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Search Results: 1 - 10 of 20482 matches for " Miyoung Kim "
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Comparison of Dissolution and Surface Reactions Between Calcite and Aragonite in L-Glutamic and L-Aspartic Acid Solutions
Miyoung Ryu,Hwan Kim,Mihee Lim,Kwangsuk You,Jiwhan Ahn
Molecules , 2010, DOI: 10.3390/molecules15010258
Abstract: We have investigated dissolution and surface reaction of calcite and aragonite in amino acid solutions of L-glutamic (L-glu) and L-aspartic acid (L-asp) at weak acidity of above pH 3. The surface reactions of calcite and aragonite were related with the dissolution. Calcite was dissolved in both solutions but the dissolution was limited by an adsorption of Ca-carboxylate salt. Aragonite was neither dissolved nor reacted in amino acid solutions because the crystal surface consisted of a hard to dissolve structure.
Interfacial microscopic mechanism of free energy minimization in Omega precipitate formation
Sung Jin Kang,Young-Woon Kim,Miyoung Kim,Jian-Min Zuo
Physics , 2014,
Abstract: Precipitate strengthening of light metals underpins a large segment of industry.Yet, quantitative understanding of physics involved in precipitate formation is often lacking, especially, about interfacial contribution to the energetics of precipitate formation.Here, we report an intricate strain accommodation and free energy minimization mechanism in the formation of Omega precipitates (Al2Cu)in the Al_Cu_Mg_Ag alloy. We show that the affinity between Ag and Mg at the interface provides the driving force for lowering the heat of formation, while substitution between Mg, Al and Cu of different atomic radii at interfacial atomic sites alters interfacial thickness and adjust precipitate misfit strain. The results here highlight the importance of interfacial structure in precipitate formation, and the potential of combining the power of atomic resolution imaging with first-principles theory for unraveling the mystery of physics at nanoscale interfaces.
Proton Pump Inhibitors Exert Anti-Allergic Effects by Reducing TCTP Secretion
Sunghee Choi,Hyun Jung Min,Miyoung Kim,Eun Sook Hwang,Kyunglim Lee
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0005732
Abstract: Extracellular translationally controlled tumor protein (TCTP) is known to play a role in human allergic responses. TCTP has been identified outside of macrophages, in activated mononuclear cells, and in biological fluids from allergic patients. Even TCTP devoid of signal sequences, is secreted to extracellular environment by an yet undefined mechanism. This study is aimed at understanding the mechanism of TCTP release and its regulation. A secondary goal is to see if inhibitors of TCTP release can serve as potential anti-allergic asthmatic drugs.
A Signature-Based Data Security Technique for Energy-Efficient Data Aggregation in Wireless Sensor Networks
Min Yoon,Miyoung Jang,Hyeong-Il Kim,Jae-Woo Chang
International Journal of Distributed Sensor Networks , 2014, DOI: 10.1155/2014/272537
Abstract: Data aggregation techniques have been widely used in wireless sensor networks (WSNs) to solve the energy constraint problems of sensor nodes. They can conserve the significant amount of energy by reducing data packet transmission costs. However, many data aggregation applications require privacy and integrity protection of the real data while transmitting data from the sensing nodes to a sink node. The existing schemes for supporting both privacy and integrity, that is, iCDPA, and iPDA, suffer from high communication cost, high computation cost, and data propagation delay. To resolve the problems, we propose a signature-based data security technique for protecting sensitive data aggregation in WSNs. To support privacy-preserving data aggregation and integrity checking, our technique makes use of the additive property of complex numbers. Out of two parts of a complex number, the real part is used to hide the sampled data of a sensor node from its neighboring nodes and adversaries, whereas the imaginary part is used for data integrity checking at both data aggregators and the sink node. Through a performance analysis, we prove that our privacy-preserving data aggregation scheme outperforms the existing schemes up to 50% in terms of communication and computation overheads as well as up to 3 times in terms of integrity checking and data propagation delay. 1. Introduction Wireless sensor networks (WSNs) have been widely studied in ubiquitous computing environment. The WSNs can be applied to various types of applications, such as environment management and military monitoring [1–4]. However, the sensor nodes that form WSNs have resource constraints such as limited power, slow processor, and less memory. For these reasons, it is essential to improve the energy efficiency of sensor nodes (or WSN) in order to enhance the quality of application service [5–10]. The first issue of WSNs is to reduce energy consumption in WSNs. Because the amount of energy consumption for communication is the greatest, it is important to reduce communication overhead. For reducing communication cost, transmitting the required and partially processed data is more meaningful than sending a large amount of raw data. In general, sending raw data causes the energy consumption of sensor nodes because duplicated messages are sent to the same node, called implosion, as well as neighboring nodes receive the duplicated messages if two nodes share the same observing region, called overlapping. In recent years, data aggregation has been actively used to combine data coming from many sensor
