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Search Results: 1 - 10 of 158355 matches for " Mohamed-Alaa-Eldeen H. Mohamed "
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Concomitant Chemoradiation Using Gemcitabine in Locally Advanced Hepatocellular Carcinoma  [PDF]
Mohamed-Alaa-Eldeen H. Mohamed
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.912084
Abstract: Purpose: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Most of patients present with advanced disease that cannot be treated with curative or ablative intent. The aim of the study was to assess the therapeutic benefit of concurrent chemoradiotherapy (CCRT) in patients with advanced HCC and to identify factors that predict OS. Methods: Patients with radiologically or biopsy proven primary HCC from 2010 to 2013 were included in the study. Gemcitabine was given in a dose of 70 mg/m2 once weekly for three weeks during external beam radiotherapy 30 Gy/2 Gy/fraction/five fractions per week in the Clinical Oncology Department, Assiut, Egypt. Results: Forty-nine patients were eligible but forty patients were evaluable for assessment. The partial response rate (PR) was 35% (14 patients), 16 patients (40%) had stable disease (SD) and the progressive disease was 25%. Painful hepatomegaly was significantly relieved in 70% of patients. Transaminases rose as grade 3 toxicity in 15% of patients. Longer overall survival (OS) was significantly observed in patients with performance status 0, child-Pugh A, Barcelona Clinic Liver cancer Stage B, PR and α fetoprotein level decrement. Conclusion: Concurrent chemoradiotherapt provides an acceptable response and palliation of pain in advances HCC. Our findings showed that better survival for patients with good performance and liver functions.
Integrated Geophysical, Remote Sensing and GIS Studies for Groundwater Assessment, Abu Zenima Area, West Sinai, Egypt  [PDF]
Mohamed H. Khalil, Khalid S. Ahmed, Alaa Eldin H. Elnahry, Alaa N. Hasan
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.59078

The integration between advanced techniques for groundwater exploration is necessary to protect and to manage the vital resources. Enhanced Thematic Mapper Landsat (ETM+) images, a geographic information system (GIS), hydrological modeling and direct current (DC) resistivity geoelectrical techniques were used in integrated manner to identify the groundwater potentialities in the study area. The study area is approximately 1195 km2, located at the western portion of south Sinai. From the results of the eight thematic layers as input to GIS model, the suitable locations for dams could be estimated in the two main drainage basins Matulla and Tayiba.

Powder Metallurgical Fabrication and Microstructural Investigations of Aluminum/Steel Functionally Graded Material  [PDF]
Mahmoud M. Nemat-Alla, Moataz H. Ata, Mohamed R. Bayoumi, Wael Khair-Eldeen
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.212228
Abstract: Aluminum/steel electric transition joints (ETJs) are used in aluminum reduction cell for the purpose of welding aluminum rod and steel bracket components. Solid state welding process used for joining aluminum and steel at the electric transition joints have the drawbacks of cracking and separation at the interface surfaces. Cracking and separation at the electric transition joints are caused by the stress singularities that developed due to the mismatch in thermal and mechanical properties of each material. To overcome the drawback of electric transition joints, aluminum/steel functionally graded may be used as electric transition joints or proposed. Therefore manufacturing and investigation of aluminum/steel functionally graded materials fabricated by powder metallurgy process were carried out through the current work. Different samples with different layers of aluminum/steel functionally graded materials were compacted using steel die and punch at the same compacted pressure and sintered temperature. After investigating the different samples of aluminum/steel functionally graded materials under different fabrication conditions, the suitable fabrication regime was determined with the aid of microscopic observations.
“Pyridopyridazine”: A Versatile Nucleus in Pharmaceutical Field  [PDF]
Mohamed A. Ibrahim, Ahmed H. Elmenoufy, Mohamed Elagawany, Mohammed M. Ghoneim, Alaa Moawad
Journal of Biosciences and Medicines (JBM) , 2015, DOI: 10.4236/jbm.2015.310008
Abstract: Pyridopyridazines are an important kind of nitrogen atom containing heterocyclic compounds due to their synthetic and pharmacological versatility. This fused heterocycle system represents a common structural feature for many bioactive compounds showing a variety of pharmacological activities which makes it an attractive scaffold for the design and development of new drugs. This mini review summarizes an updated information described in recent literature, about the most relevant pharmacological properties of pyridopyridazines derivatives.
