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匹配条件: “Mohammed Ishaq” ,找到相关结果约5259条。
ACE I/D gene polymorphism in diabetic nephropathy: Clinical implications
M. Kaleemullah Khan,N. Parimala,Mohammed Ishaq,Mohammed Siraj
Journal of Medical and Allied Sciences , 2011,
Abstract: Diabetic nephropathy (DN) is a major microvascular complication accounting for about 30% of End-Stage Renal Disease (ESRD) cases. An insertion/deletion (I/D) polymorphism of the gene encoding angiotensin-I converting enzyme (ACE) is reported to be a candidate gene predisposing to diabetic nephropathy. Accordingly, we investigated the ACE I/D gene polymorphism in 52 Type 2 diabetes mellitus (T2DM) cases suffering from nephropathy as assessed by 24 hrs urinary protein levels. 50 age and sex matched healthy subjects served as controls. ACE I/D genotyping was carried out by polymerase chain reaction (PCR) amplification using allele specific primers. The frequencies of ACE DD, ID and II genotypes in the diabetic nephropathy patients were 38.5% , 50% and 11.5% and in the control subjects, 22%, 38% and 40% respectively. There was an increase of 16.5% in the frequency of DD genotype in the patients compared to controls. The frequency of D allele in the patients was 63% which was found to be statistically significant (p< 0.05, Odds ratio=2.6) compared to 41% in the controls. These results indicate that Type 2 diabetic patients with D allele (those with DD & ID genotypes) have more than two fold risk of developing nephropathy. Clinical implications of ACE genotyping in planning for patient’s management have been discussed.
Phenolic Acids and Flavonoids Profiles of Some Turkish Honeydew and Floral Honeys
Mohammed Ishaq Haroun,Ender S. Poyrazoglu,Nevzat Konar,Nevzat Artik
Journal of Food Technology , 2013, DOI: 10.3923/jftech.2012.39.45
Abstract: To characterize honeys of different botanical origin produced in Turkey, phenolic acids and flavonoids profiles were identified by HPLC. Phenolic acids such as caffeic and p-coumaric and flavonoids such as pinocembrin and chrysin were detected in all the samples of this study. All the honeydew (pine and oak) honeys contained protocatechuic acid at significant concentrations. In contrast, almost all the floral honey samples were devoid of protocatechuic acid. Hence, this compound could be botanical marker of honeydew honeys. The oak honey contained significant concentration of ellagic acid (336.8 μg/100 g). Therefore, this honeydew could be differentiated from pine honeydews by ellagic acid. On the other hand, the flavonoid kaempferol which was never detected in the honeydew honeys used in this study was detected in many floral honeys such as cotton, yayla and multifloral. Therefore, kaempferol could be a marker for some floral types of honeys. Most of the cotton honey samples contained a flavonoid called as quercetin. But they were devoid of syringic and ferulic acids. The methyl syringate was detected in highest amounts in most of the multifloral honeys and in significant concentrations in yayla honeys. The sunflower honeys were inconsistent in phenolic compounds profile. Most of the sunflower honey samples were contained quercetin. One of sunflower (Sample code: SFH09) honey samples contained myricetin in significant amount (85.2 μg/100 g).
M. Praveen Kumar,B. Mohammed Ishaq,J. Ravi Kumar Reddy,R. Pradeep Kumar
International Research Journal of Pharmacy , 2011,
Abstract: Targeting of drugs to the colon by the oral route could be achieved by different approaches including matrix and coated systems, for which the drug release is controlled by the gastrointestinal pH, transit times and intestinal flora. The method by which the drug release will be triggered by the colonic flora appears to be more interesting with regard to the selectivity. Metronidazole is only used antibiotics which can be used in colonic diseases. Matrix tablets were prepared by mixtures of Pectin and Guar gum, in which Metronidazole was selected as model drug. Six Matrix (F-I to VI) and coated (F VII to XII) tablet formulations of Metronidazole were prepared by different mixtures of pectin and guar gum then coated with Eudragit RS 100, for coated tablets. The results of drug release studies, performed according to the USP paddle method by using 0.1N hydrochloric acid for 2 hrs, pH 7.4 phosphate buffer for 3 hrs and pH 6.8 phosphate buffer for 24 hrs. And In vitro dissolution study for metronidazole tablets in Rat cecal content were performed. Matrix tablets of guar gum with metronidazole in the ratio of 1:1, 1:2 and 1:3 shows percent drug release after 24 hrs as 83%, 63% and 55% respectively. Pectin in the ratio of 1:1, 1:2 and 1:3 shows percent drug release after 24 hrs as 100%, 95% and 82% respectively. Coated tablets of guar gum with metronidazole in the ratio the ratio of 1:1, 1:2 and 1:3 shows percent drug release after 24 hrs as 96%, 60% and 52% respectively. Pectin in the ratio of 1:1, 1:2 and 1:3 shows percent drug release after 24 hrs as 97%, 99% and 95% respectively. All these batches in first two hours i.e. pH 1.2 hydrochloric acid shows very neglible release, then it showed slight increase in pH 7.4 Phosphate Buffer. Drug release up to 5 hours but it showed high and fast increase in drug release from 6th hour in pH 6.8 Phosphate buffer, as it enters in colonic pH. So natural polymers are most cheap and suitable for colonic drug delivery.
