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Search Results: 1 - 10 of 200786 matches for " Mitesh P Modi "
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PULSATILE: A TOOL FOR CIRCARDIAN RHYTHM - A REVIEW
Prasanth V.V,Mitesh P Modi,Sam T. Mathew
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: In the field of modified release, this review covers the detail aspect of a novel pulsatile drug delivery systems (PDDS) by oral administration that aims to release drugs on a programmed pattern at specific time and specific site as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance. In particular, the recent literature reports on a variety of pulsatile release systems intended for the oral route, which have been recognised as potentially beneficial to the chronotherapy of widespread diseases. Asthma, peptic or deodenal ulcer, diabetes, neurological disorder, hypertension, cardiovascular diseases, arthritis, attention deficit syndrome in children, and hypercholesterolemia these kind of diseases are promising by pulsatile drug delivery. Technically, This system is designed for chronopharmacotherapy which is based on circadian rhythm and beneficial for the drugs having chronopharmacological behavior where night time dosing is required and for the drugs having high first-pass effect and specific site of absorption in gastrointestinal tract. This controlled–release system can maintain the drug concentration within the therapeutic window with a single dose, which lowers the systemic drug level and also preserves medication that rapidly destroyed by the body. Pulsatile drug delivery system is time related or site-specific related to drug released at the desired site within the intestinal tract (e.g., the colon). Pulsatile drug delivery systems are formulated when zero order drug release is not desired. Based on these premises, the aim of this review is to outline the rational and prominent design strategies behind oral pulsatile delivery. Capsular systems, osmotic systems, soluble or erodible polymer coating and rupturable membranes etc. are summarized in this pulse article. Various marketed technologies on pulsatile drug delivery like OROS, PULSINCAP, GEOCLOCK, SODAS, CODAS, etc., were launched by pharmaceutical companies.
Crude Protein and Proline in Dry Bean Seed Respond to Weeding and Soil Fertility Regimes  [PDF]
Silindile P. Miya, Albert T. Modi
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.618277
Abstract: The objective of this study was to investigate the effect of weeds and fertilizer application on dry bean seed quality. Four dry bean (Phaseolus vulgaris L.) cultivars, Caledon (C), Ukulinga (U), Gadra (G) and uMtata (M) were planted for seed production using a field experiment designed as a split, replicated three times. There were three levels of weeding W0 (no weeding), W1 (weeding until 50% flowering) and W2 (weeding all the time until harvest). The weeding treatments were split into no fertilizer application (F0) and optimum fertilizer application (F1) according to soil fertility analysis. At harvest maturity, seeds were compared for quality with respect to size, germination and total protein content. Proline content was determined as a measure of crop response to the weed and fertilizer stresses during crop production. Although seed size was affected by management stress, seed germination was not significantly affected by weeding and fertilizer even when it was explored in terms of seed vigor by determining rate of germination and seedling size. However, weed management and fertilizer application significantly affected proline and total crude protein contents in seeds (P < 0.05). The findings of this study show that the biotic stress of weeds and abiotic stress of soil fertility can be used to determine seed physiological quality of dry bean seeds.
Characterization & Simulation Of Class AB Current Conveyor Second Generation (CCII) Based On Current Mirrors
Dhaval P. Patel,Mitesh Patel
Golden Research Thoughts , 2013, DOI: 10.9780/22315063
Abstract: Research in analog integrated circuits has recently gone in the direction of low voltage (LV) lowpower (LP) design especially in the environment of portable systems. In this area traditional voltage-mode techniques are going to be substituted by the current-mode approach which has the advantage to overcome the gain-bandwidth product limitation typical of operational amplifier. Then they do not require high voltage gains and have good performance in terms of speed bandwidth and accuracy. Inside the current-mode architectures the current-conveyor (CCII) can be considered the basic circuit block because all the active devices can be made of a suitable connection of one or two CCIIs. Recent advances in integrated circuit technology have also highlighted the usefulness of CCII solutions in a large number of signal processing applications. This project describes different topologies of CCIIs. All topologies have been simulated in different CMOS process technologies using Eldo Spice tool and layout is made using Mentor Graphics Back End tools like IC Station and DA-IC. Different characteristics such as gain, bandwidth, terminal impedances, slew rate, dynamic range, input-output current characteristic and offset are measured and tabulated for all theCCII topologies.