Preoperative Conformal Radiotherapy Concurrently with Paclitaxel/Carboplatin in Gastric Cancer  [PDF]
Shimaa Ahmed, Mayada Fawzy, Khalid Rezk, Wessam Elshrif, Mohamed Alaa, Mohamed M. H. Abd Ellah
Journal of Cancer Therapy (JCT) , 2018, DOI: 10.4236/jct.2018.96041
Abstract: Background and objectives: Surgery is the primary therapy for localized gastric cancer, but even with the best results only 40% 5-year survival can be achieved with the use of postoperative adjuvant chemoradiotherapy. Preoperative therapy might help increase the R0 resection rate, which is an independent predictor of 5-year OS. Our study hypothesized that the concurrent combination of carboplatin-paclitaxel with radiation therapy would result in a pathological CR rate, which will be in turn associated with OAS and DFS benefits. Patients and methods: prospective phase II study included 32 patients with locally advanced gastric adenocarcinoma including gastroesophageal junction who received a combination of neoadjuvant conformal radiotherapy concurrently with carboplatin-paclitaxel followed by surgery. Results: Pathological CR and R0 resection rates were 18.8% and 75% respectively. With a median follow up of 24 months, 2 years disease-free survival was 28.1% and overall survival was 51.3%. The regimen was tolerated with neither grade 4 toxicities nor deaths. Conclusion: Neoadjuvant radiotherapy concomitant with carboplatin-paclitaxel chemotherapy is a well-tolerated approach for patients with locally advanced gastric adenocarcinoma resulting in significant pathological CR and R0 resection margins as reflected by the good DFS and OS.
The effectiveness of evening primrose oil and alpha lipoic acid in recovery of nerve function in diabetic rats
Alaa Eldeen Ahmed El-kossi,Mostafa Mahmoud Abdellah,Abeer Mohamed Rashad,Sherifa Ahmad Hamed
Journal of Clinical and Experimental Investigations , 2011,
Abstract: Objectives: Diabetic polyneuropathy is a serious complication of diabetes mellitus and the most frequent neuropathy worldwide. Evening primrose oil (EPO) is rich in omega-6 essential fatty acid component and gamma-linolenic acid. Alpha lipoic acid (ALPA) has a protective effect against lipid peroxidation and helps in scavenging free radicals. Data regarding the effect of treatment with EPO on diabetic parameters and neuropathic manifestations are conflicting. This study aimed to determine the therapeutic efficacy of EPO and ALPA in correcting diabetic parameters and functional and structural neuropathic manifestations in streptozotocin (STZ) induced diabetic rats.Materials and methods: In this study, the effects of two week oral treatment with EPO (1.25 g/kg) was compared to that of ALPA (100 mg/kg) and insulin (2 IU/day), utilized singly or in combination.Results: Compared with untreated diabetic rats, EPO and ALPA resulted in reduction of serum levels of glucose (p<0.05), total cholesterol (p<0.01), triglycerides (p<0.01), low density lipoprotein cholesterol (p<0.01), thiobarbituric acid reactive substance (a marker of oxidative stress) (p<0.05), and increased in levels of high density lipoprotein cholesterol (p<0.05) and total antioxidant capacity (p<0.05). Enhanced positive effect was observed with combination therapy.Conclusion: This work indicates that EPO and ALPA, particularly when used in combination, improve glycemic control, lipid abnormalities and antioxidant capacity, thus restore the impaired functional properties of peripheral nerves to a great extent. J Clin Exp Invest 2011; 2 (3): 245-253.
