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Search Results: 1 - 10 of 13478 matches for " Mohammad Soltany-Rezaee-Rad "
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Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy
Mohammad Soltany-Rezaee-Rad,Negar Mottaghi-Dastjerdi,Neda Setayesh,Gholamreza Roshandel,Farzaneh Ebrahimifard,Zargham Sepehrizadeh
Gastroenterology Research and Practice , 2014, DOI: 10.1155/2014/185035
Abstract: To find genes involved in tumorigenesis and the development of esophageal cancer, the suppression subtractive hybridization (SSH) method was used to identify genes that are overexpressed in esophageal cancer tissues compared to normal esophageal tissues. In our SSH library, the forkhead box O3 (FOXO3), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and myeloid differentiation primary response 88 (MYD88) genes were the most highly upregulated genes, and they were selected for further studies because of their potential role in the induction of autophagy. Upregulation of these genes was also observed in clinical samples using qRT-PCR. In addition, coexpression analysis of the autophagy-related genes Beclin1, ATG12, Gabarapl, PIK3C3, and LC3 demonstrated a significant correlation between the differentially overexpressed genes and autophagy. Autophagy is an important mechanism in tumorigenesis and the development of chemoresistance in cancer cells. The upregulation of FOXO3, GAPDH, and MYD88 variants in esophageal cancer suggests a role for autophagy and provides new insight into the biology of esophageal cancer. We propose that FOXO3, GAPDH, and MYD88 are novel targets for combating autophagy in esophageal cancer. 1. Introduction Esophageal cancer is one of the most aggressive and life-threatening types of carcinoma in developing countries, and it has a high incidence rate in some geographical regions, particularly in the “Asian esophageal cancer belt,” which extends from the Caspian Littoral in Iran, Turkmenistan, Uzbekistan, and Kazakhstan to the northern provinces of China [1]. Esophageal cancer is among the top 10 causes of cancer-related deaths worldwide [2]. Although some altered oncogenes and tumor suppressor genes have been identified in esophageal cancer (e.g., p53 deletion, p21 alteration, and amplification of CCND1 and c-myc), the fundamental molecular mechanisms leading to esophageal cancer remain unknown [3–6]. The identification of genes that are differentially expressed in esophageal cancer cells allows for the identification of new biomarkers and therapeutic target genes. In addition, this strategy could lead to an improved understanding of the molecular biology and mechanisms of carcinogenesis in esophageal cancer. In contrast to apoptosis, autophagy is primarily a cell survival process; thus, autophagy has been considered an important mechanism in chemoresistance and is known as a survival factor for tumor cells in the early stages of tumorigenesis [7–10]. In this study, suppression subtractive hybridization (SSH) was used to identify
Traumatic posterior urethral fistula to hip joint following gunshot injury: a case report
Ahmad Rezaee, Behzad Narouie, Rahim Haji-Rajabi, Mohammad Ghasemi-rad, Abdolsamad Shikhzadeh
Journal of Medical Case Reports , 2009, DOI: 10.1186/1752-1947-3-133
Abstract: A 37-year-old Iranian Balochi male was shot with a firearm in the superior part of his right pelvis. He underwent primary closure on the same day. Ten months later, he developed urinary retention. He underwent retrograde urethrography and antegrade cystography which showed a stricture measuring 5 cm in length. There was also a history of progressive pain in the right hip joint accompanied by low grade fever which started 2 months after the initial injury. Hip X-ray showed evidence of an acetabular cavity and femoral head destruction diagnostic of complicated septic arthritis. The patient subsequently underwent reconstructive surgery for the urethral stricture and urethral fistula via a transperineal approach followed by total hip arthroplasty.Hip joint contamination with urine following a urethro-acetabular fistula can lead to severe and disabling complications such as septic arthritis. We recommend that every clinician should keep these fistulas in mind as a complication of penetrating urethral injury and every attempt should be made for their early diagnosis and prompt treatment.Urethral injuries are uncommon and occur most often in men. The membranous urethra which passes through the pelvic floor and voluntary urinary sphincter are the portion of posterior urethra most likely to be injured [1].Blunt trauma of the posterior urethra accounts for 90% of urethral injuries while penetrating injuries are extremely rare [1]. The physical findings for penetrating urethral trauma are the same as those found in blunt urethral trauma, i.e. high riding prostate, blood at the urethral meatus, bladder distension, inability to void, gross hematuria, scrotal, perineal, or penile hematoma, and difficulty passing Foley's catheter [2]. The late complications of posterior urethral injury are bleeding, urinary extravasation, pelvic abscess, and destruction of the posterior urethra, urinary diversion, urethral fistulas and urethral stricture [2]. Peri-urethral or perivesical urinary e
A primary carcinoid tumor of the breast
Setare Soltany,Mohammad Faranoush
Koomesh , 2009,
Abstract: Carcinoids are the most common neuroendocrine tumors, which arise commonly in thegastrointestinal or respiratory tract. Breast carcinoid is rare and may be primary or metastatic. Primarybreast carcinoids account for <1% of primary breast cancer and can be mistaken with other primarybreast cancer. Immunohistochemical analysis can be useful in diagnosis. Here we reported a 78 yearsold women with right breast mass. Mass resected and patient worked up for extramammary origin.Finally primary breast carcinoid tumor was diagnosed for the patient and modified radical mastectomyand axillary node dissection performed. No adjuvant therapy was used. .
