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Search Results: 1 - 10 of 465528 matches for " Mohamed I.M.; Mishra "
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Pattern of adverse drug reactions reported by the community pharmacists in Nepal
Palaian,Subish; Ibrahim,Mohamed I.M.; Mishra,Pranaya;
Pharmacy Practice (Internet) , 2010, DOI: 10.4321/S1886-36552010000300008
Abstract: the pharmacovigilance program in nepal is less than a decade old, and is hospital centered. this study highlights the findings of a community based pharmacovigilance program involving the community pharmacists. objectives: to collect the demographic details of the patients experiencing adverse drug reactions (adr) reported by the community pharmacists; to identify the common drugs causing the adrs, the common types of adrs; and to carry out the causality, severity and preventability assessments of the reported adrs. methods: the baseline knowledge-attitude-practices (kap) of 116 community pharmacists from pokhara valley towards drug safety was evaluated using a validated (cronbach alpha=0.61) kap questionnaire having 20 questions [(knowledge 11, attitude 5 and practice 4) maximum possible score 40]. thirty community pharmacists with high scores were selected for three training sessions, each session lasting for one to two hours, covering the basic knowledge required for the community pharmacists for adr reporting. pharmacist from the regional pharmacovigilance center visited the trained community pharmacists every alternate day and collected the filled adr reporting forms. results: altogether 71 adrs, from 71 patients (37 males) were reported. antibiotics/ antibacterials caused 42% (n=37) of the total adrs followed by non steroidal anti-inflammatory drugs [25% (n=22)]. ibuprofen/paracetamol combination accounted for ten adrs. the most common type of adr was itching [17.2 % (n=20), followed by generalized edema [8.6 % (n=10)]. in order to manage the adrs, the patients needed medical treatment in 69% (n=49) of the cases. over two third (69%) of the adrs had a "possible" association with the suspected drugs and a high percentage (70.4%) were of "mild (level 2)" type. nearly two third [64.7 % (n=46)] of the adrs were "definitely preventable". conclusion: the common class of drugs known to cause adrs was antibacterial/ antibiotics. ibuprofen/ paracetamol combination use
Parent′s knowledge and management of their children′s ailments in Malaysia
Dawood,Omar T.; Ibrahim,Mohamed I.M.; Palaian,Subish;
Pharmacy Practice (Internet) , 2010, DOI: 10.4321/S1886-36552010000200003
Abstract: minor ailments like sore throat, fever, cough and diarrhea can be relieved with over-the-counter (otc) medications such as paracetamol or other traditional remedies, without seeking for consultation from general practitioners. parents usually take the responsibility to come up with some kind of treatment for their children. objective: (1) to evaluate the parents′ medical knowledge about otc medicines which are usually used by the parents to treat their children and (2) to evaluate the parents′ management in dealing with their children′s ailments, and (3) to evaluate the association between medical knowledge and the management of children′s ailments related to medicine use among the parents. methods: a cross-sectional survey was conducted to measure the parents′ knowledge about their children′s ailments. subjects were selected and information was obtained in september 2008. non-probability convenient sampling method was used. parents were recruited from the general public to answer the questionnaires. results: 197 parents filled in the questionnaires. from the total respondents, 48.2% of them were male. this study showed that most respondents have medium knowledge (6.11 sd=3.6) and a moderate management (4.39 sd=2.7). the results showed that there is a significant difference between the knowledge and the management level of ailments (p=0.033). regarding the education level of the parents and the socioeconomic status, the p-value showed there was a significant difference between parents′ knowledge and their education level (p=0.012). conclusion: this study showed that parents have inadequate knowledge and some misconception about how to go about treating their children when they are unwell. it is hoped that by identifying weak areas in parents′ management to their children′s ailments, better planned educational and behavioral modification efforts can be made to elevate the knowledge level among the parents when they medically treat their children.
Synthetic amino acid-analogs of γ-aminobutyric acid
I.M. Ejimadu
Bulletin of the Chemical Society of Ethiopia , 1989,
Abstract: Bull. Chem. Soc. Ethiop., 2(2) 57-60 (1989).
Potential Nephrotoxicity in African Mud Catfish (Clarias gariepinus) Following Exposure to Compost Derived Humic Acid
I.M. Adekunle
Pakistan Journal of Biological Sciences , 2010,
Abstract: Influence of compost-derived Humic Acid (HA) on nephrotoxicity in juvenile African mud catfish (Clarias gariepinus) was evaluated in static water culture. Fish samples were exposed to different HA concentrations (0, 100, 250, 500 and 1000 mg L-1) for 45 days at 5 samples per aquarium. Renal function was assessed spectrophotometrically via levels of serum albumin, measured using bromocresol green, creatinine by Jaffe method and urea by Nesslerization method. Results revealed that the mean value of albumin or urea in the exposed group (I), at each HA concentration, was lower than the value found in the control group (II). Creatinine was relatively higher in I relative to II. Significant (p<0.05) variations for I and II were obtained at 250 to 1000 mgHA L-1 for the three biomarkers. Relative to increasing HA concentration, decreasing albumin (0.84 to 0.43 g dL-1: r = -0.114; p> 0.10), urea ( 5.21 to 1.95 mg dL-1; r = -0.586; p> 0.10) and increasing creatinine (0.20 to 1.53 mg dL-1: r = +0.704; p> 0.10) were recorded; r is correlation coefficient. Changes in urea were not predictive of nephrotic syndrome but alterations in albumin and creatinine revealed induced nephrotoxicity, especially at elevated HA concentrations (above 100 mg L-1). Overall, the effect of humic acid was dose-dependent. Further studies at various humic acid concentrations, especially below 100 mg L-1, are required to establish the actual nephrotoxic dose.
