PVA Nanofibers Containing Ofloxacin-Cyclodextrin Inclusion Complex: Improve Optical Stability of Ofloxacin
Open Journal of Organic Polymer Materials (OJOPM)
(α-CD), ofloxacin (OFL) and
polyethylene glycol (PEG) was prepared via two methods to produce nanocontainers
with desirable stability. The effect of PEG as compatible
solubilizing agent and mixing condition (in ultrasonic
bath) were investigated in formation of
an inclusion complex between α-CD/OFL.
Obtained complexes were examined by FTIR, H-NMR, SEM, EDX and UV which indicated the formation of an
inclusion complex between α-CD/OFL, in turn, is a mixture of the cage and channel
structures. Differences between 1H-NMR, FTIR and XRD spectra of OFL,
CDs and inclusion complex indicated the formation of α-CD/OFL and supramolecular containers in solid phase. These inclusion complexes loaded in PVA-based
nanofibers for smart nanofibers with controlled release manner and higher
stability of OFL. Obtained nanofiber showed that nanofibers containing CDs/OFL
under sonic energy containing higher
degree of OFL.