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Search Results: 1 - 10 of 14419 matches for " Moataz Abd El Ghany "
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The Population Structure of Vibrio cholerae from the Chandigarh Region of Northern India
Moataz Abd El Ghany ,Jagadish Chander,Ankur Mutreja,Mamoon Rashid,Grant A. Hill-Cawthorne,Shahjahan Ali,Raeece Naeem,Nicholas R. Thomson,Gordon Dougan,Arnab Pain
PLOS Neglected Tropical Diseases , 2014, DOI: 10.1371/journal.pntd.0002981
Abstract: Background Cholera infection continues to be a threat to global public health. The current cholera pandemic associated with Vibrio cholerae El Tor has now been ongoing for over half a century. Methodology/Principal Findings Thirty-eight V. cholerae El Tor isolates associated with a cholera outbreak in 2009 from the Chandigarh region of India were characterised by a combination of microbiology, molecular typing and whole-genome sequencing. The genomic analysis indicated that two clones of V. cholera circulated in the region and caused disease during this time. These clones fell into two distinct sub-clades that map independently onto wave 3 of the phylogenetic tree of seventh pandemic V. cholerae El Tor. Sequence analyses of the cholera toxin gene, the Vibrio seventh Pandemic Island II (VSPII) and SXT element correlated with this phylogenetic position of the two clades on the El Tor tree. The clade 2 isolates, characterized by a drug-resistant profile and the expression of a distinct cholera toxin, are closely related to the recent V. cholerae isolated elsewhere, including Haiti, but fell on a distinct branch of the tree, showing they were independent outbreaks. Multi-Locus Sequence Typing (MLST) distinguishes two sequence types among the 38 isolates, that did not correspond to the clades defined by whole-genome sequencing. Multi-Locus Variable-length tandem-nucleotide repeat Analysis (MLVA) identified 16 distinct clusters. Conclusions/Significance The use of whole-genome sequencing enabled the identification of two clones of V. cholerae that circulated during the 2009 Chandigarh outbreak. These clones harboured a similar structure of ICEVchHai1 but differed mainly in the structure of CTX phage and VSPII. The limited capacity of MLST and MLVA to discriminate between the clones that circulated in the 2009 Chandigarh outbreak highlights the value of whole-genome sequencing as a route to the identification of further genetic markers to subtype V. cholerae isolates.
Recombinations in Staphylococcal Cassette Chromosome mec Elements Compromise the Molecular Detection of Methicillin Resistance in Staphylococcus aureus
Grant A. Hill-Cawthorne, Lyndsey O. Hudson, Moataz Fouad Abd El Ghany, Olaf Piepenburg, Mridul Nair, Andrew Dodgson, Matthew S. Forrest, Taane G. Clark, Arnab Pain
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101419
Abstract: Clinical laboratories are increasingly using molecular tests for methicillin-resistant Staphylococcus aureus (MRSA) screening. However, primers have to be targeted to a variable chromosomal region, the staphylococcal cassette chromosome mec (SCCmec). We initially screened 726 MRSA isolates from a single UK hospital trust by recombinase polymerase amplification (RPA), a novel, isothermal alternative to PCR. Undetected isolates were further characterised using multilocus sequence, spa typing and whole genome sequencing. 96% of our tested phenotypically MRSA isolates contained one of the six orfX-SCCmec junctions our RPA test and commercially available molecular tests target. However 30 isolates could not be detected. Sequencing of 24 of these isolates demonstrated recombinations within the SCCmec element with novel insertions that interfered with the RPA, preventing identification as MRSA. This result suggests that clinical laboratories cannot rely solely upon molecular assays to reliably detect all methicillin-resistance. The presence of significant recombinations in the SCCmec element, where the majority of assays target their primers, suggests that there will continue to be isolates that escape identification. We caution that dependence on amplification-based molecular assays will continue to result in failure to diagnose a small proportion (~4%) of MRSA isolates, unless the true level of SCCmec natural diversity is determined by whole genome sequencing of a large collection of MRSA isolates.
