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Search Results: 1 - 10 of 1139 matches for " Mukhopadhyay DK "
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Psychological comorbidity of chronic low back pain
Khatua DK,Ghosh S,Mukhopadhyay DK,Goswami N
Indian Journal of Physical Medicine and Rehabilitation , 2011,
Abstract: Chronic low back pain (CLBP) is a common complaint among patients attending Physical Medicine Department. Psychological factors like depression, anxiety and somatisation were found to be associated with it. 100 patients with CLBP and their age, sex and economic conditions matched controls were screened with a validated Bengali version of GHQ-28. Study subjects with GHQ score four or more were evaluated for psychiatric disorder with standardized diagnostic interview. Among 100 cases 99% scored for or more in GHQ-28 and 91% had some form of psychiatric disorders was more among females both among cases and controls. Depression, somatisation disorder and generalized anxiety disorder were more prevalent among CLBP patients.
Leptin gene polymorphism in Indian Sahiwal cattle by single strand conformation polymorphism (SSCP) (Short communication)
PP Dubey, A Sharma, DS Gour, Prashant, A Jain, CS Mukhopadhyay, A Singh, BK Joshi, DK Kumar
South African Journal of Animal Science , 2008,
Abstract: Leptin, a 16-Kilo dalton protein produced by the obesity (ob) gene, plays an important role in the regulation of feed intake, energy metabolism, growth and reproduction in cattle. The genetic variation of the leptin gene in Sahiwal cattle (Bos indicus) was investigated using an optimized non-radioactive polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis of 13 amplified fragments covering almost the entire gene. Twenty-eight SSCP band patterns were detected from 10 of these fragments in a sample of 202 Sahiwal cattle. Polymorphisms were detected in the samples, indicating that Sahiwal cattle have high genetic variability in the entire leptin gene. This result opens interesting prospects for future breeding programmes and conservation strategies. These leptin gene variants can be sequenced and screened in the entire population to develop single nucleotide polymorphisms (SNPs) for association studies with different productive and reproductive performances and marker assisted selection.
Clusters of Moderate Size Earthquakes along Main Central Thrust (MCT) in Himalaya  [PDF]
Basab Mukhopadhyay
International Journal of Geosciences (IJG) , 2011, DOI: 10.4236/ijg.2011.23034
Abstract: The Main Central Thrust (MCT) in Himalaya is seismically active in segments. In recent times, strain release within these active segments produce five spatial clusters (A to E; Figure 1). The seismicity within the cluster zones occurs in two depth bands; corresponding to the base of upper and lower crust. Depth sections across the clusters illustrate gently dipping subducted Indian Plate, overriding Tibetan Plate and compressed Sedimentary Wedge in between, with mid crustal ramping of MCT. Several presumptions / hypotheses have been put forward to decipher the causes of clustering along MCT. These are segmental activation of MCT, cross fault interactions, zones of arc parallel and arc perpendicular compressions, pore pressure perturbations, low heat flow zones etc. But these hypotheses need to be evaluated in the future after more ground level data are available. The maximum size of seismic threat that MCT can produce is inferred to be around Mw 7.0 in those clusters.
The pattern of immunologic and virologic responses to Highly Active Antiretroviral Treatment (HAART): Does success bring further challenges?
DK Misgena
Ethiopian Journal of Health Development , 2011,
Abstract: Background: Since the advent of HAART, there is a significant reduction in opportunistic Infections (OIs), morbidity, mortality and HIV transmission. However, the low antiretroviral Therapy (ART) coverage in resource-limited countries (42%) and the presence of globally 500-800 thousand patients on first-line having to required switch to second-line drugs in 2010 are some concerns. Other challenges related to HAART include: lifelong therapy, failed treatment response, optimal time to start treatment and switching regimens, drug interaction, toxicity, cardiovascular risks, drug resistance, lost to follow-up, immune reconstitution inflammatory syndrome (IRIS), early mortality, and lack of restoration of solid immunity against HIV. To achieve the goals of ART, national ART programmes focus on the vital patient monitoring systems including clinical, immunologic, virologic, adherence, lost to follow-up and mortality. Objectives: This review is aimed at addressing the profile of immunovirological responses to HAART and the factors associated with, with a special emphasis on the drawbacks of immunologic assessment to diagnose virologic failures. Main findings: WHO recommends clinical and immunological assessments as surrogates of plasma viral load (VL) to identify first-line treatment failures in resource-poor settings. However, immunological tools have poor sensitivity (20-30%) and specificity (86-90%) to identify virologic failures that may lead to continue with failed regimen or to unnecessary switch of regimen which could result in a more complex profile of resistance. There are three main types of immunovirologic responders in clinical practice: concordant responders (40-60%), concordant non-responders (12-27.3%), and discordant responders that include lack of CD4+ increases despite viral suppression (7-48%), and optimal CD4+ responses in the absence of viral suppression (5-23.8%), whereby the risk of morbidity and mortality is higher in the concordant non-responders and discordant responders. Conclusions: ART benefits a substantial number of HIV patients even in resource-poor settings. Since clinicoimmunological assessments have lower performance in diagnosing virologic failures, moving towards the availability of VL testing to confirm treatment failures, if not pre-HAART resistance testing, is a logical and timely approach for resource limited countries like Ethiopia where the long-term effect of the roll-out ART is not well investigated. However, the high cost and technical demand of VL testing, lack of experience of health professionals, weak infrastructure and health care system, the unavailability and high costs of second-line drugs could be the major challenges during expansion of VL testing. Moreover, longitudinal studies on long-term effects of HAART, and surveys focused on transmitted or acquired HIV drug resistance, and Early Warning Indicators are highly pertinent.