A Context-Aware Approach for the Spatial Data Infrastructure Portal  [PDF]
Zahra Rezaee, Mohammad Reza Malek
International Journal of Geosciences (IJG) , 2015, DOI: 10.4236/ijg.2015.61006
Abstract: The infrastructure of most of the practical and construction activity in communities is based on correct understanding and proper use of spatial data in GIS1and SDI2. Optimal and efficient use of infrastructure systems of the spatial data by users, depends on how to search and access of user to proper and desired data among informative sources of various organizations. Search operation and access of users to various information of multiple sources located on Spatial Data Infrastructure Network is confusing and time-consuming due to diversity and relatively high volume of spatial information. Because there are numerous classes and subclasses of various complications on the pattern of SDI, unaware user to the pattern may be confused in select displaying the proper spatial layer. In optimum condition, the user should have access to the appropriate data type based on his status and task and environmental conditions. Making intelligent Graphical User Interface by inference based on task information user and his expertise, the appropriate information and consistent with conditions will be achieved. Selecting and displaying of spatial layers related to the technical-organizational approach of system user provides him special assistance both in terms of filtering the irrelevant data and speed of operation in access optimal information than non-selective displaying state. For this purpose, designing and employment context-aware techniques in servicing user interface of system based on recognition of the technical expertise of the user can be a good solution in data adaptive displaying and context-aware servicing to users.
Endoscopic Resection of Lower Ureter in Upper Urinary Tract Tumors
Mohammad Ali Mohammadzadeh Rezaee
Urology Journal , 2004,
Abstract: Purpose: To evaluate the efficacy and safety of endoscopic resection of lower ureter in upper urinary tract tumor cases. Materials and Methods: Five patients with transitional cell carcinoma (TCC) of the upper urinary tract were enrolled in this study. Nephrectomy was carried out through a flank incision and distal ureter with a cuff of bladder, which was removed using endoscopic approach. Complications and recurrence rate were evaluated. Results: A total of 5 patients with upper urinary tract tumor underwent the endoscopic resection of lower ureter. All the patients had grade I transitional cell tumor. Two patients had suffered from bladder TCC treated previously. During the follow-up two cases developed bladder tumor: one, 18 months and another, one year postoperatively, both in the base of bladder, which was managed successfully by transurethral resection (TUR). Conclusion: Endoscopic resection of lower ureter in selected patients with upper urinary tract tumors can lead to lower morbidity, shorter operation time, and higher patient's satisfaction. Despite the minority of cases in this study, it seems that this method is applicable in selected cases.
Lifetime Optimization via Network Sectoring in Cooperative Wireless Sensor Networks  [PDF]
Hadi Jamali Rad, Bahman Abolhassani, Mohammad Abdizadeh
Wireless Sensor Network (WSN) , 2010, DOI: 10.4236/wsn.2010.212108
Abstract: Employing cooperative communication in multihop wireless sensor networks provides the network with significant energy efficiency. However, the lifetime of such a network is directly dependant upon the lifetime of each of its individual sections (or clusters). Ignoring the fact that those sections close to sink have to forward more data (their own data plus the data received from the previous sections) and hence die sooner with considering equal section sizes, leads to a sub-optimal lifetime. In this paper, we optimize the section sizes of a multihop cooperative WSN so that it maximizes the network lifetime. Simulation results demonstrate a significant lifetime enhancement for the proposed optimal sectoring.
On an M/G/1 Queueing Model with k-Phase Optional Services and Bernoulli Feedback  [PDF]
Sayeedeh Abdollahi, Mohammad Reza Salehi Rad
Journal of Service Science and Management (JSSM) , 2012, DOI: 10.4236/jssm.2012.53033
Abstract: In this article an M/G/1 queueing model with single server, Poisson input, k-phases of heterogeneous services and Bernoulli feedback design has been considered. For this model, we derive the steady-state probability generating function (PGF) of queue size at the random epoch and at the service completion epoch. Then, we derive the Laplace-Stieltjes Transform (LST) of the distribution of response time, the means of response time, number of customers in the system and busy period.
