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Search Results: 1 - 10 of 6914 matches for " Muhammad Martuza "
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Low Cost Design of a Hybrid Architecture of Integer Inverse DCT for H.264, VC-1, AVS, and HEVC
Muhammad Martuza,Khan A. Wahid
VLSI Design , 2012, DOI: 10.1155/2012/242989
Abstract: The paper presents a unified hybrid architecture to compute the integer inverse discrete cosine transform (IDCT) of multiple modern video codecs—AVS, H.264/AVC, VC-1, and HEVC (under development). Based on the symmetric structure of the matrices and the similarity in matrix operation, we develop a generalized “decompose and share” algorithm to compute the IDCT. The algorithm is later applied to four video standards. The hardware-share approach ensures the maximum circuit reuse during the computation. The architecture is designed with only adders and shifters to reduce the hardware cost significantly. The design is implemented on FPGA and later synthesized in CMOS 0.18?um technology. The results meet the requirements of advanced video coding applications. 1. Introduction In recent years, different video applications use different video standards, such as H.264/AVC [1], VC-1 [2], and AVS [3]. To improve the coding efficiency further, recently a joint collaboration team on video coding (JCT-VC) is drafting a next generation video coding standards, known tentatively as high efficient video coding (HEVC or H.265) [4]. The target bit rate is half of that of H.264/AVC. Besides, several other effective techniques are proposed in the draft to reduce the complexity of the encoder such as improved intrapicture coding, and simpler VLC coefficients [5]. As a result of these new features, experts predict that the HEVC will dominate the future multimedia market. In order to meet up the present and future demands of different multimedia applications, it becomes necessary to develop a unified video decoder that can support all popular video standards on a single platform. In recent years, there is a growing interest to develop multistandard inverse transform architectures for advanced multimedia applications. However, most of them do not support AVS, the video codec developed by Chinese government that became the core technology of China Mobile Multimedia Broadcasting (CMMB) [6]. None of the existing works supports the HEVC; thought it is not finalized yet, considering the future prospective of the HEVC [7], it is important to start exploring possible implementation in hardware of the transform unit discussed in the draft. In this paper, we present a new generalized algorithm and its hardwire implementation of an 8 × 8 IDCT architecture. The scheme is based on matrix decomposition with sparse matrices and offset computations. These sparse matrices are derived in a way that can be reused maximum number of times during decoding different inverse matrices. All multipliers
Anesthesia for Suboccipital Craniotomy in a Patient with Lymphangioleiomyomatosis: A Case Report
Robert A. Peterfreund,Emily Luman,Robert L. Martuza
Case Reports in Pulmonology , 2012, DOI: 10.1155/2012/804789
Abstract: Lymphangioleiomyomatosis (LAM) is a rare pulmonary condition often presenting with spontaneous pneumothorax. Imaging or biopsy confirm the diagnosis. Published case reports describe the anesthetic management of patients with LAM undergoing brief procedures. No reports describe the anesthetic management for lengthy neurosurgical procedures. We describe anesthetic management for craniotomy in a patient with LAM. Clinical Features. A woman presented with 2 spontaneous left pneumothoraces. She received a diagnosis of LAM by imaging. She did well after pleurodesis. Hearing loss and tinnitus led to brain imaging demonstrating a large left cerebello-pontine angle mass. She presented for elective craniotomy to remove the mass while preserving cranial nerve function. Our technique for general endotracheal anesthesia aimed to reduce the likelihood of another pneumothorax while providing good surgical conditions and permitting neuromonitoring. Conclusion. We demonstrate the successful anesthetic management of a patient with LAM undergoing a lengthy suboccipital craniotomy for a posterior fossa mass.
