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The Relationship between Lipid Profile and Erectile Dysfunction
Mohammadreza Nikoobakht,Maziar Pourkasmaee,Hamidreza Nasseh
Urology Journal , 2005,
Abstract: Purpose: To evaluate the relationship between serum lipids including cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride and erectile dysfunction (ED). Materials and Methods: From January 2000 to June 2003, 100 patients with organic ED, who were referred to our center, were selected and their lipid profile (Cholesterol, Triglyceride, HDL, LDL) were assessed. The results were compared with those in 100 healthy individuals. Results: Mean age of men in the study and control groups were 43.72 ± 9.76 and 43.59 ± 10.51 years, respectively. Mean plasma cholesterol and LDL levels in individuals suffering from erectile dysfunction were significantly higher than controls (P = 0.04 and P = 0.02, respectively). However, no difference in the mean plasma triglyceride and HDL levels was seen. Odds Ratios for high plasma cholesterol level (> 240 mg/dl) and high plasma LDL level (> 160 mg/dl) were 1.74 and 1.97, respectively (r2 = 0.04 and r2 = 0.04). Using linear regression analysis, the regression coefficient for cholesterol and LDL versus the International Index of Erectile Dysfunction Questionnaire (IIEF) score were -0.036 and -0.035, respectively (95% confidence interval: 0.98 - 2.5 for cholesterol and 1.13 - 2.81 for LDL). Conclusion: The impact of total cholesterol and particularly LDL on men’s erectile function underlines the role of hyperlipidemia treatment in prevention of ED and emerges a holistic management in ED patients.
Seminal Plasma Magnesium and Premature Ejaculation: a Case-Control Study
Mohammadreza Nikoobakht,Mehdi Aloosh,Mohammad Hasani
Urology Journal , 2005,
Abstract: Introduction: Our aim was to determine the relationship between genuine premature ejaculation and serum and seminal plasma magnesium. Materials and Methods: In a case-control study carried out between January 2002 and December 2003, 19 patients with premature ejaculation were evaluated and compared with 19 patients without premature ejaculation. Patients with organic and psychogenic causes were excluded. Seminal plasma and serum magnesium levels were measured using atomic absorption spectrophotometery. Results: Seminal plasma magnesium levels in study patients (94.73 ± 10.87 mg/L) were significantly lower than they were in controls (116.68 ± 11.63 mg/L, P < 0.001), but there were no such differences regarding serum magnesium levels (study patients, 20.26 ± 2.66 mg/L; controls, 20.73 ± 2.80 mg/L). Semen–to–serum-magnesium ratio was significantly lower in patients with premature ejaculation (P < 0.001). Also, a reverse relationship between body mass index and genuine premature ejaculation was found (P = 0.027).Conclusion: Genuine premature ejaculation has a significant relationship with decreased levels of seminal plasma magnesium. Further studies are needed to clarify the actual role of magnesium in the physiology of the male reproductive tract, especially its association with premature ejaculation.
