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OALib Journal期刊

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The Microsponge Drug Delivery System : For Delivering an Active Ingredient by Controlled Time Release
John I. D’souza,Harinath N. More
Pharmaceutical Reviews , 2008,
Abstract: The expanding arena of emerging drugs, increased sensitivity to clinical outcomes and healthcare costs are driving the need for alternative drug delivery methods and devices. The drug delivery technology landscape has become highly competitive and rapidly evolving. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. New classes of pharmaceuticals, biopharmaceuticals (peptides, proteins and DNA-based therapeutics) are fueling the rapid evolution of drug delivery technology. These new drugs typically cannot be effectively delivered by conventional means. The benefits from targeted, localized delivery of therapeutic agents are other driving forces for the market. Drug delivery systems (DDS) that can precisely control the release rates or target drugs to a specific body site have had an enormous impact on the health care system. Carrier technology offers an intelligent approach for drug delivery by coupling the drug to a carrier particle such as microspheres, nanoparticles, liposomes, etc. which modulates the release and absorption characteristics of the drug. Microspheres constitute an important part of these particulate DDS by virtue of their small size and efficient carrier characteristics. 1
ANTIMICROBIAL AND PHYTOCHEMICAL SCREENING OF DIFFERENT LEAF EXTRACTS OF MEMECYLON UMBELLATUM BURM
Suresh G. Killeda,Harinath N. More
International Research Journal of Pharmacy , 2012,
Abstract: Nine different solvents based on extractive values were used for extraction. Extraction of air dried coarse leaf powder was carried out by maceration and soxhletion. Extracts were dried under reduced pressure and screened for phytoconsituents. Yield was found maximum with methanol extract (28.36g) followed by aqueous (15.72g) and minimum with solvent ether (0.375g). Dried extracts were tested for antimicrobial activity using doxycycline, ciprofloxacin and fluconazole as standards along with individual solvent as controls. Cylindrical cup plate method was used for activity using 8mm dia. borer. Zones of inhibition were measured by zone reader after 24h of incubation for bacteria and 48h for fungi. Acetone extracts showed maximum antimicrobial activity followed by n-butanol, ethyl acetate, methanol and ethanol. Aqueous and pet. ether extracts showed activity only against S. aureus while ether extracts showed activity only against E. coli and chloroform extract only against B. subtilis. All the organic solvent extracts failed to show antifungal activity. Ethanolic extract obtained by Soxhlet extraction showed maximum antibacterial activity against Micrococcus luteus. MIC for butanol, ethyl acetate and methanol was found 0.5mg while in other extracts it was more up to 15mg. Polar solvents showed presence of tannins, glycosides, proteins and organic acids while non polar solvents showed presence of steroids, triterpenes and polysaccharides.
Spectrophotometric estimation of ambroxol hydrochloride and cetirizine hydrochloride in tablets
Bhatia Neela,Ganbavale Santosh,More Harinath
Asian Journal of Pharmaceutics , 2008,
Abstract: A simple, rapid, accurate, precise and reproducible simultaneous equation method has been developed for simultaneous estimation of ambroxol hydrochloride and cetirizine hydrochloride in tablets. Ambroxol hydrochloride has absorbance maxima at 243 nm, while cetirizine hydrochloride has absorbance maxima at 229 nm in glass-distilled water. The method developed involves no separation or extraction process. The proposed methods were successfully applied to the determination of ambroxol hydrochloride and cetirizine hydrochloride in tablets, with high percentage of recovery, good accuracy, and acceptable precision. Different analytical performance parameters such as linearity, precision, accuracy, limit of detection, limit of quantitation, and robustness were determined according to International Conference on Harmonization ICH Q2B guidelines. Results of analysis of formulation given as percentage of label claim ± relative standard deviation were found to be 99.27 ± 0.8083 and 102.43 ± 1.5357 for ambroxol hydrochloride and cetirizine hydrochloride respectively. Results of recovery studies given as percentage of label claim ± relative standard deviation were found to be 99.88 ± 0.3811 and 100.36 ± 2.0480 for ambroxol hydrochloride and cetirizine hydrochloride respectively.