Flip-Flop HSV-BAC: bacterial artificial chromosome based system for rapid generation of recombinant herpes simplex virus vectors using two independent site-specific recombinases
Toshihiko Kuroda, Robert L Martuza, Tomoki Todo, Samuel D Rabkin
BMC Biotechnology , 2006, DOI: 10.1186/1472-6750-6-40
Abstract: We have developed an HSV-BAC system, termed the Flip-Flop HSV-BAC system, for the rapid generation of oncolytic HSV vectors. This system has the following features: (i) two site-specific recombinases, Cre and FLPe, are used sequentially to integrate desired sequences and to excise the BAC sequences, respectively; and (ii) the size of the HSV-BAC-insert genome exceeds the packaging limit of HSV so only correctly recombined virus grows efficiently. We applied this to the construction of an HSV-BAC plasmid that can be used for the generation of transcriptionally-targeted HSV vectors. BAC sequences were recombined into the UL39 gene of HSV ICP4-deletion mutant d120 to generate M24-BAC virus, from which HSV-BAC plasmid pM24-BAC was isolated. An ICP4 expression cassette driven by an exogenous promoter was re-introduced to pM24-BAC by Cre-mediated recombination and nearly pure preparations of recombinant virus were obtained typically in two weeks. Insertion of the ICP4 coding sequence alone did not restore viral replication and was only minimally better than an ICP4-null construct, whereas insertion of a CMVIE promoter-ICP4 transgene (bM24-CMV) efficiently drove viral replication. The levels of bM24-CMV replication in tumor cells varied considerably compared to hrR3 (UL39 mutant).Our Flip-Flop HSV-BAC system enables rapid generation of HSV vectors carrying transgene inserts. By introducing a tumor-specific-promoter-driven ICP4 cassette into pM24-BAC using this system, one should be able to generate transcriptionally-targeted oncolytic HSV vectors. We believe this system will greatly facilitate the screening of a plethora of clinically useful tumor-specific promoters in the context of oncolytic HSV vectors.Oncolytic virus therapy is a new modality of cancer treatment, which has shown promising results in clinical trials [1]. Oncolytic viruses are designed to selectively replicate in and kill cancer cells without harming normal tissue. Since reporting the successful treatmen
Anesthesia for Suboccipital Craniotomy in a Patient with Lymphangioleiomyomatosis: A Case Report
Robert A. Peterfreund,Emily Luman,Robert L. Martuza
Case Reports in Pulmonology , 2012, DOI: 10.1155/2012/804789
Abstract: Lymphangioleiomyomatosis (LAM) is a rare pulmonary condition often presenting with spontaneous pneumothorax. Imaging or biopsy confirm the diagnosis. Published case reports describe the anesthetic management of patients with LAM undergoing brief procedures. No reports describe the anesthetic management for lengthy neurosurgical procedures. We describe anesthetic management for craniotomy in a patient with LAM. Clinical Features. A woman presented with 2 spontaneous left pneumothoraces. She received a diagnosis of LAM by imaging. She did well after pleurodesis. Hearing loss and tinnitus led to brain imaging demonstrating a large left cerebello-pontine angle mass. She presented for elective craniotomy to remove the mass while preserving cranial nerve function. Our technique for general endotracheal anesthesia aimed to reduce the likelihood of another pneumothorax while providing good surgical conditions and permitting neuromonitoring. Conclusion. We demonstrate the successful anesthetic management of a patient with LAM undergoing a lengthy suboccipital craniotomy for a posterior fossa mass. 1. Introduction Lymphangioleiomyomatosis (LAM) is a rare pulmonary condition manifested by cyst formation in the lungs. Previous reports describe anesthesia management for patients with LAM needing brief surgical procedures, typically in the abdomen or chest. We present the anesthesia management of a patient with LAM undergoing a lengthy suboccipital craniotomy. LAM primarily affects the lung. Proliferation of smooth muscle-like cells produces obstruction of the vasculature, the lymphatics, and the airway resulting in pulmonary cyst formation [1, 2]. Other organs, particularly the kidney, may also be affected. The prevalence of LAM is about 1?:?1,000,000 in the general population, predominantly in women. The initial presentation is typically with respiratory symptoms, often with pneumothorax as a physical finding. The precise etiology of LAM remains undetermined, but an association with tuberous sclerosis suggests a common genetic cause [3–5]. A patient with a large suboccipital mass presented for craniotomy. We were confronted with the question of how to anesthetize this patient. Only a few case reports found in a PubMed search discuss management of patients with LAM requiring general anesthesia. The majority of these reported patients had relatively brief obstetric, abdominal, or thoracic procedures [6–13]. The literature search returned no publications describing a patient undergoing a lengthy and complex neurosurgical procedure. With the patient’s written informed
Plasma Internal Energy for Toroidal Elliptic Plasmas with Triangularity  [PDF]
Muhammad Asif
Journal of Modern Physics (JMP) , 2011, DOI: 10.4236/jmp.2011.21002
Abstract: The Plasma internal energy is not conserved on a magnetic surface if nonlinear flows are considered. The analysis here presented leads to a complicated equation for the plasma internal energy considering nonlinear flows in the collisional regime, including viscosity and in the low-vorticity approximation. Tokamak equilibrium has been analyzed with the magnetohydrodynamics nonlinear momentum equation in the low vorticity case. A generalized Grad–Shafranov-type equation has been also derived for this case.
Dressing after Dressing: Sadra’s Interpretation of Change  [PDF]
Muhammad Kamal
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.31009
Abstract:

This paper deals with the doctrine of transubstantial change advocated by Mulla Sadra in which substances as well as accidents are thought to be in constant and gradual change. Against Aristotle’s doctrine of accidental change, Mulla Sadra argues that no stable ground can bring about change and since substance is renewable it cannot carry identity of a changing existent. Here we investigate whether identity is possible or not. If it is possible then what becomes a ground for establishing identity of changing substances.