COCM: Class Based Optimized Congestion Management Protocol for Healthcare Wireless Sensor Networks  [PDF]
Abbas Ali Rezaee, Mohammad Hossein Yaghmaee, Amir Masoud Rahmani
Wireless Sensor Network (WSN) , 2013, DOI: 10.4236/wsn.2013.57017

Wireless Sensor Networks (WSNs) consist of numerous sensor nodes which can be used in many new emerging applications like healthcare. One of the major challenges in healthcare environments is to manage congestion, because in applications, such as medical emergencies or patients remote monitoring, transmitted data is important and critical. So it is essential in the first place to avoid congestion as much as possible and in cases when congestion avoidance is not possible, to control the congestion. In this paper, a class based congestion management protocol has been proposed for healthcare applications. We distinguish between sensitive, non-sensitive and control traffics, and service the input traffics based on their priority and quality of service requirements (QoS). The proposed protocol which is called COCM avoids congestion in the first step using multipath routing. The proposed AQM algorithm uses separate virtual queue's condition on a single physical queue to accept or drop the incoming packets. In cases where input traffic rate increases and congestion cannot be avoided, it mitigates congestion by using an optimized congestion control algorithm. This paper deals with parameters like end to end delay, packet loss, energy consumption, lifetime and fairness which are important in healthcare applications. The performance of COCM was evaluated using the OPNET simulator. Simulation results indicated that COCM achieves its goals.

Comparison of the influence of oral and rectal acetaminophen on level of pain relief after circumcision
Setareh Soltany,Mohammad Foroozeshfard,Jafar Alavy Toussy,Afsaneh Ghaumi
Koomesh , 2008,
Abstract: Introduction: Postoperative pain is a major problem in day-care pediatric surgery andacetaminophen is a common drug, which is used for pain control in infants. The aim of this study wasto compare the effect of oral and rectal acetaminophen and also to evaluate the effect of loading singledose of rectal acetaminophen before surgery in pain relief after circumcision.Material & Methods: In a randomized clinical trial, 45 children (3 to 6 years old) were divided into3 groups before circumcision. The first group was received rectal acetaminophen (40 mg/kg) beforeand oral acetaminophen (15 mg/kg/qid) after circumcision. The second group was given rectal and thethird group received oral acetaminophen (both 15 mg/kg/qid) after circumcision. Pain scores wasmeasured every three hours and the amount of sleep hours in the first 24-hours after circumcision.Results: In the study, pain scores and amount of sleep hours in the first group were significantlylower and higher than other groups. There was no significant difference in pain scores between othergroups (second and third) but the amount of sleep hours was higher in second group.Conclusion: Efficacy of oral and rectal acetaminophen (15 mg/kg/qid) was similar in pain reliefafter circumcision but rectal acetaminophen had more sedative effect .In addition, the high dose ofrectal acetaminophen (40 mg/kg) before circumcision significantly led to pain reduction in the first 24-hours after circumcision.
Determination of ecstasy components in human urine by gas chromatography using a dispersive liquid-liquid microextraction procedure
Mashayekhi, Hossein Ali;Rezaee, Mohammad;
Journal of the Brazilian Chemical Society , 2012, DOI: 10.1590/S0103-50532012005000032
Abstract: a new method was developed for preconcentration and determination of ecstasy compounds, 3,4-methylenedioxyamphetamine (mda), 3,4-methylenedioxymethylamphetamine (mdma), 3,4-methylenedioxyethylamphetamine (mdea) and 3,4-methylenedioxypropylamphetamine (mdpa), in urine samples using dispersive liquid-liquid microextraction (dllme) and gas chromatography (gc) with flame ionization detection (gc-fid). the method was based on the formation of tiny droplets of an organic extractant in prepared sample solution using water, immiscible organic solvent (cs2) dissolved in water-miscible organic disperser solvent (acetone). the organic phase, which extracted mda, mdea, mdma and mdpa from the prepared sample solution, was separated by centrifugation. parameters affecting extraction efficiency were investigated and optimized. under the optimum conditions, linearities of the method were 1.0-500 μg l-1 for mdea and mdpa and 2.5-500 μg l-1 for mda and mdma. the limits of detection (lods, s/n = 3, signal-to-noise ratio) were in the range from 0.3 to 0.8 μg l-1. the method was successfully applied to the determination of analytes in urine samples.
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