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Search Results: 1 - 10 of 3046 matches for " Moon Tae-Woong "
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Association of the UCP-1 single nucleotide polymorphism A-3826G with the dampness-phlegm pattern among Korean stroke patients
Lim Ji,Ko Mi,Moon Tae-Woong,Cha Min
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-180
Abstract: Background Patients with stroke have various syndromes and symptoms. Through pattern identification (PI), traditional Korean medicine (TKM) classifies the several syndromes and symptoms of stroke patients into five categories: Fire-heat (FH), Dampness-phlegm (DP), Yin-deficiency (YD), Qi-deficiency (QD) and Blood-stasis (BS). DP has been associated with obesity and hyperlipidemia. Uncoupling protein-1 (UCP-1), which plays a major role in thermogenesis and energy expenditure can increase the risk of obesity and can be related metabolic disorders. In this study, we elucidated the association of three polymorphisms located in the UCP-1 promoter and coding region with DP among Korean stroke patients. Methods 1,593 patients with cerebral infarction (583/DP, 1,010/non-DP) and 587 normal subjects were enrolled. The genotypes A-3826G, G-1766A and Ala64Thr (G+1068A) for each subject were determined by polymerase chain reaction with TaqMan probes and five percent of subjects were re-genotyped by sequencing method to confirm the accuracy of genotyping. The results were analyzed using a multiple logistic regression model to evaluate the genetic associations: the UCP-1polymorphisms of normal versus those of DP subjects and those of normal versus those of non-DP subjects. Results A significantly higher percentage of subjects in the DP group possessed the A-3826G G allele than the A allele (OR=1.508, p=0.006). Furthermore, the number of subjects with the GG type of A-1766G was significantly lower in the non-DP group than the normal group in the recessive model (OR=0.606, p=0.042). In addition, an analysis of the relationship among 2 SNPs of UCP-1 and lipid serum concentration showed that the serum level of HDL cholesterol was significantly higher in subjects with the A-3826G G allele in the normal group (p=0.032). Serum triglyceride and HDL cholesterol were also associated with the A-1766G variant in the recessive model (p=0.002, p=0.046). Conclusions These results suggest that that the A-3826G and A-1766G UCP-1 polymorphisms, which are related to obesity, might be candidate genetic markers for the DP pattern in the TKM diagnosis system.
Patterns of Nutrient Intake among Male and Female High School-Aged Cross-Country Skiers and Speed Skaters  [PDF]
Tae-Woong Oh, Sanae Okubo, Sakura Tanaka, Tatsuki Naka
Food and Nutrition Sciences (FNS) , 2018, DOI: 10.4236/fns.2018.92010
This study aimed to determine the appropriate nutritional intakes and dietary habits of high school-aged cross-country skiers and speed skaters. The subjects, all high school students from N Prefecture, included 18 male cross-country skiers, 5 male speed skaters, 10 female cross-country ski players and 4 female speed skaters. Physical measurements, food intake frequency survey results, bone mineral density and exercise stress test outcomes, and lactic acid measurements were evaluated. Female athletes in both sports had higher body fat percentages relative to the average range stated for female athletes. Male speed skaters had a significantly higher maximum oxygen in-take than that male cross-country skiers did. By contrast, this parameter did not differ significantly among female athletes. A negative correlation was observed between the fat free mass and muscle mass, and a positive correlation was observed among the body fat percentage, fat percentage, and fat mass. Both male and female athletes had protein intake ratios within the reference ranges. All athletes except male speed skaters had lipid energy ratios that were higher than the upper limit of the reference value. Both male and female athletes also reported carbohydrate energy ratios within the reference ranges, but had cereal energy ratios below the reference values. Athletes should pay attention to the ingestion of various nutrients to ensure a sufficient energy intake. Accordingly, adolescent athletes should consume daily meals containing a good balance of staple foods, main dishes, side dishes, milk and other dairy products, and fruits.
