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Search Results: 1 - 10 of 223817 matches for " Monica C. Serra "
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Protein and Amino Acid Supplementation Does Not Alter Proteolytic Gene Expression following Immobilization
Jennifer A. Bunn,Thomas W. Buford,Monica C. Serra,Richard B. Kreider,Darryn S. Willoughby
Journal of Nutrition and Metabolism , 2011, DOI: 10.1155/2011/539690
Abstract: Objective. To determine if supplementation of protein and amino acids (PAA) decreases skeletal muscle expression of atrophy-related genes, muscle mass, and strength during immobilization in humans. Methods. Twenty males wore a lower-limb immobilization boot for 28 days and consumed either a PAA supplement (28 g protein) or carbohydrate placebo (28 g maltodextrose), while consuming their normal daily diet. Testing sessions included dietary analysis, lower-leg girth and body composition measurements, strength testing, and gastrocnemius muscle biopsies. Muscle was analyzed for mRNA expression of markers in the ubiquitin and calpain systems, myostatin, TNF-α, and NF-κB. Results. All genes of interest increased over time (<.05), but there was no difference between groups. Lower-leg girth decreased over time (=0.02); however, there were no significant changes in body composition or strength. Conclusion. Short-term lower-limb disuse, despite the absence of significant muscle atrophy, is associated with increases in skeletal muscle gene expression of several proteolysis-related genes. These changes do not appear to be altered by oral PAA supplementation.
Protein and Amino Acid Supplementation Does Not Alter Proteolytic Gene Expression following Immobilization
Jennifer A. Bunn,Thomas W. Buford,Monica C. Serra,Richard B. Kreider,Darryn S. Willoughby
Journal of Nutrition and Metabolism , 2011, DOI: 10.1155/2011/539690
Abstract: Objective. To determine if supplementation of protein and amino acids (PAA) decreases skeletal muscle expression of atrophy-related genes, muscle mass, and strength during immobilization in humans. Methods. Twenty males wore a lower-limb immobilization boot for 28 days and consumed either a PAA supplement (28?g protein) or carbohydrate placebo (28?g maltodextrose), while consuming their normal daily diet. Testing sessions included dietary analysis, lower-leg girth and body composition measurements, strength testing, and gastrocnemius muscle biopsies. Muscle was analyzed for mRNA expression of markers in the ubiquitin and calpain systems, myostatin, TNF-α, and NF-κB. Results. All genes of interest increased over time ( ), but there was no difference between groups. Lower-leg girth decreased over time ( ); however, there were no significant changes in body composition or strength. Conclusion. Short-term lower-limb disuse, despite the absence of significant muscle atrophy, is associated with increases in skeletal muscle gene expression of several proteolysis-related genes. These changes do not appear to be altered by oral PAA supplementation. 1. Introduction Muscle atrophy is characterized by a reduction in muscle protein synthesis or an increase in protein degradation [1–4] that results in decreased fiber diameter, force production, and fatigue resistance [5]. Muscle atrophy is often caused by injury [6], fasting [7–11], disease [12–21], or immobilization [1, 8, 10, 11, 22–27]. In all forms of muscle atrophy, there appears to be a shift in the balance between synthesis and degradation, but during unloading and disuse conditions, the decrease in protein synthesis appears to drive the loss of muscle mass, while the rate of protein degradation remains fairly constant [28, 29]. During limb immobilization, the rate of protein synthesis and degradation is affected by the removal of a mechanical stimulus [30], thereby triggering the ubiquitin proteolytic system (UPS), calcium-activated protease system (CAS), and myostatin to carry out skeletal muscle proteolysis. Protein degradation via the UPS is carried out by the ubiquitin molecule and a series of enzymes (E1, E2, E3) tagging a specific protein for destruction. The protein is then taken into the 26S proteasome where degradation occurs [31, 32]. Calpains mediate skeletal muscle degradation through digestion of individual myofibrillar proteins [33–37] and tend to influence gene expression through the cleavage of specific transcription factors, thereby affecting the UPS [38]. Research regarding myostatin
Impact of Serum Nutritional Status on Physical Function in African American and Caucasian Stroke Survivors
Monica C. Serra,Charlene E. Hafer-Macko,Frederick M. Ivey,Richard F. Macko,Alice S. Ryan
Stroke Research and Treatment , 2014, DOI: 10.1155/2014/174308
Abstract: Background. The purpose of this study is to compare serum nutritional profiles in chronic stroke survivors to a representative sample of US Adults (NHANESIII) and determine whether these serum markers differed by race and impact physical function in stroke. Methods. Fasting serum samples were collected for analysis of lipids, uric acid, and albumin in 145 African American (AA) and 111 Caucasian (C) stroke survivors (age: 60 ± 1 years [mean ± SEM]). A six-minute walk was performed in a subset of stroke survivors (N = 134). Results. Triglycerides were higher and HDL-cholesterol and albumin lower in C than AA women stroke survivors (Ps < 0.05). Uric acid was lower in C than AA stroke survivors (P < 0.05). Compared to NHANESIII, HDL-cholesterol, albumin, and hemoglobin generally were lower (Ps < 0.05) and lipids were more favorable in stroke (Ps < 0.01). Uric acid was related to six-minute walk performance among a subset of stroke survivors (P < 0.05). Conclusion. In stroke, racial differences exist with regard to serum nutritional risk, but these differences are similar to that observed in the general population. Regardless of race, nutritional risk appears elevated above that of the general population with regard to many of the serum markers. As a modifiable biomarker, uric acid should be monitored closely as it may provide insight into the functional risk of stroke survivors. 1. Introduction Both suboptimal or excessive caloric intake and poor dietary quality affect nutritional risk and may hinder recovery from stroke. In as little as six months following discharge from an initial stroke incident, ~41% of survivors are at nutritional risk, based upon patient interviews regarding appetite, digestion, mobility, and swallowing difficulties [1]. Another study shows that 11% of stroke survivors with initial motor deficits and communication impairment still require feeding assistance six months after stroke [2]. Further, we have previously shown that well into the chronic phase of stroke recovery (>6 months), survivors are obese and have greater intramuscular fat relative to muscle area in their affected limb [3], indicating imbalanced dietary intake relative to energy expenditure. While these data suggest that poor caloric intake exists in chronic stroke, little data are currently available regarding diet quality in stroke. Difficulties with speech and cognition may interfere with obtaining accurate dietary records to assess dietary quality in those chronically disabled by stroke. However, several serum biomarkers commonly found on general comprehensive
?Ha disminuido la mortalidad por cáncer vesicular en Chile?
