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Search Results: 1 - 10 of 462209 matches for " Moiz A. Siddiqui "
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A Review of Structure Activity Relationship of Amiodarone and Its Derivatives  [PDF]
Moiz A. Siddiqui, Amjad Khan, Mehreen Zaka
Open Journal of Medicinal Chemistry (OJMC) , 2016, DOI: 10.4236/ojmc.2016.62003
Abstract: Structure Activity Relationship forms the basis of Rational Drug Design in the circles of pharmaceutical and medicinal chemistry. Appropriate knowledge of functional outcomes of structural modifications is crucial in conferring desired pharmacological properties to a chemical compound. Amiodarone is a classical antiarrythmic agent with a long list of adverse effects. This article attempts to review the structure activity relationship of some of the homologues of amiodarone in order to determine the most clinically desirable molecule.
NOS3 894G > T Gene Polymorphism: A Potential Risk Factor of Stroke in Bahraini Patients  [PDF]
Manal A. Fadl, Adel A. AlJishi, Safa Taha, Moiz Bakhiet
World Journal of Neuroscience (WJNS) , 2018, DOI: 10.4236/wjns.2018.81009
Abstract: The endothelial nitric oxide synthase (eNOS) encoded by the NOS3 gene is responsible for the synthesis of a vasoactive endothelium-derived nitric oxide (NO). The genetic polymorphism of this gene explains, in part, why some people are prone to develop stroke than others. In this study we conducted a case control study in Bahrainis to investigatefor the first time” the relationship between NOS3 894G > T (rs1799983) and 786T > C (rs2070744) polymorphisms with the stroke predisposition in Bahraini population. Detection of NOS3 polymorphism was performed by PCR RFLP genotyping method. The level of NO among cases and controls was measured using ELISA. A total of 93 unrelated stroke patients and 86 controls were included in the study. The three types of stroke; Ischemic, hemorrhagic and transient ischemic attack were reported (91.4%, 7.5% and 1.1% respectively). No significant gender difference was observed (P = 0.74). Having previous stroke was a highly significant risk factor of the disease (P = 0.001, OR = 1.4), where as a family history of stroke was not (OR = 0.11). The analysis provides evidence that the mutant 894GT + TT genotypes of NOS3 894G > T polymorphism were positively associated with stroke predisposition and it increased the risk of
Blunt Abdominal Trauma Leading to Pancreatic Injury in Childhood. Delay in Diagnosis Leads to Poor Outcomes—A Case Presentation  [PDF]
Zohaib A. Siddiqui, Fahd Husain, Midhat N. Siddiqui
International Journal of Clinical Medicine (IJCM) , 2016, DOI: 10.4236/ijcm.2016.712087
Abstract: This case report illustrates the difficulty in diagnosing paediatric patients with life threatening pancreatic injuries. A high index of suspicion is essential as late diagnosis significantly affects outcomes. A 9-year-old child presented with epigastric pain following an accident on his pushbike. The patient was examined in paediatric accident and emergency (A/E) and was discharged. He returned twice more to A/E and on the third visit, 5 days after the initial incident, a CT scan was performed. This showed a classical injury to the body of the pancreas with a collection in the lesser sac. The patient was transferred to the regional hepato-pancreato-biliary unit (HPB unit) and underwent surgery. Pancreatic injuries can be difficult to detect clinically and patients may be well on initial presentation with normal observations and routine bloods. Early CT scanning confirms the diagnosis and results in early specialist referral and better outcomes.
Role of Monoaminergic System in the Etiology of Olive Oil Induced Antidepressant and Anxiolytic Effects in Rats
Tahira Perveen,Bilal Moiz Hashmi,Saida Haider,Saiqa Tabassum,Sadia Saleem,Munnawar Ahmed Siddiqui
ISRN Pharmacology , 2013, DOI: 10.1155/2013/615685
Abstract: Olive oil is the major component of the Mediterranean diet and has rich history of nutritional and medicinal uses. In the present study, the antidepressant and anxiolytic effects and their neurochemical basis following repeated administration of extravirgin olive oil were monitored. Male albino Wistar rats were used during study. Animals of test group were given olive oil orally at the dose of 0.25?mL/kg daily for 4 weeks. Control rats received equal volume of water. Elevated-plus maze (EPM) test and forced swim test (FST) were performed for the assessment of anxiety and depression like symptoms. An increase in time spent in open arm in EPM and increased struggling time in FST following long-term administration of olive oil indicate that olive oil has anxiolytic and antidepressant properties. Neurochemical results showed that repeated administration of olive oil decreased the levels of brain 5-HT (5-hydroxytryptamine), 5-HIAA (5-hydroxyindoleacetic acid), and levels of DA (dopamine); however, levels of DA metabolite HVA (homovalinic acid) were increased. Hence, present findings suggest that olive oil has neuroprotective effects. It reduces behavioral deficits via altering 5-HT and DA metabolism. So it could be used as a therapeutic substance for the treatment of depression and anxiety. 1. Introduction Olive (Olea europaea) is in the family Oleaceae that is used throughout the world especially in the Mediterranean region. It is full of nutrients and vitamins. Extravirgin olive oil is derived from the first pressing of the olives. It has the most delicate flavor and antioxidant benefits [1]. Olive oil is rich in monounsaturated fatty acids (MUFAs) and has excellent health benefits [2]. Olive oil is composed mainly of mixed triglyceride esters of oleic acid, palmitic acid, and other fatty acids, along with the traces of squalene (up to 0.7%) and sterols (about 0.2%; phytosterol & tocosterols). It also contains group of antioxidants that are esters of tyrosol and hydroxytyrosols, including oleocanthal, oleuropein, vitamin E, and carotenoids. Oleuropein is a chemical that prevents the oxidation of LDL (low density lipoproteins) particles [3]. Evidence from epidemiological studies suggests that a higher proportion of monounsaturated fats in the diet are linked with a reduction in the risk of coronary heart disease [4]. It has been reported that olive oil consumption has favorable effects on cholesterol regulation and LDL cholesterol oxidation and it also exerts antiplatelet [5], anti-inflammatory, antithrombotic, and antihypertensive as well as vasodilatory
Retinal sensitivity in astigmatism and meridional amblyopia
Goel B,Maheshwari R,Moiz A
Indian Journal of Ophthalmology , 1984,
Robust Human Motion Detection and Tracking In Dynamic Background
Moiz A. Hussain,Dr. G. U. Kharat
International Journal of Soft Computing & Engineering , 2013,
Abstract: Background subtraction is very important part ofsurveillance applications for successful segmentation of movingobjects from video sequences. We present a novel & robustalgorithm, for human motion detection and tracking in dynamicscenes based on background modelling technique to analyze theillumination change for detection & tracking of moving objects.Successive frame difference is taken and compared for therequired set threshold for the changing pixel detection.Experimental result shows the high performance of the proposedmethod for human tracking in noisy backgrounds.
