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Search Results: 1 - 10 of 3469 matches for " Mohhamad Hossein Nasr Esfahani "
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Treatment of Recalcitrant Electrical Burn Ulcer with Application of Topical Trichloroacetic Acid and Autologous Cultured Fibroblast
Mohammad Ali Nilforoushzadeh, Mohhamad Hossein Nasr Esfahani, Mehr Afarin Fesharaki, Amir Hossein Siadat and Elaheh HaftBaradaran
Cell & Tissue Transplantation & Therapy , 2012, DOI: 10.4137/CTTT.S3779
Abstract: In this case report, we present a case of deep, partial-thickness, recalcitrant electrical burn ulcer that was healed completely using tissue debridement with topical 50% TCA (Trichloroacetic acid) and application of autologous fibroblasts. To the best of our knowledge, this is the first time that the application of topical TCA along with autologous fibroblasts have been used for the treatment of an electrical burn ulcer with a satisfactory result.
Treatment of atrophic cutaneous leishmaniasis scar using autologous fibroblasts and keratinocytes (a case report and literature review):
Mohammad Ali Nilforoushzadeh,Mohhamad Hossein Nasr Esfahani,Mehr Afarin Fesharaki,Amir Hossein Siadat
Journal of Research in Medical Sciences , 2010,
Abstract: In this case report we present a case of wide, deep, atrophic cutaneous leishmaniasis scar that was improved significantly using injection of autologus fibroblasts, dermabrasion and dressing with autologus keratinocytes and fibroblasts. To our best knowledge, it is the first time that separate cultured fibroblasts and keratinocytes are used in conjunction with dermabrasion for treatment of cutaneous leishmaniasis scar. We have started this procedure as an extensive research on patients with leishmaniasis scar that will be reported in the future.
Silver Doped Nanostructure Composite Photocatalyst Film Synthesized by Sol-Gel Spin and Dip Coating Technique on Glass
Mojtaba Nasr-Esfahani,Mohammad Hossein Habibi
International Journal of Photoenergy , 2008, DOI: 10.1155/2008/628713
Abstract: New composite films (P25SGF-MC-Ag, MPC500SGF-MC-Ag, and ANPSGF-MC-Ag) have been synthesized by a modified sol-gel method using different particle sizes of TiO2 powder and silver addition. Nanostructure TiO2/Ag composite thin films were prepared by a sol-gel spin and dip coating technique. while, by introducing methyl cellulose (MC) porous, TiO2/Ag films were obtained after calcining at a temperature of 500°C. The as-prepared TiO2 and TiO2/Ag films were characterized by X-ray diffractometry, and scanning electron microscopy to reveal the structural and morphological differences. In addition, the photocatalytic properties of these films were investigated by degrading methyl orange (MO) under UV irradiation. After 500°C calcination, the microstructure of MC-TiO2 film without Ag addition exhibited a microstructure, while significant sintering effect was noticed with Ag additions and the films exhibited a porous microstructure. Nanostructure anatase-phase TiO2 can be observed with respect to the sharpening of XRD diffraction peaks. The photodegradation of porous TiO2 deposited with 5×10?4 mol Ag exhibited the best photocatalytic efficiency, where 69% methyl orange can be decomposed after UV exposure for 1 hour.
Origin and Role of DNA Damage in Varicocele
Mohammad Hossein Nasr Esfahani,Marziyeh Tavalaee
International Journal of Fertility & Sterility , 2012,
Abstract: Varicocele is considered as one of the main etiologies of male infertility. Along with altered semenparameters, increased DNA fragmentation is believed to play an important role in varicocele-inducedinfertility. DNA damage may result from intra- or extra-testicular factors. Among these, apoptosis,abnormal chromatin packaging and oxidative stress are the most researched and are addressedin this review. Significant evidence suggests that varicoceles have a harmful effect on testicularfunction and a varicocelectomy not only prevents progressive decline in testicular function, but alsoreverses the damage. However, the degree to which varicocele repair improves pregnancy rates andthe success of assisted reproductive technology (ART) remains controversial. Therefore, the role ofvaricocele repair on DNA fragmentation is also discussed.
