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Search Results: 1 - 10 of 20942 matches for " Mithilesh Kumar "
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MODIFIED RELEASE FORMULATIONS TO ACHIEVE THE QUALITY TARGET PRODUCT PROFILE (QTPP)
Mithilesh Kumar Jha
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Modified Release (MR) Formulations have a modification in the release mechanism. Modified release dosage forms are developed by altering drug absorption or the site of drug release in order to achieve predetermined clinical objectives. Modified drug release from dosage forms is complemented by the allied processes of drug design, of dosage administration, and of membrane transport and absorption of drug to the biological site of action. Modified-release drugs have complex formulations that can offer an advantage over standard medication for some patients. Modified-release preparations should only be used where there is a clear clinical advantage over conventional-release preparations. In general, Modified-release preparations should be reserved for specific patients where there is a problem with compliance, effectiveness or side-effects which these preparations could help overcome. Modified–release technologies have become indispensable to resolving critical technical, therapeutic, and marketing challenges, such as improving patience compliance, less dosage timings, better safety, better indications, delivering poorly soluble and poorly absorbable API’s, product differentiation, patent protection, product life-cycle extension, and better margins. Modified-release formulation design can be conducted for oral and non-oral administration routes. Possible therapeutic benefits of an MR product include improved efficacy and reduced adverse events, increased convenience and patient compliance, optimized performance, a greater selectivity of activity, or new indications.
Faster Exact and Parameterized Algorithm for Feedback Vertex Set in Tournaments
Mithilesh Kumar,Daniel Lokshtanov
Computer Science , 2015,
Abstract: A tournament is a directed graph T such that every pair of vertices are connected by an arc. A feedback vertex set is a set S of vertices in T such that T - S is acyclic. In this article we consider the Feedback Vertex Set problem in tournaments. Here input is a tournament T and integer k, and the task is to determine whether T has a feedback vertex set of size at most k. We give a new algorithm for Feedback Vertex Set in Tournaments. The running time of our algorithm is upper bounded by O(1.618^k + n^{O(1)}) and by O(1.46^n). Thus our algorithm simultaneously improves over the fastest known parameterized algorithm for the problem by Dom et al. running in time O(2^kk^{O(1)} + n^{O(1)}), and the fastest known exact exponential time algorithm by Gaspers and Mnich with running time O(1.674^n). On the way to prove our main result we prove a new partitioning theorem for undirected graphs. In particular we show that the vertices of any undirected m-edge graph of maximum degree d can be colored white or black in such a way that for each of the two colors, the number of edges with both endpoints of that color is between m/4-d/2 and m/4+d/4.
UWB Printed Slot Antenna with Improved Performance in Time and Frequency Domains
Mithilesh Kumar;Ananjan Basu;Shiban Kishen Koul
PIER C , 2011, DOI: 10.2528/PIERC10090904
Abstract: A microstrip-fed slot antenna is proposed for short-range UWB communication. First, the characteristics of a circular monopole UWB antenna, as a representative of a class of UWB antennas seen in the literature, are examined in time (pulse-shape) and frequency (reflection and transmission coefficients) domains. From these measurements, certain limitations of this class of antennas are brought out, which are not widely recognized. We then demonstrate that with proper optimization the traditional microstrip-fed slot antenna overcomes these defects and is an excellent candidate for UWB communication systems. This claim is justified with measurements in time domain and frequency domain.
Circuits and Active Antennas for Ultra-Wide Band Pulse Generation and Transmission
Mithilesh Kumar;Ananjan Basu;Shiban Kishen Koul
PIER B , 2010, DOI: 10.2528/PIERB10052103
Abstract: In this paper, the design and development of a novel active antenna including circuits for Ultra-wide band (UWB) pulse generation and transmission have been described. In this design a pulse with pulse-width approximately 150 ps and amplitude 500 mV (peak-to-peak) was generated using a single high electron mobility transistor (HEMT) as the active device (and an optional Schottky diode for enhanced performance), this being the simplest circuit for generating UWB pulses as far as we know. This circuit was integrated with a newly designed UWB planar microstripfed slot antenna, which is an active antenna in the sense that in addition to radiating the signal, it also acts as a filter, which tailors the spectrum of the transmitted pulse to a shape close to that recommended for UWB communications. We have also given a quantitative analysis, which explains the operation of the circuit.
Role of disodium cromoglycate in vernal conjunctivitis
Vajpayee Rasik,Kumar Salil,Sharma Mithilesh
Indian Journal of Ophthalmology , 1985,
Abstract:
Relationship of disease intensity with weather and management of web blight of winged bean
MITHILESH KUMAR and S.C. DUBEY*
Indian Phytopathology , 2012,
Abstract: Web blight (Thanatephorus cucumeris = Rhizoctonia solam) of winged bean (Psophocarpous tetragonolobus) appeared during second week of September in 1999 and 2000 and increased gradually till maturity. Apparent infection rate was maximum during September 10 to 17, 1999 and 2000. Weather parameters were correlated with disease development. Significantly negative contribution of minimum temperature was observed in the prediction of disease development through multiple regression analysis equation and accounted for more than 80% variation in disease. Vitavax, bavistin, blitox-50, contaf, tilt, captaf and SAAF completely inhibited the mycelial growth of the pathogen. Seed treatment with Glioc/adium virens (Trichoderma virens) + vitavax was found most effective in vitro. Under field conditions, integration of seed treatment (G. virens + vitavax) and spraying of tilt gave minimum disease incidence and high pod yield followed by integration of seed treatment and spraying of contaf.
