mm Hg to 29.3+/-8 mm Hg in the postcardiopulmonary bypass period and subsequently to 25.5+/-7 mm Hg in the intensive care unit. There was a corresponding increase in the minute volume requirements from a pre-cardiopulmonary bypass value of 6.8+/-1 L/min to 8.0+/-1 L/min in the post cardiopulmonary bypass period and then to 9.4+/-1.2 L/min in the postoperative period. We conclude that there is a significant decrease in the pulmonary blood volume and a subsequent decrease in the pulmonary artery pressure after a successful mitral valve replacement in patients with pulmonary arterial hypertension. This is associated with a significant increase in the requirement of minute ventilation to maintain normocarbia.
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