Design and evaluation of transdermal drug delivery system of gliclazide
Shinde Anilkumar,Shinde Amit,More Harinath
Asian Journal of Pharmaceutics , 2010,
Abstract: Transdermal systems are ideally suited for diseases that demand chronic treatment. Hence, an anti-diabetic agent of both therapeutic and prophylactic usage has been subjected to transdermal investigation. Gliclazide, a second-generation hypoglycemic agent, faces problems like its poor solubility, poor oral bioavailability with large individual variation and extensive metabolism. In the present work, transdermal matrix-type patches were prepared by film casting techniques on mercury using polymers like HPMC, Eudragit RL-100, and chitosan. Also an attempt was made to increase the permeation rate of drug by preparing an inclusion complex with hydroxypropyl β-cyclodextrin (HP β-CD). The possibility of a synergistic effect of chemical penetration enhancers (CPE) (propylene glycol and oleic acid) on the transdermal transport of the drug was also studied. Folding endurance was found to be high in patches containing higher amount of the Eudragit. There was increase in tensile strength with an increase in Eudragit in the polymer blend. In vitro drug release profile indicates that the drug release is sustained with increasing the amount of Eudragit in patches. The patches containing inclusion complex of drug showed higher permeation flux compared with patches containing plain drug. The result of the synergistic effect indicates that the HP β- CD in conjunction with other CPE showed a higher permeation flux.
Development and characterization of transdermal therapeutics system of tramadol hydrochloride
Shinde Anil,Garala Kevin,More Harinath
Asian Journal of Pharmaceutics , 2008,
Abstract: The present work was designed to develop suitable transdermal matrix patches of tramadol hydrochloride, a non-steroidal anti-inflammatory drug, using hydroxy propyl methyl cellulose (HPMC), Eudragit RL-100 and Eudragit RS-100 with triethyl citrate as a plasticizer and dimethyl sulfoxide (DMSO) as a penetration enhancer. Different batches developed using Eudragit RL-100 : HPMC and Eudragit RS-100 : HPMC in ratio of 2 : 8, 4 : 6, 6 : 4, and 8 : 2. Drug - excipients interaction study was further carried out using Fourier transform infrared (FTIR) spectroscopic technique. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness, and folding endurance. In vitro diffusion studies were performed using cellulose acetate membrane (pore size 0.45 μ ) in a Franz′s diffusion cell. The concentration of diffused drug was measured using UV-visible spectrophotometer (Jasco V-530) at lmax 275 nm. The batch containing Eudragit RL-100 : HPMC (8 : 2) showed 79.65% release within 12 h and batch containing Eudragit RL-100 : HPMC (2 : 8) showed only 58.30% release in 12 h. This is because that the Eudragit produce crystallization free patch.
ESTIMATION OF SUGARS AND MINERALS IN HEALTHY AND INFECTED PARTS OF MEMECYLON UMBELLATUM BURM
Killedar Suresh Ganpati,More Harinath Nivruti
International Journal of Research in Ayurveda and Pharmacy , 2010,
Abstract: Different parts of Memecylon umbellatum were found infected during rainy season by fungi. To investigate the effect of these fungi on some of the basic metabolites like minerals and sugars, the present study was undertaken. Here we have collected healthy and infected leaves and bark samples from infected plants in rainy season (July-August). Sugar content was estimated by simple titrimetric method using benedict’s quantitative reagent and mineral contents were estimated by atomic absorption using acid hydrolysis method. Both healthy and infected parts showed presence of reducing and non reducing sugars along with minerals such as iron, calcium, magnesium, manganese, lead etc. Total sugar content was found maximum in inflorescence (526.31mg/dl) and minimum in case of root (128.20 mg/dl). The reducing and non reducing sugars were also found maximum (294.11 mg/dl and 232.20 mg/dl) in inflorescences compare to all other parts studied. In case of inflorescence the difference between reducing and non reducing sugar is less (61.91 mg/dl) while in bark it was found more (164.51 mg/dl) compare to other parts tested. Healthy bark (5.898 mg/100g) and leaves (4.980mg/100g) showed maximum content of iron compare to other healthy and infected parts. Infected leaves and bark showed more deposition of calcium and magnesium compare to healthy leaves while all other minerals were decreased with respect to healthy leaves and bark which indicates the utilization of these minerals by pathogenic fungus specially iron content to great extent.
Gastroretentive Drug Delivery System : An Overview
Mr. Shinde Anilkumar J,Dr. More Harinath N.
Pharmaceutical Reviews , 2008,
Abstract: Several approaches have been proposed to retain the dosage forms in the stomach. These methods include bioadhesive system, swelling system and expanding system and floating system.In fact the buoyant dosage unit enhances gastric residence time( GRT) without affecting the intrinsic rate of emptying. Unfortunately floating devices administered in a single unit form ( Hydrodynamically balanced system) HBS are unreliable in prolonging the GRT owing to their ‘ all- or- nothing’ emptying process and, thus they may causes high variability in bioavailibity and local irritation due to large amount of drug delivered at a particular site of the gastrointestinal tract.
