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Search Results: 1 - 10 of 401255 matches for " Modarres Gilani M "
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Inhibin as a tumor marker of ovarian cancer in postmenopausal women
Modarres Gilani M,Karimi M
Tehran University Medical Journal , 2010,
Abstract: "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Inhibin is a dimeric glycoprotein that has a depressive effect on the anterior hypophys secretion. The level of this tumor marker is undetectable in menopause women. In patients with gynecological cancer, especially granulosa and epidermal-type (mucinous), ovarian cancers considerable increase in the serum level of inhibin has been reported. The increased level of inhibin has been reported in patients with recurrent ovarian cancer."n"nMethods: We measured total serum inhibin and CA125 tumor marker level in 38 postmenopausal women with pathologically confirmed ovarian cancer before and after surgery out of 51 suspected women. Our control group were postmenopausal women that attended to our clinic for routine gynecologic check up. Both tumor markers were measured in these patients too."n"nResults: Among 38 women with ovarian cancer, 13(34.2%) had elevated serum levels of total inhibin. Among the 16 women with serous adenocarcinoma, 3 patients (18.8%) had elevated serum levels of inhibin. All the three women with granulosa cell tumor had elevated serum levels of inhibin (100%) and 3 of 4(75%) women with mucinous ovarian cancer had the same result. three out of 38 women in control group had elevated serum levels of inhibin. Among all 38 patients, 6(15.7%) showed tumor recurrence, that all were concomitant with rising of both serum CA125 and Inhibin levels (p=0/001)."n"nConclusions: Serum inhibin level is a usefull tumor marker in granulosa cell and in mucinous tumor of ovary. In this study combined inhibin and CA125 assay showed better results in early detection of ovarian cancer in comparison to either CA125 or inhibin alone.
Neural Tube Defect: Rate of Occurrence in 28449 Neonates
L Safdarian,B AlaIei,M Modarres Gilani
Iranian Journal of Pediatrics , 2001,
Abstract: In a retrospective study of 28449 deliveries in a period of 5 years (1993-1997) in the nurseries of the 2 major teaching hospitals of the Tehran university of medical sciences we found 67 cases of neural tube defect (NTD), I.e. 2.4 per 1000 deliveries. Spina bifida (56.5% of NTD cases) was the most frequent anomaly. In 95.5% of NTD cases, mothers had no history of giving birth to a child with NTD. Hydrocephaly was the most common anomaly associated with NTD
F. Ghaemmaghami,M. Modarres Gilani,M. Marjani,A. Mousavi
Acta Medica Iranica , 2003,
Abstract: This study has been designed to compare visual inspection of cervix with acetic acid (VIA test) with cytology as an accepted method for screening of cervical carcinoma and its precursors. 1200 eligible women were examined by both Pap-smear and VIA tests in Imam Khomeini Hospital, a referral general hospital in Tehran, Iran. Those who had abnormal results in one or both of the screening tests (n = 308) and those who had clinically suspicious lesions even if the tests were negative in addition to 10% of otherwise normal patients with negative tests (totally 290 patients) were referred for colposcopy and biopsy if mandated. From 598 patients who were introduced to colposcopy services, 355 patients required biopsies or endocervical curettage (ECC). Those with CIN I or worse lesions diagnosed by histology were considered true-positive. VIA results were positive in 191 women (16.1%) and cytology was abnormal (for ASCUS or worse lesions) in 226 women (19%). VIA and cytology detected 130 (74%, 95% CI: 68%-81%) and 126 (72%, 95% CI: 65%-79%) cases respectively, yielding a sensitivity ratio of 1.03. VIA detected 31 lesions which were cytologically negative and cytology detected 27 lesions which were negative by VIA; 18 cancerous and precancerous lesions were missed in both modalities. The approximate specificities of VIA and cytology were 94% (95% CI: 93%-95%) and 90.2% (95% CI: 88%-92%) respectively. Also, the positive predictive values were 68.1% (95% CI: 61%-75%) and 55.7% (95% CI: 49%-62%) respectively. These results indicate that VIA and cytology had very similar performance in detecting CIN I or worse lesions in this study.
