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Search Results: 1 - 10 of 720429 matches for " Mosselhi A. M. Mohamed "
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Microwave Assisted Synthesis of Some New Fused 1,2,4-Triazines Bearing Thiophene Moieties With Expected Pharmacological Activity
Hosam A. Saad,Mohamed M. Youssef,Mosselhi A. Mosselhi
Molecules , 2011, DOI: 10.3390/molecules16064937
Abstract: Rapid and efficient solvent-free synthesis of 4-amino-3-mercapto-6-[2-(2-thienyl)vinyl]-1,2,4-triazin-5(4H)-one 1 under microwave irradiation is described. Some new fused heterobicyclic nitrogen systems such as 1,2,4-triazino[3,4-b][1,3,4]thiadiazinones, 1,3,4-thiadiazolo[2,3-c][1,2,4]triazinone and pyrazolo[5,1-c]-[1,2,4]triazine-7-carbonitrile, have been synthesized by treatment of 1 with bifunctional oxygen and halogen compounds, CS2/KOH and malononitrile via heterocyclization reactions, in addition to some uncondensed triazines. Structures of the products have been deduced from their elemental analysis and spectral data (IR, 1H-NMR, 13C-NMR). Select new synthesized compounds were screened as anticancer agents, with some showing activity as cytotoxic agents against different cancer cell lines.
Cyclocondensation Reactions of Hydrazonoyl Chlorides with Some Azines: Synthesis of New Fused Heterocycles of Expected Microbiological Activity  [PDF]
Mosselhi A. M. Mohamed, Liala M. B. Abu-Alola, Ohoud N. A. Al-Zaidi, Hosam A. H. Saad
International Journal of Organic Chemistry (IJOC) , 2017, DOI: 10.4236/ijoc.2017.71002
Abstract: New functionalized fused heterocycles, such as, 1,3,6,9,11-pentasubstituted-pyrido[3,2-f:6,5-f']bis([1,2,4]triazolo[4,3-a]-pyrimidin-5(1H)-ones (6) and 1,3-disubstituted-7-[(E)-2-(thiophen-2-yl)ethenyl]-1,4,9,9a-tetrahydro-6H-[1,2,4]triazino[4,3-b][1,2,4,5]-tetrazin-6-ones (16) were synthesized via reaction of the hydrazonoyl chlorides (1) with 1,3,6-triphenyl-9-thioxo-9,10-dihydro-pyrimido [4,5-b]pyrido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidin-5,7(1H,8H)-di-one (5) and 4-amino-6-[(2-thiophen-2-yl)ethenyl]-3-thioxo-3,4-dihydro-[1,2,4]triazin-5(2H)-one (11), respectively. The mechanism and the regioselectivity of the studied reactions have been discussed. The biological activity of the products has been evaluated against some fungi and bacteria species. The tested compounds exhibited moderate activity against the bacteria species.
Nucleosides 10: Synthesis of New Derivatives of Pyrimidine and Fused Pyrimidine Nucleosides of Expected Biological Activity  [PDF]
Laila M. Break, Mosselhi A. M. Mohamed, Ohoud A. A. Al-Thubaiti, Fatma E. M. Eibaih
International Journal of Organic Chemistry (IJOC) , 2019, DOI: 10.4236/ijoc.2019.93010
Abstract: Pyrimidines, such as 6-amino-2-thio and 2-methylthiouracils and fused pyrimidines, such as thienopyrimidines reacted with 1-O-acetyl-2,3,5-tri-O- benzoyl-β-D-ribofuranose to get new derivatives of the corresponding nucleosides. The obtained protected nucleosides were deprotected by methanolic sodium methoxide to get the corresponding free uracil and thienopyrimidine nucleosides. The new nucleosides formed were tested for biological activity against some of microorganism (some fungi and bacteria species). Some of the tested products showed moderate activity and the results were reported.
Synthesis, Acidity Constants and Tautomeric Structure of the Diazonium Coupling Products of 2-(Benzylsulfanyl)-7H-purin-6-one in Its Ground and Excited States
Elham S. Darwish,Mosselhi A. Mosselhi,Farag M. Altalbawy,Hosam A. Saad
Molecules , 2011, DOI: 10.3390/molecules16108788
Abstract: A series of new 8-arylhydrazono-2-(benzylsulfanyl)-7H-purin-6-ones 6 were synthesized, their electronic absorption spectra in different organic solvents of varying polarities were investigated and their acid dissociation constants in both the ground and excited states were determined spectrophotometrically. The tautomeric structures of such products were elucidated by spectral analyses and correlation of their acid dissociation constants with the Hammett equation. The results indicated that the studied compounds 6 exist predominantly in the hydrazone tautomeric form 6A in both the ground and excited states.
Nucleosides 8 [18]: Ribosylation of Fused Quinazolines—Synthesis of New [1,2,4]Triazolo[5,1-b]- and [1,2,4]Triazino[3,2-b]quinazoline Nucleosides of Fluorescence Interest
Laila Mohamed Break,Mosselhi Abdelnabi Mosselhi,Nagi Mohamed Elshafai
Journal of Chemistry , 2013, DOI: 10.1155/2013/612756
Abstract:
Optimal Convergence Analysis for Convection Dominated Diffusion Problems  [PDF]
M. A. Mohamed Ali
Journal of Applied Mathematics and Physics (JAMP) , 2013, DOI: 10.4236/jamp.2013.13004
Abstract:

In classical mixed finite element method, the choice of the finite element approximating spaces is restricted by the imposition of the LBB consistency condition. The method of H1-Galerkin mixed finite element method avoids completely the imposition of such a condition on the approximating spaces. In this article, we discuss and analyze error estimates for Convection-dominated diffusion problems using H1-Galerkin mixed finite element method, along with the method of characteristics. Optimal order of convergence has been achieved for the error estimates of a two-step Euler backward difference scheme.