DEVELOPMENT AND IN VITRO EVALUATION OF TRANSDERMAL PATCHES OF LOVASTATIN AS A ANTILIPIDEMIC DRUG
Shinde Anilkumar J,Paithane Manoj B,More Harinath N
International Research Journal of Pharmacy , 2010,
Abstract: In present work was designed to develop suitable transdermal matrix patches of Lovastatin (LS), using hydroxy propyl methyl cellulose (HPMC) and Eudragit RL 100 with Triethyl citrate as a plasticizer. A 32 full factorial design was employed, the amount of HPMC( X1) and Eudragit RL- 100( X2), was used as independent variables. The folding endurance, tensile strength, moisture content, moisture uptake and diffusion of drug were selected as dependent variables. The Casting solvent technique was employed for the preparation of HPMC, ERL-100 film. The dry films were evaluated for Physical appearance, thickness uniformity, moisture content, moisture uptake, tensile strength, flatness and folding endurance. In vitro diffusion studies were performed using cellulose acetate membrane (pore size 0.45 μ) in a Franz’s diffusion cell. The concentration of diffused drug was measured using UV-visible spectrophotometer (Jasco V-530) at λ max 254 nm. The experimental results shows that the patch containing HPMC in higher proportion gives increase in the release of drug. It indicates that as the concentration of X2 (Eudragit RL 100) increase, the drug release from the matrix was decrease. The present study has demonstrated the potential of the fabricated matrix film for prolonged release of Lovastatin.
Microscopic Evaluation of Leaves of Memecylon umbellatum Burm
Suresh G. Killedar,Harinath N. More,Sameer J. Nadaf
Advances in Agriculture , 2014, DOI: 10.1155/2014/104849
Abstract: Objective. Aim of present work is to perform the microscopic evaluation and physicochemical analysis and to explore the morphology parameters of Memecylon umbellatum Burm leaves. Methods. Fresh, dried and desiccated powdered leaf samples were studied for their morphology, microscopy, organoleptic characters, and an assortment of other WHO recommended methods for standardisation. Results. The microscopy revealed the dorsiventral nature of the leaf. Midrib showed presence of nonlignified phloem, lignified xylem with well-defined xylem fibers, vessels, and parenchyma. Presence of Phloecentric vascular bundles surrounded by endodermis and crystal sheath. Well-defined patches of collenchyma were observed above and below the vascular bundles in the midrib area. Trichomes are mostly absent and stomata (anomocytic) were observed on both epidermal surfaces. Conclusions. It can be concluded that the microscopic analysis and pharmacognostic parameters can serve as tool for developing standards for proper authentication, quality, and purity of Memecylon umbellatum Burm leaves. 1. Introduction Memecylon umbellatum Burm (family: Melastomataceae) is a small evergreen shrub or tree which grows up to 8–14?m tall having young tree branches and bears numerous umbellate cymes. The plant is known as “Anjani” in Sanskrit, Anakkayavu in Malayalam, and “Ironwood tree” in English. It is distributed mostly in coastal regions of the Deccan peninsula, the eastern and southern part of India all along the Western Ghats and in the Andaman islands [1, 2]. It is also found distributed in Orissa, Assam, Sylhet, Tenasserim, Ceylon, Malay, Peninsula-Malay, and Archipelago [3]. Different extracts of Memecylon umbellatum Burm Inflorescences [4] and bark [5] have been evaluated for its antimicrobial potential. Estimation of total content of tannin [6] and seasonal variation of tannin content in different parts has also been carried out [7]. Estimation of sugars and minerals in healthy and infected parts has also been carried out [8]. Different root extract have been reported to possess antioxidant activity [9], while leaves of Memecylon umbellatum have also been evaluated for their antimicrobial activity [10]. Use of leaves was also reported in snakebite [11]. The seeds are used to cure cough and sedative [12]. The leaf powder has antidiabetic potential [13]. Leaves are used to treat eye troubles, gonorrhea, leucorrhea, wounds [14], and skin diseases [15]. It also has an antioxidant property [16]. The leaves are reported to possess antiviral activity [17–19]. Wound healing activity of
DEVELOPMENT AND IN VITRO EVALUATION OF CHITOSAN GEL FOR WOUND HEALING ACTIVITY
Shinde Anilkumar J.,Khade Kishorkumar M,Kadam Atul R.,More Harinath N
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: The present study aims to evaluate the wound healing activity of gel containing chitosan in rats. Chitosan is reported for wound healing activity, four optimized gel formulations were prepared, out of that CG-4 showed promising physical properties like colour, pH, consistancy, spreadability, extrudability as that of marketed wound healing cream formulations. Topical application of the test formulation CG-4 gel formulation was used for treatment group, which has showed significant wound healing activity in excision wound model. Percentage wound closure, period of complete epithelisation and scar size reduction on complete epithelisation showed P value<0.001 as comparable to marketed formulation (1%w/w). Dead space wound studies also showed significant increase in Hydroxyproline content indicating promotion of collagen formation and ultimately wound healing activity. The present study thus offers a valuable insight into the claimed wound healing potential of the test formulation.
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