Possible Role of the Glycogen Synthase Kinase-3 Signaling Pathway in Trimethyltin-Induced Hippocampal Neurodegeneration in Mice
Juhwan Kim, Miyoung Yang, Sung-Ho Kim, Jong-Choon Kim, Hongbing Wang, Taekyun Shin, Changjong Moon
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070356
Abstract: Trimethyltin (TMT) is an organotin compound with potent neurotoxic effects characterized by neuronal destruction in selective regions, including the hippocampus. Glycogen synthase kinase-3 (GSK-3) regulates many cellular processes, and is implicated in several neurodegenerative disorders. In this study, we evaluated the therapeutic effect of lithium, a selective GSK-3 inhibitor, on the hippocampus of adult C57BL/6 mice with TMT treatment (2.6 mg/kg, intraperitoneal [i.p.]) and on cultured hippocampal neurons (12 days in vitro) with TMT treatment (5 μM). Lithium (50 mg/kg, i.p., 0 and 24 h after TMT injection) significantly attenuated TMT-induced hippocampal cell degeneration, seizure, and memory deficits in mice. In cultured hippocampal neurons, lithium treatment (0–10 mM; 1 h before TMT application) significantly reduced TMT-induced cytotoxicity in a dose-dependent manner. Additionally, the dynamic changes in GSK-3/β-catenin signaling were observed in the mouse hippocampus and cultured hippocampal neurons after TMT treatment with or without lithium. Therefore, lithium inhibited the detrimental effects of TMT on the hippocampal neurons in vivo and in vitro, suggesting involvement of the GSK-3/β-catenin signaling pathway in TMT-induced hippocampal cell degeneration and dysfunction.
Effect of Hydraulic Activity on Crystallization of Precipitated Calcium Carbonate (PCC) for Eco-Friendly Paper
Jung-Ah Kim,Gi-Chun Han,Mihee Lim,Kwang-Suk You,Miyoung Ryu,Ji-Whan Ahn,Toyohisa Fujita,Hwan Kim
International Journal of Molecular Sciences , 2009, DOI: 10.3390/ijms10114954
Abstract: Wt% of aragonite, a CaCO3 polymorph, increased with higher hydraulic activity (°C) of limestone in precipitated calcium carbonate (PCC) from the lime-soda process (Ca(OH)2-NaOH-Na2CO3). Only calcite, the most stable polymorph, was crystallized at hydraulic activity under 10 °C, whereas aragonite also started to crystallize over 10 °C. The crystallization of PCC is more dependent on the hydraulic activity of limestone than CaO content, a factor commonly used to classify limestone ores according to quality. The results could be effectively applied to the determination of polymorphs in synthetic PCC for eco-friendly paper manufacture.
Comparison of the MicroScan, VITEK 2, and Crystal GP with 16S rRNA sequencing and MicroSeq 500 v2.0 analysis for coagulase-negative Staphylococci
Miyoung Kim, Se Heo, Soon Choi, Hyelin Kwon, Jeong Park, Moon-Woo Seong, Do-Hoon Lee, Kyoung Park, Junghan Song, Eui-Chong Kim
BMC Microbiology , 2008, DOI: 10.1186/1471-2180-8-233
Abstract: The MicroScan, VITEK 2, and Crystal GP systems correctly identified 82.5%, 87.5%, and 67.5% of the isolates, respectively. Misidentification was the main problem in MicroScan (10.8%) and Crystal GP (23.3%) systems, whereas the main problem of VITEK 2 was low-level discrimination (7.5%).None of the 3 phenotypic systems tested could accurately and reliably identify CNS at the species level. Further verifications such as biochemical testing or 16S rRNA sequencing together with analysis using a comparable database might be helpful in this regard.Because of their ubiquity and low virulence, coagulase-negative staphylococci (CNS) have generally been considered to be nonpathogens or simple contaminants. Recently, their clinical significance is being increasingly recognized with the elucidation of their pathogenicity. CNS can form biofilms and have been demonstrated to exhibit antibiotic resistance [1,2]. S. epidermidis, S. haemolyticus, and S. lugdunensis, to a lesser extent, are well-known etiological agents of implanted device-mediated infections [2-5]. S. saprophyticus can cause community-acquired infections of the uropoietic tract. Hence, species-level identification of CNS is necessary for correct guidance of clinicians in terms of appropriate treatment strategy, and a wide variety of identification methods have been proposed.Many automated phenotypic identification systems are commercially available, including the MicroScan (Dade Behring, West Sacramento, CA, USA), VITEK 2 (bioMérieux, Maray l'Etoile, France), and Crystal GP (Becton Dickinson, Sparks, MD, USA) systems. On the basis of metabolic activities and/or morphological features, these systems enable microbiologists to identify bacterial isolates at the species level with greater ease, accuracy, and rapidity than that previously achieved [6]. However, these systems have several potential problems: (i) different strains in one species may not exhibit a specific characteristic, (ii) isolates from old cultures may