Preoperative Corporal Biopsy as a Predictor of Postoperative Results in Venoocclusive Erectile Dysfunction
Mohammadreza Nikoobakht,Ali Saraji,Alimohammad Meysamie
Urology Journal , 2005,
Abstract: Introduction: Our aim was to investigate the association of corporeal cavernosal pathology with venoocclusive erectile dysfunction (ED) and whether preoperative corporeal biopsy can help predict postoperative results. Materials and Methods: A total of 36 patients with venoocclusive ED underwent corporeal cavernosal biopsy and venous ligation. Preoperative assessment included complete physical examination, international index of erectile dysfunction (IIEF) scoring, nocturnal penile tumescence, penile Doppler ultrasonography, cavernosography, and, if needed, cavernosometry. Three months after surgery, all patient parameters were reevaluated and compared with the preoperative results. Biopsy results of 43 patients with penile fracture were used for controls. Results: The mean follow-up was 49.0 ± 24.1 months. The mean age of the patients with ED was 32.1 ± 8.6 years. Venous leakage was clearly revealed by cavernosography in all patients, preoperatively. The IIEF score and peak systolic velocity of the cavernosal artery in the patients did not differ postoperatively. The mean end diastolic velocity (EDV), however, decreased from 11.0 cm/s to 5.1 cm/s (P = .023). Only 2 patients had satisfactory penile rigidity after venous ligation, 2 were helped by intracorporeal injection to achieve full rigidity, and 1 used oral sildenafil to achieve full rigidity. Pathologically, 23 patients had a slight decrease of cavernosal smooth muscle cells, while in 9 patients, the cavernosal smooth muscles were markedly decreased and replaced by collagen fibers. Four patients had normal histologies, and all responded either partially or completely to surgical therapy. In the control group, 41 of 43 patients had a normal histologies, and 2 had a slight decrease of smooth muscle cell mass. Conclusion: Decreased cavernosal smooth muscle mass may impair erectile function. Its association with venoocclusive ED may be a poor prognostic factor of the outcome of surgical therapy. For the preoperative evaluation of patients, we propose cavernosal biopsy.
Improvement of Erectile Dysfunction after Kidney Transplantation: the Role of the Associated Factors
Abdolrasoul Mehrsai,Shahram Mousavi,Mohammadreza Nikoobakht,Tina Khanlarpoor
Urology Journal , 2006,
Sexual Dysfunction in Epileptic Men
Mohammadreza Nikoobakht,Mahmood Motamedi,Amirhossein Orandi,Alipasha Meysamie
Urology Journal , 2007,
Abstract: Introduction: The aim of this study was to evaluate the frequency of sexual dysfunction among epileptic patients. Materials and Methods: Eighty married men between 22 and 50 years with a confirmed diagnosis of epilepsy were enrolled in this study. Patients with other neurological diseases, hypertension, cardiovascular diseases, diabetes mellitus, underlying urogenital diseases, and impaired general health status were excluded. Furthermore, those with mental health problems were identified by the standardized General Health Questionnaire-28 and were excluded. Demographic and clinical characteristics of the disease were evaluated, and sexual function was assessed by the self-administered questionnaire of the International Index of Erectile Function-15 (IIEF-15). Results: Of 80 patients, 34 (42.5%) had erectile dysfunction. There were no differences between the patients in the 3 age groups in the IIEF scores. Type of seizure had a significant correlation with erectile function score (P = .008). None of the IIEF domains scores were different between the patients with controlled epilepsy and those with uncontrolled epilepsy during the previous 6 months. However, frequency of epileptic seizures (before treatment) correlated with the scores for erectile function (r = 0.31; P = .005), orgasmic function (r = 0.23; P = .04), and sexual desire (r = 0.24; P = .03). Conclusion: It seems that the main aspects of sexual activity such as erectile function, orgasmic function, and sexual desire are frequently impaired in epileptic patients. Our findings were also indicative of a higher risk of sexual dysfunction in patients with partial seizures.
A Giant Congenital Posterior Urethral Diverticulum Associated with Renal Dysplasia
Shahram Mousavi,Abdolrasoul Mehrsai,Mohammadreza Nikoobakht,Amir Reza Abedi
Urology Journal , 2006,
Urethroscopic Management of Iatrogenic Urethral Injuries
M.R Nikoobakht
Tehran University Medical Journal , 2005,
Abstract: Background: This study was conducted to evaluate results of urethroscopic management of iatrogenic urethral injuries due to gynecological operations. Materials and Methods: From November 2001 till November 2003, 12 iatrogenic urethral injuries which were managed with mean time 12 hours (Range= 6-72) after gynecological operations were included in this study. 3 months after urethroscopy and distending, patients were evaluated with IVP. Mean time of clinical follow up was 12 months (range= 4-29). Results: 7 patients with urethral stricture were found and considering fluoroscopy guided urethral dilatation with balloon in 2 of them, urethroscopy and distending was successful in 6 patients (85/7%). In 5 patients with complete dissection of urethra, urethroscopy and distending was successful only in 1 of them (20%). All patients were discharged after 24 hours and in follow up IVP after 3 months. Results were satisfactory in 6 of 7 patients. One of patients needed re-distending due to stricture. Conclusion: Urethroscopic approach as first step in management of iatrogenic urethral injuries seems reasonable and cost benefit, specially in ligating lesions.