Evaluation of the Quality for the Egyptian Red Sea Coastal Waters during 2011-2013  [PDF]
Mamdouh A. Fahmy, Laila M. Abdel Fattah, Ahmed M. Abdel-Halim, Mohamed A. Aly-Eldeen, Ehssan M. Abo-El-Khair, Hoda H. Ahdy, Hoda H. Ahdy, Ahmed Hemeilly, Ahmed Abu El-Soud, Mohamed A. Shreadah
Journal of Environmental Protection (JEP) , 2016, DOI: 10.4236/jep.2016.712145
To assess the quality of the Egyptian Red Sea coastal waters for the sustainable use and development, due to its importance for the national income, four field campaigns were annually carried out during the period from 2011-2013 to investigate the hydrography, nutrient salts, heavy metals and petroleum hydrocarbons. Except for the area of Bir Shalatein, the results of beach litter cleared out that the shoreline of the studied area is not affected by man-made litter. No sewage could be observed. The results of the present study showed that water temperature followed seasonal changes in air temperature. Red Sea water is more saline than adjacent Arabian Sea. DO revealed high values and presence of well oxygenated waters. Minor changes in the distribution of pH, BOD, DOM and COD, revealed that limited effects of human impacts and depend mainly on the dynamics of its water as well as on the geographical location. Low Chl-a and TSM concentrations and high transparency revealed that also the effect of human impacts is almost negligible. Significantly higher sea water temperatures, TSM, pH, DO, BOD, DOM, and COD were observed in summer season compared to their corresponding values in winter season. Dissolved inorganic nitrogen concentrations were quite low because there is little nutrient input from soil, agriculture and pollution on land. Based on the annual mean values, the pattern concentrations of dissolved inorganic nitrogen forms followed the order: NO3 > NH4 > NO2. The Red Sea coastal waters are classified as oligotrophic to mesotrophic state. A remarkable increase of PO4 concentration was observed in the middle Red Sea stations due to huge amounts of effluents enriched with phosphate from the main shipping and industry of Phosphate Companies. SiO4 displayed a large variability due to the supply of SiO4, which flows in the Red Sea through the strait of Bab El-Mandab, biological consumption, organic matter decomposition and the partial dissolution of quartz particle transported to the sea from the surrounding desert during sand storms. Concentrations of ammonia, phosphorus, total nitrogen, and total phosphorus were significantly higher in summer compared to their corresponding values in winter. In general, the majority of TN and TP in winter were in the form of organic-N (91.3%) and organic P (96.8%). The mean DIN/DIP ratio revealed high nitrogen concentrations in comparison with that of phosphorous and the surface coastal waters of the
Vitamin D and inflammation in the prevention of type 2 diabetes: public health relevance
Alaa Badawi,Eman Sadoun,Mohamed H. Al Thani
Reviews in Health Care , 2012, DOI: 10.7175/rhc.26934243-255
Abstract: The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide. To reduce the disease risk and burden at the population level, preventative strategies should be developed with minimal cost and effort and with no side-effects. Low-grade inflammation resulting from imbalances in the innate immune system has been associated with an array of chronic disorders that predispose to the later development of T2DM (e.g., obesity, metabolic syndrome, and insulin resistance). As a result, inflammation may contribute to the pathogenesis of T2DM. Therefore, attenuation of this inflammatory response via modulating the innate immune system could lead to improved insulin sensitivity and delayed disease onset. Dietary supplementation with vitamin D may represent a novel strategy toward the prevention and control of T2DM at the population level due to its anti-inflammatory and antioxidant properties. This review examines current knowledge linking T2DM to chronic low-grade inflammation and the role of vitamin D in modulating this relationship. The concept that vitamin D, via attenuating inflammation, could be employed as a novel preventive measure for T2DM is evaluated in the context of its relevance to health care and public health practices.
