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Search Results: 1 - 10 of 202748 matches for " Misleidy Nápoles Morales "
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Intensity Modulated Radiotherapy (IMRT) in the Planning of Hypofractionated Treatment in Head and Neck Tumors  [PDF]
Misleidy Nápoles Morales, Rogelio Díaz Moreno
International Journal of Clinical Medicine (IJCM) , 2018, DOI: 10.4236/ijcm.2018.99056
Abstract: Head and neck cancer (HNCC) is the sixth most common cancer with an incidence of approximately 600,000 cases per year and 300,000 annual deaths worldwide1y2. In Cuba, cancer of the larynx is the fourth cause in incidence, being the fourth cause of cancer death in men. Radiotherapy constitutes an important modality in the control of these tumors and the Intensity Modulated Radiotherapy (IMRT) is a new advance in this field. With it, it is possible to improve dose distribution, decreasing the dose in adjacent healthy tissues and escalating dose in tumor. In this work we present 33 patients of National Institute of Oncology and Radiobiology in Cuba (INOR), in whom the IMRT was used as a treatment technique with a hypofractionation of the dose. Their response was observed at the end of the treatment and one month later. 56% (19) of the patients had a complete response to treatment at the primary site of the tumor and neck. 10% (3) had no response, progressed. 11 of the patients had no response at the lymph node site at the end of treatment, 8 of these 11 had complete remission one month after radiotherapy ended.
Manejo multidisciplinario en la recidiva de carcinoma epidermoide de conducto auditivo externo. Presentación de un caso Multidisciplinary handling of epidermoid carcinoma in the external auditory canal. Presentation of a case
Misleidy Nápoles Morales,Orlando Cruz García,Juan Carlos Alfonso Coto,Pedro Pablo Morales
Revista M??dica Electr?3nica , 2011,
Abstract: Se presenta un paciente de 42 a os con el diagnóstico de un carcinoma epidermoide bien diferenciado de conducto auditivo externo (CAE), diagnosticado en junio de 2008. El mismo recibió radioterapia como tratamiento con intención curativa a dosis radical 66 Gy. En enero de 2010, comenzó con aumento de volumen exagerado del conducto auditivo externo, discutiéndose en los servicios de Neurocirugía, Radioterapia y Cirugía Reconstructiva del Instituto Nacional de Oncología y Radiobiología. Al paciente se le realiza la exéresis total del tumor, una radioterapia intraoperatoria fraccionada con electrones (EIORT) y reconstrucción local con colgajo músculo cutáneo del pectoral mayor. El tratamiento resultó ser tolerado por el paciente aumentándole su expectativa y calidad de vida. A 42 year-old patient is presented with the diagnostic of an Epidermoid Carcinoma of the external auditory canal on June 2008. He had got a radical radiotherapy as treatment with a completely response but in January 2010 he return with the tumour in the same place. It was the reason to discuss this patient in different department as Neurosurgery, Radiotherapy and Reconstructive Surgery. This patient received a total remove of the tumour, Intraoperative Radiotherapy with electron (EIORT) and a local reconstruction with mayor Pectoral Muscle. As Result the treatments were bear by the patient increasing his expectative and quality life.