Intelligent Approaches for Vectorizing Image Outlines  [PDF]
Muhammad Sarfraz
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.512B016
Abstract: Two computing approaches, based on linear and conic splines, are proposed here in reviewed and extended for vectorizing image outlines. Both of the approaches have various phases including extracting outlines of images, detecting corner points from the detected outlines, and curve fitting. Interpolation splines are the bases of the two approached. Linear spline approach is straight forward as it does not have a degree of freedom.in terms of some shape controller in its description. However, the idea of the soft computing approach, namely simulated annealing, has been utilized for conic splines. This idea has been incorporated to optimize the shape parameters in the description of the generalized conic spline. Both of the linear and conic approaches ultimately produce optimal results for the approximate vectorization of the digital contours obtained from the generic shapes.
Travelling Wave Solution of the Fisher-Kolmogorov Equation with Non-Linear Diffusion  [PDF]
Muhammad Shakeel
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.48A021
Abstract: In this paper we study one-dimensional Fisher-Kolmogorov equation with density dependent non-linear diffusion. We choose the diffusion as a function of cell density such that it is high in highly cell populated areas and it is small in the regions of fewer cells. The Fisher equation with non-linear diffusion is known as modified Fisher equation. We study the travelling wave solution of modified Fisher equation and find the approximation of minimum wave speed analytically, by using the eigenvalues of the stationary states, and numerically by using COMSOL (a commercial finite element solver). The results reveal that the minimum wave speed depends on the parameter values involved in the model. We observe that when diffusion is moderately non-linear, the eigenvalue method correctly predicts the minimum wave speed in our numerical calculations, but when diffusion is strongly non-linear the eigenvalues method gives the wrong answer.
Removal of Pesticides from Water Using Granular Activated Carbon and Ultrafiltration Membrane—A Pilot Plant Study  [PDF]
Muhammad Zahoor
Journal of Encapsulation and Adsorption Sciences (JEAS) , 2013, DOI: 10.4236/jeas.2013.33009
Abstract:

The use of powdered activated carbon for fouling control in the membrane processes is limited by some secondary problems associated with its use, like cake formation, long backwash times and blackening of pipes. Granular activated carbon (GAC) was used as an alternative of powdered activated carbon due to its large particle size which was kept from being entering into the membrane system. The secondary problems associated with the use of powdered activated carbon as foul control were not observed for granular activated carbon. Langmuir and Freundlich adsorption were used to describe the adsorption of 2,4-D and paraquat on GAC. Adsorption capacity of adsorbent was high for 2,4-D as compared to paraquat. Also, the R2 value was high for Langmuir model as compared to Freundlich model. Retention percentage of 2,4-D by membrane was high and thus the decline in permeate flux was high as compared to paraquat in ultrafiltration (UF) membrane process. 100% retention of 2,4-D was achieved in GAC/UF hybrid system. Improved permeate fluxes were observed for both contaminants in the hybrid system.

Challenges of Mass Casualty Management at a Regional Trauma Centre in Sub-Saharan Africa  [PDF]
Muhammad Oboirien
Health (Health) , 2014, DOI: 10.4236/health.2014.66068
Abstract: Background: Mass Casualty incidents usually overwhelm the capabilities of any centre. It is an event whose nature is undetermined, unexpected and disrupts the normal trauma care in a hospital. Hospitals have established protocols to deal with mass casualty when it arises. Objectives: We sought to profile the presentations of mass casualty incidents and challenges in management in a regional trauma Centre in North-West Nigeria. Methodology: A retrospective look at the records of mass casualty presentations in our centre over a 12-month period (January-December 2011) was done. A mass casualty event in our setting is the presentation to our facility of eight or more patients from the same cause at the same. Results: There were a total of 18 mass casualty presentations with an average of 1.5 per month. There were a total of 236 victims including those brought in dead (BID). Males were 203 (86%) and females 33 (16%) with an M:F ratio of 6:1. Majority of the victims 222 (94%) were above 16 years and all the victims had a common mechanism of injury which was Road traffic crashes. One hundred and forty-three (61%) of the victims sustained lacerations and bruises while 31 (13%) were polytraumatized. Sixty-two (26%) of the victims were BID’S from the scenes of the Road Crashes. The outcome was that 131 (75%) of the victims were treated and discharged while 41 (24%) were admitted for further management. Two (1%) patients died during resuscitation and within 24 hours. Conclusion: Mass casualty presentations are a regular event in our centre hence there is the need for the establishment of a protocol and regular mass casualty drills to cope with future occurrences.
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