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Implementation of New Cell Site in Telecom Sector
Amita Sharma,Monish Gupta
International Journal of Computer Technology and Applications , 2012,
Abstract: This paper revaluates the basic requirements for the installation and implementation of new cell site in telecom sector and will discuss the impact of various physical and environmental conditions on the installation process.
MICROENCAPSULATION: ADVANCEMENTS IN APPLICATIONS
Arsh Chanana,Mahesh Kumar Kataria,Monish Sharma,Ajay Bilandi
International Research Journal of Pharmacy , 2013,
Abstract: Microcapsule is a tiny sphere including core material/internal phase or fill, coated with/surrounded by wall know as shell, coating or membrane. The usual size range of the microcapsule lies between 1 to 1000 μm. The technique is usually applied for targeted drug delivery, protection of the molecule and stability if the core material. Microencapsulation system offers potential advantages over conventional drug delivery systems and also established as unique carrier systems for many pharmaceuticals. This article contains the traditional and the recent pharmaceutical applications of microecapsules. The microcapsules are widely applied in pharmaceutical for Novel drug Delivery System (NDDS), latest formulations, Delivery of DNA Vaccines, Pro Drug Approach, Biodegradable and biocompatible material. Other then pharmaceutical microcapsules are widely used in delivery of probiotic, pesticide industry, food technology, beverages and cell immobilization etc. Although significant advances have been made in the field of microencapsulation, still many challenges need to be rectified during the appropriate selection of core materials, coating materials and process techniques.
PRION PROTEIN AS A PATHOGEN: A REVIEW
Bhupender Kumar Nimiwal,Manish K Jalandhra,Monish Sharma,Prof. Sanjeev Thacker
International Journal of Biomedical and Advance Research , 2012, DOI: 10.7439/ijbar.v3i7.574
Abstract: Prion proteins (PrP) are associated with transmissible spongiform encephalopathies (TSE), which are invariably fatal diseases characterized by loss of motor control, dementia, and paralysis wasting. The a€ protein-onlya€ hypothesis proposes that TSEs are caused by the conversion of a ubiquitous a€ cellular forma€ of PrP (PrPC) into an aggregated a€ scrapie forma€ (PrPSc). According to this model, the prion protein (PrP) would at the same time be target and infectious agent in TSEs, which could explain that this class of diseases can be traced to infectious, inherited, and spontaneous origins. PrPSc
Clinical Implication of Cough CPR in Cardiac Cath Lab
Monish S Rau,Arun Maheshwari
Indian Anaesthetists' Forum , 2013,
Abstract: A 60 year-old-male with inferoposterior ST-elevation myocardial infarction (STEMI) was shifted to cardiac cath lab for primary percutaneous coronary intervention (PCI). Coronary angiography revealed right coronary artery (RCA) dominance with complete occlusion of the RCA in mid vessel. During angioplasty, the patient developed reperfusion induced Bezold Jarisch Reflex (BJR) with profound bradycardia along with decrease in systolic pressure. The patient was asked to cough. The use of cough-CPR maintained the consciousness as the patient was getting syncopal. This report focuses on BJR and cough-CPR specific to interventional cardiology practice within the catheterization laboratory. Awareness of the fact that BJR may develop due to successful restoration of flow which can be managed with cough CPR, atropine and fluids can avoid the administration of vasoconstrictors.
Current status of minimally invasive management of pediatric upper urinary tract calculi
Kolla Surendra,Wadhwa Pankaj,Aron Monish
Journal of Indian Association of Pediatric Surgeons , 2006,
Abstract: The surgical management of pediatric upper urinary tract calculi has evolved from open surgery to minimally invasive techniques. With advancement in instrumentation, endourological procedures are being performed more commonly in children. However, the endourological management of renal and ureteral stones in the pediatric population is considered challenging, owing to the smaller size of the urinary tract. Various minimally invasive techniques that are being applied in the management of pediatric urolithiasis, include shock wave lithitripsy (SWL), percutaneous nephrolithotomy (PCNL), ureterorenoscopy and a combination of these procedures. The role of SWL is well established and is considered the first line of treatment in the management of urinary calculi in pediatric patients. Recent reports have confirmed the safety of PCNL and ureteroscopy in children, although they are not as widely practiced in children as in adults. This article reviews literature published till October 2005, pertaining to the minimally invasive management of pediatric upper urinary tract calculi.
Ex Vivo Fluorescence Molecular Tomography of the Spine
Monish Pimpalkhare,Jin Chen,Vivek Venugopal,Xavier Intes
International Journal of Biomedical Imaging , 2012, DOI: 10.1155/2012/942326
Abstract: We investigated the potential of fluorescence molecular tomography to image ex vivo samples collected from a large animal model, in this case, a dog spine. Wide-field time-gated fluorescence tomography was employed to assess the impact of multiview acquisition, data type, and intrinsic optical properties on the localization and quantification accuracy in imaging a fluorescent inclusion in the intervertebral disk. As expected, the TG data sets, when combining early and late gates, provide significantly better performances than the CW data sets in terms of localization and quantification. Moreover, the use of multiview imaging protocols led to more accurate localization. Additionally, the incorporation of the heterogeneous nature of the tissue in the model to compute the Jacobians led to improved imaging performances. This preliminary imaging study provides a proof of concept of the feasibility of quantitatively imaging complex ex vivo samples nondestructively and with short acquisition times. This work is the first step towards employing optical molecular imaging of the spine to detect and characterize disc degeneration based on targeted fluorescent probes. 1. Introduction Fluorescence molecular tomography (FMT) is an emerging preclinical imaging modality that provides means to retrieve the 3D bio-distribution of a fluorescent marker noninvasively [1, 2]. FMT is a subsurface imaging modality that involves capturing 2D surface measurements and casting an inverse problem to obtain quantitative 3D maps. FMT is based on a forward model of light excitation propagation in diffusive medium and light emission propagation from fluorophores to the detectors on the boundary. Localization and quantification of pathological tissue can be obtained by retrieving the spatially varying fluorophore distribution from the measurements obtained from the excitation and emission wavelengths. One key aspect of FMT is the use of near-infrared (NIR) fluorescence probes, which have been identified to be the most effective for in vivo imaging. In this spectral window, the attenuation of biotissues is minimal, allowing the use of low laser power sources, and hence, no tissue damage even under prolonged illumination. Also, the relatively low absorption properties of the samples at these wavelengths allow to sense minute concentration of the fluorophore. FMT typically offers higher sensitivity compared to other modalities, such as micro CT or micro MRI [3] and is relatively inexpensive. FMT is also capable of imaging various molecular targets using multiple agents with different
Rowell′s Syndrome
Dogra Alka,Minocha Y,Gupta Monish,Capalash Pun
Indian Journal of Dermatology, Venereology and Leprology , 2000,
Abstract: A 65-year old woman presented with long standing history of lupus erythematosus with episodic eruption of erythema mutiforme - like lesions. Immunological investigations revealed positive rheumatoid factor, ANF and histology was consistent with the clinical findings.