Effect of Human Sperm MTT Viability Test on Outcome of Intracytoplasmic Sperm Injection
Roshanak Aboutorabi,Mohammad Hossein Nasr Esfahani,Hossein Baharvand
Cell Journal , 2006,
Abstract: Introduction: The aim of this study was to evaluate the effect of human sperm MTT viability assay on outcome of intracytoplasmic sperm injection. MTT is a tetrazolium salt, routinely used for cell proliferation and cytotoxicity assays. Materials and Methods: 50μl of processed semen was treated with MTT solution, while the remaining used as the control. Meanwhile, 109 donated human oocytes (metaphase II) obtained from 12 patients were divided into two groups. Fifty five oocytes were injected using MTT positive sperms, while 54 oocytes were injected with sperms from the control group. Then the injected oocytes were cultured and observed at 18, 42, 66, 90, and 114 hours pos- ICSI. Finally, the fertilization and embryo development rates were compared in both groups. Results: No significant differences were observed between fertilization and embryo development rates in the MTT and control groups. Conclusion: In future studies after approving that the MTT has not cytotoxic or teratogenic effects, then sperm MTT viability assay might be useful for ICSI in patients with absolute or severe asthenospermia or in patients with highly deformed sperm tails
Photochemical Characterization and Photocatalytic Properties of a Nanostructure Composite Film
Mohammad Hossein Habibi,Mojtaba Nasr Esfahani,Terry A. Egerton
International Journal of Photoenergy , 2007, DOI: 10.1155/2007/13653
Abstract: An efficient and new composite titania film photocatalyst was fabricated by sol-gel technique, using precalcined nanopowder titanium dioxide filler mixed with a sol, spin coating, and heat treatment. The structural and photocatalytic properties of these films were characterized using SEM, XRD, and UV/Vis spectroscopies. Problems of film inhomogenity and defects which caused peeling and cracking during calcination because of film shrinkage were overcome by using methylcellulose (MC) as a dispersant. Composite films heat-treated at approximately 500∘C have the greatest hardness values. Surface morphology of composite deposits by scanning electron microscopy (SEM) showed that the composite films have much rougher surface than films made without MC. Photocatalytic activities of the composites film were evaluated through the degradation of three commercial diazo textile dyes, Light Yellow X6G (C.I. Reactive Yellow 2), Solophenyl red 3BL (C.I. Direct 80), and Tertrodirect light blue R (C.I. Direct blue 71) as a model pollutant.
Effect of PolyVinyl Pyrrolidone on Sperm Membrane Integrity and Chromatin Status
Mohammad Hossein Nasr Esfahani,Shahnaz Razavi,Mohammad Mardani,Roshanak Aboutorabi
International Journal of Fertility & Sterility , 2008,
Abstract: Background: The aim of present study is to evaluate the effect of PolyVinyl Pyrrolidone (PVP)routinly used during ICSI procedure on sperm membrane integrity, and sperm chromatin status.Materials and Methods: This study was carried out on 21 semen samples from the infertile menreferring to Isfahan Fertility and Infertility Center. The processed semen samples were divided intotwo portions. One portion was added to Ham’s F10+ 10% PVP, and the other portion was addedto Ham’s F10 as a control group. Hypo-osmotic swelling test (HOST), SDS, and SDS+EDTA testswere carried out on the control and PVP groups at 15, 30, and 60min.Results: The results show that sperm membrane integrity measured by HOST, and sperm chromatinstability measured by SDS test, reduces by increasing the exposure time to PVP. However, theability of sperm chromatin undergoing decondensation (that has been assessed by SDS+EDTA),does not show any changes by increasing the exposure time to PVP.Conclusion: The results of current study shows that reducing the exposure time of sperm to PVPmay protect sperm membrane, and chromatin integrity.
Can Altered Expression of HSPA2 in Varicocele Patients Lead to Abnormal Spermatogenesis?