Lucr?ri ?tiin?ifice : Management Agricol , 2009,
Abstract: This paper investigates the effects of credit constraints on the Romanian farm investment behaviour. In order to do the empirical investigation the simulative approach is used in the construction of a model generically named SIMULPACROM. This one is then used in 21 farms specialised in crop production taken from the FDAN sample. The financial scenarios show that the barrowing possibilities importantly affect both the farm’s net revenue and its investment behaviour. The farm size and its indebt degree are variables which can explain the credit constraints.
Goal-oriented approach to diagnostics in management of an enterprise
I.M. Semenenko
Marketing ì Mened?ment Innovacìj , 2012,
Abstract: Problems which occur while performing diagnostics of the state of an enterprise and the results of its activity have been revealed. The inexpediency of using problem approach to diagnostics in management of an enterprise in modern conditions of economic management has been defined. The significance and essence of goal-oriented approach to diagnostics in management of an enterprise have been revealed. It has been set that the management decisions, developed using the goal-oriented approach to diagnostics, are more efficient.
Direction of use of instruments of classic concept of municipal marketing in development of competitiveness of a city
I.M. Budnikevich
Marketing ì Mened?ment Innovacìj , 2011,
Abstract: The prerequisites of formation of the concept of classical marketing in Ukraine are considered in the paper. The definition of the municipal marketing in the framework of the classical concept is offered. The role of marketing instruments in formation of competitive advantages of the city is determined. The variants of segmentation of city environment and strategies of municipal marketing towards target markets are described. The experience of Dresden (Germany) in the field of realization of marketing concept is studied.
Preconditions for creation and use of innovative financial instruments in Ukraine’s derivatives market
I.M. Burdenko
Marketing ì Mened?ment Innovacìj , 2012,
Abstract: This article explores evolution of domestic market of derivatives, its main stages and brief description. Preconditions for creation and use of innovative financial instruments in derivatives market of Ukraine are analysed. For each stage of derivatives markets evolution were defined main trends of its development.
Treatment optimization in patients with stable angina pectoris: focus on verapamil SR
I.M. Sokolov
Rational Pharmacotherapy in Cardiology , 2011,
Abstract: Possibilities of angina pectoris pharmacotherapy are analyzed. Achievement of target heart rate (HR) 55-60 beats per minute in these patients is possible due to three classes of antianginal medications that slow down HR: beta blockers (BB), If-channel inhibitors, nondihydropyridine calcium channel blockers (CCB). Nondihydropyridine CCB verapamil in slow release (SR) formulation is focused. The main results of randomized clinical trials (APSIS, VHAS, CRIS, EVERESTH, VAMPHYRE, INVEST, VESPA, DAVIT-1, DAVIT-2), which have proven efficacy and safety, are presented. Verapamil SR is indicated for the treatment of angina pectoris in patients without history of myocardial infarction (MI); angina patients experienced MI without systolic heart failure and with contraindications to BB; angina with arterial hypertension; left ventricular diastolic dysfunction; peripheral arteries obliterating atherosclerosis; silent myocardial ischemia; vasospastic angina; angina associated with supraventricular cardiac arrhythmias (especially in permanent atrial fibrillation) except Wolff-Parkinson-White and Lown-Ganong-Levine syndromes; after coronary angioplasty and the placement of bare metal stents.
Effect of Selenium on Cadmium Induced Gonadotoxicity in Male Rats
I.M. Alhazza
Journal of Biological Sciences , 2005,
Abstract: The present study was conducted to investigate the possible effect of Selenium (Sel) against Cadmium (Cd) toxicity on hormones and gonads of male rats. Male rats were divided into three groups. First group served as control, second group administrated s.c. cadmium chloride (2.5 mg kg -1) and third group injected s.c. with Sel (0.35 mg kg -1) and Cd. In the last group, the animals were treated with Sel one hour before Cd treatment. Blood samples were collected and eight animals were sacrificed after two, four, six and eight weeks. Plasma testosterone, FSH and LH were assayed using enzyme immunoassay method. The sperm quality was evaluated. Cd in the testes was determined using atomic absorption. The weights of body, testes and accessory sex organs were recorded. The treatment of the rats with Cd results in a significant decrease of testosterone, LH, sperm motility (%), body gain and weights of testes, epididymis, vas deference, seminal vesicle and prostate gland. On the other hand, the sperm abnormalities and FSH concentration increased significantly in Cd treated rats. Cd content in the testes of second group and third group increased in a time-related fashion. Cd concentration in the testes of rats treated with Cd and Sel was less than that of rats injected with Cd alone. Sel was found to reduce the deleterious effects of Cd.
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