Sesamol: A Natural Phenolic Compound with Promising Anticandidal Potential
Moiz A. Ansari,Zeeshan Fatima,Saif Hameed
Journal of Pathogens , 2014, DOI: 10.1155/2014/895193
Abstract: We investigated the antifungal effects of sesamol (Ses), a natural phenolic compound, and exemplified that it could be mediated through disruption of calcineurin signaling pathway in C. albicans, a human fungal pathogen. The repertoire of antifungal activity not only was limited to C. albicans and its six clinical isolates tested but also was against non-albicans species of Candida. Interestingly, the antifungal effect of Ses affects neither the MDR efflux transporter activity nor passive diffusion of drug. We found that C. albicans treated with Ses copies the phenotype displayed by cells having defect in calcineurin signaling leading to sensitivity against alkaline pH, ionic, membrane, salinity, endoplasmic reticulum, and serum stresses but remained resistant to thermal stress. Furthermore, the ergosterol levels were significantly decreased by 63% confirming membrane perturbations in response to Ses as also visualized through transmission electron micrographs. Despite the fact that Ses treatment mimics the phenotype of compromised calcineurin signaling, it was independent of cell wall integrity pathway as revealed by spot assays and the scanning electron micrographs. Taken together, the data procured from this study clearly ascertains that Ses is an effectual antifungal agent that could be competently employed in treating Candida infections. 1. Introduction Candida albicans, an opportunistic human fungal pathogen, is the most common cause of the invasive fungal diseases [1]. It resides normally within the host body but during the immunosuppressed or immunocompromised conditions like AIDS, cancer, and organ transplant; it can cause several diseases such as oral thrush, vulvovaginitis, esophagitis, and cutaneous infections. It is also among the most common causative agents for nosocomial infections in patients who have undergone surgery or organ transplantation, have diabetes, and take excessive antibiotics and are neutropenic [2, 3]. Some of the most common isolates from candidiasis and candidemia are C. albicans, Candida glabrata, Candida krusei, Candida tropicalis, and Candida parapsilosis [4]. Among all Candida species C. albicans is the most prominent causative agent of the diseases [5]. Due to daily augmentation in cases of the patients suffering from the diseases caused by Candida species, it has become unavoidable to find the cure for this evader. Present treatment regime includes several classes of antifungal which are in use to treat the infection caused by the fungal pathogens. For instance azoles, polyenes and allylamines target ergosterol
Performance Analysis of HR Portal Domain Components Extraction
N. Md. Jubair Basha,Salman Abdul Moiz,A. A. Moiz Qyser
Computer Science , 2012,
Abstract: Extraction of components pertaining to a particular domain not only reduces the cost but also helps in delivering a quality product. However, the advantages of the Component Level Interaction's (CLI's) are not clearly presented. In the first part of the paper the design of HR Portal application is described. Later the results are simulated using the Netbeans Profiler tool which exposes and highlights the performance characteristics of component based system pertaining to HR domain.
-Algebras of Topological Stable Rank 1
Akhlaq A. Siddiqui
International Journal of Mathematics and Mathematical Sciences , 2007, DOI: 10.1155/2007/37186
Abstract: In 1976, Kaplansky introduced the class JB*-algebras which includes all C*-algebras as a proper subclass. The notion of topological stable rank 1 for C*-algebras was originally introduced by M. A. Rieffel and was extensively studied by various authors. In this paper, we extend this notion to general JB*-algebras. We show that the complex spin factors are of tsr 1 providing an example of special JBW*-algebras for which the enveloping von Neumann algebras may not be of tsr 1. In the sequel, we prove that every invertible element of a JB*-algebra 𝒥 is positive in certain isotope of 𝒥; if the algebra is finite-dimensional, then it is of tsr 1 and every element of 𝒥 is positive in some unitary isotope of 𝒥. Further, it is established that extreme points of the unit ball sufficiently close to invertible elements in a JB*-algebra must be unitaries and that in any JB*-algebras of tsr 1, all extreme points of the unit ball are unitaries. In the end, we prove the coincidence between the λ-function and λu-function on invertibles in a JB*-algebra.
Objective Structured Clinical Examination: a valid and reliable assessor of clinical competency
A U Siddiqui
International Journal of Students' Research , 2011, DOI: 10.5549/ijsr.1.3.72-75
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