Synthesis, Tautomeric Structure and Antimicrobial Activity of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones
Thoraya Abdel Reheem Farghaly,Mastoura Mohamed Edrees,Mosselhi Abdelnabi Mosselhi
Molecules , 2012, DOI: 10.3390/molecules17078483
Abstract: A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4-phenyl- [1,2,4]triazepino[2,3-a]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthesized compounds was also evaluated. The results indicated that some of these compounds have moderate activity towards bacteria.
Risk Factors for Stroke in Sulaimaniyah Iraqi Kurdistan Region-Iraq  [PDF]
Ahmed Saeed Mohamed, Mohamed A. M. Alshekhani
International Journal of Clinical Medicine (IJCM) , 2016, DOI: 10.4236/ijcm.2016.79070
Abstract: Background: Stroke is a frequent medical problem and a leading cause of death and disability worldwide. Several conditions and lifestyle factors have been associated with stroke. Aim: To evaluate risk factors in stroke patients in Sulaimani city. Results: 110 patients with stroke were included in this study, hypertension was found to be the most common risk factor in current study. Out of 110 cases, 83 (75.5%) were hypertensive. Peak stroke-prone age was (60 - 69) year for male, (70 - 79) year for female. We found a statistically significant relation between level of TSC, LDL with ischemic stroke (r = 0.4047, P < 0.0001) and (r = 0.4052 P < 0.0001) respectively. While there was a significant inverse relation between HDL and ischemic stroke (Correlation coefficient = ?0.4862, P < 0.0001). On the other hand, there was no significant relation between level of TG and ischemic stroke (r = 0.2403, P < 0.0114). Also correlation statistic between TSC/HDL, LDL/HDL and result of CT scan, showed that there is statistical significance correlation between infarction and value of atherogenic index, (r = 0.5301, P < 0.0001, r = 0.4990, P < 0.0001) respectively, but there is no correlation between haemorhage & the index. Conclusion: Hypertension is the leading risk factor of stroke. It is therefore essential to detect and treat hypertension at its outset. High value of atherogenic index mostly associated with ischemic stroke .while no relation found with haemorhagic stroke.
Preparation of biocompatible magnetic microspheres with chitosan  [PDF]
Mohamed K. Nasra, Moustafa M. Mohamed, Mohamed A. Elblbesy, Bothaina A. Hefney
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2011, DOI: 10.4236/jbnb.2011.22024
Abstract: Microsphere is a term used for small spherical particles, with diameters in the micrometer range (typically 1μm to 1000μm (1mm)). Microspheres are sometimes referred to as microparticles. Microspheres can be manufactured from various natural and synthetic materials. The present work we prepared chitosan magnetic microspheres (CMMS) with simple crosslinking method. The obtained CMMS were in size range of 1000-2600 nm with average particle size of 1800nm. All the essential characterizations of prepared CMMS were done and the results were in a good agreement with other magnetic microspheres prepared with different method. To test the biocompatibility of CMMS with blood, the effect of them on erythrocytes aggregation and blood hemolysis were studied. Our results showed that CMMS work as good compatible materials with blood.
Deleterious Nonsynonymous SNP Found within HLA-DRB1 Gene Involved in Allograft Rejection in Sudanese Family: Using DNA Sequencing and Bioinformatics Methods  [PDF]
Mohamed M. Hassan, Sofia B. Mohamed, Mohamed A. Hussain, Amar A. Dowd
Open Journal of Immunology (OJI) , 2015, DOI: 10.4236/oji.2015.54018
Abstract: Renal transplantation provides the best long-term treatment for chronic renal failure. Single-nucleotide polymorphisms (SNPs) play a major role in the understanding of the genetic basis of many complex human diseases. Also, the genetics of human phenotype variation could be understood by knowing the functions of these SNPs. It is still a major challenge to identify the functional SNPs in a disease-related gene. This work explored how SNPs mutations in HLA-DRB1 gene could affect renal transplantation rejection. This study was carried out in Ahmed Gasim Hospital, Renal Dialysis Center during the period, from September 2012 to November 2013. Blood samples from five Sudanese patients (different families) with known renal transplantation rejection were collected before hemodialysis, furthermore one blood sample for control. DNA sequences results and detected SNPs were analyzed using bioinformatics tools (BLAST, SIFT, nsSNP Analyzer, PolyPhen, I-mutant, BioEdit, CPH, Chimera, Box shade and Project Hope). In addition, international databases were used for datasets [NCBI, Uniprot]. Results showed that, three SNPs were detected; two of three SNPs were predicted as tolerant or benign (rs1059575, novel) and one was deleterious (rs17885437). This study concluded that the identification of pathological SNPs could be an answer to unknown causes for a lot of organ transplantation rejection cases.
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