Developing indicators of pattern identification in patients with stroke using traditional Korean medicine
Ju Lee, Tae-Yong Park, Jungsup Lee, Tae-Woong Moon, Jiae Choi, Byoung-Kab Kang, Mi Ko, Myeong Lee
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-136
Abstract: We sorted out stroke patterns with an expert committee organized by the Korean Institute of Oriental Medicine. The expert committee composed a document for a standardized pattern of identification for stroke based on the traditional Korean medical literature, and we evaluated the clinical significance of the document through a field test.We established five stroke patterns from the traditional Korean medical literature and extracted 117 indicators required for diagnosis. The indicators were evaluated by a field test and verified by the expert committee.This study sought to develop indicators of PI based on the traditional Korean medical literature. This process contributed to the standardization of traditional Korean medical diagnoses.Pattern identification is a system of diagnosis in traditional Korean medicine (TKM) that is characterized by its own theoretical basis and practical experience [1]. This unique system entails a comprehensive symptom analysis and an investigation of the illness, its cause and nature, the patient's physical condition and the patient's treatment through four examinations (inspection, listening and smelling, inquiry and palpation) [2]. TKM has advantages, such as one-to-one personalized care accompanying the patient's diagnosis. However, these characteristics are criticized because of the ambiguous process of diagnosis. Different ways of pattern identifications are often used for diagnosis by different Oriental medical clinicians in identical patients [3]. Oriental medical clinicians have claimed that differences exist between Western medicine and TKM in terms of therapy and the objective for treating and diagnosing patients. However, standardized and objective methods for diagnosis in TKM are needed. The Korea Institute of Oriental Medicine (KIOM) has conducted a fundamental study for the standardization and objectification of pattern identification in TKM for stroke (SOPI-Stroke) since 2005 [4-6]. We organized a committee comprised of p
Differential Association of Uncoupling Protein 2 Polymorphisms with Pattern Identification among Korean Stroke Patients: A Diagnostic System in Traditional Korean Medicine
Ji Hye Lim,Mi Mi Ko,Hoyoung Lee,Ho Yeon Go,Tae-Woong Moon,Min Ho Cha,Myeong Soo Lee
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/532078
Abstract: Uncoupling protein 2 (UCP2), a mitochondrial protein present in many organs and cell types, is known to dissipate the proton gradient formed by the electron transport chain. Its function is correlated with predictive parameters, such as obesity, diabetes, and metabolic syndromes. We analyzed the distribution of UCP2 polymorphisms in stroke patients diagnosed with one of the following four stroke subtypes based on the TKM standard pattern identification (PI): Qi-deficiency (QD), Dampness and Phlegm (D&P), Yin-deficiency (YD), and Fire and Heat (F&D). We studied a total of 1,786 stroke patients (397/QD, 645/D&P, 223/YD, and 522/F&D, 586/normal). Genotyping for the G-1957A, G-866A and A55V UCP2 polymorphisms was performed using the TaqMan. G-866A and A55V were significantly associated with the D&P and H&F subtypes. The frequency of subjects with the A allele of G-866A was significantly lower than the frequency of subjects with the GG type. The A55V polymorphism was also shown similar effect with G-866A in the dominant model. In contrast, no SNPs were shown to be associated with the QD or YD subtypes in this study. These results showed that the G-866A and A55V UCP2 polymorphisms may be genetic factors for specific PI types among Korean stroke patients.
Chair-rising and 3-min walk: A simple screening test for functional mobility  [PDF]
Tae-Woong Oh, Izumi Tabata, Jin-Hwan Kim, Tae-Hyun Lee, Tatsuki Naka
Open Journal of Preventive Medicine (OJPM) , 2012, DOI: 10.4236/ojpm.2012.21013
Abstract: Aging induces decrease of locomotor capacity and its decrease is associated with an increased risk of falls. Several lines of evidence indicate that both change in muscle power and aerobic fitness are causative. Mobility tests are usually based on a maximal exercise stress test; however, this test is often difficult and sometimes frightening to older persons. Therefore, the objective of this study was to examine age and gender differences in 3-min walk distance test (3WDT), and time of chair-rising test (CRT) of functional mobility. 153 men and 159 women aged from 20 to 78 years were recruited as subjects of the present study. The body composition measured the height, body mass (BM), body mass index (BMI), lean tissue mass (LTM), and waist circumference (WC). The Functional mobility tests measured the peak oxygen uptake (VO2peak), 3WDT, leg extension strength (LES), and times of CRT. Both in men and women, height and BMI, WC decreased and increased, respectively, with age. Height, BM, LTM, WC in men are higher than in women. We found no correlation between ages and 3WDT in women and a significant, negative correlation in men. All parameters of fitness performance were negatively correlated with age. Both in men and women, all parameters of fitness performance were positively correlated with sex. Both in men and women, VO2peak, 3WDT, and LES decreased with age. All parameters of fitness performance in men are higher than in women. Both in men and women were observed for the correlation between 3WDT and VO2peak, LES and CRT respectively. Although as the correlation coefficient between 3WTD and VO2peak, LES and CRT were low (r = 0.28 - 0.38), an error may occur, this study shows that 3WDT and CRT test can be a feasible method of providing the information for muscle power and aerobic fitness, possibly avoiding the need for a maximal stress test.