Radioterapia de intensidad modulada: resultados preliminares de los primeros pacientes atendidos en Cuba Intensity Modulated Radiotherapy: preliminary results of the first patients in Cuba
Misleidy Nápoles Morales,Eduardo Larrinaga Cortina,Rodolfo Alfonso Laguardia,Carlos Calderón Marín
Revista Cubana de Medicina , 2012,
Abstract: Introducción: la radioterapia de intensidad modulada es una técnica moderna donde se modula la intensidad de haz de radiaciones para irradiar el tejido tumoral y disminuir al máximo la dosis recibida por los tejidos sanos. El Instituto de Oncología y Radiobiología (INOR), pionero en emplear la técnica en Latinoamérica, presenta sus resultados preliminares. Métodos: se presentó un estudio prospectivo realizado en 31 pacientes a los cuales se les diagnosticó un tumor de cabeza y cuello y fueron tratados con radioterapia de intensidad modulada, desde mayo de 2008 hasta mayo de 2010. Resultados: las edades de los pacientes incluidos en el estudio estaban comprendidas entre los 45 y 70 a os con una mediana de 58 a os. Predominó el sexo masculino con 87 %. Las etapas clínicas localmente avanzadas fueron las más frecuentes. Con el empleo de esta técnica no hubo interrupción del tratamiento por toxicidades o complicaciones importantes. El 89 % de los pacientes mantiene controlada su enfermedad y solo 4 de ellos tuvieron recaída: 3, locorregionalmente y 1 a distancia. Las complicaciones más frecuentes durante el tratamiento fueron la radiomucositis, la disfagia y la disfonía, pero generalmente toleradas por los pacientes con el suministro de tratamientos de sostén. La xerostomía no se presentó en estos pacientes porque en la planificación de la técnica se protegen las parótidas como órganos de riesgo (OR). Conclusiones: el mayor control locorregional del tumor y la disminución de las complicaciones durante el tratamiento indican la superioridad de la técnica. Introduction: the intensity modulated radiotherapy (IMRT) is a current technique where the beam radiations intensity to irradiate the tumoral tissue and to decrease at maximum the dose received by healthy tissues. The Institute of Oncology and Radiobiology (INOR), pioneer in the use of this technique in Latin America, offers its preliminary results. Methods: a prospective study was conducted in 31 patients diagnosed with a head and neck tumor treated with radiotherapy of modulated intensity from May, 2008 to May, 2010. Results: ages of patients included in present study were between 45-70 years with a mean of 58 years. There was predominance of male sex for a 87%. The clinical stages locally advances were the more frequent. With the use of this technique there was not interruption of treatment from toxicities or significant complications. The 89 % of patients maintain controlled its diseases and only 4 of them had relapses: three in a loco-regional way and another one at distance. The more frequent complica
Radioterapia de intensidad modulada en el tratamiento de tumores en pediatría, primeros casos en Cuba: first cases in Cuba Intensity Modulated Radiotherapy in treatment of tumors in children
José Alert Silva,Ivonne Chon Rivas,Misleidy Nápoles Morales,Lourdes Pérez Pe?a
Revista Cubana de Pediatr?-a , 2011,
Abstract: INTRODUCCIóN. La radioterapia de intensidad modulada (IMRT) constituye una técnica de alta precisión basada en la definición volumétrica tridimensional de la anatomía del tumor y de los órganos críticos o en riesgo. Con el objetivo de asegurar la posibilidad de aplicar la IMRT en Cuba, en casos seleccionados de tumores en ni os y adolescentes, se instrumentó un proyecto de investigación cuyos resultados se documentan en este informe. MéTODOS. Se realizaron las primeras irradiaciones con IMRT en ni os y adolescentes cubanos, con edades entre 6 y 18 a os. La técnica empleada es la basada en aperturas geométricas y optimización inversa. Las irradiaciones fueron realizadas con un acelerador lineal con fotones de 6 MV, con colimador multiláminas. Las dosis de radiaciones administradas variaron según el tipo de tumor, y de acuerdo con las normas de radioterapia y la presencia de órganos críticos. Todos los pacientes fueron evaluados semanalmente, con controles radiológicos mediante placas portales electrónicas. RESULTADOS. Los pacientes irradiados (5) tenían los tumores siguientes: linfoma no-Hodgking del seno maxilar (1), glioma del tallo cerebral (1), linfoma no-Hodgking abdominal (1), condrosarcoma mesenquimatoso parameníngeo (1) y hemangiopericitoma parameníngeo (1). Las dosis de irradiación recibidas variaron entre 24 y 62 Gy. Fueron empleados entre 5 y 8 campos, con variaciones entre 10 y 20 segmentos. CONCLUSIONES. Se realizaron en Cuba las primeras irradiaciones con IMRT en ni os y adolescentes, y se debe continuar extendiendo su empleo en aquellos casos donde su utilidad sea mayor. INTRODUCTION. The intensity modulated radiotherapy (IMRT) is a high performance technique based on the three-dimensional volumetric definition of tumor anatomy and of critical organs or at risk. To assure the possibility to apply the IMRT in Cuba in selected cases of tumors in children and adolescents, authors designed a research project whose results are documented in present report. METHODS. The first irradiations with IMRT in Cuban children and adolescents aged between 6 -18 were carried out. The technique used is that based on the geometric openings and inverse optimization. Irradiations were applied using a linear accelerator with 6 MV photons, with multileaf collimator. Doses administered varied according to the type of tumor, the radiotherapy standards and the presence of critical organs. All patients were assessed weekly with radiologic controls using electronic portal plates. RESULTS. Irradiated patients (5) had the following tumors: non-Hodgkin lymphoma of maxill