Juvenile Rheumatoid Arthritis in Children with Ebstein barr virus Infection
Y. Aghighi,Modarres Gilani Sh,M. Razavi,A. Zamani
Pakistan Journal of Biological Sciences , 2007,
Abstract: Juvenile Rheumatoid Arthritis (JRA) is a disease of unknown etiology. A total of 50 patients with JRA who were hospitalized in the Pediatrics Rheumatology Ward of Imam Khomeini Hospital in Tehran during the years 2001-2002, were assessed serologically (IgM and IgG specific viral capsid antigens) for EBV infection and their response to therapy was studied. Minimum age of the patients was at least 6 months and mean age was 60.96 plus/minus 43.46 months. EBV infection was seen in 44 (88%) patients 24 of whom were girls and 20 boys. Ninety two percent of girls and 83% boys were infected with the virus. Ebstein barr virus (EBV) infection was seen in 33 cases, 6 cases, 4 cases and 1 case in the polyarticular, pauciarticular, systemic and spondylitis group, respectively. Fifty four percent of EBV-positive patients with JRA did not respond to the classic therapy. EBV virus is involved in the pathogenesis of JRA and patients with EBV are in greater risk of developing JRA.
Fertility preservation in young women with endometrial carcinoma; report of three cases
Mousavi A.S,Behtash N,Karimi Zarchi M,Modarres Gilani M
Tehran University Medical Journal , 2007,
Abstract: Background: Although endometrial cancer is primarily a disease of the postmenopausal female, 25% of patients are premenopausal, with 3-5% in women 40 years old or younger. The younger group of women with endometrial carcinoma are frequently nulligravid with a history of infertility, and a strong desire to preserve fertility. This may pose a therapeutic dilemma for both patients and treating physician. Case report: We reported 3 young patients with atypical; complex hyperplasia or early stage endometrial cancer that treated with conservative hormonal therapy. Conclusion: Medical treatment of young patients with endometrial carcinoma and complex atypical hyperplasia who wish to preserve fertility is a reasonable and appealing option. A comprehensive evaluation prior to counseling the patient should include A complete history and physical examination. A formal D&C with review of history with an experienced gyn-onc pathologist. Evaluation of the pelvic and abdomen preferably with contrast-enhanced MRI or transvaginal ultrasound. In patients found to have a clinical stage I grade I tumor and who want to preserve fertility , thorough counseling include risks and benefits, and explanation that the data is partial and incomplete due to the lack of appropriate controlled studies is mandatory. In patients considered for medical treatment, a high dose progestin regimen should be started with endometrial sampling every 3 months until complete regression of the tumor is documented. Although most responses are long standing, there is a small risk of progression during or after cessation of progestin therapy.
M. Modarres-Gilani,F. Ghaemmaghami,S. Ansaripoor,M. Shariat F. Zaeri
Acta Medica Iranica , 2004,
Abstract: Larger tumor burden leads to higher serum CA-125 levels and the ability to perform optimal tumor cytoreduction of advanced ovarian cancer is also a function of tumor bulk. The purpose of this study was to identify the ability of preoperative serum CA-125 to predict possibility of optimal primary tumor cytoreduction in epithelial ovarian carcinoma (EOC). A total of 90 patients with EOC were evaluated in a prospective study from 2000 to 2002. Preoperative serum CA-125 levels were determined, using a solid phase immunoassay. We used a receiver operating characteristic curve to identify the CA-125 level with the maximal prognostic power in predicting optimal versus suboptimal debulking. The median CA-125 level for the 90 patients was 500 U/ml (range 13 to 5000 U/ml). Seventy patient (78%) had stage III or ΙV based on staging system of the International Federation of Gynecology and Obstetrics (FIGO) for ovarian carcinoma. Optimal cytoreduction (diameter of largest residual tumor less than 1 cm) was obtained in 44 patients (62.9%) with stage III-ΙV. Preoperative CA- 125 value less than 450 U/ml had a positive predictive value for optimal cytoreduction of 78%, but a poor negative predictive value of 50% in advanced EOC. In patients with advanced EOC, at a cutoff 450 U/ml, 78% underwent optimal debulking, whereas 50% of patients with preoperative CA-125 level above 450 U/ml were still able to undergo optimal debulking. Preoperative CA-125 does not seem to be a reliable predictor of optimal cytoreduction.