Knowledge and performance among nurses before and after a training programme on patient falls  [PDF]
Nagwa Younes Abou El Enein, Azza Saad Abd El Ghany, Ashraf Ahmad Zaghloul
Open Journal of Nursing (OJN) , 2012, DOI: 10.4236/ojn.2012.24053
Abstract: Background: Patient falls in hospitals are common and affect approximately 2% to 17% of patients during their hospital stay. Patient falls are a nursingsensitive quality indicator in the delivery of inpatient services. Objective: To assess the effect of educational training program on nurses’ knowledge and performance regarding prevention of fall at one of the health insurance organization hospitals in Alexandria. Setting: The study was conducted at 284 bed general hospital affiliated with the Health Insurance Organization in Alexandria. Design: A quasi-experimental design was followed. Participants: The study sample included all nurses of different ranks working at four departments namely, orthopedic, medical, surgical, ICU unit. Results: There was a significant difference regarding all factors under study before and after the educational programme except for two individual factors, old age (p = 0.84), overall poor health status (p = 0.38), and two health factors, uses aids (p = 0.50), treatment by heparin (p = 1.00), and two environmental factors, poor lighting (p = 0.34), loose cords or wires (p = 0.30) and bells (p = 0.30), and one miscellaneous factor, patient education (p = 0.85) and tidy environment(p = 0.85). All departments showed posttest performance improvement, the total performance median for departments regarding environmental factor (p = 0.04) and health education (p = 0.001). Conclusion: Education programmes should be regularly, updated in view of changing knowledge and work practices.
Shielding Properties of Lead Zinc Borate Glasses  [PDF]
Samir Yousha El-Kameesy, Sahar Abd El-Ghany, Moenis Abd El-Hakam Azooz, Yaser Abd Allah El-Gammam
World Journal of Condensed Matter Physics (WJCMP) , 2013, DOI: 10.4236/wjcmp.2013.34033
Abstract:

In the present work, ZnO·PbO·B2O3 glasses are prepared to be used as g-ray shielding materials. The attenuation properties of these glasses with different concentrations of PbO (20% - 70%) have been investigated at photon energies 662, 1173, 1332 and 2614 keV. The optical absorption spectra of some glass samples have been measured from 200 to 1100 nm before and after g-ray irradiation. The analyses of these spectra have been interpreted and discussed.

Evaluation of Autogenous Avibacterium paragallinarum Bacterins in Chickens
Wafaa A. Abd El-Ghany
International Journal of Poultry Science , 2011,
Abstract: In this investigation, a trial for preparation and evaluation of locally prepared (autogenous) bacterin against the infection with Avibacterium paragallinarum (Avi. paragallinarum) causing infectious coryza disease in layer chickens was done. Two types of adjuvant (aluminum hydroxide and mineral oil based) were compared. At 6 weeks of age, one hundred layer chickens were divided into equally distributed 4 groups each containing 25 birds. Group (1) was vaccinated with Avi. paragallinarum autogenous bacterin containing aluminum hydroxide, while group (2) received Avi. paragallinarum autogenous bacterin containing mineral oil. Both types of bacterins were given in a dose of 0.5 ml/bird and administered intramuscularly (IM). Booster dose of both types of the autogenous bacterins was given in group 1 and 2 at 9 weeks of age. Chickens of group (3) were kept without vaccination. Birds in groups 1, 2 and 3 were challenged with (106 CFU) of live Avi. paragallinarum culture by inoculation into the nasal sinus at 12 weeks old. Group (4) was left as blank control negative (not vaccinated or challenged). Birds after challenge were kept under complete daily observation for 7 days. Signs, mortalities, postmortem lesions, protection rate and reisolation rate of the organism were taken as criteria for bacterin evaluation, also agglutination test were performed on sera to determine the immune response to bacterin at the doses intervals. The results revealed that whatever the type of adjuvant, both different adjuvanted types' bacterines were effective and safe in prevention of infection against Avi. paragallinarum in layers when administered at 6 and boosted at 9 weeks of age.