Dissociation of Progressive Dopaminergic Neuronal Death and Behavioral Impairments by Bax Deletion in a Mouse Model of Parkinson's Diseases
Tae Woo Kim, Younghye Moon, Kyungjin Kim, Jeong Eun Lee, Hyun Chul Koh, Im Joo Rhyu, Hyun Kim, Woong Sun
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025346
Abstract: Parkinson's disease (PD) is a common, late-onset movement disorder with selective degeneration of dopaminergic (DA) neurons in the substantia nigra (SN). Although the neurotoxin 6-hydroxydopamine (6-OHDA) has been used to induce progressive degeneration of DA neurons in various animal models of PD, the precise molecular pathway and the impact of anti-apoptotic treatment on this neurodegeneration are less understood. Following a striatal injection of 6-OHDA, we observed atrophy and progressive death of DA neurons in wild-type mice. These degenerating DA neurons never exhibited signs of apoptosis (i.e., caspase-3 activation and cytoplasmic release of cytochrome C), but rather show nuclear translocation of apoptosis-inducing factor (AIF), a hallmark of regulated necrosis. However, mice with genetic deletion of the proapoptotic gene Bax (Bax-KO) exhibited a complete absence of 6-OHDA-induced DA neuron death and nuclear translocation of AIF, indicating that 6-OHDA-induced DA neuronal death is mediated by Bax-dependent AIF activation. On the other hand, DA neurons that survived in Bax-KO mice exhibited marked neuronal atrophy, without significant improvement of PD-related behavioral deficits. These findings suggest that anti-apoptotic therapy may not be sufficient for PD treatment, and the prevention of Bax-independent neuronal atrophy may be an important therapeutic target.
Inhibitory Effect of Inflexinol on Nitric Oxide Generation and iNOS Expression via Inhibition of NF- Activation
Jae Woong Lee,Moon Soon Lee,Tae Hun Kim,Hwa Jeong Lee,Seong Su Hong,Young Hee Noh,Bang Yeon Hwang,Jai Seup Ro,Jin Tae Hong
Mediators of Inflammation , 2007, DOI: 10.1155/2007/93148
Abstract: Inflexinol, an ent-kaurane diterpenoid, was isolated from the leaves of Isodon excisus. Many diterpenoids isolated from the genus Isodon (Labiatae) have antitumor and antiinflammatory activities. We investigated the antiinflammatory effect of inflexinol in RAW 264.7 cells and astrocytes. As a result, we found that inflexinol (1, 5, 10 μM) suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) as well as the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells and astrocytes. Consistent with the inhibitory effect on iNOS and COX-2 expression, inflexinol also inhibited transcriptional and DNA binding activity of NF-κB via inhibition of IκB degradation as well as p50 and p65 translocation into nucleus. These results suggest that inflexinol inhibits iNOS and COX-2 expression through inhibition of NF-κB activation, thereby inhibits generation of inflammatory mediators in RAW 264.7 cells and astrocytes, and may be useful for treatment of inflammatory diseases.
