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Search Results: 1 - 10 of 1034 matches for " Mirjana Radenkovic "
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The Effect of Ginkgo Biloba (EGb 761) on Epileptic Activity in Rabbits
Vesna Ivetic,Mira Popovic,Nada Naumovic,Mirjana Radenkovic,Vesna Vasic
Molecules , 2008, DOI: 10.3390/molecules13102509
Abstract: Different animal models are used to evaluate the process of epileptogenesis. In this investigation the kindling model of epilepsy was used. The epileptic focus was induced in Chinchilla rabbits by stimulation of the hippocampus with electric stimuli. We presumed that the extracts of Ginkgo biloba affect the formation of kindling epilepsy. Bioelectric activity of the brain was registered throughout the development of kindling with and without standardized extracts from dried ginkgo leaves (EGb 761). For each animal the following has been determined: the values of the minimum current strength necessary for the origination of threshold after-discharge (AD) – discharges appearing after the cessation of stimulation; duration of the threshold AD; number of stimulations necessary for the origination of full kindling; time latency for the development of full kindling; number of spontaneous epileptogenic discharges manifested in EEG two days following the formation of full kindling during 60-minute registration. The results show that the process of epileptogenesis was influenced by EGb 761. It has been established that if the animals received EGb 761, significantly weaker minimum current strength was necessary for the development of the epileptogenic focus and the AD were longer, while the number of necessary electrostimulations for the appearance of full kindling was less and the latency was shorter.
Milan Ciric,Slavimir Veljkovic,Mirjana Radenkovic,Snezana Cekic
Acta Medica Medianae , 2004,
Abstract: The effects of verapamil on glomerular changes and tubular system in rats were analyzed in gentamicin nephrotoxicity. Epithel desquamation of proximal tubules and degenerative changes in glomerular was detected in animals treated by gentamicin (100 mg/kg body mass/24h). In animals, treated by gentamicin, the decreasing of sodium and potassium appeared in comparison to the control group. The combination of verapamil and gentamicin resulted in lower kidney damage than gentamicin itself, so the level of sodium concentration in serum and potassium concentration was higher in the third experimental group. Nephron morphological changes were lower by simultaneous treatment of gentamicin and verapamil. Consequently, the obtaind results support hypothesis that verapamil is a protective factor in gentamicin nephrotoxicity.
Milan Ciric,Slavimir Veljkovic,Mirjana Radenkovic,Snezana Cekic
Acta Medica Medianae , 2004,
Abstract: The aim of the research is to analyze glomerular and tubular epithel changes in Gentamicin nephrotoxicity. Degenerative changes were detected in cortex of animals treated by Gentamicin were detected (100 mg/kg body mass/24 h). The nephron morphological changes were the most intensified in tubular system: as desquamation of proximal tubules and necrosis in glomerular capillary loops. In animals, treated by Gentamicin the decreasing of sodium serum concentration (p<0,01) and potassium (p<0,05) took place while there was the increasing of urea (p<0,001) and creatinine (p<0,001) comparing to the control group. Our biochemical and morphological findings support hypothesis that Gentamicin causes exacerbation of renal function and lead to kidney insufficiency.
Mirjana Radenkovic,Slavimir Veljkovi?,Ranka Samrdzic,Milan ?iri?
Acta Medica Medianae , 2000,
Abstract: The influence of the non-selective blocker of the muscarinic receptors, namely of the atropine (1,7 x10-10 - 5x10-7). upon thependulousmovements of the proximal and of the distal colon of the rabbit was studied. In the correct proportion to the concentration the atropine reduces the amplitude of both the proximal (r=0,98; P<0,001) and of the distal colon (r= 0,97; P < 0,001). On the basis of the ED50 values - that amount to 7,7 ± 0,03 x 10-7 M for the proximal colon and 3,5 ± 0,06 x 10-5 M for the distal colon, the atropine recluces for twenty times the amplitude of the pendulousmovements of the rabbit's distal colon. Likewise, it reduces for dozen times the frequency of the pendulous movements of the distal colon (ED50 = 5 ± 0,02 x 10-6M) with respect to the proximal one (ED50 = 4,7 ± 0,06 x I0-5M). The atropine does not change the tone of the proximal colon (average relaxation is 5,47 ± 2,32 %) while it induces the concentrically-dependent relaxation of the distal colon (maximal relaxation amounts to 38.03 + 8,34). The ED50 values for the atropine while affecting the distal colon tone is 1,7 ± 0,03 x 10-6M.