The In-vitro and In-vivo Evaluation of Tiamulin and Tilmicosin for the Treatment of Mycoplasma gallisepticum Infected Broiler Chickens
Wafaa A. Abd El-Ghany
International Journal of Poultry Science , 2009,
Abstract: This study was undertaken to evaluate the efficacy of some antimicrobials containing tiamulin and tilmicosin (as active principles) against Mycoplasma gallisepticum (MG) infection both in-vitro and in-vivo. For in-vitro investigation, the Minimum Inhibitory Concentration (MIC) of tiamulin and tilmicosin against MG organism was done. However, the in-vivo evaluation of tiamulin and tilmicosin against field MG infection was carried out on a commercial broiler chicken farm taken from MG infected farm and proved to have such infection through bacteriological and serological examination at day old. Once the birds suffered from respiratory signs at 22 days of age, this flock was divided into three separate houses. Chickens in house (1) were kept as MG-infected without treatment; chickens in the house (2) were treated with tiamulin in the drinking water (1 gram/1.5 liter) for 3 successive days and the birds in house (3) were also treated with tilmicosin in the drinking water (0.3 ml/liter) for 3 successive days. Just after appearance of the first clinical signs and mortalities, the clinical signs score was recorded, the birds were weighed and the serum samples were collected for serological examination. The clinical signs and the mortalities in each house were recorded daily during and after the treatment course till the end of the study (42 days of age). The body weight of the birds in each house was determined weekly till 6 weeks of age. Twenty birds from each house were sacrificed weekly for recording the air-sac lesion score and for re-isolation of MG. The air-sac lesion score and the re-isolation of MG were also detected from the dead birds. Serum samples were collected from sacrificed 20 birds just after appearance of clinical signs and from each house at the end of the work (42 days of age) for detecting the presence of antibodies for MG infection using serum plate agglutination test. The results of the in-vitro assessment revealed that the MIC of tiamulin and tilmicosin (μg/ml) was 0.1 and 0.05; respectively. In-vivo evaluation of tiamulin and tilmicosin denoted that there were significant (p<0.05) differences between MG-infected non-treated house and the treated houses, Tiamulin and tilmicosin succeeded in inducing significant reduction (p<0.05) in the mean clinical score, mortality rate, mean gross air-sac lesion score, re-isolation rate of MG and absence of MG antibodies in the treated houses than the infected control group. Moreover, significant (p<0.05) improvement in the mean body weights was observed in the treated chickens than the infected ones
Assessment of Sub-Endometrial Junction Zone by 3-Dimensional Transvaginal Ultrasound in Unexplained Recurrent Implantation Failure and Its Effect on ICSI Outcomes  [PDF]
Abd El-Naser Abd El-Gaber Ali, Syed A. Taha, Mohammed F. Abd El-Ghany, Mustafa M. Khodry, Ahmed M. Abbas
Open Journal of Obstetrics and Gynecology (OJOG) , 2019, DOI: 10.4236/ojog.2019.91006
Abstract: BACKGROUND: Sub-endometrial junction zone (JZ) plays an important role in most of reproductive functions. OBJECTIVE: To find out the effect of the sub-endometrial JZ thickness assessment by 3-D trans-vaginal ultrasound (TVUS) on intracytoplasmic sperm injection (ICSI) outcomes in patients with unexplained recurrent implantation failure (RIF). SETTING: ART Unit of Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University, Qena, Egypt. DURATION: From April 2016 to October 2018. STUDY DESIGN: A prospective observational study. METHDS: Fifty couples with history of unexplained RIF in previous ICSI cycles and prepared for another ICSI cycle (group I)
A CDMA Based Scalable Hierarchical Architecture for Network-On-Chip
Ahmed A. El Badry,Mohamed A. Abd El Ghany
International Journal of Computer Science Issues , 2012,
Abstract: A Scalable hierarchical architecture based Code-Division Multiple Access (CDMA) is proposed for high performance Network-on-Chip (NoC). This hierarchical architecture provides the integration of a large number of IPs in a single on-chip system. The network encoding and decoding schemes for CDMA transmission are provided. The proposed CDMA NoC architecture is compared to the conventional architecture in terms of latency, area and power dissipation. The overall area required to implement the proposed CDMA NoC design is reduced by 24.2%. The design decreases the latency of the network by 40%. The total power consumption required to achieve the proposed design is also decreased by 25%.