The Genetic Diversity and Phylogenetic Characteritics of Rotavirus VP4(P) Genotypes in Children With Acute Diarrhea
Rahbarimanesh A,Saberi H,Modarres Gilani Sh,Salamati P
Tehran University Medical Journal , 2011,
Abstract: Background: Acute gastroenteritis is a major cause of morbidity and mortality among children in developing countries. Rotaviruses are recognized as the most common etiologic factors of gastroenteritis. In this study, we determined the epidemiologic features, clinical symptoms and molecular structure of rotavirus VP4(P) genotypes in children with acute diarrhea in Bahrami Hospital in Tehran Iran, during 2009 for justifying the routine use of rotavirus vaccines in children. Methods: One hundred fifty fecal samples from 150 children with acute diarrhea in Bahrami Pediatric Hospital in Tehran, Iran were collected from January to December 2009. The patients’ mean age was 20.90+18.19 years (ranging from 1 month to 14 years). Fecal samples were transported on ice to the laboratory of virology department of Pasture Institute of Iran. The demographic and clinical data for each case were entered in an author-devised questionnaire. Group A rotavirus was detected by dsRNA-PAGE. Subsequently, rotavirus genotyping (VP4) was performed by semi-nested multiple RT-PCR and the phylogenetic tree of the Rotavirus nucleotides was constructed. The data were analyzed by statistical tests including Wilcoxon signed and Mann-Whitney U. Results: Rotavirus was isolated in 19.3% of the samples, more than 90% of which had long RNA patterns. The predominant genotype (VP4) was P[8] (86%) and other genotypes respectively were P[6] (6.9%) and P[4] (6.9%). Conclusion: A high prevalence of the P[8] genotype was found to be the cause of acute diarrhea. The analysis of P[8] genotype sequence showed a high level of similarity of the virus in this study with those of other Asian countries.
Frequency of Different Types of Ovarian Cancer in Vali-e-Asr Hospital (Tehran University of Medical Sciences) 2001-2003
Mitra Modarres Gilani,Fariba Behnamfar,Fatemeh Zamani,Narges Zamani
Pakistan Journal of Biological Sciences , 2007,
Abstract: Purpose of this study was to report histology specific age adjusted ovarian cancer incidence rates from 2001-2003 in Tehran University Hospital (valie-Asr hospital). This was a case series study including all microscopically confirmed cases of ovarian malignancies from 2001-2003. There were 152 cases of ovarian cancer, 102 (67.1%) epithelial type, 26 (17.1%) germ cell tumors, 14 (9.2%) sex cord stromal and 10 (6.6%) metastatic ovarian tumors. Present results were compatible with results from nonwestern countries. Epithelial type tumors and sexcord-stromal tumors were more prevalent after the age 50 (40 and 44.4%consequently). Germ cell tumors were more prevalent before 20 (16 cases, 61.5%) (χ2 = 42.54, p-value = 0.000). Stage of disease in epithelial type tumors was advanced in most of patients but most germ cell tumors and sexcord-stromal tumors were stage I (χ2 = 19.6, p-value = 0.000). Present study showed that epithelial ovarian tumors in comparison to western countries are less frequent in Iran but still this histologic type is the most prevalent type of ovarian malignancy in this area of the world. Of course in younger patients we can predict more probability of germ cell tumors with more localized disease and better prognosis.
A.A. Rahbarimanesh,S. Karimi Sh. Modarres Gilani
Acta Medica Iranica , 2004,
Abstract: According to statistical data from WHO, respiratory tract infections are among the most important health problems all over the world. Differentiating viral from other causes of respiratory infections is difficult, but a good knowledge of viral etiologic factors can guide the physicians in the diagnosis and treatment of the disease. We carried out this descriptive, case-series study to evaluate the relative frequency of parainfluenza virus (PIV) infections in upper and lower respiratory tract infections. A total of 263 three children with respiratory infection were studied from autumn 1998 to autumn 2000. We prepared samples from their nasopharynx with sterile swabs for viral culture and study of cytopathic effects of PIV. Thirty six cases had positive culture for PIV (14%). There was a significant statistical correlation between the prevalence of PIV infection and age of patients. The highest prevalence was in the of 1-5 years old age group. There was also a correlation with season, and majority of cases were seen in autumn and spring (P< 0.0001). There was no significant correlation between PIV infection and sex. PIV infection had significant correlation with croup and bronchiolitis (P<0.0001). PIV plays an important role in causing lower respiratory tract infections.
Premature rupture of membrane (PROM)
Modarres,M. Moshrefy,M.
Hayat Journal of Faculty of Nursing & Midwifery , 2002,
Abstract: For diagnosing PROM, the need has been acutely felt for special care in obstetrics. Coordinated management for patient care between the clinician and midwives is the custom in several obstetric care centers. Diagnosis and treatment by the physician has greatly facilitated the work of midwives, to the extent that they now play an important role in the special nursing of women in solving obstetrics. This article reviews important topics such as: epidemiology, physiology, pathology and patho-physiology. It also covers preventive measures, objective and subjective evaluation, diagnostic tests and management of PROM, as well as the psychological aspects of hazards for motherhood, fetus and childbirth.
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