Diffuse Myelitis after Treatment of Cerebral Aspergillosis in an Immune Competent Patient
Reza Mollahoseini,Mahdi Nikoobakht
Acta Medica Iranica , 2011,
Abstract: Presentation of an unusual case of cerebral aspergillosis in an immune competent patient who was treated successfully but symptoms and signs of a demyelinating process following initial recovery has been occurred. A 29-year-old male with focal seizure. Brain MRI revealed small multiple hemispheric and dural lesions. An open biopsy was conducted. Histological evaluation revealed hyphe-like structure in the necrotic area, within vessel walls, and lumina, suggestive aspergillus fumigatus . Furthermore, brancheal hyphae in potassium hydrxide15% and colonies on sabourud dextrose agar were observed. Based of the above findings the patient underwent anti fungal therapy. The patient recovered and continued a normal life however a follow up MRI was performed after 3 months from recovery. No significant abnormality was observed from the MRI procedure. One month later the patient developed signs and symptoms of spinal cord involvement which seemed to be the result of myelitis. A brain MR showed no abnormalities .Therefore it seemed reasonable to administer corticosteroid as a treatment for suspected active demyelinating process. During the above treatment, signs and symptoms of myelopathy disappeared and a whole spine MRI showed remarkable improvement.
Managing prolactinoma during pregnancy
Maziar Azar,Mehdi Nikoobakht
Journal of Family and Reproductive Health , 2010,
Abstract: Objective:Prolactinomas are the most common pituitary tumors in pregnant women. We conducted this study on pregnant women with prolactinoma to determine their clinical symptoms and signs and eventual necessity to medical therapy."nMaterials and methods:A descriptive study was performed on 85 pregnant women with prolactinoma.Patients were followed up by physical examination, imaging, and perimetry for diagnosis of visual field defect. If tumor was increased in size perimetry was performedin order to determine eventual visual field defect (VFD). Patients with progressive visual field defect had absolute indication for trans sphenoidal surgery (TSS).In other cases with progressive enlargement of adenoma size but without VFD bromocriptine was administered. Patients without increasing adenoma size were just followed up."nResults:In this study 72 patients (84%) had microadenomas, 7 patients (8%) had macroadenomas without previous medical or surgical therapy and 6 patients (7%) had macroadenomas with previous medical therapy with bromocriptine. Totally 20 patients (23 %) had tumor enlargement during pregnancy and was symptomatic in 7 patients (8.2%). There was significant difference between 3 groups according to incidence of symptomatic tumor enlargement.(p<0.05)Conclusion:Macroprolactinomas are more likely to enlarge during pregnancy than microprolactinomas. In our study conservative management was successfully done in all patients without surgery or medical therapy.
Side effects of herbal drugs used in dermatologic disorders  [PDF]
Gita Faghihi, Mohammadreza Radan
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2011, DOI: 10.4236/jcdsa.2011.11001
Abstract: Because of the awareness of the environmental damage caused by industrialization, a trend has developed to use products with natural ingredients. Herbal products have been used for the treatment of disease, most commonly in the last century. As herbal supplements become more popular, several adverse side effects have been reported in users who also take other medications. In dermatology ,many botanicals are used especially with regard to cosmetic benefits of natural topical products on skin aging process,so dermatologists should face with higher side effects of these types of drugs.The most common presentation of topical aromatherapy side effects are contact dermatitis and the second in order will be contact urticarial reactions.
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