Quality of Canola Oil Obtained by Conventional and Supercritical Fluid Extraction  [PDF]
Rabie Khattab, Curtis Rempel, Miyoung Suh, Usha Thiyam
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.312A128
Abstract:

Quality of canola oil obtained by the supercritical fluid extraction (SFE), using CO2 with ethanol as a co-solvent, was evaluated and compared to that of the conventionally-obtained oils using either n-hexane or chloroform methanol mixture. Physical characteristics, chemical properties, fatty acid composition and phenolic profile of oils were investigated. The SFE oil showed significantly lower melting point, peroxide value (PV) and higher free fatty acids (FFAs) and iodine value (IV) than the n-hexane-extracted one. There were no significant differences in the fatty acid composition of different oils. The SFE oil showed significantly higher phenolic content (35.91, 10.15, 3.16, 0.32 and47.48mg/g of sinapic acid, sinapine, sinapoyl glucose, canolol and total phenolics) as compared to 0.08, 0.70, 0.88, 0.45 and0.71mg/g, respectively in the n-hexane-extracted oil. These results indicate the superiority of SFE and advocate its use for the extraction of highly stable and functional canola oil for further health and nutraceutical uses. The present results have an industrial and technological relevance as SFE could be competitive with the traditional extraction techniques providing an environmental approach and enhancing the obtained oil quality and stability. After recovery of the initial installation costs, SFE could be more economic than conventional extraction. However, further economical studies are needed to validate this last conclusion.

Valproic Acid Decreases Cell Proliferation and Color Preference in the Zebrafish Larvae  [PDF]
Bongkyu Lee, Sujeong Lee, Miyoung Choi, Chang-Joong Lee
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.512007
Abstract: Valproic acid (VPA) is widely used as an antiepileptic drug or mood stabilizer. In this study, we evaluated the effects of treatment with 2 mM VPA for 3 h on cell proliferation in the telencephalic area of zebrafish larvae using bromodeoxyuridine (BRDU) to label dividing cells. It was demonstrated that 2 mM VPA exposure for 3 h at 2 and 3 days post-fertilization (dpf) larvae decreased cell proliferation in the telencephalic area of 5 dpf larvae. The reduced cell proliferation was not restored at 10 dpf larvae. The quantitative real-time PCR (qRT-PCR) data indicated that mRNA expression levels of WNT signaling pathway-related factors such as β-catenin, LEF1, and gsk3β were altered in the zebrafish larvae treated with 2 mM VPA at 2 and 3 pdf. It was also demonstrated that 2 mM VPA exposure affected color preference of the zebrafish larvae, reducing blue color preference at 5 dpf larvae. The altered color preference was restored at 10 dpf larvae. These results suggest that VPA exposure may cause molecular, cellular, and behavioral alterations in early developmental stage of the zebrafish.
Dimerization of Translationally Controlled Tumor Protein Is Essential For Its Cytokine-Like Activity
Miyoung Kim, Hyun Jung Min, Hee Yeon Won, Heejin Park, Ji-Chul Lee, Heung-Woo Park, Junho Chung, Eun Sook Hwang, Kyunglim Lee
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0006464
Abstract: Background Translationally Controlled Tumor Protein (TCTP) found in nasal lavage fluids of allergic patients was named IgE-dependent histamine-releasing factor (HRF). Human recombinant HRF (HrHRF) has been recently reported to be much less effective than HRF produced from activated mononuclear cells (HRFmn). Methods and Findings We found that only NH2-terminal truncated, but not C-terminal truncated, TCTP shows cytokine releasing activity compared to full-length TCTP. Interestingly, only NH2-terminal truncated TCTP, unlike full-length TCTP, forms dimers through intermolecular disulfide bonds. We tested the activity of dimerized full-length TCTP generated by fusing it to rabbit Fc region. The untruncated-full length protein (Fc-HrTCTP) was more active than HrTCTP in BEAS-2B cells, suggesting that dimerization of TCTP, rather than truncation, is essential for the activation of TCTP in allergic responses. We used confocal microscopy to evaluate the affinity of TCTPs to its putative receptor. We detected stronger fluorescence in the plasma membrane of BEAS-2B cells incubated with Del-N11TCTP than those incubated with rat recombinant TCTP (RrTCTP). Allergenic activity of Del-N11TCTP prompted us to see whether the NH2-terminal truncated TCTP can induce allergic airway inflammation in vivo. While RrTCTP had no influence on airway inflammation, Del-N11TCTP increased goblet cell hyperplasia in both lung and rhinal cavity. The dimerized protein was found in sera from allergic patients, and bronchoalveolar lavage fluids from airway inflamed mice. Conclusions Dimerization of TCTP seems to be essential for its cytokine-like activity. Our study has potential to enhance the understanding of pathogenesis of allergic disease and provide a target for allergic drug development.
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