N. V. Mahipal Reddy,B. Mohammed Ishaq,V. S. Thiruvengada Rajan,C. Gopinath
International Research Journal of Pharmacy , 2013, DOI: 10.7897/2230-8407.04329
Abstract: Metaxalone, a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains and othermusculoskeletal conditions. A simple, accurate, precise, reproducible, highly sensitive, economic UV spectrophotometric method has been developed for the estimation of metaxalon in bulk and tablet dosage form. In this method metaxalon showed maximum absorbance at 280 nm in methanol. The developed spectrophotometric method was validated in accordance with ICH guidelines. Linearity of the method was found to be 5 - 160μg/ml. The method obeyed Beer’s law in the concentration range of 5 -160 μg/ml. The LOD and LOQ were found to be 3.489μg/ml and 10.575μg/ml respectively. A mean recovery of metaxalon in tablet dosage form was found to be 99.69%.the method was found to be simple, accurate, precise, specific, sensitive, reproducible and can be directly and easily applied to tablet dosage form.
Ishaq Ahmed
The Professional Medical Journal , 1999,
Abstract: Secxia and cavina1 have divided the risk factors for carcinoma gallbladder into three main groups: local,systemic and genetic.
Electroproduction of K* mesons at CLAS
Ishaq Hleiqawi
Physics , 2004, DOI: 10.1016/j.nuclphysa.2005.03.017
Abstract: The electroproduction of K$^{*0}$ mesons using the CLAS detector is described. Data for two electron beam energies, 4.056 and 4.247 GeV, were measured and the normalized yields are compared.
Lexsegment ideals are sequentially Cohen-Macaulay
Muhammad Ishaq
Mathematics , 2010,
Abstract: The associated primes of an arbitrary lexsegment ideal $I\subset S=K[x_1,...,x_n]$ are determined. As application it is shown that $S/I$ is a pretty clean module, therefore, $S/I$ is sequentially Cohen-Macaulay and satisfies Stanley's conjecture.
Values and bounds of the Stanley depth
Muhammad Ishaq
Mathematics , 2010,
Abstract: We give different bounds for the Stanley depth of a monomial ideal $I$ of a polynomial algebra $S$ over a field $K$. For example we show that the Stanley depth of $I$ is less or equal with the Stanley depth of any prime ideal associated to $S/I$. Also we show that the Stanley conjecture holds for $I$ and $S/I$ when the associated prime ideals of $S/I$ are generated by disjoint sets of variables.
Upper bounds for the Stanley depth
Muhammad Ishaq
Mathematics , 2010,
Abstract: Let $I\subset J$ be monomial ideals of a polynomial algebra $S$ over a field. Then the Stanley depth of $J/I$ is smaller or equal with the Stanley depth of $\sqrt{J}/\sqrt{I}$. We give also an upper bound for the Stanley depth of the intersection of two primary monomial ideals $Q$, $Q'$, which is reached if $Q$, $Q'$ are irreducible, ht$(Q+Q')$ is odd and $\sqrt{Q}$, $\sqrt{Q'}$ have no common variable.
Monomial ideals of minimal depth and trivial modifications
Muhammad Ishaq
Mathematics , 2012,
Abstract: Let $S$ be a polynomial algebra over a field. We study classes of monomial ideals (as for example lexsegment ideals) of $S$ having minimal depth. In particular, Stanley's conjecture holds for these ideals. Also we show that if Stanley's conjecture holds for a square free monomial ideal then it holds for all its trivial modifications.

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