Reliability and validity of the Korean standard pattern identification for stroke (K-SPI-Stroke) questionnaire
Byoung-Kab Kang, Tae Yong Park, Tae Woong Moon, Ju Ah Lee, Mi Mi Ko, Jiae Choi, Myeong Soo Lee
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-55
Abstract: Between September 2006 and December 2010, 2,905 patients from 11 Korean medical hospitals were asked to complete the K-SPI-Stroke questionnaire as a part of project ' Fundamental study for the standardization and objectification of pattern identification in traditional Korean medicine for stroke (SOPI-Stroke). Each patient was independently diagnosed by two TKM physicians from the same site according to one of four patterns, as suggested by the Korea Institute of Oriental Medicine: 1) a Qi deficiency pattern, 2) a Dampness-phlegm pattern, 3) a Yin deficiency pattern, or 4) a Fire-heat pattern. We estimated the internal consistency using Cronbach’s α coefficient, the discriminant validity using the means score of patterns, and the predictive validity using the classification accuracy of the K-SPI-Stroke questionnaire.The K-SPI-Stroke questionnaire had satisfactory internal consistency (α?=?0.700) and validity, with significant differences in the mean of scores among the four patterns. The overall classification accuracy of this questionnaire was 65.2 %.These results suggest that the K-SPI-Stroke questionnaire is a reliable and valid instrument for estimating the severity of the four patterns.
Nonlinear Dynamical Friction of a Circular-Orbit Perturber in a Gaseous Medium
Woong-Tae Kim
Physics , 2010, DOI: 10.1088/0004-637X/725/1/1069
Abstract: We use three-dimensional hydrodynamic simulations to investigate the nonlinear gravitational responses of gas to, and the resulting drag forces on, very massive perturbers moving on circular orbits. This work extends our previous studies that explored the cases of low-mass perturbers on circular orbits and massive perturbers on straight-line trajectories. The background medium is assumed to be non-rotating, adiabatic with index 5/3, and uniform with density rho0 and sound speed a0. We model the gravitating perturber using a Plummer sphere with mass Mp and softening radius rs in a uniform circular motion at speed Vp and orbital radius Rp, and run various models with differing R=rs/Rp, Mach=Vp/a0, and B=G*Mp/(a0^2*Rp). A quasi-steady density wake of a supersonic model consists of a hydrostatic envelope surrounding the perturber, an upstream bow shock, and a trailing low-density region. The continuous change in the direction of the perturber motion makes the detached shock distance reduced compared to the linear-trajectory cases, while the orbit-averaged gravity of the perturber gathers the gas toward the center of the orbit, modifying the background preshock density to rho1=(1 + 0.46B)*rho0 depending weakly on Mach. For sufficiently massive perturbers, the presence of a hydrostatic envelope makes the drag force smaller than the prediction of the linear perturbation theory, resulting in F = 4*pi*rho1*(G*Mp/Vp)^2 * (0.7/etaB) for etaB = B/(Mach^2 -1) > 0.1; the drag force for low-mass perturbers with etaB < 0.1 agrees well with the linear prediction. The nonlinear drag force becomes independent of R as long as R < etaB/2, which places an upper limit on the perturber size for accurate evaluation of the drag force in numerical simulations.
Fuzzy Based Assignment Method of Filtering Nodes in Wireless Sensor Networks  [PDF]
Soo Young Moon, Tae Ho Cho
Wireless Sensor Network (WSN) , 2012, DOI: 10.4236/wsn.2012.42006
Abstract: Wireless sensor networks (WSNs) are networked systems that are able to sense various events and report the events to a user to enable appropriate responses. One of security threats to a WSN is false data injection attacks in which an attacker steals some sensor nodes in the network and injects forged event messages into the network through the captured nodes. As a result, the intermediate nodes on the forwarding paths of the false event messages waste their limited energy. Additionally, the network cannot provide the user with correct information. There have been many studies on en-route detection of false event messages for WSNs. Yang et al. proposed the commutative cipher-based en-route filtering scheme (CCEF) which establishes a secure session between a sink node and a cluster head (CH) based on the commutative cipher. In CCEF, each intermediate node on the path between the sink node and the CH receives an event message and verifies the authenticity of the session based on a probability. Due to the probabilistic approach, it is hard to adapt to the change of false traffic ratio in the network and energy inefficiency may occur. We propose a filtering scheme which applies a deterministic approach to assign filtering nodes to a given session. The proposed method consumes less energy than that of CCEF without sacrificing security.
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