Natural radioactivity of some spring and bottled mineral waters from several central Balkan sites, as a way of their characterization
Journal of the Serbian Chemical Society , 2007,
Abstract: In this work, a study of the radioactive content of some spring and bottled mineral waters originating frommetamorphic rock areas was carried out.Ahigh content of radium isotopes (226Ra, 228Ra), was found by radiometric analysis in the spring waters: Studenica (226Ra: 289 mBq/L), ^ibutkovica (226Ra: 92, 4 mBq/L, 228Ra: 610 mBq/L), and Crni Guber (226Ra: 120 mBq/L, 228Ra: 1170 mBq/L). On the other hand, the radiochemical results showed a higher concentration of 238U in the bottled mineral water samples (dissolved uranium concentrations were from 0.21 mBq/L, for "Kopaonik" to 71.5mBq/L fo "Skadarska") than in the spring water samples (dissolved uranium concentrations were very low 10 mBq/L). The concentrations of all the present naturally occuring radionuclides: 238U, 234U, 232Th, 230Th, 228Th, 228Ra and 226Ra were determined by alpha/gamma spectrometric analysis. The activity ratios 234U/238U, 226Ra/230Th and 228Th/232Th, 228Ra/228Th were calculated and are discussed as an indication of the radioactive disequilibrium in bothe the 238U and 232Th radioactive series. The high contents of radium isotopes with respect to the equilibrium values expected from the respective parents 232Th/(232Th series) and 230Th (238U series) found in the spring water samples is the main evidence for the existence of significant radioactive disequilibrium in both the radioactive series.
Depleted uranium in the air during the cleanup operations at Cape Arza
Journal of the Serbian Chemical Society , 2004,
Abstract: Cape Arza was contaminated with depleted uranium (DU) in the air strikes of NATO aeroplanes on May 30, 1999. The cleanup and decontamination of the site started in 2001. Here the results of air monitoring performed during the cleanup operations in Spring 2002. are presented. The collected air samples were analyzed by high-resolution alpha spectrometry. The obtained concentrations of airborne uranium are about ten times higher than the average value usually reported for air. The ratio of the 234U/238U activities indicates the presence of depleted uranium in the air during the cleanup action, due to resuspension and soil disturbance in the contaminated teritory.
Relaxant Effect of the Ethanol Extract of Helichrysum plicatum (Asteraceae) on Isolated Rat Ileum Contractions
Dubravka Bigovic,Suzana Brankovic,Dusanka Kitic,Mirjana Radenkovic,Teodora Jankovic,Katarina Savikin,Slavoljub Zivanovic
Molecules , 2010, DOI: 10.3390/molecules15053391
Abstract: Helichrysum plicatum (Turkish Helichrysum) has been used in folk medicine for the treatment of gastric and hepatic disorders. The aim of the present study was to examine the relaxant activity of an extract of H. plicatum flowers on isolated rat ileum. Segments of ileum of rats were suspended in an organ bath. Cumulative concentrations of H. plicatum ethanol extract induced a relaxant effect on spontaneous rat ileum contractions. H. plicatum extract caused a mean contractile response of 81.68 ± 6.17% (at a dose of 0.01 mg/mL) and 30.08 ± 9.07% (at a dose of 1 mg/mL). A similar effect was observed with papaverine (0.01–3 μg/mL). H. plicatum extract (0.01–1 mg/mL) relaxed high K+ (80 mM) precontractions, an effect similar to that caused by papaverine (0.01–3 μg/mL). The plant extract (0.03–0.3 mg/mL) also induced a significant depression of the cumulative concentration response curve for acetylcholine (5–1500 nM) (p < 0.01). Atropine (140 nM) abolished the acetylcholine effect. The extract (0.03–0.3 mg/mL) reduced the histamine (1–300 nM) and BaCl2 (3–900 μM) induced contractions (p < 0.01). Our results showed the relaxant effect of the ethanol extract of Helichrysum plicatum flowers on the isolated rat intestine Extract of H. plicatum can inhibit the spontaneous ileum contractions and contractions induced by acetylcholine, histamine, barium and potassium ions.
