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Search Results: 1 - 10 of 282 matches for " Moa Fransson "
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CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
Moa Fransson, Elena Piras, Joachim Burman, Berith Nilsson, Magnus Essand, BinFeng Lu, Robert A Harris, Peetra U Magnusson, Eva Brittebo, Angelica SI Loskog
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-112
Abstract: CD4+ T cells were modified utilizing a lentiviral vector system to express a chimeric antigen receptor (CAR) targeting myelin oligodendrocyte glycoprotein (MOG) in trans with the murine FoxP3 gene that drives Treg differentiation. The cells were evaluated in vitro for suppressive capacity and in C57BL/6 mice to treat EAE. Cells were administered by intranasal (i.n.) cell delivery.The engineered Tregs demonstrated suppressive capacity in vitro and could efficiently access various regions in the brain via i.n cell delivery. Clinical score 3 EAE mice were treated and the engineered Tregs suppressed ongoing encephalomyelitis as demonstrated by reduced disease symptoms as well as decreased IL-12 and IFNgamma mRNAs in brain tissue. Immunohistochemical markers for myelination (MBP) and reactive astrogliosis (GFAP) confirmed recovery in mice treated with engineered Tregs compared to controls. Symptom-free mice were rechallenged with a second EAE-inducing inoculum but remained healthy, demonstrating the sustained effect of engineered Tregs.CNS-targeting Tregs delivered i.n. localized to the CNS and efficiently suppressed ongoing inflammation leading to diminished disease symptoms.
Surgical misadventure: A case for thoughtful patient preoperative assessment
MOA Samaila
Nigerian Journal of Surgical Research , 2005,
Abstract: Breast abscess is a common problem in women particularly in lactating women in Tropical Africa. Occasionally a chronic breast abscess may mimic carcinoma of the breast. This is a case presentation of a 45-year old woman who presented with a 1year history of progressively increasing right breast swelling associated with enlarged axillary lymph nodes. It was diagnosed breast cancer and patient had a radical mastectomy in a peripheral hospital. Histology of the specimen however revealed a chronic breast abscess with granulation tissue formation,extensive fibrosis of the surrounding breast tissue and nodal hyperplasia. Patient recovered uneventfully and was discharged home. An assessment of the psychological impact of losing a breast in this patient was not possible as patient was lost to follow up. Optimal clinical examination by the surgeon and preoperative cytological diagnosis would ensure that the patient is spared unnecessary mutilating surgery. Nigerian Journal of Surgical Research Vol. 7(1&2) 2005: 214-215
Adnexal skin tumors in Zaria, Nigeria
Samaila MOA
Annals of African Medicine , 2008,
Abstract: Background : Adnexal skin tumors share many features in common and differentiate along one line. Their detailed morphological classification is difficult because of the variety of tissue elements and patterns seen. They may be clinically confused with other cutaneous tumors. The aim of this report is to review and classify all adnexal tumors seen in a pathology department over a 16 year period. Method : A 16-year retrospective analysis of all adnexal skin tumors seen in a large University Teaching Hospital in Nigeria from January 1991- December 2006. All tissue specimens were fixed in 10% formalin, processed in paraffin wax and stained with Haematoxylin and Eosin. Histology slides were retrieved, studied and lesions characterized. Results : Fifty-two adnexal tumors were seen, accounting for 0.9% of all cutaneous tumors seen within the same period. The median age was 33 years (range: 4 days -70 years). Clinical presentations varied from discreet swellings and nodules to ulcerated masses. Five patients presented with recurrent lesions. Only two cases had a clinical diagnosis of adnexal tumor. Twenty-four (46%) of the lesions were distributed in the head and neck region. Duration of symptoms was 2 months to 15 years (median: 12months). Tumours of the sweat gland were the commonest– 41(78.8%); they comprised predominantly eccrine acrospiroma (17), characterized histologically by solid nests of round to polygonal cells with clear to eosinophilic cytoplasm, forming tubules in areas. Tumours of sebaceous gland were 7 (13.5%); they comprised mainly Nevus sebaceous of Jadassohn (6), composed of immature sebaceous glands and pilar structures microscopically and a solitary sebaceous adenoma. Tumours of hair follicle were 4 (7.7%) and included trichoepithelioma, characterized microscopically by multiple horn cysts and epithelial tracts connecting abortive pilar structures and a trichofolliculoma. Forty-six lesions (88.5%) were benign and six (11.5%) malignant. Conclusion : Adnexal skin tumors have distinct histological patterns which differentiates them from other cutaneous tumors. They are commonly distributed in the head, neck and trunk. The commonest variants are those of eccrine sweat gland origin. Malignant adnexal tumors are uncommon in our setting.