Spectrum of Microbial Flora in Diabetic Foot Ulcer and Its Antibiotic Sensitivity Pattern in Tertiary Care Hospital in Ahmedabad, Gujarat
Manisha Jain,Mitesh H Patel,Nidhi K Sood,Dhara J Modi
National Journal of Medical Research , 2012,
Abstract: Introduction: A Prospective study “Spectrum of Microbial flora in diabetic foot ulcer and its antibiotic sensitivity pattern” was carried out in a tertiary care hospital, Ahmedabad on 125 patients in which 85 were male patients and 40 were female patients. Material and Methods: Swabs samples were collected from the edge and margins of ulcers and organism were identified by gram staining culture and biochemical reactions. Results: Out of 125 specimens 108 specimens showed growth of organisms. Total 157 aerobic organisms were isolated from culture positive specimens. It represents an average of 1.25 organisms per case. Among these organisms, 130 gram negative and 27 gram positive organisms were isolated. Pseudomonas aeruginosa (30.57%) was predominant organism followed by Klebsiella spp. (22.29%). Staphylococcus aureus were 12.74% in which Methicillin resistant S. aureus (MRSA) was 55%. Conclusion: incidence of growth was 86.4% in which Pseudomonas aeruginosa (30.57%) is most common isolate. Organisms in mixed infections showed multidrug resistance as compared to single isolated strain. Diabetic foot infections are polymicrobial in nature. As the Wagner’s grade increased, the prevalence of isolates also increased. [National J of Med Res 2012; 2(3.000): 354-357]
A comparative solubility enhancement profile of valdecoxib with different solubilization approaches
Modi A,Tayade P
Indian Journal of Pharmaceutical Sciences , 2007,
Abstract: Solubility enhancement of poorly aqueous soluble drug is an important aspect of formulation development. Although there is plethora of reports of solubility improvement using different techniques, a comparative study of different solubilization approaches are few. Valdecoxib chemically designated as 4-(5-methyl-3-phenyl-4-isoxazolyl) benzenesulfonamide is a novel potent COX-2 inhibitor having poor aqueous solubility (10 mg/ml). Since it is poorly water-soluble, various techniques could be applied to increase its aqueous solubility. Objective of present study was to provide a comparison of effect of various solubilization techniques, namely micellar solubilization, cyclodextrin complexation and cosolvency, on solubility of valdecoxib. Solubility of valdecoxib was determined in various ionic and nonionic surfactants using phase solubility analysis. Similar type of study was performed using different water:cosolvent mixture. In addition, solubility improvement by use of 2 novel hydrophilic β -cyclodextrin derivatives, hydroxypropyl β -cyclodextrin and sulfobutyl ether-7-β -cyclodextrin was examined. Results showed that highest solubility (70 fold) was achieved with use of Cremophor EL followed by Tween 80 and sulfobutyl ether-7-β -cyclodextrin. It was found that surfactants with higher HLB values were better solubilizers. Solubilization capacity was found to increase with increase in hydrocarbon chain of surfactant, suggesting hydrocarbon core of micelles as locus of solubilization. Similarly, less polar solvents were found to increase solubility by greater extent, thus accentuating hydrophobic interaction mechanism. Among cyclodextrin, higher binding constant and solubility enhancement was obtained by use of sulfobutyl ether-7-β -cyclodextrin. Thus, the study generated an important dataset so as to compare effect of various solubilizers on solubility of valdecoxib.
A Study of Schottky Barrier Height Inhomogeneity on In/P-Silicon
B.P. Modi
Journal of Nano- and Electronic Physics , 2011,
Abstract: The current-voltage characteristics of In/p-Si Schottky diode measured over a temperature range of 120-360 K have been interpreted on the basis of thermionic emission across an inhomogenous Schottky contact. The experiment shows that the apparent barrier height Φbe increases and ideality factor decreases from 0.26 eV and 6.36 at 120 K to 0.70 eV and 1.91 at 360 K respectively. The variation of effective Schottky barrier height and ideality factor with temperature has been explained considering lateral inhomogeneties at the metal-semiconductor interface. We have also discussed whether or not the junction current has been connected themionic field emission (TFE) mechanisms.
Hot Corrosion Behavior of Sol-Gel Nano Structured Zirconia Coated 9Cr1Mo Ferritic Steel in Alkali Metal Chlorides and Sulphates Deposit Systems at High Temperatures  [PDF]
Gazala Ruhi, O. P. Modi, I. B. Singh
Journal of Surface Engineered Materials and Advanced Technology (JSEMAT) , 2013, DOI: 10.4236/jsemat.2013.31A008
Abstract:

Fused salt accelerated hot corrosion is quite common in gas turbines, fossil fuelled devices, waste inclinators, pyrochemical systems, etc. Presence of fused salt on metal surface dissolves their existing oxide layer. This results in an increase in oxidation rate of the metal. Since, zirconia coating is well recognized for corrosion protection under high temperature oxidative environment, we have developed zirconia coating on 9Cr1Mo ferritic steel and their oxidation performance was evaluated in LiCl-NaCl and Na2SO4-K2SO4 salts deposit system in air atmosphere at 650?C and 850?C, respectively. Before coating development, zirconium based sol was synthesized using zirconium (IV) propoxide as a precursor. Oxidation test results indicated that the zirconia coated specimens shows more than two times higher corrosion resistance in LiCl-NaCl and three time higher corrosion resistance in Na2SO4-K2SO4 salt deposit, respectively.

