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Search Results: 1 - 10 of 1614 matches for " Mostafa Lashkarbolooki "
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Comparison between Modeling of Cetirizine Solubility Using Different Approaches: Semi-Empirical Density Based Correlations vs. Peng-Robinson EoS  [PDF]
Mostafa Lashkarbolooki, Ali Zeinolabedini Hezave
Open Access Library Journal (OALib Journal) , 2015, DOI: 10.4236/oalib.1101715
Abstract: The tunable nature of the solubility of various compounds, including molecules of pharmaceutical and biological interest, in supercritical fluids (SCFs) makes SCF extraction technology attractive for many separation and purification processes. Among the different influencing parameters, the most important one in the supercritical based processes is the knowledge of solubility of model solute. But, experimental measurement of the solubility of all pharmaceuticals in wide ranges of temperature and pressure is not only cost effective but also impossible in some cases. Regarding this fact, during the past decades, several approaches are proposed to model the solubility of the compounds in the supercritical fluids especially carbon dioxide. In this way, in the current investigation, two different approaches including five semi-empirical density based correlations (Mendez-Santiago and Teja (MST), Bartle et al., Chrastil, Kumar and Johnston (KJ) and Hezave et al.) and Peng-Robinson equation of state are used to find if it is possible to correlate the solubility of cetirizine with acceptable deviation as a function of temperature and pressure. The results reveal that among the examined approaches Hezave and Lashkarbolooki model leads to better overall correlative capability with average absolute relative deviation of 5.04% although Peng-Robinson EoS leads to lower AARD % of 3.85 % in 338 K isotherm.
Micronization of Cetirizine Using Rapid Expansion of Supercritical Carbon Dioxide  [PDF]
Ali Zeinolabedini Hezave, Mostafa Lashkarbolooki, Feridun Esmaeilzadeh
Open Access Library Journal (OALib Journal) , 2015, DOI: 10.4236/oalib.1101277
Abstract: During the past decades, producing micro- and nano-particles of drugs is gaining attention since it is possible to modify the solubility of insoluble drugs in the gastronical fluids significantly. Respect to this fact, in the current investigation, rapid expansion of supercritical carbon dioxide (RESS) for fabricating the micro-particles of cetirizine is investigated. In this way, different operational conditions including extraction pressure (160 - 220 bar), extraction temperature (308 - 328 K), nozzle length (1 - 8 mm), and nozzle diameter (450 - 1700 μm) are examined. The performed experiments revealed that among the examined operational conditions, nozzle diameter and extraction pressure introduce significant effects on the reduction of particle size compared with the other examined parameters. The results revealed that it is possible to reduce the cetirizine particles from 98.52 μm to 0.53 μm using RESS. In addition, scanning electron microscopy (SEM) analysis is performed to investigate the effect of different operational parameters on the morphology of the particles of cetirizine. The results demonstrate that RESS not only is able to reduce the particle size of the cetirizine, but also is able to change the morphology of the cetirizine particles from the irregular shape to spherical form.
Screening and PVT Analysis on Explored-Not-Productive Southern Iranian Oilfields  [PDF]
Mostafa Lashkarbolooki, Mehdi Bayt, Ali Zeinolabedini Hezave, Shahab Ayatollahi, Hosein Vahdani
Open Access Library Journal (OALib Journal) , 2015, DOI: 10.4236/oalib.1101437
Abstract: One of the main concerns of each petroleum engineer is the selection of the best EOR method to maximize the oil production from the reservoir. In this regard, one of the explored-not-productive southern Iranian oil fields was considered as the objective of this study to find which enhanced oil recovery (EOR) method is the proper method to apply on this reservoir. Therefore, a procedure capable of combining the data extracted from different sources ranging from worldwide field experiences to the existing tables into a unified expert system is used. This expert system is based on Bayesian network analysis in order to sort the proper EOR techniques for further assessment by economical and environmental criteria. In addition, after collecting of surface samples at the gas and liquid separator, and subsequently recombined with solution gas oil ratio, several tests including constant composition expansion (CCE) (flash vaporization, flash liberation flash expansion, pressure-volume relations), differential vaporization (differential liberation differential expansion) and solubility and swelling tests were performed.
Use of an Energy-Like Integral to Study the Motion of an Axi-Symmetric Satellite under Drag and Radiation Pressure  [PDF]
Ahmed Mostafa
International Journal of Astronomy and Astrophysics (IJAA) , 2015, DOI: 10.4236/ijaa.2015.53019
Abstract: The axi-symmetric satellite problem including radiation pressure and drag is treated. The equations of motion of the satellite are derived. An energy-like is given for a general drag force function of the polar angle θ, and then it is used to find a relation for the orbit equation of the satellite with initial conditions satisfying the vanishing of arbitrarily choosing higher derivatives of the velocity.