Modification of water application uniformity among closed circuit trickle irrigation systems  [PDF]
Hani A.-G. Mansour, Mohamed Yousif Tayel, Mohamed A. Abd El-Hady, David A. Lightfoot, Abdel-Ghany Mohamed El-Gindy
Agricultural Sciences (AS) , 2010, DOI: 10.4236/as.2010.11001
Abstract: The aim of this research was determine the ma- ximum application uniformity of closed circuit trickle irrigation systems designs. Laboratory tests carried out for Two types of closed circuits: a) One manifold for lateral lines or Closed circuits with One Manifold of Trikle Irrigation System (COMTIS); b) Closed circuits with Two Manifolds of Trikle Irrigation System (CTMTIS), and c) Traditional Trikle Irrigation System (TTIS) as a control. Three lengths of lateral lines were used, 40, 60, and 80 meters. PE tubes lateral lines: 16 mm diameter; 30 cm emitters distance, and GR built-in emitters 4 lph when operating pressure 1 bar. Experiments were conducted at the Agric. Eng. Res. Inst., ARC, MALR, Egypt. With COMTIS the emitter flow rate was 4.07, 3.51, and 3.59 lph compared to 4.18, 3.72, and 3.71 lph with CTMTIS and 3.21, 2.6, and 2.16 lph with TTIS (lateral lengths 40, 60, and 80 meters respectively). Uniformity varied widely within individual lateral lengths and between circuit types. Under CTMTIS uniformity values were 97.74, 95.14, and 92.03 %; with COMTIS they were 95.73, 89.45, and 83.25 %; and with TTIS they were 88.27, 84.73, and 80.53 % (for lateral lengths 40, 60, 80 meters respectively). The greatest uniformity was observed under CTMTIS and COMTIS when using the shortest lateral length 40 meters, then lateral length 60 meters, while the lowest value was observed when using lateral length 80 meters this result depends on the physical and hydraulic characteristics of the emitter and lateral line. CTMTIS was more uniform than either COMTIS or TTIS. Friction losses were decreased with CTMTIS in the emitter laterals at lengths 40 meters compared to TTIS and COMTIS. Therefore, differences may be related to increased friction losses when using TDIS and COMDIS.
Ocular Changes in Egyptian Children on Regular Hemodialysis  [PDF]
Somaya Mohamed Abd El-Ghany, Manal Abd El-Salam, Mona Mohamed Farag, Ola Ali El-Ashwah
International Journal of Clinical Medicine (IJCM) , 2019, DOI: 10.4236/ijcm.2019.106028
Abstract: Background: Chronic Kidney disease (CKD) may cause ocular disorders for many reasons such as uraemia, haemodialysis and hypertension. Aim: To study the ocular changes in a group of Egyptian children with chronic kidney disease on regular hemodialysis. Subjects and Methods: This cross-sectional comparative study was conducted on 30 children on regular hemodialysis and another 30 age and sex-matched healthy children as controls. Their ages ranged from 4 to 17 years. Complete ophthalmological examination including; visual acuity and refraction, anterior segment examination, intraocular pressure (IOP), fundus examination and colored photography were assessed in the same line with routine laboratory investigations for children on regular hemodialysis and their controls. The relation of ocular disorders with related clinical and biochemical variables was measured statistically. Results: The most common eye abnormalities recorded were decreased visual acuity in Lt eye (73.3%) and Rt eye (60%), followed by corneal & conjunctiva calcification were (16.7%) and (13.3%) respectively and fundal changes (13.3%) of the study population. A significant positive relation was found between fundal changes particularly tortuous blood vessel abnormalities with the duration of hemodialysis and serum creatinine level. Conclusion: Ocular abnormalities are common than expected in children on regular hemodialysis. Visual acuity disorder is the major ocular abnormalities recorded in those patients. Regular ophthalmologic assessment is recommended in children to prevent longer-term visual complications.
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