A Study of Extended Spectrum ?-Lactamase (ESBL) and AmpC ?-Lactamase Producing Klebsiella Pneumoniae in Neonatal Intensive Care Unit at Tertiary Care Hospital, Ahmedabad
Modi Dhara J, Patel Bhaumik V, Patel Mitesh H, Bhatt Seema S, Sood Nidhi K, Vegad Mahendra M
National Journal of Community Medicine , 2012,
Abstract: Background & objectives: Clinical laboratories need to develop quick screening methods for detection of Extended Spectrum ?-Lactamases (ESBL) & Amplified C (AmpC) ?-Lactamase, so that the appropriate medication can be started without delay. Here, we reported the screening & confirmatory methods for detection of ESBL & AmpC in Klebsiella pneumoniae in Neonatal Intensive Care Unit (NICU). Methods: We had tested 600 blood culture samples from the NICU patients. From the positive bacterial isolates, Klebsiella pneumoniae were screened for ESBL & AmpC production followed by confirmatory methods as per Clinical Laboratory Standard Institute (CLSI) guidelines. Results: Out of the 600 blood culture, 266 were positive for microbial growth. Among them, Klebsiella pneumoniae were in 54 patients. Out of 54 Klebsiella pneumoniae, 48 were positive for ESBL in screening method. Out of 48, 41 isolates were ESBL positive & 4 were AmpC positive by Confirmatory test (Modified Three Dimensional Method for AmpC). Interpretation & conclusions: The prevalence of ESBL & AmpC producing Klebsiella pneumoniae in NICU at our institute is 75.92% & 7.4% which is very alarming, and it requires strict implementation of infection control guidelines in NICU by safe hygiene practices, restricted use of broad spectrum antibiotics as empirical therapy in septicemic cases and also formulation of uniform antibiotic policy for such patients based on the current trend of antibiotic resistance. This can be helpful in preventing emergence of multidrug resistance in such organisms.
Environmental Impact Assessment of Road from Ujjain to Jaora
AshwiniJajda Modi,N. P. Shinkar
International Journal of Engineering and Advanced Technology , 2012,
Abstract: This paper is related to“Environmental Impact Assessment of Road from Ujjain to Jaora”. As the EIA report i.e. Environmental Impact Assessment contains the detail study about the positive as well as negative effects on the plants, human, animals and Environment. Our capacity for destruction is illustrated through the deterioration of the ozone layer, through the extinction of species, and through mass deforestation and desertification. In many parts of the world, economic development projects directed at improving levels of material comfort have had unintended detrimental effects on people and natural resources. Water, land, and air have been degraded to the point where they can no longer sustain existing levels of development and quality of life.We know that as, India is an developing country and economic development in developing countries has been focused on immediate economic gains environmental protection has not been a priority because the economic losses from environmental degradation often occur long after the economic benefits of development have been realized.
Growth temperature and plant age influence on nutritional quality of Amaranthus leaves and seed germination capacity#
AT Modi
Water SA , 2007,
Abstract: As a leafy vegetable, Amaranthus can be harvested at different stages of plant growth, ranging from young seedlings to the late juvenile stage, but data on the changes in leaf nutritional value with plant age are scanty. The objective of this study was to determine the effect of growth temperature on Amaranthus leaf yield and nutritional quality at different stages of plant growth. Five species, A. hybridus var. cruentus, A. hypochondriacus, A. tricolor, A. thunbergii and A. hybridus were compared for their response to hot (33/27oC), warm (27/21oC) and cool (21/15oC) temperature regimes (day/night) in separate glasshouses. Plants were harvested at 20, 40 and 60 d after sowing and leaf yield, minerals (Ca, P and Fe), total protein content, amino acid (methionine and lysine) content and antioxidant activity (inhibition of linoleic acid oxidation) were determined. Seed yield and germination capacity, during two years of after-ripening, were also determined. Results showed that leaf protein content differed significantly (P < 0.01) between species. It was also significantly (P < 0.01) influenced by the growth temperature and stage of plant growth. The pattern of changes in the amounts of lysine and methionine was comparable to that of protein content, but A. thunbergii showed significantly higher amino acid content than the other species. Amaranthus leaves also contained significantly (P < 0.01) more lysine than methionine, regardless of the species and growth temperature. The phosphorus content of leaves was not significantly affected by temperature and stage of plant development, and there were also no significant differences between species. However, the amounts of both calcium and iron changed significantly (P < 0.05) with stages of plant development and with increasing temperatures for all species. The antioxidant activity of Amaranthus leaves increased consistently with plant age and there were significant (P < 0.01) differences between stages of plant development and growth temperature. Warm temperature regimes were most favourable (P < 0.01) for biomass accumulation in all species. Seed production under cool and hot temperatures significantly (P < 0.01) decreased seed germination capacity for all species, but germination improved in response to after-ripening. It is recommended that for greater nutritional benefit, Amaranthus should be grown under warm conditions and younger leaves are preferable.
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