Mohammad Hossein Nasr Esfahani,Homayoun Abbasi,Zahra Mirhosseini,Nazem Ghasemi
International Journal of Fertility & Sterility , 2010,
Abstract: Background: Heat shock protein A2 (HSPA2) is correlated with sperm maturity and function.Therefore, dysfunctional expression of this gene results in abnormal spermatogenesis. On the otherhand, DNA damage in spermatozoa is considered to be an important cause of male infertility, andthe presence of sperm with DNA fragmentation and chromatin abnormalities in human ejaculatesis well documented, in particular in men with poor semen quality. Therefore, the aim of this studyis to evaluate HSPA2 expression and its relation with DNA fragmentation, protamine deficiencyinvolved in DNA packaging and semen parameters in varicocele patients in comparison to fertilemen before and after varicocelectomy.Materials and Methods: This study included 52 fertile individuals as the control group and70 infertile individuals with varicocele as the experimental group. Sperm DNA fragmentation,protamine deficiency and relative HSPA2 expression were evaluated by the sperm chromatindispersion test, chromomycin A3 staining and RT-PCR, respectively.Results: The mean values of abnormal morphology, protamine deficiency and DNA fragmentationwere significantly lower in varicocele individuals following varicocelectomy when compared tofertile individuals. The correlation between these parameters were studied and discussed in the text.Conclusion: There is a decrease in relative HSPA2 expression which is possibly due to chronicinduced hyperthermia in varicocele individuals. Removal of this stress increases HSPA2 expressionand results in the proper folding of proteins involved in spermatogenesis; therefore resulting inimproved DNA packaging, as well as better sperm morphology and motility which may indirectlyreduce sperm DNA fragmentation.
Credibility of Chromomycin A3 Staining in Prediction of Fertility
Mohammad Hossein Nasr-Esfahani,Roshanak Aboutorabi,Shahnaz Razavi
International Journal of Fertility & Sterility , 2009,
Abstract: Background: Chromomycin A3 (CMA3) staining has been used to assess protamine deficiency.The aim of this study was to determine credibility of CMA3 along with semen parameters forassessment of fertility potential.Materials and Methods: Semen analysis and CMA3 staining were carried out on 234 fertile and178 subfertile individuals. Semen analysis was assessed according to WHO criteria. Protaminedeficiency was assessed by CMA3 staining.Results: Means, range of variables, coefficients of correlation and receiver operating characteristic(ROC) analyses of semen parameters and protamine deficiency were determined. Mean values ofthree main sperm parameters and the percentage of sperm with negative CMA3 were significantlydifferent between fertile and sub fertile groups. The results of CMA3 assessment showed significantcorrelation with sperm density, percentage of motility and normal morphology in the total population,while in the subfertile group the results of CMA3 showed significant correlation with sperm densityand normal morphology. However in fertile men, the only significant correlation was observedbetween sperm with negative CMA3 and normal morphology. ROC analyses revealed that CMA3staining has a higher potential to predict fertility status, compared to semen parameters.Conclusion: Assessment of protamine deficiency could be considered as one of the complementarytests along with semen analysis for assessment of fertility.
Etiology and Evaluation of Sperm Chromatin Anomalies
Marziyeh Tavalaee,Mohammad Hossein Nasr-Esfahani,Mohammad Reza Deemeh
International Journal of Fertility & Sterility , 2008,
Abstract: Evidence suggests that human sperm chromatin anomalies adversely affect reproductive outcomesand infertile men possess substantially amount of sperm with chromatin anomalies than fertilemen.Routine semen analysis evaluates parameters such as sperm motility and morphology, but doesnot examine the nuclear DNA integrity of spermatozoa. It has been suggested that altered nuclearchromatin structure or damaged DNA in spermatozoa could modify the special cellular functionsof human spermatozoa, and thereby affect the fertility potential. Intra-cytoplasmic sperm injection(ICSI) bypass the barriers to fertilization for such a sperm, then the effect of chromatin anomalies onthe development remains a concern. Therefore, it is essential to develop and use accurate diagnostictests, which may provide better prognostic capabilities than the standard sperm assessments. Thisreview discusses our current understanding of the structure and organization of sperm DNA,the different procedures for assessment of sperm chromatin anomalies including comet assay,Chromomycin A3 (CMA3), sperm chromatin structure assay (SCSA), acridine orange test (AOT),terminal TdT-mediated dUTP-nick-end labelling (TUNEL) assay, aniline blue and sperm chromatindispersion (SCD) test and the impact of chromatin anomalies on reproductive outcome.
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