Nanotechnology: A focus on Treatment of Tuberculosis
Nitish Kumar,Peeyush kumar,Pramod kumar,Mithilesh Kumar
International Journal of Drug Delivery , 2011,
Abstract: Despite the fact that we live in an era of advanced technology and innovation, infectious diseases, like Tuberculosis (TB), continue to be one of the greatest health challenges worldwide. The main drawbacks of conventional TB treatment are the development of multiple drug resistance, resulting in high dose requirements and subsequent intolerable toxicity. Therefore there is a need of a new system have been receiving special attention with the aim of minimizing the side effects of drug therapy, such as poor bioavailability and the selectivity of drugs. Nanoparticle-based drug delivery systems have considerable potential for treatment of TB. The important technological advantages of nanoparticles used as drug carriers are high stability, high carrier capacity, feasibility of incorporation of both hydrophilic and hydrophobic substances, and feasibility of variable routes of administration, including oral application and inhalation. Nanoparticles can also be designed to allow controlled (sustained) drug release from the matrix. These properties of nanoparticles enable improvement of drug bioavailability and reduction of the dosing frequency, and may resolve the problem of nonadherence to prescribed therapy, which is one of the major obstacles in the control of TB epidemics. In this review, we discuss the challenges with the current treatment of the disease and shed light on the remarkable potential of nanotechnology to provide more effective treatment and prevention for TB. Keywords: Tuberculosis; Nanotechnology; liposome; Polymeric nanoparticle; non-polymeric nanoparticle.
Effect of molasses binder on the physical and mechanical properties of iron ore pellets
Anand Babu Kotta,Anshuman Patra,Mithilesh Kumar,Swapan Kumar Karak
- , 2019, DOI: https://doi.org/10.1007/s12613-019-1708-x
Abstract: Molasses was used as an alternative binder to the bentonite binder. The change in moisture absorption by pellets prepared with different iron ores and different molasses contents were investigated. Iron ore properties exerted the major effect on pellet behavior and final pellet quality. The absorbed moisture content of pellets prepared without binder, bentonite-added pellets, and molasses-added pellets were in the range of 7.72%–9.95%, 9.62%–10.84%, and 6.14%?6.69%, respectively. The wet pellet compressive strength of molasses-added pellets (43–230 N/pellet) was superior to that of bentonite-added pellets (9.47–11.92 N/pellet). The compressive strength of dried molasses-modified pellets increased to 222–394 N/pellet, which is currently the highest value achieved for dried pellets.
An Ultra-Wideband Antenna with Band Reject Capability and its Characterization in Time Domain
Rishik Bazaz;Shiban Kishen Koul;Mithilesh Kumar;Ananjan Basu
PIER C , 2011, DOI: 10.2528/PIERC10122110
Abstract: In this paper a square monopole antenna has been proposed which can be used for Ultra Wideband applications. Band-notch performance is introduced by an E-shaped slot on the patch. The dimensions are optimized to give not only the usual 3-10 GHz bandwidth with rejection in the 5-6 GHz band which is commonly used for WLAN, but also short received pulse duration when transmitted and received using a pair of these antennas. The demonstration of short received pulse-width is the primary novelty reported. The performance is verified by time domain measurements, in addition to the usual antenna characterization.
Statistically Matched Wavelet Based Texture Synthesis in a Compressive Sensing Framework
Mithilesh Kumar Jha,Brejesh Lall,Sumantra Dutta Roy
ISRN Signal Processing , 2014, DOI: 10.1155/2014/838315
Abstract: This paper proposes a statistically matched wavelet based textured image coding scheme for efficient representation of texture data in a compressive sensing (CS) frame work. Statistically matched wavelet based data representation causes most of the captured energy to be concentrated in the approximation subspace, while very little information remains in the detail subspace. We encode not the full-resolution statistically matched wavelet subband coefficients but only the approximation subband coefficients (LL) using standard image compression scheme like JPEG2000. The detail subband coefficients, that is, HL, LH, and HH, are jointly encoded in a compressive sensing framework. Compressive sensing technique has proved that it is possible to achieve a sampling rate lower than the Nyquist rate with acceptable reconstruction quality. The experimental results demonstrate that the proposed scheme can provide better PSNR and MOS with a similar compression ratio than the conventional DWT-based image compression schemes in a CS framework and other wavelet based texture synthesis schemes like HMT-3S. 1. Introduction Texture data contain spatial, temporal, statistical, and perceptual redundancies. Representing texture data using standard compression schemes like MPEG-2 [1] and H.264 [2] is not efficient, as they are based on Shannon-Nyquist sampling [3] and do not account for perceptual redundancies. They are often resource consuming (as they acquire too many samples) due to its fine details in textured image and high frequency content. Variety of applications in computer vision, graphics, and image processing (such as robotics, defence, medicine, and geosciences) demands better compression with good perceptual reconstruction quality, instead of bit accurate (high PSNR) reconstruction. This is because the human brain is able to decipher important variations in data at scales smaller than those of the viewed objects. Ndjiki-Nya et al. [4–8], Bosch et al. [9, 10], Byrne et al. [11, 12], and Zhang et al. [13, 14] have proposed techniques to reconstruct visually similar texture from sample data. Statistically matched wavelet [15] is aimed at designing a filter bank that matches a given pattern in the image and can better represent the corresponding image as compared to other wavelet families. Compressive sensing (CS) technique [16] has proved that it is possible to achieve a sampling rate lower than the Nyquist rate [3] with acceptable reconstruction quality. Leveraging the concept of transform coding, compressive sensing enables a potentially large reduction in
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