The Effectiveness of Intraoperative Frozen Section Analysis of Safety Margins in Breast Conserving Surgery and the Role of Surgeon in Decreasing the Rate of Positive Margins  [PDF]
Omar Farouk, Ahmed Senbel, Mosab Shetiwy, Essam Attia, Ahmed Abdallah, Osama El-Damshety, Ashraf Khater, Sameh Roshdy, Amr Abouzid, Amr Hossam, Islam H. Metwally, Omar Hamdy, Amir M. Zaid, Mahmoud Abdelaziz, Mohamed Elmetwally, Adel Fathi, Emad-Eldeen Hamed, Khaled Abdel Wahab, Wagdi El-Kashef, Mohamed Hafez, Khaled Zalata, Mohamed Hegazy, Adel Denewer
Surgical Science (SS) , 2017, DOI: 10.4236/ss.2017.812056
Abstract: Introduction: Nowadays the more accepted surgical option for treating early breast cancer is breast conserving surgery. The main challenge in this type of surgery is to get free safety margins without need of second surgical operation, so many breast surgeons have started to depend on intraoperative frozen sections to ensure free safety margins. Aim of work: To assess our policy that we prefer to depend on intraoperative frozen section analysis to get free safety margin in breast conserving surgery from the 1st surgery, and its oncologic outcome. Patients and Methods: This is a retrospective study conducted in Oncology Center—Mansoura University (OCMU), where the data of 219 patients with breast cancer, who were managed by breast conserving surgery with intraoperative frozen section analysis of the safety margins, was analyzed. Results: The intraoperative frozen section analysis of safety margin was negative from the start in 183 (83.6%) patients, while it was positive in 36 patients (16.4%). Intraoperative decision of margin re-excision was applied for 29 patients (13.2%) in order to reach negative margin, modified radical mastectomy was offered for 4 patients (1.8%), while nipple sparing mastectomy with immediate breast reconstruction using latissimus dorsi flap was offered for 3 patients (1.4%). The postoperative paraffin results were typical with intraoperative frozen section analysis results in 216 patients (98.6%) and different results were obtained in only 3 patients (1.4%) who were managed by modified radical mastectomy in a second operation. Only 4 patients had local recurrence (1.8%) during the period of follow-up duration which was ranged from 1 to 86 months with mean ± SD (22.3 ± 14.1). Conclusion: The intraoperative frozen section analysis of safety margins in breast conserving surgery has very high-rate typical results with the paraffin section analysis and it is very helpful in decreasing the rate of second surgical operation in cases of infiltrated margins. It should be used routinely in all cases of breast conserving surgery.
Chemical Composition and Minerals Content as Influenced by Cooking of Some Saudi Traditional Diets
Abdulatif S.H. El-Jasser,Seif Eldeen Bashier Ahmed, Isam A. Mohamed Ahmed and Elfadil E. Babiker
Advance Journal of Food Science and Technology , 2011,
Abstract: The main objective of the current study was to evaluate the chemical composition of traditional diets consumed regularly in Saudi Arabia. In the present study, five Saudi Arabian traditional diets (kabsa, gursan, garish, saleeg and hunaini) were investigated for their chemical composition. The moisture, protein, fat, fiber, ash, carbohydrate and energy content of cooked kabsa, gursan, garish, saleeg and hunaini were significantly (p#0.05) differ from those of commercial and uncooked samples. Lower values of protein content were found in saleeg (2.47-2.94%) whereas higher values were found in gursan (8.5-8.67%). Higher ash content was observed in cooked saleeg (1.64%) whereas lower one was in commercial garish (0.9%). Cooking significantly (p#0.05) affect ash, fiber and carbohydrate contents of all diets. Energy content of hunaini (300-309 kcal) was higher compared to that of kabsa (126-140 Kcal), gursan (100-125 Kcal), garish (88.2-149 Kcal) and saleeg (73.3-138 Kcal). Kabsa, gursan, garish, saleeg and hunaini contained variable amounts of macro-elements (K, Ca, Na, Mg, and Mn) and trace elements (Fe, Cu and Zn). Higher K content was found in hunaini (488.5-637.5 mg/100 g), while lower content was found in kabsa (72.3-100.5 mg/100 g). Cooking significantly (p#0.05) decreased K content of kabsa, gursan, garish and saleeg, whereas it significantly (p#0.05) increased it in hunaini. Ca content of the diets showed considerable variations. Na content of the investigated diets varied from 26.3 to 584.0 mg/100 g and Fe varied from 0.04 to 9.5 mg/100 g.
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