Inhibitory Effect of Ginkgo Biloba Extract on the Tonus of the Small Intestine and the Colon of Rabbits
Vladimir Pilija,Radenkovic Mirjana,Maja Djurendic Brenesel,Mira Popovic,Vesna Ivetic,Svetlana Trivic
Molecules , 2010, DOI: 10.3390/molecules15042079
Abstract: Ginkgo biloba is widely used in folk medicine. Patients very often use the plant preparation with no concern for purity. They also tend to increase the dosage by themselves and this may result in certain insufficiently researched acute effects. Due to this extremely widespread application, the aim of this work is an examination of the possible acute effects of Ginkgo bilobaon the motility of the small and the large intestine of rabbits. Тhe effects of Gingium? - a standardized ginkgo biloba extract (GBE) [one milliliter preparation contained 8.8–10.8 mg ginkgo flavonol glycoside and 2.0–2.8 mg lactone ring-containing terpenes (ginkgolides and bilobalides)], on the tonus of isolated segments of the ileum and the colon of rabbits were examined. The experiments were carried out on isolated bowel incisions according to the Magnus method. Data was registered by physiography (Narco-Bio-System). Our results show that GBE (0.006 g/L, - 0.06 g/L) concentration-dependently reduces the tonus of the ileum and the colon of rabbits. Apart from that, GBE reduces the increase of the tonus of the ileum caused by acetylcholine (ACh), but does not change colon tonus intensified by ACh. This indicates that the effects of the used extract in the ileum are predominantly achieved through cholinergic mechanisms, while the relaxant effects in the colon are achieved in some other way.
A Numerical Method for Singular Boundary-Value Problems  [PDF]
Abdalkaleg Hamad, M. Tadi, Miloje Radenkovic
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.29100

This note is concerned with an iterative method for the solution of singular boundary value problems. It can be considered as a predictor-corrector method. Sufficient conditions for the convergence of the method are introduced. A number of numerical examples are used to study the applicability of the method.

Peut-on former à la différence ? Peut-on penser la différence dans la mobilité ? Can we train for difference ? Can we imagine difference in student mobility ?
Aline Gohard-Radenkovic
Recherche et Pratiques Pédagogiques en Langues de Spécialité : Cahiers de l'APLIUT , 2011, DOI: 10.4000/apliut.1041
Abstract: Les expériences individuelles de la mobilité se sont démultipliées, rendant la différence plus banale. Malgré ce changement de paradigme, les représentations négatives de l’autre différent, héritées d’un passé colonial, peuvent perdurer. L’anthropologie donne les moyens de penser l’autre différent, mais penser la différence, c’est aussi penser l’impensé (Laplantine 1987). Notre champ, la didactique des langues, est directement concerné : nous devons non seulement penser l’impensé mais aussi repenser le déjà pensé. Mais comment faire prendre conscience aux futurs candidats à la mobilité de ces dimensions cachées qui sous-tendent toute communication avec l’autre ? à travers des exemples concrets, je montrerai comment une approche autobiographique (récits de vie) peut développer une attitude réflexive, permettant à nos étudiants de déconstruire leurs évidences, de repenser la relation du moi à l’autre et vivre l’expérience d’une mobilité identitaire. Individual experiences of student mobility have become more and more frequent, making contact with difference more usual. In spite of this change of paradigm, negative representations of the “other as different”, inherited from a colonial past, still exist. Anthropology gives us the means to think of the “other as different”, but thinking the difference is also thinking what has not been thought (Laplantine 1987). Our field, language didactics, is directly concerned : we must not only work on the “not thought” but also work on the “already thought”. How can we make our future candidates for mobility aware of these hidden dimensions, present in any communication with the other ? Through concrete examples, we shall show how an autobiographical approach (narratives) may develop introspection, allowing our students to deconstruct their prejudices, to rethink the relationship of “myself” to the other, and to experience another identity through mobility.
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