The Predictive Value of Biopsy of the Pancreas and Its Therapeutic Impact in Autoimmune Diabetes  [PDF]
Wael Nassar, Mostafa A. Mostafa
Journal of Diabetes Mellitus (JDM) , 2014, DOI: 10.4236/jdm.2014.44041
Abstract: Diabetes Mellitus is by definition an end-stage organ failure. Type 1 diabetes mellitus (T1DM) is an autoimmune disease. Auto-inflammatory infiltrate appears to characterize the insulitis associated with T2DM. Recently, in 2013, Eva Corpos and colleagues described a comprehensive composition of peri-islet capsules and their basement membrane (BM). Virtanen I, Otonkoski T and Irving-Rodgers H.F. have reported similar descriptions few years earlier which have not been taken seriously as they deserve. Bluestone JA, Virtanen I and Irving-Rodgers H.F. and other colleagues reported that accumulation of the lymphocytes around the islets without invasion of the BM is the first step in disease induction (non-destructive insulitis phase). Invasion of the BM byleucocytic infiltration (destructive insulitis phase) occurs over a period of several years offering a good window for therapeutic intervention. Clinical symptoms appear only when 70% - 90% of β-cell mass are destroyed. This data emphasize the importance of identification and classification of such pathologic features by performing a biopsy of the pancreas with histoimmunochemistry analysis at the pre-hyperglycemic stage in a high risk genetically predisposed autoimmune suspected patient which may at least in part help to achieve new therapeutic approaches and help in halting the progression to end stage pancreatic disease (ESPD) known as diabetes mellitus. In this review we are going to emphasize the predictive role biopsy of the pancreas can build up a solid gold standard tool in diagnosis, stage and therapeutically follow up autoimmune diabetes mellitus.
Assessment of Dietary Bovine Lactoferrin in Enhancement of Immune Function and Disease Resistance in Common Carp (Cyprinus carpio)
Moein Faramarzi,Saeed Kiaalvandi,Farnaz Iranshahi,Mohammad Lashkarbolooki
Journal of Fisheries International , 2012, DOI: 10.3923/jfish.2011.41.45
Abstract: Lctoferrin (LF) is an iron-binding glycoprotein plays an important role in the non-specific immune system in fish and mammals. Common carp (Cyprinus carpio) was fed bovine LF supplemented diets (0, 200, 400 and 600 mg kg-1 diet) for 4 weeks. The effect of dietary LF on immune function and resistance to Aeromonas hydrophilla challenge was determined. The level of LF in diet had a significant force on survival following A. hydrophilla challenge with fish fed the 600 mg kg-1 LF diet having significantly superior survival than control fish. There was increase in activity of non-specific and specific immune parameters (lymphocytes count, macrophage oxidative burst, serum lysozyme and bactericidal activities against A. hydrophilla) with addition of LF to diets. While there was not a corresponding increase in activity of total leukocytic count and neutrophil adhesion test. The increased resistance to A. hydrophilla with increasing dietary concentration of LF seemed to correspond with an enhancement of non-specific immune functions. In conclusion, dietary LF supplementation could be enhances the non-specific immunity and diseases resistance in common carp (Cyprinus carpio).
Genetic Algorithm Based Performance Analysis of Self Excited Induction Generator  [PDF]
Hassan Ibrahim, Mostafa Metwaly
Engineering (ENG) , 2011, DOI: 10.4236/eng.2011.38105
Abstract: This paper investigates the effects of various parameters on the terminal voltage and frequency of self excited induction generator using genetic algorithm. The parameters considered are speed, capacitance, leakage reactance, stator and rotor resistances. Simulated results obtained using genetic algorithm facilitates in exploring the performance of self-excited induction generator. The paper henceforth establishes the application of user friendly genetic algorithm for studying the behaviour of self-excited induction.
Effect of Local and Global Scour on Lateral Response of Single Piles in Different Soil Conditions  [PDF]
Yasser E. Mostafa
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.46039
Abstract: Marine structures, offshore platforms and bridge piers are usually supported on foundation piles. These piles are subjected to lateral loading due to wind, waves and currents. Piles installed in marine or river environments are susceptible to scour depending on wave and current characteristics and soil types. In this paper, the effect of local and global scour on behavior of laterally loaded piles installed in different soil conditions has been investigated. Finite element model (FEM) using the software program PLAXIS and Winkler model using the software program LPILE were used in the analyses. Different parameters were investigated such as soil types, scour depth, scour hole dimension, pile material, submerged condition, magnitude of lateral load and load eccentricity. The results showed that scour has a significant impact on piles installed in sand and a less significant impact on piles installed in clay. Global scour has a significant impact on pile lateral displacement and bending stresses. The effect of scour is more significant if piles are subjected to large lateral loads due to the nonlinear response of pile-soil system. Effect of scour of stiff clayey soils on piles is more pronounced than that of soft clayey soils.
Design Considerations for Pile Groups Supporting Marine Structures with Respect to Scour  [PDF]
Yasser E. Mostafa
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.412106
Abstract: Piles supporting marine structures such as jetties, relieving platforms, quay walls and fixed offshore structures are subjected to lateral loads due to berthing and mooring forces, wind, waves, storm surges and current forces. This paper presents some factors that affect the design of pile groups supporting marine structures founded in cohesionless soils. Some main aspects that should be considered in the pile group design are addressed such as pile batter angle, pile group arrangement, pile spacing, pile slenderness ratio and magnitude of lateral static loading. Numerical analyses were conducted to investigate these design aspects with and without impact of scour. Different scour depths were considered to cover the possible root causes of scour around pile groups such as waves, current and ship propeller jets. The study revealed that scour has greater impact on lateral loading of pile groups compared to its impact on single piles. Pile groups with side-by-side arrangement exposed to scour are more critical than single piles and piles groups with tandem arrangement due to the combined effect of scour and pile-soil-pile interaction. It is also concluded that scour protection is not always required. More attention and considerations should be given to scour protection around piles especially if the piles are closely spaced, arranged side-by-side and if slenderness ratio is less than 12.5.
Some Results on Riemannean Multiple Barycenters  [PDF]
Mostafa Zahri, Naji Khallaf
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.27058
Abstract:

A characteristic of a special case of Riemannean barycenters on the unit circle is presented. The non-uniqueness of such barycenters leads to an interesting study of the so-called multiple barycenters. In this work, we deal with a smooth one-dimensional manifold S1 only. Some theoretical and computational analysis is listed.

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