Levels of arsenic in human hair as biomarkers of arsenic exposure in a mining community in Ghana
DK Essumang
Bulletin of the Chemical Society of Ethiopia , 2009,
Abstract: Arsenic levels were determined in human hair samples collected from a mining and non-mining community in Ghana. Hair samples were digested and analyzed using inductively coupled plasma atomic emission spectrometer (ICP–AES). Elevated levels of arsenic were found in the samples obtained from the mining community, the mean levels in the hair ranged from 0.0142–0.0515 μg/g, whereas arsenic was not detected in the hair samples from the non-mining community. The values obtained from the mining community were all below background levels set by the Agency for Toxic Substance and Disease Registry (ATSDR). The results therefore indicate that arsenic pollution may indeed be associated with mining, inducing human environmental exposure.
Childhood cancer: Early warning signs
DK Stones
Continuing Medical Education , 2010,
Clinical aplications of Trioxolane derivatives
DK Koech
African Journal of Health Sciences , 2008,
Abstract: The aqueous extracts of three medicinal plants, Carissa edulis (Forssk.) Vahl (Apocynaceae), Prunus africana (Hook.f.) Kalkm (Rosaceae) and Melia azedarach L. (Meliaceae) have shown significant reduction in the replication of human cytomegalovirus (HCMV) in human embryonic lung (HEL) fibroblasts cells in vitro. Using the plaque inhibition assay for the determination of anti-viral activity, the HEL fibroblast cells cultured in 24 well plates were infected with 1 x 102 PFU 91S HCMV and treated with various concentrations of the extracts. The plaques formed were counted after 7 days incubation at 37°C in 5% CO2 and the percent plaques inhibited were calculated against infected untreated control. The effective concentrations inhibiting plaque formation by 50% (EC50) was found between 40 to 80 μg/ml for all the extracts. The cell cytotoxic concentrations (CC50) for each of the three extracts, by the trypan blue exclusion test, gave a safe therapeutic index. These results have demonstrated the potential anti-viral activities of the extracts of the three medicinal plants at non-cytotoxic concentrations African Journal of Health Sciences Vol. 15 (1&2) 2008: pp. 1-5
Sirosporium morindina - A new species on Morinda tomentosa
Indian Phytopathology , 2012,
Goodbye, Farewell, Adieu
Tempe DK
Annals of Cardiac Anaesthesia , 2007,
Expression of thankfulness to the Editor and his team through ‘Letter to the Editor’ for well-doing job IJAV
Sharma DK
International Journal of Anatomical Variations , 2010,
Abstract: Dear Dr. Selcuk Tunali MD, PhDEditor-in-Chief / Publisher, IJAV:Thanks for putting together this article submission tool in the form of IJAV for Anatomy and my sincere compliments to you and the members of Scientific Advisory Board to take the road in this arduous journey [1]. It has made link building way easier and presented a platform for us to publish or demonstrate our works at international level.No doubt IJAV is peculiar and unique as it is an open access journal giving right to readers to “read, download, distribute, copy, print, search, or link” to the full texts of the articles free of charge. Not accepting advertisements or link/banner exchange and personally funding website are showing its transparency and compatibility towards goals and its speedy review and rapid publication making it more attractive. IJAV has initiated a collaborative and interdisciplinary approach towards medical science.Previously the publication was not chargeable but now fee is being applied for the manuscripts submitted after April 17th, 2010 and a waiver is being granted for lower income countries, students, and authors experiencing financial hardship, upon contacting the Editor-in-Chief with this waiver procedure completely confidential between the author and the Editor-in-Chief. It is a reasonable step for the maintenance of the journal by viewing the increasingly high number of submissions and fee is much less than those charged by many other journals [2].The necessity of having a simple accessible, systematized and perfect journal had been long felt in anatomy, which is now fulfilled by the nice IJAV. A sincere attempt has been made to deal. The entire approach is such as to attract and inspire the readers and researchers for a deeper dive in the subject of Anatomy.I have gone through some portion of IJAV and found interesting specially the articles titled ‘Variant origin of right testicular artery’ by Salve et al. [3], ‘Multiple variations of the branches of abdominal aorta’ by Inecikli et al. [4]. I feel the IJAV informs, educates and entertains through its myriad columns and is very useful to surgeons, clinicians and researchers of the medical field.Dear Sir, only ‘Notice of retraction’ in a recent case is not enough where article was already published in a national journal in India and one other journal [5]. Medical Council of India recommends mandatory requirement of five publications (four in nationals and one in international journal) for the promotions of Associate Professor and Professor. In my opinion, legal and punishable actions should be applied aga
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