Serra C,Iván;
Revista médica de Chile , 2001, DOI: 10.4067/S0034-98872001000900016
Abstract: this paper analyses the information of the ministry of health on gallbladder cancer mortality in chile since 1997. it becomes evident that the decrease in mortality in the last two years is only apparent and due to a statistical artifact, caused by the non validated application of the tenth international classification of diseases. there is a consensus that one of the causes for an increase in gallbladder cancer in a specific country is a decrease in cholecystectomy rates. this association has been clearly demonstrated in chile, but no control program for gallbladder cancer has been devised, considering that an early cholecystectomy is a good secondary prevention measure (rev méd chile 2001; 129; 1079-84)
Cáncer de mama en Chile: pasado, presente y futuro Breast cancer in Chile: past, present and future
Iván Serra C
Revista Chilena de Cirugía , 2011,
Abstract:
Ha disminuido la mortalidad por cáncer vesicular en Chile? Has gallbladder cancer mortality decreased in Chile?
Iván Serra C
Revista médica de Chile , 2001,
Abstract: This paper analyses the information of the Ministry of Health on gallbladder cancer mortality in Chile since 1997. It becomes evident that the decrease in mortality in the last two years is only apparent and due to a statistical artifact, caused by the non validated application of the Tenth International Classification of Diseases. There is a consensus that one of the causes for an increase in gallbladder cancer in a specific country is a decrease in cholecystectomy rates. This association has been clearly demonstrated in Chile, but no control program for gallbladder cancer has been devised, considering that an early cholecystectomy is a good secondary prevention measure (Rev Méd Chile 2001; 129; 1079-84)
Response by the authors
Uppal Monica,Srinivas C
Indian Journal of Dermatology, Venereology and Leprology , 2005,
Abstract:
Wheat induced urticaria
Uppal Monica,Srinivas C
Indian Journal of Dermatology, Venereology and Leprology , 2004,
Abstract: Wheat is widely consumed all over India in various forms - flour, daliya, maida, suji and wheat bran. Very few cases of wheat induced urticaria have been reported. This may be due to unusual features of wheat related hypersensitivity. A 35 year old female presented to us with history of chronic urticaria and angioedema. History revealed correlation between wheat intake and urticaria episodes. Prick testing was done with wheat antigen in the standard series and derivatives of raw wheat. Normal saline and histamine were used as controls. Prick testing was positive. Oral challenge induced urticaria within half an hour. This report discusses clinical features of wheat related hypersensitivity.
Hepatitis B prevention and control: Lessons from the East and the West
Monica C Robotin
World Journal of Hepatology , 2011,
Abstract: Despite being ten times more common than HIV infection, viral hepatitis has so far not commanded the same public health response worldwide, so a global viral hepatitis treatment program is still a long way from becoming a reality. However, much progress has occurred over the last few decades, with the screening of blood products, sound infection control practices and the introduction of disposable needles and syringes leading to significant reductions in nosocomial hepatitis B transmission in the developed world and increasingly in other countries. The introduction of hepatitis B vaccination in the 1980s and its integration into the Expanded Immunization Program have led to substantial reductions in chronic hepatitis B infection rates in children and to millions of lives saved. The availability of effective antiviral treatment has revolutionized treatment prospects, although access to treatment remains a significant challenge for most developed countries and remains out of reach for developing nations. Some of these breakthroughs have occurred in Asian countries, others in the West, but their unifying features are innovative research, timely clinical translation and a commitment to apply their findings to improve the health of populations, not just individuals. This paper reviews some of the challenges and opportunities for hepatitis B control at the end of the first decade of the third millennium and argues for closer East - West collaborations, to bring in fresh perspectives, avoid duplications of effort and in order to help answer many of the remaining challenges in making hepatitis B history.
Apertura del servizio SBBL
Monica Boccato,C. Merlino
Bollettino del CILEA , 1997, DOI: 10.1472/bc.v58igiugno.906
Abstract: SBBL Sistema Bibliotecario Biomedico Lombardo offre un servizio di reperimento di letteratura scientifica, attraverso banche dati su Internet, ad operatori sanitari delle Lombardia. E' di prossima apertura presso il CILEA il server che ospiterà il software e la banca dati bibliografica preposta a questo servizio.
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