Infected Osteoclastoma of the Knee: An Unusual Presentation
O. B. Pattanashetty,B. B. Dayanand,Yogesh Mapari,Monish Bami
Case Reports in Oncological Medicine , 2014, DOI: 10.1155/2014/948536
Abstract: Introduction. Giant cell tumor is a benign or locally aggressive tumor of uncertain origin that appears in mature bone, most commonly in the distal femur, proximal tibia which characteristically extends right up to the subarticular bone plate. Case Report. We report here a 35-year-old female presenting with swelling of the left knee. On examination, the swelling was solitary, about 20?×?15?cm in size with the skin over the swelling stretched and glistening. On the fifth day of hospital stay, the swelling burst open and blood tinged pus started pouring out. X-ray and MRI scan showed a well-defined T2 hyperintense expansile eccentrically located osteolytic lesion involving the metaphyseal region of the proximal tibia and extending into the subarticular space and multiple T1/T2 hypointense septations are noted within the lesion suggestive of osteoclastoma. The patient was counseled regarding the tumor and prognosis and various treatment options. She was treated successfully with above knee amputation. The tissue was sent for histopathology which confirmed osteoclastoma. Conclusion. It is important to recognize giant cell tumors early, so that they can be treated promptly with local measures to prevent morbidity and mortality in young adults. 1. Introduction Giant cell tumor is so named because it contains profusion of multinucleated osteoclast-type giant cells, giving rise to the synonym osteoclastoma. The term osteoclastoma was first used in Great Britain by Stewart in 1922. It is a benign but locally aggressive neoplasm representing approximately 5% of all primary bone tumors. It usually arises in patients in their twenties to forties. The tumor is slightly more common in female. They are typically epiphyseometaphyseal tumors, with the majority involving the distal femur and proximal tibia. The clinical history of a giant cell tumor usually includes pain and limitation of motion because of the tumor’s proximity to the joint space. Swelling occurs late in the course of the giant cell tumor. Patients presenting to the doctor early in the course of the tumor can be treated with local surgery such as thorough curettage and cryosurgery or burring of the cavity with or without phenol installation. The lesional area may then be packed with allograft or polymethyl methacrylate. Such treatment reduces the local recurrence rate to less than 20% and the prognosis is excellent if it does not recur locally [1]. If this tumor is not diagnosed and treated early, it continues to grow in size causing massive local tissue destruction and may get secondarily infected
Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research
Tove Tuntland,Richard Xu Zang,Monish Jain,Keith Hoffmaster
Frontiers in Pharmacology , 2014, DOI: 10.3389/fphar.2014.00174
Abstract: Characterizing the relationship between the pharmacokinetics (PK, concentration vs. time) and pharmacodynamics (PD, effect vs. time) is an important tool in the discovery and development of new drugs in the pharmaceutical industry. The purpose of this publication is to serve as a guide for drug discovery scientists toward optimal design and conduct of PK/PD studies in the research phase. This review is a result of the collaborative efforts of DMPK scientists from various Metabolism and Pharmacokinetic (MAP) departments of the global organization Novartis Institute of Biomedical Research (NIBR). We recommend that PK/PD strategies be implemented in early research phases of drug discovery projects to enable successful transition to drug development. Effective PK/PD study design, analysis, and interpretation can help scientists elucidate the relationship between PK and PD, understand the mechanism of drug action, and identify PK properties for further improvement and optimal compound design. Additionally, PK/PD modeling can help increase the translation of in vitro compound potency to the in vivo setting, reduce the number of in vivo animal studies, and improve translation of findings from preclinical species into the clinical setting. This review focuses on three important elements of successful PK/PD studies, namely partnership among key scientists involved in the study execution; parameters that influence study designs; and data analysis and interpretation. Specific examples and case studies are highlighted to help demonstrate key points for consideration. The intent is to provide a broad PK/PD foundation for colleagues in the pharmaceutical industry and serve as a tool to promote appropriate discussions on early research project teams with key scientists involved in PK/PD studies.
Some Wgh Inequalities for Univalent Harmonic Analytic Functions  [PDF]
Poonam Sharma
Applied Mathematics (AM) , 2010, DOI: 10.4236/am.2010.16061
Abstract: In this paper, some Wgh inequalities for univalent harmonic analytic functions defined by Wright's generalized hypergeometric (Wgh) functions to be in certain classes are observed and proved. Some consequent results are also discussed.
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