Síndrome de Rokitansky y Fibroma Pélvico Rokitansky syndrome and pelvic fibroma
Misleidy Nápoles Morales,Israel Díaz Ortega,Mario Silveira Pablos,Kenia Aguilar Fabré
Revista Cubana de Obstetricia y Ginecolog?-a , 2010,
Abstract: Se presenta una paciente de 39 a os de edad con síndrome de Rokitansky diagnosticada desde el a o 1984, la cual es valorada en el INOR por la presencia de una lesión tumoral pélvica que resultó ser un fibroleioma de la pared. This is the case of a female patient presenting with Rokitansky syndrome diagnosed from 1984, evaluated in the National Institute of Oncology and Radiobiology (NIOR) by presence of pelvic tumor lesion became a wall fibroleiomyoma.
PET/CT and Hypo-Fractionated Radiotherapy of Patients with Head and Neck Cancer  [PDF]
Misleidy Nápoles Morales, Aldo Martínez Ramirez, Juan P. Oliva Glez, Claudia González Espinosa, Joaquín González González, Carlos Fabián Calderón Marín, Waldo Quesada Cepero, Fanny López Reina, Rubén Elzaurdín Mora
International Journal of Clinical Medicine (IJCM) , 2018, DOI: 10.4236/ijcm.2018.910062
Abstract: Positron emission tomography/Computer tomography (PET/CT) is a multimodality imaging diagnostic technique that analyzes the uptake and retention of different radiopharmaceuticals by cells providing metabolic information on biochemical processes. PET/CT has been used for radiotherapy planning, providing useful information to the Radio-oncologist about the localization, size and metabolic activity of tumor lesions. In this paper, we show advantages of the 18F-FDG PET/CT respect to simple CT imaging for target volume delineation in patients with diagnosis of Squamous Head and Neck Carcinoma that has been scheduled to undergo a hypofractionated radiotherapy treatment. On ten studied patients, the target volume defined from PET/CT images was less extensive than those defined from simple CT images. In six patients the target volume was significantly less extensive and in two of them a new lymph node disease was reported, re-staging and corresponding target volume was also delineated with less extensive margins from PET/CT images. A greater accuracy in delineating the volumes and improving the distribution of doses in the planning of the radiant treatment in these patients was possible, allowing a high precision in the delivery of the prescribed dose to the target volume diminishing the maximum dose to the adjacent healthy tissues. In conclusion we show that the use of 18F-FDG PET/CT was superior than the simple CT as the primary modality of imaging for hypofractioned radiotherapy treatment planning in patients with Squamous Head and Neck Carcinoma.
Radioterapia de intensidad modulada: resultados preliminares de los primeros pacientes atendidos en Cuba
Nápoles Morales,Misleidy; Larrinaga Cortina,Eduardo; Alfonso Laguardia,Rodolfo; Calderón Marín,Carlos; Tornes Bueno,Maricel; Ropero Toirac,Ramón de Jesús;
Revista Cubana de Medicina , 2012,
Abstract: introduction: the intensity modulated radiotherapy (imrt) is a current technique where the beam radiations intensity to irradiate the tumoral tissue and to decrease at maximum the dose received by healthy tissues. the institute of oncology and radiobiology (inor), pioneer in the use of this technique in latin america, offers its preliminary results. methods: a prospective study was conducted in 31 patients diagnosed with a head and neck tumor treated with radiotherapy of modulated intensity from may, 2008 to may, 2010. results: ages of patients included in present study were between 45-70 years with a mean of 58 years. there was predominance of male sex for a 87%. the clinical stages locally advances were the more frequent. with the use of this technique there was not interruption of treatment from toxicities or significant complications. the 89 % of patients maintain controlled its diseases and only 4 of them had relapses: three in a loco-regional way and another one at distance. the more frequent complications during the treatment were the radio-mucositis, dysphagia and dysphonia, but in general were tolerated by patients with the supply of support treatment. the xerostomia wa not present in these patients due to in the planning of technique the parotid glands are protected like risk organs (ro). conclusions: the great loco-regional control of tumor and the decrease of complications during treatment indicates the superiority of the technique.