Observation of the halo of the edge-on galaxy IC5249
The MOA Collaboration
Physics , 1998,
Abstract: We report optical photometry and HI synthesis observations of the southern edge-on S_c,d galaxy IC5249. The observations were carried out primarily to determine if IC5249 has a red halo surrounding it similar to the halo that has been recently found surrounding the northern edge-on galaxy NGC5907. The galaxy IC5249 is almost perfectly edge-on, and it shows no direct sign of warping or flaring out to its optical radius. It has a low luminosity and a slow rotation velocity. We find that it has a remarkably similar halo to NGC5907. The halo is visible at a distance of 3kpc from the disk of the galaxy, and at 6kpc the surface brightness is ~ 28 mag arcsec^-2. The measured distribution of halo light is similar to the distribution expected for dark matter. Red dwarfs and red giants are possible sources of the halo light. If red dwarfs are the source, and if they are distributed like dark matter, then their density at galactocentric radius r = 8.5 kpc is (7+/-3) times the the local Galactic density of halo red dwarfs. Their total contribution to the mass of IC5249 would be about 10% of the mass of the galaxy. If red giants are the dominant source of the observed halo light, and if they are distributed like Galactic gobular clusters, then their density at r = 8.5 kpc is 1.0 +1.0-0.5 times the local Galactic density of halo giants, and they provide a gravitationally insignificant fraction of the mass of the galaxy. Further optical measurements are required to identify the source of the halo light in IC5249, and also to determine more precisely its distribution. Further radio measurements are required to examine the HI distribution and rotation velocity beyond the optical radius of the galaxy.
Series Evaluation of a Quartic Integral
Moa Apagodu
Mathematics , 2009,
Abstract: We present a new single sum series evaluation of Moll's quartic integral and present two new generalizations
One-parameter Generalizations of Ramanujan's Formula for $π$
Moa Apagodu
Mathematics , 2009,
Abstract: Several terminating generalizations of Ramanujan's formula for $\frac{1}{\pi}$ with complete WZ proofs are given.
Leiomyosarcoma uteri in a white woman
AG Adesiyun, MOA Samaila
Annals of African Medicine , 2010,
Malignant transformation in Pre-existing Naevi. A review of two cases
MOA Samaila, AG Adesiyun
Nigerian Journal of Surgical Research , 2006,
Abstract: Pigmented naevi (melanocytic naevi) are common and are widely distributed all over the body. The average number of naevi seen in a Caucasian is between twenty and thirty. They are either congenital or acquired benign neoplasm of melanocytes. They may occur as giant lesions at birth, and are more prone to malignant transformation. However, the risk of malignant transformation associated with naevi irrespective of size is well established and a variety of malignancies have been reported to arise from a naevus. The incidence of malignant transformation in naevi is 4% to 9%. We present two cases of malignant tumours arising from pre-existing naevus. The first was a 60-year old woman with a malignant melanoma arising in a vulva intradermal naevus. The second was a 51-year old woman with a basal cell carcinoma arising in a facial naevus.
A histopathological analysis of cutaneous malignancies in a tropical African population
MOA Samaila, SA Adewuyi
Nigerian Journal of Surgical Research , 2005,
Abstract: Aim: To establish the prevalence of cutaneous malignancies in Zaria, Northern Nigeria. Method: This is a histopathological analysis of three hundred and eighty two cases of cutaneous malignancies seen and diagnosed in the department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria from January 1991 to December 2000. The specimens were fixed in formalin, processed in paraffin wax and stained with haematoxylin and eosin. The slides were studied and the lesions were characterized. Results: Three hundred and eighty two cutaneous malignancies were analysed. The M: F ratio of all the tumours was 1.9:1.0. Nonmelanoma skin tumours were the commonest and accounted for 254 (66.8%). They comprised of squamous cell carcinoma 239 (62.9%), basal cell carcinoma 15 (3.9%) and malignant adnexal tumours which were the least common accounting for 2 (0.5%). Sarcomas accounted for 72(18.9%) and kaposi sarcoma 41(10.7%), was the commonest in this group. Malignant melanoma cases were 54 (14.1%). There were two peak age distributions in the 4th and 6th decades (63.6%) for all tumours. The lower limb was the prevalent site of distribution of all the tumours with sixty five percent cases. Conclusion: Cutaneous malignancies are common in our setting and the commonest was squamous cell carcinoma. Prompt and adequate treatment of chronic leg ulcers and burns injury as well as control of HIV infection should help to reduce the burden of these cancers.
Extrapulmonary tuberculosis: Fine needle aspiration cytology diagnosis
MOA Samaila, OP Oluwole
Nigerian Journal of Clinical Practice , 2011,
Abstract: Background: The increasing prevalence of extrapulmonary manifestation of tuberculosis with the HIV scourge is a cause for concern. Objective: To determine the role of fine needle aspiration cytology (FNAC) in the diagnosis of extrapulmonary tuberculosis. Patients and Methods: This is a consecutive 9-year analysis of patients with peripheral lymphadenopathy. All the patients had fine needle aspiration. Smears were made, fixed in 95% alcohol and stained with hematoxylin and eosin and Zeihl Neelsen stains. Results: 48 patients, 31 males and 17 females, were analyzed. The mean age was 27.9 years. Aspirates were mainly from cervical lymph nodes. Four patients were HIV 1 seropositive. Macroscopically, 23 (48%) of the aspirates were purulent and 7 (14.6%) had caseous material. Microscopy showed granular eosinophilic material (caseation), multinucleated giant cells, epithelioid cells, neutrophils and lymphocytes. Staining for acid-fast bacilli was positive in 23 (48%) cases. Conclusion: Early diagnosis of extrapulmonary tuberculosis in a resource- limited setting can be achieved with fine needle aspiration cytology technique (FNAC). This will ensure prompt treatment and thus reduce attendant morbidity and mortality.
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