Síndrome de Rokitansky y Fibroma Pélvico
Nápoles Morales,Misleidy; Díaz Ortega,Israel; Silveira Pablos,Mario; Aguilar Fabré,Kenia; Montero León,Jorge Felipe; Santana Gómez,José Luis; Jiménez Galainena,Julio;
Revista Cubana de Obstetricia y Ginecolog?-a , 2010,
Abstract: this is the case of a female patient presenting with rokitansky syndrome diagnosed from 1984, evaluated in the national institute of oncology and radiobiology (nior) by presence of pelvic tumor lesion became a wall fibroleiomyoma.
Manejo multidisciplinario en la recidiva de carcinoma epidermoide de conducto auditivo externo. Presentación de un caso
Nápoles Morales,Misleidy; Cruz García,Orlando; Alfonso Coto,Juan Carlos; Morales,Pedro Pablo; Calderón Marín,Carlos F; Larrinaga Cortinas,Eduardo; Marinillo Guerrero,Jorge Juan; Santodomingo Reyna,Betty;
Revista M??dica Electr?3nica , 2011,
Abstract: a 42 year-old patient is presented with the diagnostic of an epidermoid carcinoma of the external auditory canal on june 2008. he had got a radical radiotherapy as treatment with a completely response but in january 2010 he return with the tumour in the same place. it was the reason to discuss this patient in different department as neurosurgery, radiotherapy and reconstructive surgery. this patient received a total remove of the tumour, intraoperative radiotherapy with electron (eiort) and a local reconstruction with mayor pectoral muscle. as result the treatments were bear by the patient increasing his expectative and quality life.
Radioterapia de intensidad modulada en el tratamiento de tumores en pediatría, primeros casos en Cuba: first cases in Cuba
Alert Silva,José; Chon Rivas,Ivonne; Nápoles Morales,Misleidy; Pérez Pe?a,Lourdes; Larrinaga Cortina,Eduardo; Alfonso Laguardia,Rodolfo; Silvestre Patayo,Ileana; García Yip,Fernando; Lara Mas,Elier; Diaz Moreno,Rogelio;
Revista Cubana de Pediatr?-a , 2011,
Abstract: introduction. the intensity modulated radiotherapy (imrt) is a high performance technique based on the three-dimensional volumetric definition of tumor anatomy and of critical organs or at risk. to assure the possibility to apply the imrt in cuba in selected cases of tumors in children and adolescents, authors designed a research project whose results are documented in present report. methods. the first irradiations with imrt in cuban children and adolescents aged between 6 -18 were carried out. the technique used is that based on the geometric openings and inverse optimization. irradiations were applied using a linear accelerator with 6 mv photons, with multileaf collimator. doses administered varied according to the type of tumor, the radiotherapy standards and the presence of critical organs. all patients were assessed weekly with radiologic controls using electronic portal plates. results. irradiated patients (5) had the following tumors: non-hodgkin lymphoma of maxillary sinus (1), brain stem glioma (1), non-hodgkin abdominal lymphoma (1), parameningeal mesenchymatous chondrosarcoma (1) and parameningeal hemangiopericytoma (1). doses of radiation applied varied between 24 and 62 gy. between 5 and 8 fields were used with variations among 10 and 20 segments. conclusions. in cuba the first irradiations with imrt in children and adolescents and its use must to be spreading to those cases where its usefulness is greater.
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